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Showing 1 to 12 of 452 entries
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Influence of quinacrine and chloroquine on the in vitro 3'-azido-3'-deoxythymidine antiretroviral effect.

AIDS research and therapy

Torres KJ, Reyes-Terán G, Sotelo J, Jung-Cook H, Aguirre-Cruz L.
PMID: 25788967
AIDS Res Ther. 2015 Mar 19;12:7. doi: 10.1186/s12981-015-0048-9. eCollection 2015.

BACKGROUND: Antimalarials quinacrine (Qc) and chloroquine (Cq) intercalate DNA, potentiate the activity of other drugs and have lysosomotropic, anti-inflammatory and antiviral activities that could increase the effect of the 3'-azido-3'-deoxythymidine (AZT) antiretroviral agent. The aim of the current study...

Papular Mucinosis Associated with Systemic Lupus Erythematosus.

Annals of dermatology

Lee WJ, Park GH, Chang SE, Lee MW, Choi JH, Moon KC, Koh JK.
PMID: 27303200
Ann Dermatol. 2008 Dec;20(4):233-6. doi: 10.5021/ad.2008.20.4.233. Epub 2008 Dec 31.

Papulonodular mucinosis (PNM) is a rare variant of lupus erythematosus (LE) eruptions, and PNM is characterized histologically by diffuse dermal mucin without any typical epidermal inflammatory changes. We herein describe a case of papular mucinosis that was characterized by...

The Potential of β Carbolin Alkaloids to Hinder Growth and Reverse Chloroquine Resistance in Plasmodium falciparum.

Iranian journal of parasitology

Ibraheem ZO, Abdul Majid R, Mohd Noor S, Mohd Sidek H, Basir R.
PMID: 26811724
Iran J Parasitol. 2015 Oct-Dec;10(4):577-83.

BACKGROUND: Nowadays, scourge of malaria as a fatalistic disease has increased due to emergence of drug resistance and tolerance among different strains of Plasmodium falciparum. Emergence of chloroquine (CQ) resistance has worsened the calamity as CQ is still considered...

Recent Antimalarials in Giardiasis.

The Indian medical gazette

Poddar J, Chhetri MK.
PMID: 29015512
Ind Med Gaz. 1954 Mar;89(3):155-157.

No abstract available.

Effects of nutrition interventions during pregnancy on low birth weight: an overview of systematic reviews.

BMJ global health

da Silva Lopes K, Ota E, Shakya P, Dagvadorj A, Balogun OO, Peña-Rosas JP, De-Regil LM, Mori R.
PMID: 29018583
BMJ Glob Health. 2017 Sep 22;2(3):e000389. doi: 10.1136/bmjgh-2017-000389. eCollection 2017.

INTRODUCTION: Low birth weight (LBW, birth weight less than 2500 g) is associated with infant mortality and childhood morbidity. Poor maternal nutritional status is one of several contributing factors to LBW. We systematically reviewed the evidence for nutrition-specific (addressing...

Potential antimalarials from African natural products: A reviw.

Journal of intercultural ethnopharmacology

Lawal B, Shittu OK, Kabiru AY, Jigam AA, Umar MB, Berinyuy EB, Alozieuwa BU.
PMID: 26649238
J Intercult Ethnopharmacol. 2015 Oct-Dec;4(4):318-43. doi: 10.5455/jice.20150928102856. Epub 2015 Oct 29.

Malaria remains an overwhelming infectious disease with significant health challenges in African and other endemic countries globally. Resistance to antimalarial drugs has become one of the most momentous challenges to human health, and thus has necessitated the hunt for...

Bioinformatic Identification of Peptidomimetic-Based Inhibitors against Plasmodium falciparum Antigen AMA1.

Malaria research and treatment

Alam A.
PMID: 25580351
Malar Res Treat. 2014;2014:642391. doi: 10.1155/2014/642391. Epub 2014 Dec 18.

Plasmodium falciparum apical membrane antigen 1 (PfAMA1) is a valuable vaccine candidate and exported on the merozoite surface at the time of erythrocyte invasion. PfAMA1 interacts with rhoptry neck protein PfRON2, a component of the rhoptry protein complex, which...

Neurorickettsioses: a rare presentation with stroke in a young adult.

Journal of clinical and diagnostic research : JCDR

Kumar S P, K P.
PMID: 25478386
J Clin Diagn Res. 2014 Oct;8(10):MD03-4. doi: 10.7860/JCDR/2014/9646.4996. Epub 2014 Oct 20.

Acute stroke-like presentations due to rickettsial infections have been sparsely reported in literature. We report a young patient who presented with high grade fever and acute encephalopathy with right hemiplegia. CT head showed left cerebral, bilateral thalamic and midbrain...

How do antimalarial drugs reach their intracellular targets?.

Frontiers in pharmacology

Basore K, Cheng Y, Kushwaha AK, Nguyen ST, Desai SA.
PMID: 25999857
Front Pharmacol. 2015 May 05;6:91. doi: 10.3389/fphar.2015.00091. eCollection 2015.

Drugs represent the primary treatment available for human malaria, as caused by Plasmodium spp. Currently approved drugs and antimalarial drug leads generally work against parasite enzymes or activities within infected erythrocytes. To reach their specific targets, these chemicals must...

The role of drug delivery systems in health care: the case of self- medication.

African journal of health sciences

Mwenesi HA.
PMID: 12150643
Afr J Health Sci. 1994 Feb;1(1):42-48.

Up to 80 % of illness episodes are first defined, diagnosed and treated at the household-level. In the developing world especially, approximately half the population has no access to public health services. It is obvious then that other sources...

The development and spread of drug-resistant malaria.

Parasitology today (Personal ed.)

Wernsdorfer WH.
PMID: 15463395
Parasitol Today. 1991 Nov;7(11):297-303. doi: 10.1016/0169-4758(91)90262-m.

Resistance of Plasmodium falciparum to chloroquine has emerged in the late 1950s and has now conquered the large majority of areas where this species is endemic. Resistance to alternative drugs has already occurred in several parts of the world...

Drug, dosage, activity, studies of antimalarials by physical methods--II.

Bioinformation

Murthy VR, Raghuram DV, Murthy PN.
PMID: 18084644
Bioinformation. 2007 May 20;2(1):12-6. doi: 10.6026/97320630002012.

Studies pertaining to drug-DNA interactions in treating a disease efficiently have taken an important place in recent times. Murthy and colleagues were active in correlating the drug activity, with physical parameters like refractivity, susceptibility, molecular electron ionization cross-section and...

Showing 1 to 12 of 452 entries