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Detection of phenotype-specific therapeutic vulnerabilities in breast cells using a CRISPR loss-of-function screen.

Molecular oncology

Barkovskaya A, Goodwin CM, Seip K, Hilmarsdottir B, Pettersen S, Stalnecker C, Engebraaten O, Briem E, Der CJ, Moestue SA, Gudjonsson T, Maelandsmo GM, Prasmickaite L.
PMID: 33759347
Mol Oncol. 2021 Aug;15(8):2026-2045. doi: 10.1002/1878-0261.12951. Epub 2021 May 01.

Cellular phenotype plasticity between the epithelial and mesenchymal states has been linked to metastasis and heterogeneous responses to cancer therapy, and remains a challenge for the treatment of triple-negative breast cancer (TNBC). Here, we used isogenic human breast epithelial...

Cite
Barkovskaya A, Goodwin CM, Seip K, et al. Detection of phenotype-specific therapeutic vulnerabilities in breast cells using a CRISPR loss-of-function screen. Mol Oncol. 2021;15(8):2026-2045doi: 10.1002/1878-0261.12951.
Barkovskaya, A., Goodwin, C. M., Seip, K., Hilmarsdottir, B., Pettersen, S., Stalnecker, C., Engebraaten, O., Briem, E., Der, C. J., Moestue, S. A., Gudjonsson, T., Maelandsmo, G. M., & Prasmickaite, L. (2021). Detection of phenotype-specific therapeutic vulnerabilities in breast cells using a CRISPR loss-of-function screen. Molecular oncology, 15(8), 2026-2045. https://doi.org/10.1002/1878-0261.12951
Barkovskaya, Anna, et al. "Detection of phenotype-specific therapeutic vulnerabilities in breast cells using a CRISPR loss-of-function screen." Molecular oncology vol. 15,8 (2021): 2026-2045. doi: https://doi.org/10.1002/1878-0261.12951
Barkovskaya A, Goodwin CM, Seip K, Hilmarsdottir B, Pettersen S, Stalnecker C, Engebraaten O, Briem E, Der CJ, Moestue SA, Gudjonsson T, Maelandsmo GM, Prasmickaite L. Detection of phenotype-specific therapeutic vulnerabilities in breast cells using a CRISPR loss-of-function screen. Mol Oncol. 2021 Aug;15(8):2026-2045. doi: 10.1002/1878-0261.12951. Epub 2021 May 01. PMID: 33759347; PMCID: PMC8333781.
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New Anti-Chemokine Oral Drug XC8 in the Treatment of Asthma Patients with Poor Response to Corticosteroids: Results of a Phase 2A Randomized Controlled Clinical Trial.

Pulmonary therapy

Romanova J, Chikina E, Rydlovskaya A, Pohl W, Renner A, Zeifman A, Chuchalin A, Nebolsin V.
PMID: 33095411
Pulm Ther. 2020 Dec;6(2):351-369. doi: 10.1007/s41030-020-00134-5. Epub 2020 Oct 23.

INTRODUCTION: A significant number of patients with moderate asthma remain symptomatic despite treatment with inhaled corticosteroids (ICS). These patients do not yet meet the criteria for oral corticosteroids (OCS) and monoclonal antibodies. The new anti-chemokine oral drug XC8 could...

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Romanova J, Chikina E, Rydlovskaya A, et al. New Anti-Chemokine Oral Drug XC8 in the Treatment of Asthma Patients with Poor Response to Corticosteroids: Results of a Phase 2A Randomized Controlled Clinical Trial. Pulm Ther. 2020;6(2):351-369doi: 10.1007/s41030-020-00134-5.
Romanova, J., Chikina, E., Rydlovskaya, A., Pohl, W., Renner, A., Zeifman, A., Chuchalin, A., & Nebolsin, V. (2020). New Anti-Chemokine Oral Drug XC8 in the Treatment of Asthma Patients with Poor Response to Corticosteroids: Results of a Phase 2A Randomized Controlled Clinical Trial. Pulmonary therapy, 6(2), 351-369. https://doi.org/10.1007/s41030-020-00134-5
Romanova, Julia, et al. "New Anti-Chemokine Oral Drug XC8 in the Treatment of Asthma Patients with Poor Response to Corticosteroids: Results of a Phase 2A Randomized Controlled Clinical Trial." Pulmonary therapy vol. 6,2 (2020): 351-369. doi: https://doi.org/10.1007/s41030-020-00134-5
Romanova J, Chikina E, Rydlovskaya A, Pohl W, Renner A, Zeifman A, Chuchalin A, Nebolsin V. New Anti-Chemokine Oral Drug XC8 in the Treatment of Asthma Patients with Poor Response to Corticosteroids: Results of a Phase 2A Randomized Controlled Clinical Trial. Pulm Ther. 2020 Dec;6(2):351-369. doi: 10.1007/s41030-020-00134-5. Epub 2020 Oct 23. PMID: 33095411; PMCID: PMC7671956.
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Final Report on the Key Comparison CCM.P-K4.2012 in Absolute Pressure from 1 Pa to 10 kPa.

Metrologia

Ricker J, Hendricks J, Bock T, Dominik P, Kobata T, Torres J, Sadkovskaya I.
PMID: 28216793
Metrologia. 2017;54. doi: 10.1088/0026-1394/54/1A/07002.

The report summarizes the Consultative Committee for Mass (CCM) key comparison CCM.P-K4.2012 for absolute pressure spanning the range of 1 Pa to 10 000 Pa. The comparison was carried out at six National Metrology Institutes (NMIs), including National Institute...

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Ricker J, Hendricks J, Bock T, et al. Final Report on the Key Comparison CCM.P-K4.2012 in Absolute Pressure from 1 Pa to 10 kPa. Metrologia. 2017;54doi: 10.1088/0026-1394/54/1A/07002.
Ricker, J., Hendricks, J., Bock, T., Dominik, P., Kobata, T., Torres, J., & Sadkovskaya, I. (2017). Final Report on the Key Comparison CCM.P-K4.2012 in Absolute Pressure from 1 Pa to 10 kPa. Metrologia, 54. https://doi.org/10.1088/0026-1394/54/1A/07002
Ricker, Jacob, et al. "Final Report on the Key Comparison CCM.P-K4.2012 in Absolute Pressure from 1 Pa to 10 kPa." Metrologia vol. 54 (2017). doi: https://doi.org/10.1088/0026-1394/54/1A/07002
Ricker J, Hendricks J, Bock T, Dominik P, Kobata T, Torres J, Sadkovskaya I. Final Report on the Key Comparison CCM.P-K4.2012 in Absolute Pressure from 1 Pa to 10 kPa. Metrologia. 2017;54. doi: 10.1088/0026-1394/54/1A/07002. PMID: 28216793; PMCID: PMC5312806.
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Superdirective dimers of coupled self-resonant split ring resonators: Analytical modelling and numerical and experimental validation.

Scientific reports

Vallecchi A, Radkovskaya A, Li L, Faulkner G, Stevens CJ, Shamonina E.
PMID: 31937860
Sci Rep. 2020 Jan 14;10(1):274. doi: 10.1038/s41598-019-56988-6.

Superdirective antennas developed over the last century have received renewed interest in recent years from the development of metamaterials. These arrays of electromagnetic resonators (or meta-atoms) carrying short wavelength electro- and/or magneto-inductive waves support current distributions with very high...

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Vallecchi A, Radkovskaya A, Li L, et al. Superdirective dimers of coupled self-resonant split ring resonators: Analytical modelling and numerical and experimental validation. Sci Rep. 2020;10(1):274doi: 10.1038/s41598-019-56988-6.
Vallecchi, A., Radkovskaya, A., Li, L., Faulkner, G., Stevens, C. J., & Shamonina, E. (2020). Superdirective dimers of coupled self-resonant split ring resonators: Analytical modelling and numerical and experimental validation. Scientific reports, 10(1), 274. https://doi.org/10.1038/s41598-019-56988-6
Vallecchi, A, et al. "Superdirective dimers of coupled self-resonant split ring resonators: Analytical modelling and numerical and experimental validation." Scientific reports vol. 10,1 (2020): 274. doi: https://doi.org/10.1038/s41598-019-56988-6
Vallecchi A, Radkovskaya A, Li L, Faulkner G, Stevens CJ, Shamonina E. Superdirective dimers of coupled self-resonant split ring resonators: Analytical modelling and numerical and experimental validation. Sci Rep. 2020 Jan 14;10(1):274. doi: 10.1038/s41598-019-56988-6. PMID: 31937860; PMCID: PMC6959271.
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High compression deep learning based single-pixel hyperspectral macroscopic fluorescence lifetime imaging .

Biomedical optics express

Ochoa M, Rudkouskaya A, Yao R, Yan P, Barroso M, Intes X.
PMID: 33149959
Biomed Opt Express. 2020 Sep 02;11(10):5401-5424. doi: 10.1364/BOE.396771. eCollection 2020 Oct 01.

Single pixel imaging frameworks facilitate the acquisition of high-dimensional optical data in biological applications with photon starved conditions. However, they are still limited to slow acquisition times and low pixel resolution. Herein, we propose a convolutional neural network for...

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Ochoa M, Rudkouskaya A, Yao R, et al. High compression deep learning based single-pixel hyperspectral macroscopic fluorescence lifetime imaging . Biomed Opt Express. 2020;11(10):5401-5424doi: 10.1364/BOE.396771.
Ochoa, M., Rudkouskaya, A., Yao, R., Yan, P., Barroso, M., & Intes, X. (2020). High compression deep learning based single-pixel hyperspectral macroscopic fluorescence lifetime imaging . Biomedical optics express, 11(10), 5401-5424. https://doi.org/10.1364/BOE.396771
Ochoa, M, et al. "High compression deep learning based single-pixel hyperspectral macroscopic fluorescence lifetime imaging ." Biomedical optics express vol. 11,10 (2020): 5401-5424. doi: https://doi.org/10.1364/BOE.396771
Ochoa M, Rudkouskaya A, Yao R, Yan P, Barroso M, Intes X. High compression deep learning based single-pixel hyperspectral macroscopic fluorescence lifetime imaging . Biomed Opt Express. 2020 Sep 02;11(10):5401-5424. doi: 10.1364/BOE.396771. eCollection 2020 Oct 01. PMID: 33149959; PMCID: PMC7587256.
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Epigenetic clock and DNA methylation analysis of porcine models of aging and obesity.

GeroScience

Schachtschneider KM, Schook LB, Meudt JJ, Shanmuganayagam D, Zoller JA, Haghani A, Li CZ, Zhang J, Yang A, Raj K, Horvath S, Kankovskaya A.
PMID: 34523051
Geroscience. 2021 Oct;43(5):2467-2483. doi: 10.1007/s11357-021-00439-6. Epub 2021 Sep 15.

DNA-methylation profiles have been used successfully to develop highly accurate biomarkers of age, epigenetic clocks, for many species. Using a custom methylation array, we generated DNA methylation data from n = 238 porcine tissues including blood, bladder, frontal cortex,...

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Schachtschneider KM, Schook LB, Meudt JJ, et al. Epigenetic clock and DNA methylation analysis of porcine models of aging and obesity. Geroscience. 2021;43(5):2467-2483doi: 10.1007/s11357-021-00439-6.
Schachtschneider, K. M., Schook, L. B., Meudt, J. J., Shanmuganayagam, D., Zoller, J. A., Haghani, A., Li, C. Z., Zhang, J., Yang, A., Raj, K., Horvath, S., & Kankovskaya, A. (2021). Epigenetic clock and DNA methylation analysis of porcine models of aging and obesity. GeroScience, 43(5), 2467-2483. https://doi.org/10.1007/s11357-021-00439-6
Schachtschneider, Kyle M, et al. "Epigenetic clock and DNA methylation analysis of porcine models of aging and obesity." GeroScience vol. 43,5 (2021): 2467-2483. doi: https://doi.org/10.1007/s11357-021-00439-6
Schachtschneider KM, Schook LB, Meudt JJ, Shanmuganayagam D, Zoller JA, Haghani A, Li CZ, Zhang J, Yang A, Raj K, Horvath S, Kankovskaya A. Epigenetic clock and DNA methylation analysis of porcine models of aging and obesity. Geroscience. 2021 Oct;43(5):2467-2483. doi: 10.1007/s11357-021-00439-6. Epub 2021 Sep 15. PMID: 34523051; PMCID: PMC8599541.
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Interface Driven Effects in Magnetization-Induced Optical Second Harmonic Generation in Layered Films Composed of Ferromagnetic and Heavy Metals.

Materials (Basel, Switzerland)

Mamonov E, Kolmychek I, Radovskaya V, Pashen'kin I, Gusev N, Maydykovskiy A, Temiryazeva M, Temiryazev A, Murzina T.
PMID: 34206723
Materials (Basel). 2021 Jun 26;14(13). doi: 10.3390/ma14133573.

Properties of nanolayers can substantially differ from those of bulky materials, in part due to pronounced interface effects. It is known that combinations of layers of heavy and ferromagnetic metals leads to the appearance of specific spin textures induced...

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Mamonov E, Kolmychek I, Radovskaya V, et al. Interface Driven Effects in Magnetization-Induced Optical Second Harmonic Generation in Layered Films Composed of Ferromagnetic and Heavy Metals. Materials (Basel). 2021;14(13)doi: 10.3390/ma14133573.
Mamonov, E., Kolmychek, I., Radovskaya, V., Pashen'kin, I., Gusev, N., Maydykovskiy, A., Temiryazeva, M., Temiryazev, A., & Murzina, T. (2021). Interface Driven Effects in Magnetization-Induced Optical Second Harmonic Generation in Layered Films Composed of Ferromagnetic and Heavy Metals. Materials (Basel, Switzerland), 14(13), . https://doi.org/10.3390/ma14133573
Mamonov, Evgeniy, et al. "Interface Driven Effects in Magnetization-Induced Optical Second Harmonic Generation in Layered Films Composed of Ferromagnetic and Heavy Metals." Materials (Basel, Switzerland) vol. 14,13 (2021). doi: https://doi.org/10.3390/ma14133573
Mamonov E, Kolmychek I, Radovskaya V, Pashen'kin I, Gusev N, Maydykovskiy A, Temiryazeva M, Temiryazev A, Murzina T. Interface Driven Effects in Magnetization-Induced Optical Second Harmonic Generation in Layered Films Composed of Ferromagnetic and Heavy Metals. Materials (Basel). 2021 Jun 26;14(13). doi: 10.3390/ma14133573. PMID: 34206723; PMCID: PMC8269653.
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Targeting p130Cas- and microtubule-dependent MYC regulation sensitizes pancreatic cancer to ERK MAPK inhibition.

Cell reports

Waters AM, Khatib TO, Papke B, Goodwin CM, Hobbs GA, Diehl JN, Yang R, Edwards AC, Walsh KH, Sulahian R, McFarland JM, Kapner KS, Gilbert TSK, Stalnecker CA, Javaid S, Barkovskaya A, Grover KR, Hibshman PS, Blake DR, Schaefer A, Nowak KM, Klomp JE, Hayes TK, Kassner M, Tang N, Tanaseichuk O, Chen K, Zhou Y, Kalkat M, Herring LE, Graves LM, Penn LZ, Yin HH, Aguirre AJ, Hahn WC, Cox AD, Der CJ.
PMID: 34192548
Cell Rep. 2021 Jun 29;35(13):109291. doi: 10.1016/j.celrep.2021.109291.

To identify therapeutic targets for KRAS mutant pancreatic cancer, we conduct a druggable genome small interfering RNA (siRNA) screen and determine that suppression of BCAR1 sensitizes pancreatic cancer cells to ERK inhibition. Integrative analysis of genome-scale CRISPR-Cas9 screens also...

Cite
Waters AM, Khatib TO, Papke B, et al. Targeting p130Cas- and microtubule-dependent MYC regulation sensitizes pancreatic cancer to ERK MAPK inhibition. Cell Rep. 2021;35(13):109291doi: 10.1016/j.celrep.2021.109291.
Waters, A. M., Khatib, T. O., Papke, B., Goodwin, C. M., Hobbs, G. A., Diehl, J. N., Yang, R., Edwards, A. C., Walsh, K. H., Sulahian, R., McFarland, J. M., Kapner, K. S., Gilbert, T. S. K., Stalnecker, C. A., Javaid, S., Barkovskaya, A., Grover, K. R., Hibshman, P. S., Blake, D. R., Schaefer, A., Nowak, K. M., Klomp, J. E., Hayes, T. K., Kassner, M., Tang, N., Tanaseichuk, O., Chen, K., Zhou, Y., Kalkat, M., Herring, L. E., Graves, L. M., Penn, L. Z., Yin, H. H., Aguirre, A. J., Hahn, W. C., Cox, A. D., & Der, C. J. (2021). Targeting p130Cas- and microtubule-dependent MYC regulation sensitizes pancreatic cancer to ERK MAPK inhibition. Cell reports, 35(13), 109291. https://doi.org/10.1016/j.celrep.2021.109291
Waters, Andrew M, et al. "Targeting p130Cas- and microtubule-dependent MYC regulation sensitizes pancreatic cancer to ERK MAPK inhibition." Cell reports vol. 35,13 (2021): 109291. doi: https://doi.org/10.1016/j.celrep.2021.109291
Waters AM, Khatib TO, Papke B, Goodwin CM, Hobbs GA, Diehl JN, Yang R, Edwards AC, Walsh KH, Sulahian R, McFarland JM, Kapner KS, Gilbert TSK, Stalnecker CA, Javaid S, Barkovskaya A, Grover KR, Hibshman PS, Blake DR, Schaefer A, Nowak KM, Klomp JE, Hayes TK, Kassner M, Tang N, Tanaseichuk O, Chen K, Zhou Y, Kalkat M, Herring LE, Graves LM, Penn LZ, Yin HH, Aguirre AJ, Hahn WC, Cox AD, Der CJ. Targeting p130Cas- and microtubule-dependent MYC regulation sensitizes pancreatic cancer to ERK MAPK inhibition. Cell Rep. 2021 Jun 29;35(13):109291. doi: 10.1016/j.celrep.2021.109291. PMID: 34192548; PMCID: PMC8340308.
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Detection of phenotype-specific therapeutic vulnerabilities in breast cells using a CRISPR loss-of-function screen.

Molecular oncology

Barkovskaya A, Goodwin CM, Seip K, Hilmarsdottir B, Pettersen S, Stalnecker C, Engebraaten O, Briem E, Der CJ, Moestue SA, Gudjonsson T, Maelandsmo GM, Prasmickaite L.
PMID: 33759347
Mol Oncol. 2021 Aug;15(8):2026-2045. doi: 10.1002/1878-0261.12951. Epub 2021 May 01.

Cellular phenotype plasticity between the epithelial and mesenchymal states has been linked to metastasis and heterogeneous responses to cancer therapy, and remains a challenge for the treatment of triple-negative breast cancer (TNBC). Here, we used isogenic human breast epithelial...

Cite
Barkovskaya A, Goodwin CM, Seip K, et al. Detection of phenotype-specific therapeutic vulnerabilities in breast cells using a CRISPR loss-of-function screen. Mol Oncol. 2021;15(8):2026-2045doi: 10.1002/1878-0261.12951.
Barkovskaya, A., Goodwin, C. M., Seip, K., Hilmarsdottir, B., Pettersen, S., Stalnecker, C., Engebraaten, O., Briem, E., Der, C. J., Moestue, S. A., Gudjonsson, T., Maelandsmo, G. M., & Prasmickaite, L. (2021). Detection of phenotype-specific therapeutic vulnerabilities in breast cells using a CRISPR loss-of-function screen. Molecular oncology, 15(8), 2026-2045. https://doi.org/10.1002/1878-0261.12951
Barkovskaya, Anna, et al. "Detection of phenotype-specific therapeutic vulnerabilities in breast cells using a CRISPR loss-of-function screen." Molecular oncology vol. 15,8 (2021): 2026-2045. doi: https://doi.org/10.1002/1878-0261.12951
Barkovskaya A, Goodwin CM, Seip K, Hilmarsdottir B, Pettersen S, Stalnecker C, Engebraaten O, Briem E, Der CJ, Moestue SA, Gudjonsson T, Maelandsmo GM, Prasmickaite L. Detection of phenotype-specific therapeutic vulnerabilities in breast cells using a CRISPR loss-of-function screen. Mol Oncol. 2021 Aug;15(8):2026-2045. doi: 10.1002/1878-0261.12951. Epub 2021 May 01. PMID: 33759347; PMCID: PMC8333781.
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Patient's experience with blended video- and internet based cognitive behavioural therapy service in routine care.

Internet interventions

Etzelmueller A, Radkovsky A, Hannig W, Berking M, Ebert DD.
PMID: 30135780
Internet Interv. 2018 Feb 23;12:165-175. doi: 10.1016/j.invent.2018.01.003. eCollection 2018 Jun.

INTRODUCTION: Internet-based guided self-help and face-to-face CBT have shown to be effective in the treatment of depression, but both approaches might not be an available treatment option for all patients. A treatment which blends internet-based guided self-help with video-based...

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Etzelmueller A, Radkovsky A, Hannig W, et al. Patient's experience with blended video- and internet based cognitive behavioural therapy service in routine care. Internet Interv. 2018;12:165-175doi: 10.1016/j.invent.2018.01.003.
Etzelmueller, A., Radkovsky, A., Hannig, W., Berking, M., & Ebert, D. D. (2018). Patient's experience with blended video- and internet based cognitive behavioural therapy service in routine care. Internet interventions, 12165-175. https://doi.org/10.1016/j.invent.2018.01.003
Etzelmueller, Anne, et al. "Patient's experience with blended video- and internet based cognitive behavioural therapy service in routine care." Internet interventions vol. 12 (2018): 165-175. doi: https://doi.org/10.1016/j.invent.2018.01.003
Etzelmueller A, Radkovsky A, Hannig W, Berking M, Ebert DD. Patient's experience with blended video- and internet based cognitive behavioural therapy service in routine care. Internet Interv. 2018 Feb 23;12:165-175. doi: 10.1016/j.invent.2018.01.003. eCollection 2018 Jun. PMID: 30135780; PMCID: PMC6096318.
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Proteoglycans as Mediators of Cancer Tissue Mechanics.

Frontiers in cell and developmental biology

Barkovskaya A, Buffone A, Žídek M, Weaver VM.
PMID: 33330449
Front Cell Dev Biol. 2020 Nov 30;8:569377. doi: 10.3389/fcell.2020.569377. eCollection 2020.

Proteoglycans are a diverse group of molecules which are characterized by a central protein backbone that is decorated with a variety of linear sulfated glycosaminoglycan side chains. Proteoglycans contribute significantly to the biochemical and mechanical properties of the interstitial...

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Barkovskaya A, Buffone A, Žídek M, et al. Proteoglycans as Mediators of Cancer Tissue Mechanics. Front Cell Dev Biol. 2020;8:569377doi: 10.3389/fcell.2020.569377.
Barkovskaya, A., Buffone, A., Žídek, M., & Weaver, V. M. (2020). Proteoglycans as Mediators of Cancer Tissue Mechanics. Frontiers in cell and developmental biology, 8569377. https://doi.org/10.3389/fcell.2020.569377
Barkovskaya, Anna, et al. "Proteoglycans as Mediators of Cancer Tissue Mechanics." Frontiers in cell and developmental biology vol. 8 (2020): 569377. doi: https://doi.org/10.3389/fcell.2020.569377
Barkovskaya A, Buffone A, Žídek M, Weaver VM. Proteoglycans as Mediators of Cancer Tissue Mechanics. Front Cell Dev Biol. 2020 Nov 30;8:569377. doi: 10.3389/fcell.2020.569377. eCollection 2020. PMID: 33330449; PMCID: PMC7734320.
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Targeting p130Cas- and microtubule-dependent MYC regulation sensitizes pancreatic cancer to ERK MAPK inhibition.

Cell reports

Waters AM, Khatib TO, Papke B, Goodwin CM, Hobbs GA, Diehl JN, Yang R, Edwards AC, Walsh KH, Sulahian R, McFarland JM, Kapner KS, Gilbert TSK, Stalnecker CA, Javaid S, Barkovskaya A, Grover KR, Hibshman PS, Blake DR, Schaefer A, Nowak KM, Klomp JE, Hayes TK, Kassner M, Tang N, Tanaseichuk O, Chen K, Zhou Y, Kalkat M, Herring LE, Graves LM, Penn LZ, Yin HH, Aguirre AJ, Hahn WC, Cox AD, Der CJ.
PMID: 34192548
Cell Rep. 2021 Jun 29;35(13):109291. doi: 10.1016/j.celrep.2021.109291.

To identify therapeutic targets for KRAS mutant pancreatic cancer, we conduct a druggable genome small interfering RNA (siRNA) screen and determine that suppression of BCAR1 sensitizes pancreatic cancer cells to ERK inhibition. Integrative analysis of genome-scale CRISPR-Cas9 screens also...

Cite
Waters AM, Khatib TO, Papke B, et al. Targeting p130Cas- and microtubule-dependent MYC regulation sensitizes pancreatic cancer to ERK MAPK inhibition. Cell Rep. 2021;35(13):109291doi: 10.1016/j.celrep.2021.109291.
Waters, A. M., Khatib, T. O., Papke, B., Goodwin, C. M., Hobbs, G. A., Diehl, J. N., Yang, R., Edwards, A. C., Walsh, K. H., Sulahian, R., McFarland, J. M., Kapner, K. S., Gilbert, T. S. K., Stalnecker, C. A., Javaid, S., Barkovskaya, A., Grover, K. R., Hibshman, P. S., Blake, D. R., Schaefer, A., Nowak, K. M., Klomp, J. E., Hayes, T. K., Kassner, M., Tang, N., Tanaseichuk, O., Chen, K., Zhou, Y., Kalkat, M., Herring, L. E., Graves, L. M., Penn, L. Z., Yin, H. H., Aguirre, A. J., Hahn, W. C., Cox, A. D., & Der, C. J. (2021). Targeting p130Cas- and microtubule-dependent MYC regulation sensitizes pancreatic cancer to ERK MAPK inhibition. Cell reports, 35(13), 109291. https://doi.org/10.1016/j.celrep.2021.109291
Waters, Andrew M, et al. "Targeting p130Cas- and microtubule-dependent MYC regulation sensitizes pancreatic cancer to ERK MAPK inhibition." Cell reports vol. 35,13 (2021): 109291. doi: https://doi.org/10.1016/j.celrep.2021.109291
Waters AM, Khatib TO, Papke B, Goodwin CM, Hobbs GA, Diehl JN, Yang R, Edwards AC, Walsh KH, Sulahian R, McFarland JM, Kapner KS, Gilbert TSK, Stalnecker CA, Javaid S, Barkovskaya A, Grover KR, Hibshman PS, Blake DR, Schaefer A, Nowak KM, Klomp JE, Hayes TK, Kassner M, Tang N, Tanaseichuk O, Chen K, Zhou Y, Kalkat M, Herring LE, Graves LM, Penn LZ, Yin HH, Aguirre AJ, Hahn WC, Cox AD, Der CJ. Targeting p130Cas- and microtubule-dependent MYC regulation sensitizes pancreatic cancer to ERK MAPK inhibition. Cell Rep. 2021 Jun 29;35(13):109291. doi: 10.1016/j.celrep.2021.109291. PMID: 34192548; PMCID: PMC8340308.
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Showing 1 to 12 of 12 entries