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Showing 1 to 12 of 41 entries
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Network Neurodegeneration in Alzheimer's Disease via MRI Based Shape Diffeomorphometry and High-Field Atlasing.

Frontiers in bioengineering and biotechnology

Miller MI, Ratnanather JT, Tward DJ, Brown T, Lee DS, Ketcha M, Mori K, Wang MC, Mori S, Albert MS, Younes L.
PMID: 26284236
Front Bioeng Biotechnol. 2015 May 15;3:54. doi: 10.3389/fbioe.2015.00054. eCollection 2015.

This paper examines MRI analysis of neurodegeneration in Alzheimer's Disease (AD) in a network of structures within the medial temporal lobe using diffeomorphometry methods coupled with high-field atlasing in which the entorhinal cortex is partitioned into eight subareas. The...

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Miller MI, Ratnanather JT, Tward DJ, et al. Network Neurodegeneration in Alzheimer's Disease via MRI Based Shape Diffeomorphometry and High-Field Atlasing. Front Bioeng Biotechnol. 2015;3:54doi: 10.3389/fbioe.2015.00054.
Miller, M. I., Ratnanather, J. T., Tward, D. J., Brown, T., Lee, D. S., Ketcha, M., Mori, K., Wang, M. C., Mori, S., Albert, M. S., Younes, L. (2015). Network Neurodegeneration in Alzheimer's Disease via MRI Based Shape Diffeomorphometry and High-Field Atlasing. Frontiers in bioengineering and biotechnology, 354. https://doi.org/10.3389/fbioe.2015.00054
Miller, Michael I, et al. "Network Neurodegeneration in Alzheimer's Disease via MRI Based Shape Diffeomorphometry and High-Field Atlasing." Frontiers in bioengineering and biotechnology vol. 3 (2015): 54. doi: https://doi.org/10.3389/fbioe.2015.00054
Miller MI, Ratnanather JT, Tward DJ, Brown T, Lee DS, Ketcha M, Mori K, Wang MC, Mori S, Albert MS, Younes L. Network Neurodegeneration in Alzheimer's Disease via MRI Based Shape Diffeomorphometry and High-Field Atlasing. Front Bioeng Biotechnol. 2015 May 15;3:54. doi: 10.3389/fbioe.2015.00054. eCollection 2015. PMID: 26284236; PMCID: PMC4515983.
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Correction: Piperlongumine Blocks JAK2-STAT3 to Inhibit Collagen-Induced Platelet Reactivity Independent of Reactive Oxygen Species†.

PloS one

Yuan H, Houck KL, Tian Y, Bharadwaj U, Hull K, Zhou Z, Zhu M, Wu X, Tweardy DJ, Romo D, Fu X, Zhang Y, Zhang J, Dong JF.
PMID: 26727022
PLoS One. 2016 Jan 04;11(1):e0146626. doi: 10.1371/journal.pone.0146626. eCollection 2016.

No abstract available.

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Yuan H, Houck KL, Tian Y, et al. Correction: Piperlongumine Blocks JAK2-STAT3 to Inhibit Collagen-Induced Platelet Reactivity Independent of Reactive Oxygen Species†. PLoS One. 2016;11(1):e0146626doi: 10.1371/journal.pone.0146626.
Yuan, H., Houck, K. L., Tian, Y., Bharadwaj, U., Hull, K., Zhou, Z., Zhu, M., Wu, X., Tweardy, D. J., Romo, D., Fu, X., Zhang, Y., Zhang, J., & Dong, J. F. (2016). Correction: Piperlongumine Blocks JAK2-STAT3 to Inhibit Collagen-Induced Platelet Reactivity Independent of Reactive Oxygen Species†. PloS one, 11(1), e0146626. https://doi.org/10.1371/journal.pone.0146626
Yuan, Hengjie, et al. "Correction: Piperlongumine Blocks JAK2-STAT3 to Inhibit Collagen-Induced Platelet Reactivity Independent of Reactive Oxygen Species†." PloS one vol. 11,1 (2016): e0146626. doi: https://doi.org/10.1371/journal.pone.0146626
Yuan H, Houck KL, Tian Y, Bharadwaj U, Hull K, Zhou Z, Zhu M, Wu X, Tweardy DJ, Romo D, Fu X, Zhang Y, Zhang J, Dong JF. Correction: Piperlongumine Blocks JAK2-STAT3 to Inhibit Collagen-Induced Platelet Reactivity Independent of Reactive Oxygen Species†. PLoS One. 2016 Jan 04;11(1):e0146626. doi: 10.1371/journal.pone.0146626. eCollection 2016. PMID: 26727022; PMCID: PMC4699745.
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WITHDRAWN: Intrinsic molecular characteristics of inhibiting STAT3 activation and dimerization through targeting the phosphotyrosine binding site within the SH2 domain-A molecular dynamics study.

Journal of structural biology

Fan Y, Kong R, Tweardy DJ, Wong ST.
PMID: 23428430
J Struct Biol. 2013 Feb 18; doi: 10.1016/j.jsb.2013.02.005. Epub 2013 Feb 18.

This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy.

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Fan Y, Kong R, Tweardy DJ, et al. WITHDRAWN: Intrinsic molecular characteristics of inhibiting STAT3 activation and dimerization through targeting the phosphotyrosine binding site within the SH2 domain-A molecular dynamics study. J Struct Biol. 2013;doi: 10.1016/j.jsb.2013.02.005.
Fan, Y., Kong, R., Tweardy, D. J., & Wong, S. T. (2013). WITHDRAWN: Intrinsic molecular characteristics of inhibiting STAT3 activation and dimerization through targeting the phosphotyrosine binding site within the SH2 domain-A molecular dynamics study. Journal of structural biology, . https://doi.org/10.1016/j.jsb.2013.02.005
Fan, Yubo, et al. "WITHDRAWN: Intrinsic molecular characteristics of inhibiting STAT3 activation and dimerization through targeting the phosphotyrosine binding site within the SH2 domain-A molecular dynamics study." Journal of structural biology vol. (2013). doi: https://doi.org/10.1016/j.jsb.2013.02.005
Fan Y, Kong R, Tweardy DJ, Wong ST. WITHDRAWN: Intrinsic molecular characteristics of inhibiting STAT3 activation and dimerization through targeting the phosphotyrosine binding site within the SH2 domain-A molecular dynamics study. J Struct Biol. 2013 Feb 18; doi: 10.1016/j.jsb.2013.02.005. Epub 2013 Feb 18. PMID: 23428430.
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Monoclonal Antibodies Specific for STAT3β Reveal Its Contribution to Constitutive STAT3 Phosphorylation in Breast Cancer.

Cancers

Bharadwaj U, Kasembeli MM, Eckols TK, Kolosov M, Lang P, Christensen K, Edwards DP, Tweardy DJ.
PMID: 25268166
Cancers (Basel). 2014 Sep 29;6(4):2012-34. doi: 10.3390/cancers6042012.

Since its discovery in mice and humans 19 years ago, the contribution of alternatively spliced Stat3, Stat3β, to the overall functions of Stat3 has been controversial. Tyrosine-phosphorylated (p) Stat3β homodimers are more stable, bind DNA more avidly, are less...

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Bharadwaj U, Kasembeli MM, Eckols TK, et al. Monoclonal Antibodies Specific for STAT3β Reveal Its Contribution to Constitutive STAT3 Phosphorylation in Breast Cancer. Cancers (Basel). 2014;6(4):2012-34doi: 10.3390/cancers6042012.
Bharadwaj, U., Kasembeli, M. M., Eckols, T. K., Kolosov, M., Lang, P., Christensen, K., Edwards, D. P., & Tweardy, D. J. (2014). Monoclonal Antibodies Specific for STAT3β Reveal Its Contribution to Constitutive STAT3 Phosphorylation in Breast Cancer. Cancers, 6(4), 2012-34. https://doi.org/10.3390/cancers6042012
Bharadwaj, Uddalak, et al. "Monoclonal Antibodies Specific for STAT3β Reveal Its Contribution to Constitutive STAT3 Phosphorylation in Breast Cancer." Cancers vol. 6,4 (2014): 2012-34. doi: https://doi.org/10.3390/cancers6042012
Bharadwaj U, Kasembeli MM, Eckols TK, Kolosov M, Lang P, Christensen K, Edwards DP, Tweardy DJ. Monoclonal Antibodies Specific for STAT3β Reveal Its Contribution to Constitutive STAT3 Phosphorylation in Breast Cancer. Cancers (Basel). 2014 Sep 29;6(4):2012-34. doi: 10.3390/cancers6042012. PMID: 25268166; PMCID: PMC4276954.
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Corrigendum to "TTI-101: A competitive inhibitor of STAT3 that spares oxidative phosphorylation and reverses mechanical allodynia in mouse models of neuropathic pain" [Biochem. Pharmacol. 192 (2021) 114688].

Biochemical pharmacology

Kasembeli MM, Singhmar P, Ma J, Edralin J, Tang Y, Adams C, Heijnen CJ, Kavelaars A, Tweardy DJ.
PMID: 34864607
Biochem Pharmacol. 2022 Jan;195:114860. doi: 10.1016/j.bcp.2021.114860. Epub 2021 Dec 02.

No abstract available.

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Kasembeli MM, Singhmar P, Ma J, et al. Corrigendum to "TTI-101: A competitive inhibitor of STAT3 that spares oxidative phosphorylation and reverses mechanical allodynia in mouse models of neuropathic pain" [Biochem. Pharmacol. 192 (2021) 114688]. Biochem Pharmacol. 2021;195:114860doi: 10.1016/j.bcp.2021.114860.
Kasembeli, M. M., Singhmar, P., Ma, J., Edralin, J., Tang, Y., Adams, C., Heijnen, C. J., Kavelaars, A., & Tweardy, D. J. (2022). Corrigendum to "TTI-101: A competitive inhibitor of STAT3 that spares oxidative phosphorylation and reverses mechanical allodynia in mouse models of neuropathic pain" [Biochem. Pharmacol. 192 (2021) 114688]. Biochemical pharmacology, 195114860. https://doi.org/10.1016/j.bcp.2021.114860
Kasembeli, Moses M, et al. "Corrigendum to "TTI-101: A competitive inhibitor of STAT3 that spares oxidative phosphorylation and reverses mechanical allodynia in mouse models of neuropathic pain" [Biochem. Pharmacol. 192 (2021) 114688]." Biochemical pharmacology vol. 195 (2022): 114860. doi: https://doi.org/10.1016/j.bcp.2021.114860
Kasembeli MM, Singhmar P, Ma J, Edralin J, Tang Y, Adams C, Heijnen CJ, Kavelaars A, Tweardy DJ. Corrigendum to "TTI-101: A competitive inhibitor of STAT3 that spares oxidative phosphorylation and reverses mechanical allodynia in mouse models of neuropathic pain" [Biochem. Pharmacol. 192 (2021) 114688]. Biochem Pharmacol. 2022 Jan;195:114860. doi: 10.1016/j.bcp.2021.114860. Epub 2021 Dec 02. PMID: 34864607; PMCID: PMC8718107.
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Motion Artifact Reduction In Photoplethysmography For Reliable Signal Selection.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

Mao R, Tweardy M, Wegerich SW, Goergen CJ, Wodicka GR, Zhu F.
PMID: 34892399
Annu Int Conf IEEE Eng Med Biol Soc. 2021 Nov;2021:5625-5630. doi: 10.1109/EMBC46164.2021.9630595.

Photoplethysmography (PPG) is a non-invasive and economical technique to extract vital signs of the human body. Although it has been widely used in consumer and research grade wrist devices to track a user's physiology, the PPG signal is very...

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Mao R, Tweardy M, Wegerich SW, et al. Motion Artifact Reduction In Photoplethysmography For Reliable Signal Selection. Annu Int Conf IEEE Eng Med Biol Soc. 2021;2021:5625-5630doi: 10.1109/EMBC46164.2021.9630595.
Mao, R., Tweardy, M., Wegerich, S. W., Goergen, C. J., Wodicka, G. R., & Zhu, F. (2021). Motion Artifact Reduction In Photoplethysmography For Reliable Signal Selection. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference, 20215625-5630. https://doi.org/10.1109/EMBC46164.2021.9630595
Mao, Runyu, et al. "Motion Artifact Reduction In Photoplethysmography For Reliable Signal Selection." Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference vol. 2021 (2021): 5625-5630. doi: https://doi.org/10.1109/EMBC46164.2021.9630595
Mao R, Tweardy M, Wegerich SW, Goergen CJ, Wodicka GR, Zhu F. Motion Artifact Reduction In Photoplethysmography For Reliable Signal Selection. Annu Int Conf IEEE Eng Med Biol Soc. 2021 Nov;2021:5625-5630. doi: 10.1109/EMBC46164.2021.9630595. PMID: 34892399.
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Visualizing synaptic plasticity in vivo by large-scale imaging of endogenous AMPA receptors.

eLife

Graves AR, Roth RH, Tan HL, Zhu Q, Bygrave AM, Lopez-Ortega E, Hong I, Spiegel AC, Johnson RC, Vogelstein JT, Tward DJ, Miller MI, Huganir RL.
PMID: 34658338
Elife. 2021 Oct 18;10. doi: 10.7554/eLife.66809.

Elucidating how synaptic molecules such as AMPA receptors mediate neuronal communication and tracking their dynamic expression during behavior is crucial to understand cognition and disease, but current technological barriers preclude large-scale exploration of molecular dynamics in vivo. We have...

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Graves AR, Roth RH, Tan HL, et al. Visualizing synaptic plasticity in vivo by large-scale imaging of endogenous AMPA receptors. Elife. 2021;10doi: 10.7554/eLife.66809.
Graves, A. R., Roth, R. H., Tan, H. L., Zhu, Q., Bygrave, A. M., Lopez-Ortega, E., Hong, I., Spiegel, A. C., Johnson, R. C., Vogelstein, J. T., Tward, D. J., Miller, M. I., & Huganir, R. L. (2021). Visualizing synaptic plasticity in vivo by large-scale imaging of endogenous AMPA receptors. eLife, 10. https://doi.org/10.7554/eLife.66809
Graves, Austin R, et al. "Visualizing synaptic plasticity in vivo by large-scale imaging of endogenous AMPA receptors." eLife vol. 10 (2021). doi: https://doi.org/10.7554/eLife.66809
Graves AR, Roth RH, Tan HL, Zhu Q, Bygrave AM, Lopez-Ortega E, Hong I, Spiegel AC, Johnson RC, Vogelstein JT, Tward DJ, Miller MI, Huganir RL. Visualizing synaptic plasticity in vivo by large-scale imaging of endogenous AMPA receptors. Elife. 2021 Oct 18;10. doi: 10.7554/eLife.66809. PMID: 34658338; PMCID: PMC8616579.
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Motion Artifact Reduction In Photoplethysmography For Reliable Signal Selection.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

Mao R, Tweardy M, Wegerich SW, Goergen CJ, Wodicka GR, Zhu F.
PMID: 34892399
Annu Int Conf IEEE Eng Med Biol Soc. 2021 Nov;2021:5625-5630. doi: 10.1109/EMBC46164.2021.9630595.

Photoplethysmography (PPG) is a non-invasive and economical technique to extract vital signs of the human body. Although it has been widely used in consumer and research grade wrist devices to track a user's physiology, the PPG signal is very...

Cite
Mao R, Tweardy M, Wegerich SW, et al. Motion Artifact Reduction In Photoplethysmography For Reliable Signal Selection. Annu Int Conf IEEE Eng Med Biol Soc. 2021;2021:5625-5630doi: 10.1109/EMBC46164.2021.9630595.
Mao, R., Tweardy, M., Wegerich, S. W., Goergen, C. J., Wodicka, G. R., & Zhu, F. (2021). Motion Artifact Reduction In Photoplethysmography For Reliable Signal Selection. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference, 20215625-5630. https://doi.org/10.1109/EMBC46164.2021.9630595
Mao, Runyu, et al. "Motion Artifact Reduction In Photoplethysmography For Reliable Signal Selection." Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference vol. 2021 (2021): 5625-5630. doi: https://doi.org/10.1109/EMBC46164.2021.9630595
Mao R, Tweardy M, Wegerich SW, Goergen CJ, Wodicka GR, Zhu F. Motion Artifact Reduction In Photoplethysmography For Reliable Signal Selection. Annu Int Conf IEEE Eng Med Biol Soc. 2021 Nov;2021:5625-5630. doi: 10.1109/EMBC46164.2021.9630595. PMID: 34892399.
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Correction: Impact of epidural analgesia on the systemic biomarker response after hepatic resection.

Oncotarget

Vicente D, Patino M, Marcus R, Lillemoe H, Limani P, Newhook T, Lee A, Tzeng CW, Segraves-Chun Y, Tweardy D, Gottumukkala V, Vauthey JN, Aloia T, Cata JP.
PMID: 31695849
Oncotarget. 2019 Oct 29;10(59):6397. doi: 10.18632/oncotarget.27295. eCollection 2019 Oct 29.

[This corrects the article DOI: 10.18632/oncotarget.26549.].

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Vicente D, Patino M, Marcus R, et al. Correction: Impact of epidural analgesia on the systemic biomarker response after hepatic resection. Oncotarget. 2019;10(59):6397doi: 10.18632/oncotarget.27295.
Vicente, D., Patino, M., Marcus, R., Lillemoe, H., Limani, P., Newhook, T., Lee, A., Tzeng, C. W., Segraves-Chun, Y., Tweardy, D., Gottumukkala, V., Vauthey, J. N., Aloia, T., & Cata, J. P. (2019). Correction: Impact of epidural analgesia on the systemic biomarker response after hepatic resection. Oncotarget, 10(59), 6397. https://doi.org/10.18632/oncotarget.27295
Vicente, Diego, et al. "Correction: Impact of epidural analgesia on the systemic biomarker response after hepatic resection." Oncotarget vol. 10,59 (2019): 6397. doi: https://doi.org/10.18632/oncotarget.27295
Vicente D, Patino M, Marcus R, Lillemoe H, Limani P, Newhook T, Lee A, Tzeng CW, Segraves-Chun Y, Tweardy D, Gottumukkala V, Vauthey JN, Aloia T, Cata JP. Correction: Impact of epidural analgesia on the systemic biomarker response after hepatic resection. Oncotarget. 2019 Oct 29;10(59):6397. doi: 10.18632/oncotarget.27295. eCollection 2019 Oct 29. PMID: 31695849; PMCID: PMC6824875.
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Prevention of trauma and hemorrhagic shock-mediated liver apoptosis by activation of stat3alpha.

International journal of clinical and experimental medicine

Moran A, Akcan Arikan A, Mastrangelo MA, Wu Y, Yu B, Poli V, Tweardy DJ.
PMID: 18997875
Int J Clin Exp Med. 2008;1(3):213-47. Epub 2008 Jun 15.

Trauma is a major cause of mortality in the United States. Death among those surviving the initial insult is caused by multiple organ failure (MOF) with the liver among the organs most frequently affected. We previously demonstrated in rodents...

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Moran A, Akcan Arikan A, Mastrangelo MA, et al. Prevention of trauma and hemorrhagic shock-mediated liver apoptosis by activation of stat3alpha. Int J Clin Exp Med. 2008;1(3):213-47
Moran, A., Akcan Arikan, A., Mastrangelo, M. A., Wu, Y., Yu, B., Poli, V., & Tweardy, D. J. (2008). Prevention of trauma and hemorrhagic shock-mediated liver apoptosis by activation of stat3alpha. International journal of clinical and experimental medicine, 1(3), 213-47.
Moran, Ana, et al. "Prevention of trauma and hemorrhagic shock-mediated liver apoptosis by activation of stat3alpha." International journal of clinical and experimental medicine vol. 1,3 (2008): 213-47.
Moran A, Akcan Arikan A, Mastrangelo MA, Wu Y, Yu B, Poli V, Tweardy DJ. Prevention of trauma and hemorrhagic shock-mediated liver apoptosis by activation of stat3alpha. Int J Clin Exp Med. 2008;1(3):213-47. Epub 2008 Jun 15. PMID: 18997875; PMCID: PMC2581418.
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Targeting transcription factors in cancer: Challenges and evolving strategies.

Drug discovery today. Technologies

Redell MS, Tweardy DJ.
PMID: 24980527
Drug Discov Today Technol. 2006;3(3):261-7. doi: 10.1016/j.ddtec.2006.09.010.

As investigators uncover the molecular pathways leading to cancer, an abundance of potential molecular targets is accumulating. Among these targets, transcription factors are especially promising. This review discusses the reasons for focusing targeting efforts on transcription factors and highlights...

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Redell MS, Tweardy DJ. Targeting transcription factors in cancer: Challenges and evolving strategies. Drug Discov Today Technol. 2006;3(3):261-7doi: 10.1016/j.ddtec.2006.09.010.
Redell, M. S., & Tweardy, D. J. (2006). Targeting transcription factors in cancer: Challenges and evolving strategies. Drug discovery today. Technologies, 3(3), 261-7. https://doi.org/10.1016/j.ddtec.2006.09.010
Redell, Michele S, and Tweardy, David J. "Targeting transcription factors in cancer: Challenges and evolving strategies." Drug discovery today. Technologies vol. 3,3 (2006): 261-7. doi: https://doi.org/10.1016/j.ddtec.2006.09.010
Redell MS, Tweardy DJ. Targeting transcription factors in cancer: Challenges and evolving strategies. Drug Discov Today Technol. 2006;3(3):261-7. doi: 10.1016/j.ddtec.2006.09.010. PMID: 24980527.
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Entorhinal and transentorhinal atrophy in mild cognitive impairment using longitudinal diffeomorphometry.

Alzheimer's & dementia (Amsterdam, Netherlands)

Tward DJ, Sicat CS, Brown T, Bakker A, Gallagher M, Albert M, Miller M.
PMID: 28971142
Alzheimers Dement (Amst). 2017 Sep 14;9:41-50. doi: 10.1016/j.dadm.2017.07.005. eCollection 2017.

INTRODUCTION: Autopsy findings have shown the entorhinal cortex and transentorhinal cortex are among the earliest sites of accumulation of pathology in patients developing Alzheimer's disease.METHODS: Here, we study this region in subjects with mild cognitive impairment (RESULTS: We find...

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Tward DJ, Sicat CS, Brown T, et al. Entorhinal and transentorhinal atrophy in mild cognitive impairment using longitudinal diffeomorphometry. Alzheimers Dement (Amst). 2017;9:41-50doi: 10.1016/j.dadm.2017.07.005.
Tward, D. J., Sicat, C. S., Brown, T., Bakker, A., Gallagher, M., Albert, M., & Miller, M. (2017). Entorhinal and transentorhinal atrophy in mild cognitive impairment using longitudinal diffeomorphometry. Alzheimer's & dementia (Amsterdam, Netherlands), 941-50. https://doi.org/10.1016/j.dadm.2017.07.005
Tward, Daniel J, et al. "Entorhinal and transentorhinal atrophy in mild cognitive impairment using longitudinal diffeomorphometry." Alzheimer's & dementia (Amsterdam, Netherlands) vol. 9 (2017): 41-50. doi: https://doi.org/10.1016/j.dadm.2017.07.005
Tward DJ, Sicat CS, Brown T, Bakker A, Gallagher M, Albert M, Miller M. Entorhinal and transentorhinal atrophy in mild cognitive impairment using longitudinal diffeomorphometry. Alzheimers Dement (Amst). 2017 Sep 14;9:41-50. doi: 10.1016/j.dadm.2017.07.005. eCollection 2017. PMID: 28971142; PMCID: PMC5608074.
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