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Showing 1 to 12 of 1524 entries
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Use of mTOR inhibitors in the treatment of breast cancer: an evaluation of factors that influence patient outcomes.

Breast cancer (Dove Medical Press)

Jerusalem G, Rorive A, Collignon J.
PMID: 24833916
Breast Cancer (Dove Med Press). 2014 Apr 17;6:43-57. doi: 10.2147/BCTT.S38679. eCollection 2014.

Many systemic treatment options are available for advanced breast cancer, including endocrine therapy, chemotherapy, anti-human epidermal growth factor receptor 2 (HER2) therapy, and other targeted agents. Recently, everolimus, a mammalian target of rapamycin (mTOR) inhibitor, combined with exemestane, an...

Past, present, and future of hormonal therapy in recurrent endometrial cancer.

International journal of women's health

Carlson MJ, Thiel KW, Leslie KK.
PMID: 24833920
Int J Womens Health. 2014 May 02;6:429-35. doi: 10.2147/IJWH.S40942. eCollection 2014.

Endometrial cancer is a heterogeneous disease. Type I cancers are hormonally driven, typically present with a low grade at an early stage, and are of endometrioid histology. These cancers are often cured by surgery, and the rate of recurrence...

Circulating microRNAs in patients with hormone receptor-positive, metastatic breast cancer treated with dovitinib.

Clinical and translational medicine

Shivapurkar N, Vietsch EE, Carney E, Isaacs C, Wellstein A.
PMID: 28980224
Clin Transl Med. 2017 Oct 04;6(1):37. doi: 10.1186/s40169-017-0169-y.

BACKGROUND: Serial analysis of biomarkers in the circulation of patients undergoing treatment ("liquid biopsies") can provide new insights into drug effects. In particular the analysis of cell-free, circulating nucleic acids such as microRNAs (miRs) can reveal altered expression patterns...

Postoperative elevation of CA15-3 due to pernicious anemia in a patient without evidence of breast cancer recurrence.

Surgical case reports

Adachi Y, Kikumori T, Miyajima N, Inaishi T, Onishi E, Shibata M, Nakanishi K, Takeuchi D, Hayashi H, Kodera Y.
PMID: 26943450
Surg Case Rep. 2015 Dec;1(1):126. doi: 10.1186/s40792-015-0128-z. Epub 2015 Dec 30.

Cancer antigen 15-3 (CA15-3) is considered as a marker for breast cancer recurrence. However, we encountered a case where the patient showed postoperative elevation of the CA15-3 level due to pernicious anemia without evidence of breast cancer recurrence. The...

Hormonal based treatment of ovarian anaplastic ependymoma with anastrozole.

Gynecologic oncology reports

Gorski JW, Taylor JS, Zhang J, Liu J, Jazaeri AA.
PMID: 28393092
Gynecol Oncol Rep. 2017 Mar 14;20:93-96. doi: 10.1016/j.gore.2017.03.005. eCollection 2017 May.

OBJECTIVE: Ovarian anaplastic ependymoma is a rare gynecologic malignancy that poses diagnostic and treatment challenges. Treatment of sub-optimally debulked disease usually portends poor prognosis. Molecular testing of tumor specimen can identify more specific targets for additional therapy such as...

Immunolocalisation of aromatase regulators liver kinase B1, phosphorylated AMP-activated protein kinase and cAMP response element-binding protein-regulated transcription co-activators in the human testis.

Reproduction, fertility, and development

Ham S, Brown KA, Simpson ER, Meachem SJ.
PMID: 26946412
Reprod Fertil Dev. 2016 Mar 07; doi: 10.1071/RD15390. Epub 2016 Mar 07.

Although oestrogens are essential for spermatogenesis and their biosynthesis is dependent on aromatase expression, the molecular mechanism of aromatase regulation is poorly understood. Our laboratory has demonstrated that liver kinase B1 (LKB1) is a negative regulator of aromatase in...

Effects of chronic heat stress on granulosa cell apoptosis and follicular atresia in mouse ovary.

Journal of animal science and biotechnology

Li J, Gao H, Tian Z, Wu Y, Wang Y, Fang Y, Lin L, Han Y, Wu S, Haq I, Zeng S.
PMID: 27708774
J Anim Sci Biotechnol. 2016 Sep 29;7:57. doi: 10.1186/s40104-016-0116-6. eCollection 2016.

BACKGROUND: Heat stress is known to alter follicular dynamics and granulosa cell function and may contribute to the diminished reproductive efficiency commonly observed in mammals during the summer. Although several investigators have studied heat-induced ovarian injury, few reports have...

Testosterone inhibits expression of lipogenic genes in visceral fat by an estrogen-dependent mechanism.

Journal of applied physiology (Bethesda, Md. : 1985)

Holland AM, Roberts MD, Mumford PW, Mobley CB, Kephart WC, Conover CF, Beggs LA, Balaez A, Otzel DM, Yarrow JF, Borst SE, Beck DT.
PMID: 27539493
J Appl Physiol (1985). 2016 Sep 01;121(3):792-805. doi: 10.1152/japplphysiol.00238.2016. Epub 2016 Aug 18.

The influence of the aromatase enzyme on the chronic fat-sparing effects of testosterone requires further elucidation. Our purpose was to determine whether chronic anastrozole (AN, an aromatase inhibitor) treatment alters testosterone-mediated lipolytic/lipogenic gene expression in visceral fat. Ten-month-old Fischer...

Endometriosis: alternative methods of medical treatment.

International journal of women's health

Muñoz-Hernando L, Muñoz-Gonzalez JL, Marqueta-Marques L, Alvarez-Conejo C, Tejerizo-García Á, Lopez-Gonzalez G, Villegas-Muñoz E, Martin-Jimenez A, Jiménez-López JS.
PMID: 26089705
Int J Womens Health. 2015 Jun 11;7:595-603. doi: 10.2147/IJWH.S78829. eCollection 2015.

Endometriosis is an inflammatory estrogen-dependent disease defined by the presence of endometrial glands and stroma at extrauterine sites. The main purpose of endometriosis management is alleviating pain associated to the disease. This can be achieved surgically or medically, although...

Accumulation of p53 is prognostic for aromatase inhibitor resistance in early-stage postmenopausal patients with ER-positive breast cancer.

OncoTargets and therapy

Jia XQ, Hong Q, Cheng JY, Li JW, Wang YJ, Mo M, Shao ZM, Shen ZZ, Liu GY.
PMID: 25767399
Onco Targets Ther. 2015 Mar 03;8:549-55. doi: 10.2147/OTT.S76879. eCollection 2015.

OBJECTIVE: Studies have indicated that p53 protein accumulation exerts an adverse effect on the survival of breast cancer patients; however, the prognostic value of p53 protein accumulation for aromatase inhibitor (AI) resistance in ER-positive breast cancer is uncertain.METHODS: The...

Aromatase expression in lung cancer.

The Lancet. Oncology

Paterlini M.
PMID: 28581421
Lancet Oncol. 2007 Dec;8(12):1060. doi: 10.1016/S1470-2045(07)70366-2. Epub 2007 Dec 03.

No abstract available.

Breast Cancer: Abemaciclib effective in combination with aromatase inhibition.

Nature reviews. Clinical oncology

Sidaway P.
PMID: 29039423
Nat Rev Clin Oncol. 2017 Dec;14(12):714. doi: 10.1038/nrclinonc.2017.169. Epub 2017 Oct 17.

No abstract available.

Showing 1 to 12 of 1524 entries