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Showing 1 to 6 of 6 entries
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Cytotoxic CD4 T Cells-Friend or Foe during Viral Infection?.

Frontiers in immunology

Juno JA, van Bockel D, Kent SJ, Kelleher AD, Zaunders JJ, Munier CM.
PMID: 28167943
Front Immunol. 2017 Jan 23;8:19. doi: 10.3389/fimmu.2017.00019. eCollection 2017.

CD4 T cells with cytotoxic function were once thought to be an artifact due to long-term

Cardiac assessment of patients with late stage Duchenne muscular dystrophy.

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation

van Bockel EA, Lind JS, Zijlstra JG, Wijkstra PJ, Meijer PM, van den Berg MP, Slart RH, Aarts LP, Tulleken JE.
PMID: 19789685
Neth Heart J. 2009 Jun;17(6):232-7. doi: 10.1007/BF03086253.

Background. Duchenne muscular dystrophy (DMD) patients used to die mainly from pulmonary problems. However, as advances in respiratory care increase life expectancy, mortality due to cardiomyopathy rises. Echocardiography remains the standard diagnostic modality for cardiomyopathy in DMD patients, but...

Circulating gluten-specific, but not CMV-specific, CD39.

Clinical & translational immunology

Cook L, Munier CML, Seddiki N, Hardy MY, Anderson RP, Zaunders J, Tye-Din JA, Kelleher AD, van Bockel D.
PMID: 31956412
Clin Transl Immunology. 2020 Jan 12;9(1):e1096. doi: 10.1002/cti2.1096. eCollection 2020.

OBJECTIVES: Understanding the T cell receptor (TCR) repertoire of regulatory CD4METHODS: We used the OX40 assay to isolate antigen-specific Tregs by induced surface co-expression of CD25, OX40 and CD39. RACE PCR amplification and Sanger sequencing of the TCR β...

T-cell responses in primary HIV-1 infection.

Current opinion in HIV and AIDS

Streeck H, van Bockel D, Kelleher A.
PMID: 19372944
Curr Opin HIV AIDS. 2008 Jan;3(1):52-9. doi: 10.1097/COH.0b013e3282f269d6.

PURPOSE OF REVIEW: Important immunological events, especially involving T cells, occur during primary HIV-1 infection. The qualitative nature of the primary immune response to the virus may determine long-term outcome. Whereas CD4 T cells are being rapidly depleted, CD8...

Inhibition of intimal hyperplasia by the tetracycline derived mmp inhibitor doxycycline in vein graft disease in vitro and in vivo.

EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology

Lardenoye JH, de Vries MR, Deckers M, van Lent N, Hanemaaijer R, van Bockel JH, Quax PH.
PMID: 19758909
EuroIntervention. 2005 Aug;1(2):236-43.

AIMS: Intimal hyperplasia, characterised by smooth muscle cell migration and proliferation, requires extracellular matrix degradation which is mediated by matrix metalloproteinases (MMPs). In this study, the effect of tetracycline derived doxycycline, a specific MMP inhibitor of both activity and...

Innate and Adaptive Immunity in Long-Term Non-Progression in HIV Disease.

Frontiers in immunology

Zaunders J, van Bockel D.
PMID: 23630526
Front Immunol. 2013 Apr 24;4:95. doi: 10.3389/fimmu.2013.00095. eCollection 2013.

Long-term non-progressors (LTNP) were identified after 10-15 years of the epidemic, and have been the subject of intense investigation ever since. In a small minority of cases, infection with nef/3'LTR deleted attenuated viral strains allowed control over viral replication....

Showing 1 to 6 of 6 entries