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Showing 1 to 12 of 112 entries
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What is synergy? The Saariselkä agreement revisited.

Frontiers in pharmacology

Tang J, Wennerberg K, Aittokallio T.
PMID: 26388771
Front Pharmacol. 2015 Sep 01;6:181. doi: 10.3389/fphar.2015.00181. eCollection 2015.

Many biological or chemical agents when combined interact with each other and produce a synergistic response that cannot be predicted based on the single agent responses alone. However, depending on the postulated null hypothesis of non-interaction, one may end...

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Tang J, Wennerberg K, Aittokallio T. What is synergy? The Saariselkä agreement revisited. Front Pharmacol. 2015;6:181doi: 10.3389/fphar.2015.00181.
Tang, J., Wennerberg, K., & Aittokallio, T. (2015). What is synergy? The Saariselkä agreement revisited. Frontiers in pharmacology, 6181. https://doi.org/10.3389/fphar.2015.00181
Tang, Jing, et al. "What is synergy? The Saariselkä agreement revisited." Frontiers in pharmacology vol. 6 (2015): 181. doi: https://doi.org/10.3389/fphar.2015.00181
Tang J, Wennerberg K, Aittokallio T. What is synergy? The Saariselkä agreement revisited. Front Pharmacol. 2015 Sep 01;6:181. doi: 10.3389/fphar.2015.00181. eCollection 2015. PMID: 26388771; PMCID: PMC4555011.
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Searching for Drug Synergy in Complex Dose-Response Landscapes Using an Interaction Potency Model.

Computational and structural biotechnology journal

Yadav B, Wennerberg K, Aittokallio T, Tang J.
PMID: 26949479
Comput Struct Biotechnol J. 2015 Sep 25;13:504-13. doi: 10.1016/j.csbj.2015.09.001. eCollection 2015.

Rational design of multi-targeted drug combinations is a promising strategy to tackle the drug resistance problem for many complex disorders. A drug combination is usually classified as synergistic or antagonistic, depending on the deviation of the observed combination response...

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Yadav B, Wennerberg K, Aittokallio T, et al. Searching for Drug Synergy in Complex Dose-Response Landscapes Using an Interaction Potency Model. Comput Struct Biotechnol J. 2015;13:504-13doi: 10.1016/j.csbj.2015.09.001.
Yadav, B., Wennerberg, K., Aittokallio, T., & Tang, J. (2015). Searching for Drug Synergy in Complex Dose-Response Landscapes Using an Interaction Potency Model. Computational and structural biotechnology journal, 13504-13. https://doi.org/10.1016/j.csbj.2015.09.001
Yadav, Bhagwan, et al. "Searching for Drug Synergy in Complex Dose-Response Landscapes Using an Interaction Potency Model." Computational and structural biotechnology journal vol. 13 (2015): 504-13. doi: https://doi.org/10.1016/j.csbj.2015.09.001
Yadav B, Wennerberg K, Aittokallio T, Tang J. Searching for Drug Synergy in Complex Dose-Response Landscapes Using an Interaction Potency Model. Comput Struct Biotechnol J. 2015 Sep 25;13:504-13. doi: 10.1016/j.csbj.2015.09.001. eCollection 2015. PMID: 26949479; PMCID: PMC4759128.
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Cell line dependent expression of EpCAM influences the detection of circulating tumor cells with CellSearch.

Laryngoscope investigative otolaryngology

Lindgren G, Wennerberg J, Ekblad L.
PMID: 28894840
Laryngoscope Investig Otolaryngol. 2017 May 20;2(4):194-198. doi: 10.1002/lio2.83. eCollection 2017 Aug.

OBJECTIVES: The existence of circulating tumor cells has emerged as an important factor for prognosis and survival. The CellSearch method is the only circulating tumor cell detection method approved by the US Food and Drug Administration for clinical use....

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Lindgren G, Wennerberg J, Ekblad L. Cell line dependent expression of EpCAM influences the detection of circulating tumor cells with CellSearch. Laryngoscope Investig Otolaryngol. 2017;2(4):194-198doi: 10.1002/lio2.83.
Lindgren, G., Wennerberg, J., & Ekblad, L. (2017). Cell line dependent expression of EpCAM influences the detection of circulating tumor cells with CellSearch. Laryngoscope investigative otolaryngology, 2(4), 194-198. https://doi.org/10.1002/lio2.83
Lindgren, Gustaf, et al. "Cell line dependent expression of EpCAM influences the detection of circulating tumor cells with CellSearch." Laryngoscope investigative otolaryngology vol. 2,4 (2017): 194-198. doi: https://doi.org/10.1002/lio2.83
Lindgren G, Wennerberg J, Ekblad L. Cell line dependent expression of EpCAM influences the detection of circulating tumor cells with CellSearch. Laryngoscope Investig Otolaryngol. 2017 May 20;2(4):194-198. doi: 10.1002/lio2.83. eCollection 2017 Aug. PMID: 28894840; PMCID: PMC5562942.
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Theoretical model of coping among relatives of patients in intensive care units: a simultaneous concept analysis.

Journal of advanced nursing

Johansson I, Hildingh C, Wenneberg S, Fridlund B, Ahlström G.
PMID: 17078822
J Adv Nurs. 2006 Dec;56(5):463-71. doi: 10.1111/j.1365-2648.2006.04040.x.

UNLABELLED: This paper reports the development of a theoretical model of relatives' coping approaches during the patient's intensive care unit stay and subsequent recovery at home by performing an analysis of concepts generated from two empirically grounded, theoretical studies...

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Johansson I, Hildingh C, Wenneberg S, et al. Theoretical model of coping among relatives of patients in intensive care units: a simultaneous concept analysis. J Adv Nurs. 2006;56(5):463-71doi: 10.1111/j.1365-2648.2006.04040.x.
Johansson, I., Hildingh, C., Wenneberg, S., Fridlund, B., & Ahlström, G. (2006). Theoretical model of coping among relatives of patients in intensive care units: a simultaneous concept analysis. Journal of advanced nursing, 56(5), 463-71. https://doi.org/10.1111/j.1365-2648.2006.04040.x
Johansson, Ingrid, et al. "Theoretical model of coping among relatives of patients in intensive care units: a simultaneous concept analysis." Journal of advanced nursing vol. 56,5 (2006): 463-71. doi: https://doi.org/10.1111/j.1365-2648.2006.04040.x
Johansson I, Hildingh C, Wenneberg S, Fridlund B, Ahlström G. Theoretical model of coping among relatives of patients in intensive care units: a simultaneous concept analysis. J Adv Nurs. 2006 Dec;56(5):463-71. doi: 10.1111/j.1365-2648.2006.04040.x. PMID: 17078822.
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In vitro Evaluation of Calcium Phosphate Precipitation on Possibly Bioactive Titanium Surfaces in the Presence of Laminin.

Journal of oral & maxillofacial research

Bougas K, Stenport VF, Currie F, Wennerberg A.
PMID: 24421995
J Oral Maxillofac Res. 2011 Oct 01;2(3):e3. doi: 10.5037/jomr.2011.2303. eCollection 2011.

OBJECTIVES: The aim of the present study was to evaluate calcium phosphate precipitation and the amount of precipitated protein on three potentially bioactive surfaces when adding laminin in simulated body fluid.MATERIAL AND METHODS: BLASTED TITANIUM DISCS WERE PREPARED BY...

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Bougas K, Stenport VF, Currie F, et al. In vitro Evaluation of Calcium Phosphate Precipitation on Possibly Bioactive Titanium Surfaces in the Presence of Laminin. J Oral Maxillofac Res. 2011;2(3):e3doi: 10.5037/jomr.2011.2303.
Bougas, K., Stenport, V. F., Currie, F., & Wennerberg, A. (2011). In vitro Evaluation of Calcium Phosphate Precipitation on Possibly Bioactive Titanium Surfaces in the Presence of Laminin. Journal of oral & maxillofacial research, 2(3), e3. https://doi.org/10.5037/jomr.2011.2303
Bougas, Kostas, et al. "In vitro Evaluation of Calcium Phosphate Precipitation on Possibly Bioactive Titanium Surfaces in the Presence of Laminin." Journal of oral & maxillofacial research vol. 2,3 (2011): e3. doi: https://doi.org/10.5037/jomr.2011.2303
Bougas K, Stenport VF, Currie F, Wennerberg A. In vitro Evaluation of Calcium Phosphate Precipitation on Possibly Bioactive Titanium Surfaces in the Presence of Laminin. J Oral Maxillofac Res. 2011 Oct 01;2(3):e3. doi: 10.5037/jomr.2011.2303. eCollection 2011. PMID: 24421995; PMCID: PMC3886075.
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Novel Implant Coating Agent Promotes Gene Expression of Osteogenic Markers in Rats during Early Osseointegration.

International journal of biomaterials

Bougas K, Jimbo R, Xue Y, Mustafa K, Wennerberg A.
PMID: 23193408
Int J Biomater. 2012;2012:579274. doi: 10.1155/2012/579274. Epub 2012 Oct 30.

The aim of this study was to evaluate the early bone response around laminin-1-coated titanium implants. Forty-five rats distributed in three equally sized groups were provided with one control (turned) and one test (laminin-1-coated) implant and were sacrificed after...

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Bougas K, Jimbo R, Xue Y, et al. Novel Implant Coating Agent Promotes Gene Expression of Osteogenic Markers in Rats during Early Osseointegration. Int J Biomater. 2012;2012:579274doi: 10.1155/2012/579274.
Bougas, K., Jimbo, R., Xue, Y., Mustafa, K., & Wennerberg, A. (2012). Novel Implant Coating Agent Promotes Gene Expression of Osteogenic Markers in Rats during Early Osseointegration. International journal of biomaterials, 2012579274. https://doi.org/10.1155/2012/579274
Bougas, Kostas, et al. "Novel Implant Coating Agent Promotes Gene Expression of Osteogenic Markers in Rats during Early Osseointegration." International journal of biomaterials vol. 2012 (2012): 579274. doi: https://doi.org/10.1155/2012/579274
Bougas K, Jimbo R, Xue Y, Mustafa K, Wennerberg A. Novel Implant Coating Agent Promotes Gene Expression of Osteogenic Markers in Rats during Early Osseointegration. Int J Biomater. 2012;2012:579274. doi: 10.1155/2012/579274. Epub 2012 Oct 30. PMID: 23193408; PMCID: PMC3501934.
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Opposing consequences of signaling through EGF family members: Escape from CTLs could be a bait for NK cells.

Oncoimmunology

Kiessling R, Okita R, Mougiakakos D, Mao Y, Sarhan D, Wennerberg E, Seliger B, Lundqvist A, Mimura K, Kono K.
PMID: 23170279
Oncoimmunology. 2012 Oct 01;1(7):1200-1201. doi: 10.4161/onci.20685.

Oncogenes have been traditionally viewed as molecular drivers for tumor growth and survival. Recent evidence indicates that oncogenes may facilitate the escape of malignant cells from immune recognition and elimination. In this article, we discuss the implications of the...

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Kiessling R, Okita R, Mougiakakos D, et al. Opposing consequences of signaling through EGF family members: Escape from CTLs could be a bait for NK cells. Oncoimmunology. 2012;1(7):1200-1201doi: 10.4161/onci.20685.
Kiessling, R., Okita, R., Mougiakakos, D., Mao, Y., Sarhan, D., Wennerberg, E., Seliger, B., Lundqvist, A., Mimura, K., & Kono, K. (2012). Opposing consequences of signaling through EGF family members: Escape from CTLs could be a bait for NK cells. Oncoimmunology, 1(7), 1200-1201. https://doi.org/10.4161/onci.20685
Kiessling, Rolf, et al. "Opposing consequences of signaling through EGF family members: Escape from CTLs could be a bait for NK cells." Oncoimmunology vol. 1,7 (2012): 1200-1201. doi: https://doi.org/10.4161/onci.20685
Kiessling R, Okita R, Mougiakakos D, Mao Y, Sarhan D, Wennerberg E, Seliger B, Lundqvist A, Mimura K, Kono K. Opposing consequences of signaling through EGF family members: Escape from CTLs could be a bait for NK cells. Oncoimmunology. 2012 Oct 01;1(7):1200-1201. doi: 10.4161/onci.20685. PMID: 23170279; PMCID: PMC3494645.
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Early Metabolic Flare in Squamous Cell Carcinoma after Chemotherapy is a Marker of Treatment Sensitivity In Vitro.

Nuclear medicine and molecular imaging

Bjurberg M, Abedinpour P, Brun E, Baldetorp B, Borgström P, Wennerberg J, Kjellén E.
PMID: 21151484
Nucl Med Mol Imaging. 2010 Sep;44(3):165-169. doi: 10.1007/s13139-010-0034-z. Epub 2010 Jun 09.

PURPOSE: Early metabolic response with a decrease in glucose demand after cytotoxic treatment has been reported to precede tumor volume shrinkage. However, preclinical studies report of a very early rise in metabolism, a flare, following treatment. To elucidate these...

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Bjurberg M, Abedinpour P, Brun E, et al. Early Metabolic Flare in Squamous Cell Carcinoma after Chemotherapy is a Marker of Treatment Sensitivity In Vitro. Nucl Med Mol Imaging. 2010;44(3):165-169doi: 10.1007/s13139-010-0034-z.
Bjurberg, M., Abedinpour, P., Brun, E., Baldetorp, B., Borgström, P., Wennerberg, J., & Kjellén, E. (2010). Early Metabolic Flare in Squamous Cell Carcinoma after Chemotherapy is a Marker of Treatment Sensitivity In Vitro. Nuclear medicine and molecular imaging, 44(3), 165-169. https://doi.org/10.1007/s13139-010-0034-z
Bjurberg, Maria, et al. "Early Metabolic Flare in Squamous Cell Carcinoma after Chemotherapy is a Marker of Treatment Sensitivity In Vitro." Nuclear medicine and molecular imaging vol. 44,3 (2010): 165-169. doi: https://doi.org/10.1007/s13139-010-0034-z
Bjurberg M, Abedinpour P, Brun E, Baldetorp B, Borgström P, Wennerberg J, Kjellén E. Early Metabolic Flare in Squamous Cell Carcinoma after Chemotherapy is a Marker of Treatment Sensitivity In Vitro. Nucl Med Mol Imaging. 2010 Sep;44(3):165-169. doi: 10.1007/s13139-010-0034-z. Epub 2010 Jun 09. PMID: 21151484; PMCID: PMC2987232.
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Nanosized Hydroxyapatite Coating on PEEK Implants Enhances Early Bone Formation: A Histological and Three-Dimensional Investigation in Rabbit Bone.

Materials (Basel, Switzerland)

Johansson P, Jimbo R, Kozai Y, Sakurai T, Kjellin P, Currie F, Wennerberg A.
PMID: 28793409
Materials (Basel). 2015 Jun 25;8(7):3815-3830. doi: 10.3390/ma8073815.

Polyether ether ketone (PEEK) has been frequently used in spinal surgery with good clinical results. The material has a low elastic modulus and is radiolucent. However, in oral implantology PEEK has displayed inferior ability to osseointegrate compared to titanium...

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Johansson P, Jimbo R, Kozai Y, et al. Nanosized Hydroxyapatite Coating on PEEK Implants Enhances Early Bone Formation: A Histological and Three-Dimensional Investigation in Rabbit Bone. Materials (Basel). 2015;8(7):3815-3830doi: 10.3390/ma8073815.
Johansson, P., Jimbo, R., Kozai, Y., Sakurai, T., Kjellin, P., Currie, F., & Wennerberg, A. (2015). Nanosized Hydroxyapatite Coating on PEEK Implants Enhances Early Bone Formation: A Histological and Three-Dimensional Investigation in Rabbit Bone. Materials (Basel, Switzerland), 8(7), 3815-3830. https://doi.org/10.3390/ma8073815
Johansson, Pär, et al. "Nanosized Hydroxyapatite Coating on PEEK Implants Enhances Early Bone Formation: A Histological and Three-Dimensional Investigation in Rabbit Bone." Materials (Basel, Switzerland) vol. 8,7 (2015): 3815-3830. doi: https://doi.org/10.3390/ma8073815
Johansson P, Jimbo R, Kozai Y, Sakurai T, Kjellin P, Currie F, Wennerberg A. Nanosized Hydroxyapatite Coating on PEEK Implants Enhances Early Bone Formation: A Histological and Three-Dimensional Investigation in Rabbit Bone. Materials (Basel). 2015 Jun 25;8(7):3815-3830. doi: 10.3390/ma8073815. PMID: 28793409; PMCID: PMC5455651.
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Bone Immune Response to Materials, Part I: Titanium, PEEK and Copper in Comparison to Sham at 10 Days in Rabbit Tibia.

Journal of clinical medicine

Trindade R, Albrektsson T, Galli S, Prgomet Z, Tengvall P, Wennerberg A.
PMID: 30544551
J Clin Med. 2018 Dec 07;7(12). doi: 10.3390/jcm7120526.

Bone anchored biomaterials have become an indispensable solution for the restoration of lost dental elements and for skeletal joint replacements. However, a thorough understanding is still lacking in terms of the biological mechanisms leading to osseointegration and its contrast,...

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Trindade R, Albrektsson T, Galli S, et al. Bone Immune Response to Materials, Part I: Titanium, PEEK and Copper in Comparison to Sham at 10 Days in Rabbit Tibia. J Clin Med. 2018;7(12)doi: 10.3390/jcm7120526.
Trindade, R., Albrektsson, T., Galli, S., Prgomet, Z., Tengvall, P., & Wennerberg, A. (2018). Bone Immune Response to Materials, Part I: Titanium, PEEK and Copper in Comparison to Sham at 10 Days in Rabbit Tibia. Journal of clinical medicine, 7(12), . https://doi.org/10.3390/jcm7120526
Trindade, Ricardo, et al. "Bone Immune Response to Materials, Part I: Titanium, PEEK and Copper in Comparison to Sham at 10 Days in Rabbit Tibia." Journal of clinical medicine vol. 7,12 (2018). doi: https://doi.org/10.3390/jcm7120526
Trindade R, Albrektsson T, Galli S, Prgomet Z, Tengvall P, Wennerberg A. Bone Immune Response to Materials, Part I: Titanium, PEEK and Copper in Comparison to Sham at 10 Days in Rabbit Tibia. J Clin Med. 2018 Dec 07;7(12). doi: 10.3390/jcm7120526. PMID: 30544551; PMCID: PMC6307090.
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Drug sensitivity profiling identifies potential therapies for lymphoproliferative disorders with overactive JAK/STAT3 signaling.

Oncotarget

Kuusanmäki H, Dufva O, Parri E, van Adrichem AJ, Rajala H, Majumder MM, Yadav B, Parsons A, Chan WC, Wennerberg K, Mustjoki S, Heckman CA.
PMID: 29228628
Oncotarget. 2017 Oct 31;8(57):97516-97527. doi: 10.18632/oncotarget.22178. eCollection 2017 Nov 14.

Constitutive JAK/STAT3 signaling contributes to disease progression in many lymphoproliferative disorders. Recent genetic analyses have revealed gain-of-function

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Kuusanmäki H, Dufva O, Parri E, et al. Drug sensitivity profiling identifies potential therapies for lymphoproliferative disorders with overactive JAK/STAT3 signaling. Oncotarget. 2017;8(57):97516-97527doi: 10.18632/oncotarget.22178.
Kuusanmäki, H., Dufva, O., Parri, E., van Adrichem, A. J., Rajala, H., Majumder, M. M., Yadav, B., Parsons, A., Chan, W. C., Wennerberg, K., Mustjoki, S., & Heckman, C. A. (2017). Drug sensitivity profiling identifies potential therapies for lymphoproliferative disorders with overactive JAK/STAT3 signaling. Oncotarget, 8(57), 97516-97527. https://doi.org/10.18632/oncotarget.22178
Kuusanmäki, Heikki, et al. "Drug sensitivity profiling identifies potential therapies for lymphoproliferative disorders with overactive JAK/STAT3 signaling." Oncotarget vol. 8,57 (2017): 97516-97527. doi: https://doi.org/10.18632/oncotarget.22178
Kuusanmäki H, Dufva O, Parri E, van Adrichem AJ, Rajala H, Majumder MM, Yadav B, Parsons A, Chan WC, Wennerberg K, Mustjoki S, Heckman CA. Drug sensitivity profiling identifies potential therapies for lymphoproliferative disorders with overactive JAK/STAT3 signaling. Oncotarget. 2017 Oct 31;8(57):97516-97527. doi: 10.18632/oncotarget.22178. eCollection 2017 Nov 14. PMID: 29228628; PMCID: PMC5722580.
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Corrigendum to "Searching for drug synergy in complex dose-response landscapes using an interaction potency model" [Comput. Struct. Biotechnol. J. 13 (2015) 504-513].

Computational and structural biotechnology journal

Yadav B, Wennerberg K, Aittokallio T, Tang J.
PMID: 29991977
Comput Struct Biotechnol J. 2017 Jul 25;15:387. doi: 10.1016/j.csbj.2017.07.003. eCollection 2017.

[This corrects the article DOI: 10.1016/j.csbj.2015.09.001.].

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Yadav B, Wennerberg K, Aittokallio T, et al. Corrigendum to "Searching for drug synergy in complex dose-response landscapes using an interaction potency model" [Comput. Struct. Biotechnol. J. 13 (2015) 504-513]. Comput Struct Biotechnol J. 2017;15:387doi: 10.1016/j.csbj.2017.07.003.
Yadav, B., Wennerberg, K., Aittokallio, T., & Tang, J. (2017). Corrigendum to "Searching for drug synergy in complex dose-response landscapes using an interaction potency model" [Comput. Struct. Biotechnol. J. 13 (2015) 504-513]. Computational and structural biotechnology journal, 15387. https://doi.org/10.1016/j.csbj.2017.07.003
Yadav, Bhagwan, et al. "Corrigendum to "Searching for drug synergy in complex dose-response landscapes using an interaction potency model" [Comput. Struct. Biotechnol. J. 13 (2015) 504-513]." Computational and structural biotechnology journal vol. 15 (2017): 387. doi: https://doi.org/10.1016/j.csbj.2017.07.003
Yadav B, Wennerberg K, Aittokallio T, Tang J. Corrigendum to "Searching for drug synergy in complex dose-response landscapes using an interaction potency model" [Comput. Struct. Biotechnol. J. 13 (2015) 504-513]. Comput Struct Biotechnol J. 2017 Jul 25;15:387. doi: 10.1016/j.csbj.2017.07.003. eCollection 2017. PMID: 29991977; PMCID: PMC6032504.
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Showing 1 to 12 of 112 entries