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Showing 1 to 12 of 207 entries
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Antihyperalgesic Effect of Hesperidin Improves with Diosmin in Experimental Neuropathic Pain.

BioMed research international

Carballo-Villalobos AI, González-Trujano ME, Pellicer F, López-Muñoz FJ.
PMID: 27672659
Biomed Res Int. 2016;2016:8263463. doi: 10.1155/2016/8263463. Epub 2016 Sep 08.

Neuropathic pain is caused by a primary lesion, dysfunction, or transitory perturbation in the peripheral or central nervous system. In this study, we investigated the hesperidin antihyperalgesic effects alone or combined with diosmin in a model of neuropathic pain...

Calcium-mediated paired pulse depression in juvenile rat dorsal striatum.

Neural regeneration research

Xie Y, Jackson MF, MacDonald JF.
PMID: 25737701
Neural Regen Res. 2012 Apr 05;7(10):772-7. doi: 10.3969/j.issn.1673-5374.2012.10.008.

As the major division of the basal ganglia, neostriatum forms mutual connections with multiple brain areas and is critically involved in motor control and learning/memory. Long-term synaptic plasticity has been widely studied in different species recently. However, there are...

Global actions of nicotine on the striatal microcircuit.

Frontiers in systems neuroscience

Plata V, Duhne M, Pérez-Ortega J, Hernández-Martinez R, Rueda-Orozco P, Galarraga E, Drucker-Colín R, Bargas J.
PMID: 24223538
Front Syst Neurosci. 2013 Nov 06;7:78. doi: 10.3389/fnsys.2013.00078. eCollection 2013.

THE QUESTION TO SOLVE IN THE PRESENT WORK IS: what is the predominant action induced by the activation of cholinergic-nicotinic receptors (nAChrs) in the striatal network given that nAChrs are expressed by several elements of the circuit: cortical terminals,...

Effects of diazepam on glutamatergic synaptic transmission in the hippocampal CA1 area of rats with traumatic brain injury.

Neural regeneration research

Cao L, Bie X, Huo S, Du J, Liu L, Song W.
PMID: 25558239
Neural Regen Res. 2014 Nov 01;9(21):1897-901. doi: 10.4103/1673-5374.145357.

The activity of the Schaffer collaterals of hippocampal CA3 neurons and hippocampal CA1 neurons has been shown to increase after fluid percussion injury. Diazepam can inhibit the hyperexcitability of rat hippocampal neurons after injury, but the mechanism by which...

The trophic effect of gaba on cerebellar granule cells is mediated by gaba-receptors.

International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience

Meier E, Hansen GH, Schousboe A.
PMID: 24874866
Int J Dev Neurosci. 1985;3(4):401-7. doi: 10.1016/0736-5748(85)90074-7.

The effect of GABA, its agonist THIP (4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol), and its antagonist bicuculline methobromide on the ultrastructure of cerebellar granule cells was studied. It was found that while the density of mitochondria, the ribosomes and smooth endoplasmic reticulum was unaffected...

Effects of Ketamine on Neuronal Spontaneous Excitatory Postsynaptic Currents and Miniature Excitatory Postsynaptic Currents in the Somatosensory Cortex of Rats.

Iranian journal of medical sciences

Yuan C, Zhang Y, Zhang Y, Cao S, Wang Y, Fu B, Yu T.
PMID: 27365548
Iran J Med Sci. 2016 Jul;41(4):275-82.

BACKGROUND: Ketamine is a commonly used intravenous anesthetic which produces dissociation anesthesia, analgesia, and amnesia. The mechanism of ketamine-induced synaptic inhibition in high-level cortical areas is still unknown. We aimed to elucidate the effects of different concentrations of ketamine...

Participation of the GABA-benzodiazepine system in the inhibition of defensive burying produced by ejaculation.

Behavioural pharmacology

Fernández-Guasti A, Saldívar A.
PMID: 11175427
Behav Pharmacol. 1990;1(5):429-436.

We recently reported a reduction in defensive burying behaviour after ejaculation. The present study analyzed whether this reduction was mediated via an increase in GABAergic transmission. Two experimental series were included: in the first series the reduction in burying...

1-Magnesiotetrahydroisoquinolyloxazolines as Chiral Nucleophiles in Stereoselective Additions to Aldehydes: Auxiliary Optimization, Asymmetric Synthesis of (+)-Corlumine, (+)-Bicuculline, (+)-Egenine, and (+)-Corytensine, and Preliminary (13)C NMR Studies of 1-Lithio- and 1-Magnesiotetrahydroisoquinolyloxazolines.

The Journal of organic chemistry

Gawley RE, Zhang P.
PMID: 11667797
J Org Chem. 1996 Nov 15;61(23):8103-8112. doi: 10.1021/jo961164u.

Transmetalation of 1-lithiotetrahydroisoquinolyloxazolines with magnesium halides affords Grignard reagents that add to aldehydes with up to 80% selectivity for one of the four possible diastereomeric products. An oxazoline chiral auxiliary derived from camphor provides an optimal blend of diastereoselectivity...

Horizontal Interactions in Cat Striate Cortex: III. Ectopic Receptive Fields and Transient Exuberance of Tangential Interactions.

The European journal of neuroscience

Luhmann HJ, Greuel JM, Singer W.
PMID: 12106043
Eur J Neurosci. 1990;2(4):369-377. doi: 10.1111/j.1460-9568.1990.tb00428.x.

In this study the developmental changes of intracortical connectivity are related to changes of cortical receptor fields (RFs). The RFs of striate cortex neurons of 4- to 8.5-week-old kittens, reared under normal conditions (NR) or in a selective visual...

Phase-dependent Modulation of a Cutaneous Sensory Pathway by Glycinergic Inhibition from the Locomotor Rhythm Generator in Xenopus Embryos.

The European journal of neuroscience

Sillar KT, Roberts A.
PMID: 12106408
Eur J Neurosci. 1992 Oct;4(11):1022-1034. doi: 10.1111/j.1460-9568.1992.tb00129.x.

In immobilized Xenopus laevis embryos two classes of sensory interneuron are excited by mechanosensory Rohon - Beard neurons and rhythmically inhibited during fictive swimming. Dorsolateral commissural (DLC) interneurons are inhibited in time with rhythmic motor discharge on the same...

Synaptic Activation of GABAA Receptors Causes a Depolarizing Potential Under Physiological Conditions in Rat Hippocampal Pyramidal Cells.

The European journal of neuroscience

Avoli M.
PMID: 12106438
Eur J Neurosci. 1992 Oct;4(1):16-26. doi: 10.1111/j.1460-9568.1992.tb00105.x.

Intracellular recordings with K-acetate-filled microelectrodes were performed in slices of the adult rat hippocampus maintained in vitro at 35 - 36 degrees C to analyse the potentials associated with the orthodromic inhibitory sequence generated by CA1 pyramidal cells. In...

Mast Cell Degranulating Peptide Increases the Frequency of Spontaneous Miniature Postsynaptic Currents in CA3 Rat Hippocampal Neurons.

The European journal of neuroscience

Neuman R, Ari YB, Cherubini E.
PMID: 12106484
Eur J Neurosci. 1991 Jun;3(6):523-530. doi: 10.1111/j.1460-9568.1991.tb00839.x.

Mast cell degranulating peptide (MCDP) is a neurotoxic agent isolated from bee venom. It produces a long-term potentiation in the hippocampus. We now report that MCDP, at nanomolar concentrations, induces a reduction of a transient voltage-dependent potassium current (ID)...

Showing 1 to 12 of 207 entries