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Science. 2013 Jun 21;340(6139):1467-71. doi: 10.1126/science.1235488. Epub 2013 May 30.

GWAS of 126,559 individuals identifies genetic variants associated with educational attainment.

Science (New York, N.Y.)

Cornelius A Rietveld, Sarah E Medland, Jaime Derringer, Jian Yang, Tõnu Esko, Nicolas W Martin, Harm-Jan Westra, Konstantin Shakhbazov, Abdel Abdellaoui, Arpana Agrawal, Eva Albrecht, Behrooz Z Alizadeh, Najaf Amin, John Barnard, Sebastian E Baumeister, Kelly S Benke, Lawrence F Bielak, Jeffrey A Boatman, Patricia A Boyle, Gail Davies, Christiaan de Leeuw, Niina Eklund, Daniel S Evans, Rudolf Ferhmann, Krista Fischer, Christian Gieger, Håkon K Gjessing, Sara Hägg, Jennifer R Harris, Caroline Hayward, Christina Holzapfel, Carla A Ibrahim-Verbaas, Erik Ingelsson, Bo Jacobsson, Peter K Joshi, Astanand Jugessur, Marika Kaakinen, Stavroula Kanoni, Juha Karjalainen, Ivana Kolcic, Kati Kristiansson, Zoltán Kutalik, Jari Lahti, Sang H Lee, Peng Lin, Penelope A Lind, Yongmei Liu, Kurt Lohman, Marisa Loitfelder, George McMahon, Pedro Marques Vidal, Osorio Meirelles, Lili Milani, Ronny Myhre, Marja-Liisa Nuotio, Christopher J Oldmeadow, Katja E Petrovic, Wouter J Peyrot, Ozren Polasek, Lydia Quaye, Eva Reinmaa, John P Rice, Thais S Rizzi, Helena Schmidt, Reinhold Schmidt, Albert V Smith, Jennifer A Smith, Toshiko Tanaka, Antonio Terracciano, Matthijs J H M van der Loos, Veronique Vitart, Henry Völzke, Jürgen Wellmann, Lei Yu, Wei Zhao, Jüri Allik, John R Attia, Stefania Bandinelli, François Bastardot, Jonathan Beauchamp, David A Bennett, Klaus Berger, Laura J Bierut, Dorret I Boomsma, Ute Bültmann, Harry Campbell, Christopher F Chabris, Lynn Cherkas, Mina K Chung, Francesco Cucca, Mariza de Andrade, Philip L De Jager, Jan-Emmanuel De Neve, Ian J Deary, George V Dedoussis, Panos Deloukas, Maria Dimitriou, Guðny Eiríksdóttir, Martin F Elderson, Johan G Eriksson, David M Evans, Jessica D Faul, Luigi Ferrucci, Melissa E Garcia, Henrik Grönberg, Vilmundur Guðnason, Per Hall, Juliette M Harris, Tamara B Harris, Nicholas D Hastie, Andrew C Heath, Dena G Hernandez, Wolfgang Hoffmann, Adriaan Hofman, Rolf Holle, Elizabeth G Holliday, Jouke-Jan Hottenga, William G Iacono, Thomas Illig, Marjo-Riitta Järvelin, Mika Kähönen, Jaakko Kaprio, Robert M Kirkpatrick, Matthew Kowgier, Antti Latvala, Lenore J Launer, Debbie A Lawlor, Terho Lehtimäki, Jingmei Li, Paul Lichtenstein, Peter Lichtner, David C Liewald, Pamela A Madden, Patrik K E Magnusson, Tomi E Mäkinen, Marco Masala, Matt McGue, Andres Metspalu, Andreas Mielck, Michael B Miller, Grant W Montgomery, Sutapa Mukherjee, Dale R Nyholt, Ben A Oostra, Lyle J Palmer, Aarno Palotie, Brenda W J H Penninx, Markus Perola, Patricia A Peyser, Martin Preisig, Katri Räikkönen, Olli T Raitakari, Anu Realo, Susan M Ring, Samuli Ripatti, Fernando Rivadeneira, Igor Rudan, Aldo Rustichini, Veikko Salomaa, Antti-Pekka Sarin, David Schlessinger, Rodney J Scott, Harold Snieder, Beate St Pourcain, John M Starr, Jae Hoon Sul, Ida Surakka, Rauli Svento, Alexander Teumer, Henning Tiemeier, Frank J A van Rooij, David R Van Wagoner, Erkki Vartiainen, Jorma Viikari, Peter Vollenweider, Judith M Vonk, Gérard Waeber, David R Weir, H-Erich Wichmann, Elisabeth Widen, Gonneke Willemsen, James F Wilson, Alan F Wright, Dalton Conley, George Davey-Smith, Lude Franke, Patrick J F Groenen, Albert Hofman, Magnus Johannesson, Sharon L R Kardia, Robert F Krueger, David Laibson, Nicholas G Martin, Michelle N Meyer, Danielle Posthuma, A Roy Thurik, Nicholas J Timpson, André G Uitterlinden, Cornelia M van Duijn, Peter M Visscher, Daniel J Benjamin, David Cesarini, Philipp D Koellinger

Affiliations

  1. Department of Applied Economics, Erasmus School of Economics, Erasmus University Rotterdam, Rotterdam, Netherlands.

PMID: 23722424 PMCID: PMC3751588 DOI: 10.1126/science.1235488

Abstract

A genome-wide association study (GWAS) of educational attainment was conducted in a discovery sample of 101,069 individuals and a replication sample of 25,490. Three independent single-nucleotide polymorphisms (SNPs) are genome-wide significant (rs9320913, rs11584700, rs4851266), and all three replicate. Estimated effects sizes are small (coefficient of determination R(2) ≈ 0.02%), approximately 1 month of schooling per allele. A linear polygenic score from all measured SNPs accounts for ≈2% of the variance in both educational attainment and cognitive function. Genes in the region of the loci have previously been associated with health, cognitive, and central nervous system phenotypes, and bioinformatics analyses suggest the involvement of the anterior caudate nucleus. These findings provide promising candidate SNPs for follow-up work, and our effect size estimates can anchor power analyses in social-science genetics.

References

  1. Am J Hum Genet. 2012 Jan 13;90(1):7-24 - PubMed
  2. Neurology. 1999 Jul 13;53(1):132-9 - PubMed
  3. PLoS Genet. 2012;8(5):e1002695 - PubMed
  4. Nature. 2012 Nov 1;491(7422):119-24 - PubMed
  5. Twin Res Hum Genet. 2010 Dec;13(6):517-24 - PubMed
  6. Nature. 1985 Apr 25-May 1;314(6013):734-6 - PubMed
  7. Vaccine. 2012 Jul 6;30(32):4778-84 - PubMed
  8. J Natl Cancer Inst. 2004 Aug 18;96(16):1248-54 - PubMed
  9. Nat Genet. 2010 Jun;42(6):508-14 - PubMed
  10. PLoS Genet. 2007 Jul;3(7):e114 - PubMed
  11. Genome Res. 2007 Jun;17(6):691-707 - PubMed
  12. PLoS Genet. 2012 Sep;8(9):e1002921 - PubMed
  13. Cancer Causes Control. 2005 Apr;16(3):275-84 - PubMed
  14. PLoS Biol. 2008 Dec 23;6(12):e1 - PubMed
  15. Nat Genet. 2013 May;45(5):542-545 - PubMed
  16. Int J Epidemiol. 2006 Oct;35(5):1146-50 - PubMed
  17. PLoS One. 2008;3(10):e3395 - PubMed
  18. Int J Epidemiol. 2011 Apr;40(2):294-307 - PubMed
  19. Am J Hum Genet. 2009 Apr;84(4):445-58 - PubMed
  20. Nat Genet. 2010 Feb;42(2):137-41 - PubMed
  21. Arch Neurol. 2008 Nov;65(11):1518-26 - PubMed
  22. BMC Med Genet. 2010 Feb 18;11:28 - PubMed
  23. Bioinformatics. 2011 Aug 1;27(15):2104-11 - PubMed
  24. PLoS Genet. 2012;8(3):e1002491 - PubMed
  25. Nature. 2011 Nov 30;480(7376):201-8 - PubMed
  26. Cephalalgia. 2009 Jan;29(1):48-57 - PubMed
  27. Hum Mol Genet. 2009 Sep 15;18(18):3502-7 - PubMed
  28. Neurobiol Aging. 2007 May;28(5):735-41 - PubMed
  29. PLoS Med. 2005 Aug;2(8):e124 - PubMed
  30. J Hum Resour. 1976 Fall;11(4):447-61 - PubMed
  31. Nat Genet. 2010 Sep;42(9):739-741 - PubMed
  32. Int J Methods Psychiatr Res. 2008;17(3):121-40 - PubMed
  33. Proc Natl Acad Sci U S A. 2012 May 22;109(21):8026-31 - PubMed
  34. Int J Epidemiol. 2010 Apr;39(2):504-18 - PubMed
  35. Bioinformatics. 2009 Oct 15;25(20):2750-2 - PubMed
  36. Nat Genet. 2009 Dec;41(12):1335-40 - PubMed
  37. Nat Genet. 2011 Mar;43(3):246-52 - PubMed
  38. Acta Genet Med Gemellol (Roma). 1990;39(1):35-70 - PubMed
  39. Am J Hum Genet. 2008 Sep;83(3):359-72 - PubMed
  40. Cancer Causes Control. 2006 Mar;17(2):169-80 - PubMed
  41. Nat Genet. 2010 Nov;42(11):937-48 - PubMed
  42. J Am Geriatr Soc. 2000 Dec;48(12):1618-25 - PubMed
  43. Mol Cell Biol. 2002 Aug;22(15):5527-38 - PubMed
  44. Twin Res Hum Genet. 2006 Dec;9(6):849-57 - PubMed
  45. Nat Genet. 2012 Mar 18;44(4):369-75, S1-3 - PubMed
  46. Am J Epidemiol. 2011 Jan 1;173(1):55-63 - PubMed
  47. Bioinformatics. 2012 Jul 1;28(13):1797-9 - PubMed
  48. Am J Hum Biol. 2004 Sep-Oct;16(5):544-55 - PubMed
  49. N Engl J Med. 2008 Jun 5;358(23):2468-81 - PubMed
  50. Neuroepidemiology. 1994;13(6):308-13 - PubMed
  51. Neural Dev. 2009 Jul 14;4:27 - PubMed
  52. Eur J Hum Genet. 2011 Jul;19(7):807-12 - PubMed
  53. J Pediatr Psychol. 2004 Jun;29(4):243-57 - PubMed
  54. J Hum Genet. 2011 Nov;56(11):772-8 - PubMed
  55. Mol Psychiatry. 2012 Mar;17(3):337-49 - PubMed
  56. Twin Res Hum Genet. 2012 Dec;15(6):767-74 - PubMed
  57. Nat Genet. 2000 May;25(1):25-9 - PubMed
  58. Curr Alzheimer Res. 2012 Jul;9(6):646-63 - PubMed
  59. N Engl J Med. 2000 Jul 13;343(2):78-85 - PubMed
  60. Mol Psychiatry. 2014 Feb;19(2):253-8 - PubMed
  61. Gut. 1994 May;35(5):665-8 - PubMed
  62. J Neurosci. 2010 Nov 3;30(44):14824-34 - PubMed
  63. Nat Genet. 2008 Aug;40(8):955-62 - PubMed
  64. Acta Obstet Gynecol Scand. 2000 Jun;79(6):435-9 - PubMed
  65. Acta Paediatr Scand. 1969;193:Suppl 193:1+ - PubMed
  66. Genet Epidemiol. 2010 Dec;34(8):816-34 - PubMed
  67. Behav Genet. 1996 Mar;26(2):89-102 - PubMed
  68. Prog Neurobiol. 2008 Nov;86(3):141-55 - PubMed
  69. Am J Hum Genet. 2010 Jul 9;87(1):139-45 - PubMed
  70. J Am Soc Nephrol. 2010 Jul;21(7):1223-32 - PubMed
  71. Aging (Albany NY). 2010 Sep;2(9):612-20 - PubMed
  72. Nat Genet. 2004 Apr;36(4):388-93 - PubMed
  73. Nat Genet. 2013 Feb;45(2):124-30 - PubMed
  74. Neuron. 2003 Mar 6;37(5):787-800 - PubMed
  75. Eur J Epidemiol. 2011 Aug;26(8):657-86 - PubMed
  76. Am J Hum Genet. 2011 Jan 7;88(1):76-82 - PubMed
  77. J Public Econ. 2010 Feb 1;94(1-2):114-128 - PubMed
  78. Nat Genet. 2009 Jan;41(1):25-34 - PubMed
  79. Am Sociol Rev. 1980 Oct;45(5):723-36 - PubMed
  80. Int J Epidemiol. 2013 Feb;42(1):97-110 - PubMed
  81. PLoS One. 2009;4(5):e5472 - PubMed
  82. BMC Geriatr. 2007 Dec 05;7:28 - PubMed
  83. Am J Psychiatry. 2011 Oct;168(10):1041-9 - PubMed
  84. N Engl J Med. 2005 Oct 27;353(17):1802-9 - PubMed
  85. Genet Res (Camb). 2009 Feb;91(1):47-60 - PubMed
  86. Am J Hum Genet. 2009 Feb;84(2):210-23 - PubMed
  87. PLoS Genet. 2009 Jun;5(6):e1000504 - PubMed
  88. Twin Res. 2002 Oct;5(5):366-71 - PubMed
  89. Int J Epidemiol. 2013 Feb;42(1):76-85 - PubMed
  90. Am J Epidemiol. 2007 May 1;165(9):1076-87 - PubMed
  91. Hypertension. 2002 Jan;39(1):3-9 - PubMed
  92. Bioinformatics. 2010 Sep 1;26(17):2190-1 - PubMed
  93. Ann N Y Acad Sci. 2000 May;904:462-73 - PubMed
  94. Nat Genet. 2009 Jan;41(1):35-46 - PubMed
  95. Nat Genet. 2010 Apr;42(4):332-7 - PubMed
  96. Dev Dyn. 2011 Apr;240(4):828-38 - PubMed
  97. Arch Neurol. 2011 Dec;68(12):1569-79 - PubMed
  98. Epidemiology. 1992 Mar;3(2):143-55 - PubMed
  99. Int J Epidemiol. 2010 Apr;39(2):406-14 - PubMed
  100. J Dent Res. 2013 Jan;92(1):38-44 - PubMed
  101. Nature. 2007 Jun 7;447(7145):661-78 - PubMed
  102. Nature. 2007 Oct 18;449(7164):851-61 - PubMed
  103. Neuron. 2010 Mar 25;65(6):831-44 - PubMed
  104. Nature. 2009 Aug 6;460(7256):748-52 - PubMed
  105. Biometrics. 1999 Dec;55(4):997-1004 - PubMed
  106. Nat Genet. 2007 Jul;39(7):830-2 - PubMed
  107. Development. 1997 Aug;124(15):2923-34 - PubMed
  108. PLoS One. 2011;6(6):e20128 - PubMed
  109. J Pers Soc Psychol. 2004 Jan;86(1):130-47 - PubMed
  110. Proc Natl Acad Sci U S A. 2012 May 29;109(22):8461-6 - PubMed
  111. Hum Mol Genet. 2008 Oct 15;17(R2):R122-8 - PubMed
  112. Quant Econom. 2010;1(1):1-46 - PubMed
  113. Nature. 2010 Oct 14;467(7317):832-8 - PubMed
  114. Am J Hum Genet. 2007 Sep;81(3):559-75 - PubMed
  115. PLoS Genet. 2006 Aug 25;2(8):e132 - PubMed
  116. Eur J Public Health. 2013 Dec;23(6):986-91 - PubMed
  117. Annu Rev Econom. 2012 Jul 1;4:627-662 - PubMed
  118. PLoS One. 2013 Apr 04;8(4):e60542 - PubMed
  119. Gesundheitswesen. 2005 Aug;67 Suppl 1:S26-30 - PubMed
  120. Proc Natl Acad Sci U S A. 2010 Mar 16;107(11):5082-7 - PubMed
  121. Eur J Epidemiol. 2008;23(1):67-74 - PubMed
  122. Nat Rev Genet. 2011 Jun 17;12(7):456-7 - PubMed
  123. Nat Genet. 2010 Dec;42(12):1118-25 - PubMed
  124. PLoS Genet. 2011 Aug;7(8):e1002197 - PubMed
  125. PLoS Med. 2006 Jun;3(6):e168 - PubMed
  126. PLoS One. 2010 Mar 22;5(3):e9763 - PubMed
  127. Nature. 2011 Sep 11;478(7367):103-9 - PubMed
  128. Nat Genet. 2011 Sep 25;43(11):1082-90 - PubMed
  129. Nat Genet. 2009 Oct;41(10):1116-21 - PubMed
  130. Nat Genet. 2009 Dec;41(12):1330-4 - PubMed
  131. J Neurol. 2008 Aug;255(8):1121-6 - PubMed
  132. Nat Genet. 2007 Jul;39(7):906-13 - PubMed
  133. Hum Mol Genet. 2009 Dec 1;18(23):4650-61 - PubMed
  134. BMC Cardiovasc Disord. 2008 Mar 17;8:6 - PubMed
  135. Twin Res Hum Genet. 2013 Feb;16(1):317-29 - PubMed
  136. Bioinformatics. 2012 Oct 1;28(19):2540-2 - PubMed
  137. Nat Genet. 2010 Jul;42(7):565-9 - PubMed
  138. J Econ Perspect. 2011 Fall;25(4):57-82 - PubMed
  139. Croat Med J. 2009 Feb;50(1):4-6 - PubMed
  140. Nat Genet. 2009 Jan;41(1):18-24 - PubMed
  141. Int J Epidemiol. 2008 Dec;37(6):1220-6 - PubMed
  142. Pharmacogenomics J. 2013 Jun;13(3):218-26 - PubMed
  143. Stroke. 2005 Nov;36(11):2351-6 - PubMed
  144. Nat Genet. 2011 Jan;43(1):17-9 - PubMed
  145. Sleep Breath. 2012 Mar;16(1):205-15 - PubMed
  146. Am J Hum Genet. 2009 Jan;84(1):60-5 - PubMed
  147. Proc Natl Acad Sci U S A. 2009 Jun 2;106(22):9004-9 - PubMed
  148. Arch Pediatr Adolesc Med. 2010 Jan;164(1):9-15 - PubMed
  149. Int J Epidemiol. 2010 Dec;39(6):1452-63 - PubMed

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