Sao Paulo medical journal = Revista paulista de medicina

Lyra L, Rizzo LE, Sunahara CS, Pachito DV, Latorraca COC, Martimbianco ALC, Riera R.
PMID: 28538871
Sao Paulo Med J. 2017 Mar-Apr;135(2):192-201. doi: 10.1590/1516-3180.2017.0058200317.

CONTEXT AND OBJECTIVE:: Autism spectrum disorders (ASDs) include autistic disorder, Asperger's disorder and pervasive developmental disorder. The manifestations of ASDs can have an important impact on learning and social functioning that may persist during adulthood. The aim here was...

Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine

Sunahara S.
PMID: 5393466
Nihon Naika Gakkai Zasshi. 1969 Dec 31;58(13):3-6.

No abstract available.

ACS pharmacology & translational science

Glukhova A, Draper-Joyce CJ, Sunahara RK, Christopoulos A, Wootten D, Sexton PM.
PMID: 32219204
ACS Pharmacol Transl Sci. 2018 Sep 07;1(2):73-83. doi: 10.1021/acsptsci.8b00026. eCollection 2018 Nov 09.

G protein-coupled receptors (GPCRs) are a key drug target class. They account for over one-third of current pharmaceuticals, and both drugs that inhibit and promote receptor function are important therapeutically; in some cases, the same GPCR can be targeted...

Chemistry (Weinheim an der Bergstrasse, Germany)

Okano K, Sunahara K, Yamane Y, Hayashi Y, Mori A.
PMID: 27629814
Chemistry. 2016 Nov 07;22(46):16450-16454. doi: 10.1002/chem.201604293. Epub 2016 Oct 10.

One-pot halogen dance/Negishi cross-coupling of readily available 2,5-dibromothiophenes is described. A lithium diisopropylamide (LDA)-mediated halogen dance reaction resulted in the formation of thermodynamically stable α-lithiodibromothiophenes, which were transmetalated with ZnCl

Autophagy

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PMID: 33634751
Autophagy. 2021 Jan;17(1):1-382. doi: 10.1080/15548627.2020.1797280. Epub 2021 Feb 08.

In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been...

Nature chemical biology

Masureel M, Zou Y, Picard LP, van der Westhuizen E, Mahoney JP, Rodrigues JPGLM, Mildorf TJ, Dror RO, Shaw DE, Bouvier M, Pardon E, Steyaert J, Sunahara RK, Weis WI, Zhang C, Kobilka BK.
PMID: 30504785
Nat Chem Biol. 2019 Feb;15(2):205. doi: 10.1038/s41589-018-0182-5.

In the version of this paper originally published, the structure for epinephrine shown in Figure 1a was redrawn with an extra carbon. The structure has been replaced in the HTML and PDF versions of the article. The original and...

Proceedings of the National Academy of Sciences of the United States of America

Paggi JM, Belk JA, Hollingsworth SA, Villanueva N, Powers AS, Clark MJ, Chemparathy AG, Tynan JE, Lau TK, Sunahara RK, Dror RO.
PMID: 34921117
Proc Natl Acad Sci U S A. 2021 Dec 21;118(51). doi: 10.1073/pnas.2112621118.

Over the past five decades, tremendous effort has been devoted to computational methods for predicting properties of ligands-i.e., molecules that bind macromolecular targets. Such methods, which are critical to rational drug design, fall into two categories: physics-based methods, which...

Autophagy

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PMID: 33634751
Autophagy. 2021 Jan;17(1):1-382. doi: 10.1080/15548627.2020.1797280. Epub 2021 Feb 08.

In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been...

Proceedings of the National Academy of Sciences of the United States of America

Paggi JM, Belk JA, Hollingsworth SA, Villanueva N, Powers AS, Clark MJ, Chemparathy AG, Tynan JE, Lau TK, Sunahara RK, Dror RO.
PMID: 34921117
Proc Natl Acad Sci U S A. 2021 Dec 21;118(51). doi: 10.1073/pnas.2112621118.

Over the past five decades, tremendous effort has been devoted to computational methods for predicting properties of ligands-i.e., molecules that bind macromolecular targets. Such methods, which are critical to rational drug design, fall into two categories: physics-based methods, which...

Autophagy

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PMID: 33634751
Autophagy. 2021 Jan;17(1):1-382. doi: 10.1080/15548627.2020.1797280. Epub 2021 Feb 08.

In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been...

Autophagy

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PMID: 33634751
Autophagy. 2021 Jan;17(1):1-382. doi: 10.1080/15548627.2020.1797280. Epub 2021 Feb 08.

In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been...

Cancer discovery

Wheeler EC, Vora S, Mayer D, Kotini AG, Olszewska M, Park SS, Guccione E, Teruya-Feldstein J, Silverman L, Sunahara RK, Yeo GW, Papapetrou EP.
PMID: 34620690
Cancer Discov. 2021 Oct 07; doi: 10.1158/2159-8290.CD-21-0508. Epub 2021 Oct 07.

Mutations in splicing factors (SFs) are the predominant class of mutations in myelodysplastic syndrome (MDS), but convergent downstream disease drivers remain elusive. To identify common direct targets of mis-splicing by mutant U2AF1 and SRSF2, we performed RNA-Seq and eCLIP...