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Showing 1 to 12 of 235 entries
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School‐based obesity prevention programs: A meta‐analysis of randomized controlled trials

after-school interventions

Rabinowitz J.
GSID: N0SjPfdpZ30J
S Sobol‐Goldberg, J Rabinowitz, R Gross - Obesity, 2013 - Wiley Online Library

Objective Attempts have been made to reduce childhood obesity through school‐based programs. Systematic reviews of studies until 2006 reported a lack of consistency about …

Environmental, demographic, and medical factors related to cord blood lead levels.

Biological trace element research

Rabinowitz MB, Needleman HL.
PMID: 24263747
Biol Trace Elem Res. 1984 Feb;6(1):57-67. doi: 10.1007/BF02918321.

Blood lead was measured at birth for 11,837 infants in Boston. Extensive maternal demographic, pregnancy, and delivery characteristics were recorded for 4354 of them. For 249 of these, intensive environmental sampling was done. Many medical factors were unrelated to...

Manual specialisation and tool use in captive chimpanzees (Pan troglodytes): the effect of unimanual and bimanual strategies on hand preference.

Laterality

Hopkins WD, Rabinowitz DM.
PMID: 15513068
Laterality. 1997;2(3):267-77. doi: 10.1080/713754273.

Hand preference for tool use was assessed in a sample of captive chimpanzees (Pan troglodytes). Whether the subjects solved the tool task using either a unimanual or coordinated bimanual strategy was manipulated in the chimpanzees. No population-level hand preference...

Evidence for Intracellular and Extracellular Dimethylsulfoniopropionate (DMSP) Lyases and DMSP Uptake Sites in Two Species of Marine Bacteria.

Applied and environmental microbiology

Yoch DC, Ansede JH, Rabinowitz KS.
PMID: 16535674
Appl Environ Microbiol. 1997 Aug;63(8):3182-8. doi: 10.1128/aem.63.8.3182-3188.1997.

The kinetics of dimethylsulfoniopropionate (DMSP) uptake and dimethylsulfide (DMS) production from DMSP in two bacterial species, Alcaligenes sp. strain M3A, an isolate from estuarine surface sediments, and Pseudomonas doudoroffii, from seawater, were investigated. In Alcaligenes cells induced for DMSP...

Pharmacotherapy for alcohol dependence.

Psychiatry (Edgmont (Pa. : Township))

Wortman SM, Rabinowitz AR, Oslin DW.
PMID: 21179631
Psychiatry (Edgmont). 2005 Feb;2(2):20-3.

Alcoholism is a major public health problem that is detrimental to the affected individuals as well as to society as a whole. It has been popular belief that alcohol dependence can be controlled through will power, skill building, and...

High-throughput models for exposure-based chemical prioritization in the ExpoCast project.

Environmental science & technology

Wambaugh JF, Setzer RW, Reif DM, Gangwal S, Mitchell-Blackwood J, Arnot JA, Joliet O, Frame A, Rabinowitz J, Knudsen TB, Judson RS, Egeghy P, Vallero D, Cohen Hubal EA.
PMID: 23758710
Environ Sci Technol. 2013 Aug 06;47(15):8479-88. doi: 10.1021/es400482g. Epub 2013 Jul 11.

The United States Environmental Protection Agency (U.S. EPA) must characterize potential risks to human health and the environment associated with manufacture and use of thousands of chemicals. High-throughput screening (HTS) for biological activity allows the ToxCast research program to...

Neuropsychological Recovery Trajectories in Moderate to Severe Traumatic Brain Injury: Influence of Patient Characteristics and Diffuse Axonal Injury - Erratum.

Journal of the International Neuropsychological Society : JINS

Rabinowitz AR, Hart T, Whyte J, Kim J.
PMID: 29690938
J Int Neuropsychol Soc. 2019 Oct;25(9):998. doi: 10.1017/S1355617718000346. Epub 2018 Apr 25.

No abstract available.

The 2-oxoglutarate analog 3-oxoglutarate decreases normoxic hypoxia-inducible factor-1α in cancer cells, induces cell death, and reduces tumor xenograft growth.

Hypoxia (Auckland, N.Z.)

Koivunen P, Fell SM, Lu W, Rabinowitz JD, Kung AL, Schlisio S.
PMID: 27525289
Hypoxia (Auckl). 2016;4:15-27. doi: 10.2147/HP.S96366. Epub 2016 Mar 04.

The cellular response to hypoxia is primarily regulated by the hypoxia-inducible factors (HIFs). HIF-1α is also a major mediator of tumor physiology, and its abundance is correlated with therapeutic resistance in a broad range of cancers. Accumulation of HIF-1α...

Minor Isozymes Tailor Yeast Metabolism to Carbon Availability.

mSystems

Bradley PH, Gibney PA, Botstein D, Troyanskaya OG, Rabinowitz JD.
PMID: 30834327
mSystems. 2019 Feb 26;4(1). doi: 10.1128/mSystems.00170-18. eCollection 2019.

Isozymes are enzymes that differ in sequence but catalyze the same chemical reactions. Despite their apparent redundancy, isozymes are often retained over evolutionary time, suggesting that they contribute to fitness. We developed an unsupervised computational method for identifying environmental...

Enhancing Chimeric Antigen Receptor T Cell Anti-tumor Function through Advanced Media Design.

Molecular therapy. Methods & clinical development

Ghassemi S, Martinez-Becerra FJ, Master AM, Richman SA, Heo D, Leferovich J, Tu Y, García-Cañaveras JC, Ayari A, Lu Y, Wang A, Rabinowitz JD, Milone MC, June CH, O'Connor RS.
PMID: 32775494
Mol Ther Methods Clin Dev. 2020 Jul 09;18:595-606. doi: 10.1016/j.omtm.2020.07.008. eCollection 2020 Sep 11.

Effective chimeric antigen receptor (CAR)-T cell therapy is dependent on optimal cell culture methods conducive to the activation and expansion of T cells

Beyond Traditional Structure-Based Drug Design: The Role of Iron Complexation, Strain, and Water in the Binding of Inhibitors for Hypoxia-Inducible Factor Prolyl Hydroxylase 2.

ACS omega

Bembenek SD, Venkatesan H, Peltier HM, Rosen MD, Barrett TD, Kanelakis KC, Palomino HL, Brondstetter TI, Mirzadegan T, Rabinowitz MH.
PMID: 31179408
ACS Omega. 2019 Apr 30;4(4):6703-6708. doi: 10.1021/acsomega.9b00199. Epub 2019 Apr 12.

A combination of structure-based drug design and medicinal chemistry efforts led us from benzimidazole-2-carboxamide with modestly active hypoxia-inducible factor prolyl hydroxylase 2 inhibition to certain benzimidazole-2-pyrazole carboxylic acids that were more potent as well as orally efficacious stimulators of...

Incidence of Significant Findings of Microhematuria Workup in Women-What Guidelines Work Best?.

Urology

Rabinowitz DE, Buford K, Wood AM, Marziliano A, Perez-Orozco A, Diefenbach MA, Han J, Hall SJ, Polland A.
PMID: 32653567
Urology. 2021 May;151:19-23. doi: 10.1016/j.urology.2020.06.046. Epub 2020 Jul 09.

OBJECTIVE: To apply the American Urogynecological Society (AUGS)/American College of Obstetricians and Gynecologists (ACOG) recommendations of foregoing workup in patients under 50 years of age with less than 25 red cells per high-powered field, to a cohort of asymptomatic...

Showing 1 to 12 of 235 entries