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Showing 1 to 12 of 55 entries
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Recent Perspectives on APP, Secretases, Endosomal Pathways and How they Influence Alzheimer's Related Pathological Changes in Down Syndrome.

Journal of Alzheimer's disease & Parkinsonism

Decourt B, Mobley W, Reiman E, Shah RJ, Sabbagh MN.
PMID: 24782952
J Alzheimers Dis Parkinsonism. 2013 Mar 20;002. doi: 10.4172/2161-0460.S7-002.

Down syndrome is one of the most common genetic conditions occurring in one in 700 live births. The trisomy of chromosome 21 causes over-expression of APP which in turn is indicated in the increased production of Aβ associated with...

Application of synthetic distributions to mie scattering calculations: a dual-computer approach.

Applied optics

Reisman E, Kravitz S.
PMID: 20111433
Appl Opt. 1971 Dec 01;10(12):2777-8. doi: 10.1364/AO.10.002777.

No abstract available.

The effect of multiple family therapy on weight gain in adolescents with anorexia nervosa: pilot data.

Journal of the Canadian Academy of Child and Adolescent Psychiatry = Journal de l'Academie canadienne de psychiatrie de l'enfant et de l'adolescent

Gabel K, Pinhas L, Eisler I, Katzman D, Heinmaa M.
PMID: 25320612
J Can Acad Child Adolesc Psychiatry. 2014 Sep;23(3):196-9.

OBJECTIVE: Preliminary research suggests that multiple family therapy (MFT) may be an effective intervention for adolescent anorexia nervosa (AN). This study compared the extent of weight restoration for patients enrolled in one year of MFT compared to a matched...

Production of a recombinant antibody specific for i blood group antigen, a mesenchymal stem cell marker.

BioResearch open access

Hirvonen T, Suila H, Tiitinen S, Natunen S, Laukkanen ML, Kotovuori A, Reinman M, Satomaa T, Alfthan K, Laitinen S, Takkinen K, Räbinä J, Valmu L.
PMID: 24083089
Biores Open Access. 2013 Oct;2(5):336-45. doi: 10.1089/biores.2013.0026.

Multipotent mesenchymal stem/stromal cells (MSCs) offer great promise for future regenerative and anti-inflammatory therapies. Panels of functional and phenotypical markers are currently used in characterization of different therapeutic stem cell populations from various sources. The i antigen (linear poly-N-acetyllactosamine)...

GWAS of 126,559 individuals identifies genetic variants associated with educational attainment.

Science (New York, N.Y.)

Rietveld CA, Medland SE, Derringer J, Yang J, Esko T, Martin NW, Westra HJ, Shakhbazov K, Abdellaoui A, Agrawal A, Albrecht E, Alizadeh BZ, Amin N, Barnard J, Baumeister SE, Benke KS, Bielak LF, Boatman JA, Boyle PA, Davies G, de Leeuw C, Eklund N, Evans DS, Ferhmann R, Fischer K, Gieger C, Gjessing HK, Hägg S, Harris JR, Hayward C, Holzapfel C, Ibrahim-Verbaas CA, Ingelsson E, Jacobsson B, Joshi PK, Jugessur A, Kaakinen M, Kanoni S, Karjalainen J, Kolcic I, Kristiansson K, Kutalik Z, Lahti J, Lee SH, Lin P, Lind PA, Liu Y, Lohman K, Loitfelder M, McMahon G, Vidal PM, Meirelles O, Milani L, Myhre R, Nuotio ML, Oldmeadow CJ, Petrovic KE, Peyrot WJ, Polasek O, Quaye L, Reinmaa E, Rice JP, Rizzi TS, Schmidt H, Schmidt R, Smith AV, Smith JA, Tanaka T, Terracciano A, van der Loos MJ, Vitart V, Völzke H, Wellmann J, Yu L, Zhao W, Allik J, Attia JR, Bandinelli S, Bastardot F, Beauchamp J, Bennett DA, Berger K, Bierut LJ, Boomsma DI, Bültmann U, Campbell H, Chabris CF, Cherkas L, Chung MK, Cucca F, de Andrade M, De Jager PL, De Neve JE, Deary IJ, Dedoussis GV, Deloukas P, Dimitriou M, Eiríksdóttir G, Elderson MF, Eriksson JG, Evans DM, Faul JD, Ferrucci L, Garcia ME, Grönberg H, Guðnason V, Hall P, Harris JM, Harris TB, Hastie ND, Heath AC, Hernandez DG, Hoffmann W, Hofman A, Holle R, Holliday EG, Hottenga JJ, Iacono WG, Illig T, Järvelin MR, Kähönen M, Kaprio J, Kirkpatrick RM, Kowgier M, Latvala A, Launer LJ, Lawlor DA, Lehtimäki T, Li J, Lichtenstein P, Lichtner P, Liewald DC, Madden PA, Magnusson PK, Mäkinen TE, Masala M, McGue M, Metspalu A, Mielck A, Miller MB, Montgomery GW, Mukherjee S, Nyholt DR, Oostra BA, Palmer LJ, Palotie A, Penninx BW, Perola M, Peyser PA, Preisig M, Räikkönen K, Raitakari OT, Realo A, Ring SM, Ripatti S, Rivadeneira F, Rudan I, Rustichini A, Salomaa V, Sarin AP, Schlessinger D, Scott RJ, Snieder H, St Pourcain B, Starr JM, Sul JH, Surakka I, Svento R, Teumer A, Tiemeier H, van Rooij FJ, Van Wagoner DR, Vartiainen E, Viikari J, Vollenweider P, Vonk JM, Waeber G, Weir DR, Wichmann HE, Widen E, Willemsen G, Wilson JF, Wright AF, Conley D, Davey-Smith G, Franke L, Groenen PJ, Hofman A, Johannesson M, Kardia SL, Krueger RF, Laibson D, Martin NG, Meyer MN, Posthuma D, Thurik AR, Timpson NJ, Uitterlinden AG, van Duijn CM, Visscher PM, Benjamin DJ, Cesarini D, Koellinger PD.
PMID: 23722424
Science. 2013 Jun 21;340(6139):1467-71. doi: 10.1126/science.1235488. Epub 2013 May 30.

A genome-wide association study (GWAS) of educational attainment was conducted in a discovery sample of 101,069 individuals and a replication sample of 25,490. Three independent single-nucleotide polymorphisms (SNPs) are genome-wide significant (rs9320913, rs11584700, rs4851266), and all three replicate. Estimated...

Seeking shelter from the storm: Conservation and management of imperiled species in a changing climate.

Ecology and evolution

Walls SC, Barichivich WJ, Chandler J, Meade AM, Milinichik M, O'Donnell KM, Owens ME, Peacock T, Reinman J, Watling RC, Wetsch OE.
PMID: 31380037
Ecol Evol. 2019 May 30;9(12):7122-7133. doi: 10.1002/ece3.5277. eCollection 2019 Jun.

Climate change is anticipated to exacerbate the extinction risk of species whose persistence is already compromised by habitat loss, invasive species, disease, or other stressors. In coastal areas of the southeastern United States (USA), many imperiled vertebrates are vulnerable...

On the interpretation of linear Riemannian tangent space model parameters in M/EEG.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

Kobler RJ, Hirayama JI, Hehenberger L, Lopes-Dias C, Muller-Putz GR, Kawanabe M.
PMID: 34892464
Annu Int Conf IEEE Eng Med Biol Soc. 2021 Nov;2021:5909-5913. doi: 10.1109/EMBC46164.2021.9630144.

Riemannian tangent space methods offer state-of-the-art performance in magnetoencephalography (MEG) and electroencephalography (EEG) based applications such as brain-computer interfaces and biomarker development. One limitation, particularly relevant for biomarker development, is limited model interpretability compared to established component-based methods. Here,...

A Straightforward Method for 3D Visualization of B Cell Clusters and High Endothelial Venules in Lymph Nodes Highlights Differential Roles of TNFRI and -II.

Frontiers in immunology

Jeucken KCM, Koning JJ, van Hamburg JP, Mebius RE, Tas SW.
PMID: 34234786
Front Immunol. 2021 Jun 21;12:699336. doi: 10.3389/fimmu.2021.699336. eCollection 2021.

Whole mount tissue immunolabeling and imaging of complete organs has tremendous benefits in characterizing organ morphology. Here, we present a straightforward method for immunostaining, clearing and imaging of whole murine peripheral lymph nodes (PLNs) for detailed analysis of their...

De Novo Carcinoma after Solid Organ Transplantation to Give Insight into Carcinogenesis in General-A Systematic Review and Meta-Analysis.

Cancers

Zwart ES, Yüksel E, Pannekoek A, de Vries R, Mebius RE, Kazemier G.
PMID: 33807849
Cancers (Basel). 2021 Mar 05;13(5). doi: 10.3390/cancers13051122.

Immunosuppressive therapy after solid organ transplantation leads to the development of cancer in many recipients. Analysis of the occurrence of different types of de novo carcinomas in relation to specific immunosuppressive drugs may give insight into their carcinogenic process...

Diacylglycerol lipase alpha in astrocytes is involved in maternal care and affective behaviors.

Glia

Schuele LL, Glasmacher S, Gertsch J, Roggan MD, Transfeld JL, Bindila L, Lutz B, Kolbe CC, Bilkei-Gorzo A, Zimmer A, Leidmaa E.
PMID: 32876968
Glia. 2021 Feb;69(2):377-391. doi: 10.1002/glia.23903. Epub 2020 Sep 02.

Genetic deletion of cannabinoid CB1 receptors or diacylglycerol lipase alpha (DAGLa), the main enzyme involved in the synthesis of the endocannabinoid (eCB) 2-arachidonoylglycerol (2-AG), produced profound phenotypes in animal models of depression-related behaviors. Furthermore, clinical studies have shown that...

The effects of a sugar-sweetened beverage tax and a nutrient profiling tax based on Nutri-Score on consumer food purchases in a virtual supermarket: a randomised controlled trial.

Public health nutrition

Eykelenboom M, Olthof MR, van Stralen MM, Djojosoeparto SK, Poelman MP, Kamphuis CB, Vellinga RE, Waterlander WE, Renders CM, Steenhuis IH.
PMID: 34728000
Public Health Nutr. 2021 Nov 03;1-13. doi: 10.1017/S1368980021004547. Epub 2021 Nov 03.

OBJECTIVE: To investigate the effects of a sugar-sweetened beverage (SSB) tax and a nutrient profiling tax on consumer food purchases in a virtual supermarket.DESIGN: A randomised controlled trial was conducted with a control condition with regular food prices (n...

Regulation of adult neurogenesis by the endocannabinoid-producing enzyme diacylglycerol lipase alpha (DAGLa).

Scientific reports

Schuele LL, Schuermann B, Bilkei-Gorzo A, Gorgzadeh S, Zimmer A, Leidmaa E.
PMID: 35022487
Sci Rep. 2022 Jan 12;12(1):633. doi: 10.1038/s41598-021-04600-1.

The endocannabinoid system modulates adult hippocampal neurogenesis by promoting the proliferation and survival of neural stem and progenitor cells (NSPCs). This is demonstrated by the disruption of adult neurogenesis under two experimental conditions: (1) NSPC-specific deletion of cannabinoid receptors...

Showing 1 to 12 of 55 entries