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Showing 1 to 12 of 2885 entries
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A selective histone deacetylase-6 inhibitor improves BDNF trafficking in hippocampal neurons from Mecp2 knockout mice: implications for Rett syndrome.

Frontiers in cellular neuroscience

Xu X, Kozikowski AP, Pozzo-Miller L.
PMID: 24639629
Front Cell Neurosci. 2014 Mar 07;8:68. doi: 10.3389/fncel.2014.00068. eCollection 2014.

Rett syndrome (RTT) is a neurodevelopmental disorder caused by loss-of-function mutations in the transcriptional modulator methyl-CpG-binding protein 2 (MECP2). One of the most prominent gene targets of MeCP2 is brain-derived neurotrophic factor (Bdnf), a potent modulator of activity-dependent synaptic...

Imbalance of the Nerve Growth Factor and Its Precursor: Implication in Diabetic Retinopathy.

Journal of clinical & experimental ophthalmology

Mohamed R, El-Remessy AB.
PMID: 26807305
J Clin Exp Ophthalmol. 2015 Oct;6(5). doi: 10.4172/2155-9570.1000483. Epub 2015 Oct 25.

Diabetic retinopathy is the leading cause of blindness in working age in US and worldwide. Neurotrophins including nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3) and neurotrophin-4 (NT-4) are known to be essential for growth, differentiation and...

Effects of confinement on physiological and psychological responses and expression of interleukin 6 and brain derived neurotrophic factor mRNA in primiparous and multiparous weaning sows.

Asian-Australasian journal of animal sciences

Zhang M, Li X, Li J, Sun H, Zhang X, Bao J.
PMID: 28423876
Asian-Australas J Anim Sci. 2017 Sep;30(9):1350-1357. doi: 10.5713/ajas.17.0013. Epub 2017 Mar 25.

OBJECTIVE: The present study aimed to investigate whether the long-lasting, recurrent restricting of sows leads to the physiological and psychological reaction of discomfort.METHODS: Sows (Large White) that had experienced restricting for about 0.5 or 3 years and age-matched sows...

Regulation of Trophic Factor Expression by Innervating Target Regions in Intraocular Double Transplants.

Cell transplantation

Willis L, Quintero EM, Nelson M, Granholm AC.
PMID: 28863735
Cell Transplant. 2005 Jan;14(1):21-29. doi: 10.3727/000000005783983313.

Trophic factors have been found to play a significant role both in long-term survival processes and in more rapid and dynamic processes in the brain and spinal cord. However, little is known regarding the regulation of expression of growth...

Effect of BDNF and Other Potential Survival Factors in Models of In Vitro Oxidative Stress on Adult Spinal Cord-Derived Neural Stem/Progenitor Cells.

BioResearch open access

Hachem LD, Mothe AJ, Tator CH.
PMID: 26309791
Biores Open Access. 2015 Feb 01;4(1):146-59. doi: 10.1089/biores.2014.0058. eCollection 2015.

Transplantation of neural stem/progenitor cells (NSPCs) is a promising strategy in spinal cord injury (SCI). However, poor survival of transplanted stem cells remains a major limitation of this therapy due to the hostile environment of the injured cord. Oxidative...

Arc Interacts with the Integral Endoplasmic Reticulum Protein, Calnexin.

Frontiers in cellular neuroscience

Myrum C, Soulé J, Bittins M, Cavagnini K, Goff K, Ziemek SK, Eriksen MS, Patil S, Szum A, Nair RR, Bramham CR.
PMID: 28979192
Front Cell Neurosci. 2017 Sep 20;11:294. doi: 10.3389/fncel.2017.00294. eCollection 2017.

Activity-regulated cytoskeleton-associated protein, Arc, is a major regulator of long-term synaptic plasticity and memory formation. Here we reveal a novel interaction partner of Arc, a resident endoplasmic reticulum transmembrane protein, calnexin. We show an interaction between recombinantly-expressed GST-tagged Arc...

Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology

Agrawal R, Kalmady SV, Venkatasubramanian G.
PMID: 28449558
Clin Psychopharmacol Neurosci. 2017 May 31;15(2):115-125. doi: 10.9758/cpn.2017.15.2.115.

OBJECTIVE: Deficient brain-derived neurotrophic factor (BDNF) is one of the important mechanisms underlying the neuroplasticity abnormalities in schizophrenia. Aberration in BDNF signaling pathways directly or circuitously influences neurotransmitters like glutamate and gamma-aminobutyric acid (GABA). For the first time, this...

Identification of molecular characteristics induced by radiotherapy in rectal cancer based on microarray data.

Oncology letters

Ge C, Wu M, Chen G, Yu G, Ji D, Wang S.
PMID: 28454466
Oncol Lett. 2017 Apr;13(4):2777-2783. doi: 10.3892/ol.2017.5750. Epub 2017 Feb 20.

The present study aimed to reveal the molecular characteristics induced by radiotherapy in rectal cancer at the transcriptome level. Microarray data (ID, GSE26027) downloaded from the Gene Expression Omnibus database were re-analyzed to identify differentially expressed genes (DEGs) between...

Female gender and gastrointestinal symptoms, not brain-derived neurotrophic factor, are associated with depression and anxiety in cirrhosis.

Hepatology research : the official journal of the Japan Society of Hepatology

Xu H, Zhou Y, Ko F, Ping J, Zhang J, Zhao C, Xu L.
PMID: 27062585
Hepatol Res. 2017 Mar;47(3):E64-E73. doi: 10.1111/hepr.12723. Epub 2016 May 04.

AIM: Cirrhosis places a substantial burden on the psychological status of affected individuals. The aim of our study was to identify the associated factors of psychological distress in cirrhosis.METHODS: A total of 208 patients with cirrhosis were recruited. Each...

Detection of phosphorylated Akt and MAPK in cell culture assays.

MethodsX

Molgaard S, Ulrichsen M, Olsen D, Glerup S.
PMID: 27274457
MethodsX. 2016 Apr 29;3:386-98. doi: 10.1016/j.mex.2016.04.009. eCollection 2016.

This article describes an immunocytochemistry (ICC) method for staining against phosphorylated forms of the kinases Akt (pAkt) and MAPK (pMAPK). Phosphorylation is induced upon their activation by a number stimuli including insulin and brain-derived neurotrophic factor (BDNF), and is...

Emulsified isoflurane anesthesia decreases brain-derived neurotrophic factor expression and induces cognitive dysfunction in adult rats.

Experimental and therapeutic medicine

Zhang F, Zhu ZQ, Liu DX, Zhang C, Gong QH, Zhu YH.
PMID: 25009603
Exp Ther Med. 2014 Aug;8(2):471-477. doi: 10.3892/etm.2014.1769. Epub 2014 Jun 10.

Post-operative cognitive dysfunction (POCD) is a severe complication characterized by cognitive decline in patients following anesthesia and surgery. Previous studies have suggested that volatile anesthetics, for example isoflurane, may contribute to such impairment. In the present study, the effects...

A systematic review of neuroprotective strategies after cardiac arrest: from bench to bedside (part II-comprehensive protection).

Medical gas research

Huang L, Applegate PM, Gatling JW, Mangus DB, Zhang J, Applegate RL.
PMID: 25671079
Med Gas Res. 2014 May 20;4:10. doi: 10.1186/2045-9912-4-10. eCollection 2014.

Neurocognitive deficits remain a significant source of morbidity in survivors of cardiac arrest. We conducted a literature review of treatment protocols designed to evaluate neurologic outcome and survival following global cerebral ischemia associated with cardiac arrest. The search was...

Showing 1 to 12 of 2885 entries