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Association between lowering LDL-C and cardiovascular risk reduction among different therapeutic interventions: a systematic review and meta-analysis

Stem career interventions

Wiviott SD.
GSID: Duou_YqWZaIJ
MG Silverman, BA Ference, K Im, SD Wiviott… - Jama, 2016 - jamanetwork.com

Importance The comparative clinical benefit of nonstatin therapies that reduce low-density lipoprotein cholesterol (LDL-C) remains uncertain. Objective To evaluate the association between lowering LDL-C and relative cardiovascular risk reduction across different statin and nonstatin therapies. Data Sources and Study...

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Silverman, M. G., Ference, B. A., Im, K., Wiviott, S. D., Giugliano, R. P., Grundy, S. M., ... & Sabatine, M. S. (2016). Association between lowering LDL-C and cardiovascular risk reduction among different therapeutic interventions: a systematic review and meta-analysis. Jama, 316(12), 1289-1297.
Silverman, Michael G., et al. "Association between lowering LDL-C and cardiovascular risk reduction among different therapeutic interventions: a systematic review and meta-analysis." Jama 316.12 (2016): 1289-1297.
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Nutrigenomics approach elucidates health-promoting effects of high vegetable intake in lean and obese men.

Genes & nutrition

Pasman WJ, van Erk MJ, Klöpping WA, Pellis L, Wopereis S, Bijlsma S, Hendriks HF, Kardinaal AF.
PMID: 23595524
Genes Nutr. 2013 Sep;8(5):507-21. doi: 10.1007/s12263-013-0343-9. Epub 2013 Apr 18.

We aimed to explore whether vegetable consumption according to guidelines has beneficial health effects determined with classical biomarkers and nutrigenomics technologies. Fifteen lean (age 36 ± 7 years; BMI 23.4 ± 1.7 kg m(-2)) and 17 obese (age 40...

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Pasman WJ, van Erk MJ, Klöpping WA, et al. Nutrigenomics approach elucidates health-promoting effects of high vegetable intake in lean and obese men. Genes Nutr. 2013;8(5):507-21doi: 10.1007/s12263-013-0343-9.
Pasman, W. J., van Erk, M. J., Klöpping, W. A., Pellis, L., Wopereis, S., Bijlsma, S., Hendriks, H. F., & Kardinaal, A. F. (2013). Nutrigenomics approach elucidates health-promoting effects of high vegetable intake in lean and obese men. Genes & nutrition, 8(5), 507-21. https://doi.org/10.1007/s12263-013-0343-9
Pasman, W J, et al. "Nutrigenomics approach elucidates health-promoting effects of high vegetable intake in lean and obese men." Genes & nutrition vol. 8,5 (2013): 507-21. doi: https://doi.org/10.1007/s12263-013-0343-9
Pasman WJ, van Erk MJ, Klöpping WA, Pellis L, Wopereis S, Bijlsma S, Hendriks HF, Kardinaal AF. Nutrigenomics approach elucidates health-promoting effects of high vegetable intake in lean and obese men. Genes Nutr. 2013 Sep;8(5):507-21. doi: 10.1007/s12263-013-0343-9. Epub 2013 Apr 18. PMID: 23595524; PMCID: PMC3755133.
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A Study of the Extended Lipid Profile including Oxidized LDL, Small Dense LDL, Lipoprotein (a) and Apolipoproteins in the Assessment of Cardiovascular Risk in Hypothyroid Patients.

Journal of clinical and diagnostic research : JCDR

Bansal SK, Yadav R.
PMID: 27504276
J Clin Diagn Res. 2016 Jun;10(6):BC04-8. doi: 10.7860/JCDR/2016/19775.8067. Epub 2016 Jun 01.

INTRODUCTION: Hypothyroidism is one of the most common metabolic disorders associated with dyslipidemia which poses a higher risk of Coronary Artery Disease (CAD) in such patients. Biochemical markers which can pick up the risk promptly are becoming imperative now-a-days...

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Bansal SK, Yadav R. A Study of the Extended Lipid Profile including Oxidized LDL, Small Dense LDL, Lipoprotein (a) and Apolipoproteins in the Assessment of Cardiovascular Risk in Hypothyroid Patients. J Clin Diagn Res. 2016;10(6):BC04-8doi: 10.7860/JCDR/2016/19775.8067.
Bansal, S. K., & Yadav, R. (2016). A Study of the Extended Lipid Profile including Oxidized LDL, Small Dense LDL, Lipoprotein (a) and Apolipoproteins in the Assessment of Cardiovascular Risk in Hypothyroid Patients. Journal of clinical and diagnostic research : JCDR, 10(6), BC04-8. https://doi.org/10.7860/JCDR/2016/19775.8067
Bansal, Sanjiv Kumar, and Yadav, Rakhee. "A Study of the Extended Lipid Profile including Oxidized LDL, Small Dense LDL, Lipoprotein (a) and Apolipoproteins in the Assessment of Cardiovascular Risk in Hypothyroid Patients." Journal of clinical and diagnostic research : JCDR vol. 10,6 (2016): BC04-8. doi: https://doi.org/10.7860/JCDR/2016/19775.8067
Bansal SK, Yadav R. A Study of the Extended Lipid Profile including Oxidized LDL, Small Dense LDL, Lipoprotein (a) and Apolipoproteins in the Assessment of Cardiovascular Risk in Hypothyroid Patients. J Clin Diagn Res. 2016 Jun;10(6):BC04-8. doi: 10.7860/JCDR/2016/19775.8067. Epub 2016 Jun 01. PMID: 27504276; PMCID: PMC4963636.
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PCSK9 as a therapeutic target for cardiovascular disease.

Experimental and therapeutic medicine

Zhang PY.
PMID: 28450903
Exp Ther Med. 2017 Mar;13(3):810-814. doi: 10.3892/etm.2017.4055. Epub 2017 Jan 17.

It is well recognized that the elevated plasma level of low-density lipoprotein-cholesterol (LDL-C) is a major risk factor for atherosclerosis and cardiovascular disease (CVD). Deposition of pro-atherogenic LDL-C, on the intima of arterial wall, contributes to plaque formation and...

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Zhang PY. PCSK9 as a therapeutic target for cardiovascular disease. Exp Ther Med. 2017;13(3):810-814doi: 10.3892/etm.2017.4055.
Zhang, P. Y. (2017). PCSK9 as a therapeutic target for cardiovascular disease. Experimental and therapeutic medicine, 13(3), 810-814. https://doi.org/10.3892/etm.2017.4055
Zhang, Pei-Ying. "PCSK9 as a therapeutic target for cardiovascular disease." Experimental and therapeutic medicine vol. 13,3 (2017): 810-814. doi: https://doi.org/10.3892/etm.2017.4055
Zhang PY. PCSK9 as a therapeutic target for cardiovascular disease. Exp Ther Med. 2017 Mar;13(3):810-814. doi: 10.3892/etm.2017.4055. Epub 2017 Jan 17. PMID: 28450903; PMCID: PMC5403434.
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Consequences of AphanizomenonFlos-aquae(AFA) extract (Stemtech (TM) ) on metabolic profile of patients with type 2 diabetes.

Journal of diabetes and metabolic disorders

Sanaei M, Ebrahimi M, Banazadeh Z, Shafiee G, Khatami F, Ahadi Z, Heshmat R.
PMID: 26131436
J Diabetes Metab Disord. 2015 Jun 24;14:50. doi: 10.1186/s40200-015-0177-7. eCollection 2015.

BACKGROUND: Blue- green algae is one of the most nutrient dense foods which is rich in substances that have useful effects on human health. The purpose of this study was to evaluate the effectiveness of a water- soluble extract...

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Sanaei M, Ebrahimi M, Banazadeh Z, et al. Consequences of AphanizomenonFlos-aquae(AFA) extract (Stemtech (TM) ) on metabolic profile of patients with type 2 diabetes. J Diabetes Metab Disord. 2015;14:50doi: 10.1186/s40200-015-0177-7.
Sanaei, M., Ebrahimi, M., Banazadeh, Z., Shafiee, G., Khatami, F., Ahadi, Z., & Heshmat, R. (2015). Consequences of AphanizomenonFlos-aquae(AFA) extract (Stemtech (TM) ) on metabolic profile of patients with type 2 diabetes. Journal of diabetes and metabolic disorders, 1450. https://doi.org/10.1186/s40200-015-0177-7
Sanaei, Maryam, et al. "Consequences of AphanizomenonFlos-aquae(AFA) extract (Stemtech (TM) ) on metabolic profile of patients with type 2 diabetes." Journal of diabetes and metabolic disorders vol. 14 (2015): 50. doi: https://doi.org/10.1186/s40200-015-0177-7
Sanaei M, Ebrahimi M, Banazadeh Z, Shafiee G, Khatami F, Ahadi Z, Heshmat R. Consequences of AphanizomenonFlos-aquae(AFA) extract (Stemtech (TM) ) on metabolic profile of patients with type 2 diabetes. J Diabetes Metab Disord. 2015 Jun 24;14:50. doi: 10.1186/s40200-015-0177-7. eCollection 2015. PMID: 26131436; PMCID: PMC4485343.
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Sitagliptin reduces urinary microalbumin in experimental model of diabetic nephropathy.

Hellenic journal of nuclear medicine

Tsavdaridis I, Papadimitriou D, Karanikola D, Kalousis K, Katsouda A, Mironidou-Tzouveleki M.
PMID: 26665237
Hell J Nucl Med. 2015 Sep-Dec;18:154.

OBJECTIVE: The term Diabetic kidney disease (DKD) refers to any disease of the kidney that is a result of long-term hyperglycemia caused either by diabetes mellitus type 1 (DT1) or type 2 (DT2). When DKD coexists with macro albuminuria...

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Tsavdaridis I, Papadimitriou D, Karanikola D, et al. Sitagliptin reduces urinary microalbumin in experimental model of diabetic nephropathy. Hell J Nucl Med. 2015;18:154
Tsavdaridis, I., Papadimitriou, D., Karanikola, D., Kalousis, K., Katsouda, A., & Mironidou-Tzouveleki, M. (2015). Sitagliptin reduces urinary microalbumin in experimental model of diabetic nephropathy. Hellenic journal of nuclear medicine, 18154.
Tsavdaridis, Ioannis, et al. "Sitagliptin reduces urinary microalbumin in experimental model of diabetic nephropathy." Hellenic journal of nuclear medicine vol. 18 (2015): 154.
Tsavdaridis I, Papadimitriou D, Karanikola D, Kalousis K, Katsouda A, Mironidou-Tzouveleki M. Sitagliptin reduces urinary microalbumin in experimental model of diabetic nephropathy. Hell J Nucl Med. 2015 Sep-Dec;18:154. PMID: 26665237.
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Obstructive Sleep Apnea and Lipid Abnormalities.

Open access Macedonian journal of medical sciences

Karkinski D, Georgievski O, Dzekova-Vidimliski P, Milenkovic T, Dokic D.
PMID: 28293310
Open Access Maced J Med Sci. 2017 Mar 15;5(1):19-22. doi: 10.3889/oamjms.2017.011. Epub 2017 Jan 18.

BACKGROUND: There has been a great interest in the interaction between obstructive sleep apnea (OSA) and metabolic dysfunction, but there is no consistent data suggesting that OSA is a risk factor for dyslipidemia.AIM: The aim of this cross-sectional study...

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Karkinski D, Georgievski O, Dzekova-Vidimliski P, et al. Obstructive Sleep Apnea and Lipid Abnormalities. Open Access Maced J Med Sci. 2017;5(1):19-22doi: 10.3889/oamjms.2017.011.
Karkinski, D., Georgievski, O., Dzekova-Vidimliski, P., Milenkovic, T., & Dokic, D. (2017). Obstructive Sleep Apnea and Lipid Abnormalities. Open access Macedonian journal of medical sciences, 5(1), 19-22. https://doi.org/10.3889/oamjms.2017.011
Karkinski, Dimitar, et al. "Obstructive Sleep Apnea and Lipid Abnormalities." Open access Macedonian journal of medical sciences vol. 5,1 (2017): 19-22. doi: https://doi.org/10.3889/oamjms.2017.011
Karkinski D, Georgievski O, Dzekova-Vidimliski P, Milenkovic T, Dokic D. Obstructive Sleep Apnea and Lipid Abnormalities. Open Access Maced J Med Sci. 2017 Mar 15;5(1):19-22. doi: 10.3889/oamjms.2017.011. Epub 2017 Jan 18. PMID: 28293310; PMCID: PMC5320901.
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Prevalence of Diabetes, Obesity and Dyslipidaemia in Persons within High and Low Income Groups Living in North and South Trinidad.

Journal of clinical and diagnostic research : JCDR

Nayak SB, Rahming V, Raghunanan Y, Raghoonath C, Rahman A, Rajh D, Rambadan S, Ramdass N.
PMID: 27437244
J Clin Diagn Res. 2016 May;10(5):IC08-IC13. doi: 10.7860/JCDR/2016/18154.7875. Epub 2016 May 01.

INTRODUCTION: Diabetes Mellitus, obesity and dyslipidaemia are metabolic disorders characterized by similar risk factors, complications and outcomes including stroke, insulin resistance, MI and even death. Studies have indicated that impoverished and low income areas of developing countries are more...

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Nayak SB, Rahming V, Raghunanan Y, et al. Prevalence of Diabetes, Obesity and Dyslipidaemia in Persons within High and Low Income Groups Living in North and South Trinidad. J Clin Diagn Res. 2016;10(5):IC08-IC13doi: 10.7860/JCDR/2016/18154.7875.
Nayak, S. B., Rahming, V., Raghunanan, Y., Raghoonath, C., Rahman, A., Rajh, D., Rambadan, S., & Ramdass, N. (2016). Prevalence of Diabetes, Obesity and Dyslipidaemia in Persons within High and Low Income Groups Living in North and South Trinidad. Journal of clinical and diagnostic research : JCDR, 10(5), IC08-IC13. https://doi.org/10.7860/JCDR/2016/18154.7875
Nayak, Shivananda B, et al. "Prevalence of Diabetes, Obesity and Dyslipidaemia in Persons within High and Low Income Groups Living in North and South Trinidad." Journal of clinical and diagnostic research : JCDR vol. 10,5 (2016): IC08-IC13. doi: https://doi.org/10.7860/JCDR/2016/18154.7875
Nayak SB, Rahming V, Raghunanan Y, Raghoonath C, Rahman A, Rajh D, Rambadan S, Ramdass N. Prevalence of Diabetes, Obesity and Dyslipidaemia in Persons within High and Low Income Groups Living in North and South Trinidad. J Clin Diagn Res. 2016 May;10(5):IC08-IC13. doi: 10.7860/JCDR/2016/18154.7875. Epub 2016 May 01. PMID: 27437244; PMCID: PMC4948420.
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Predictors of Plaque Progression in Hypertensive Angina Patients with Achieved Low-Density Lipoprotein Cholesterol Less Than 70 mg/dL after Rosuvastatin Treatment.

Chonnam medical journal

Hong YJ, Jeong MH, Kim MC, Kim WJ, Kim HK, Park KH, Sim DS, Kim JH, Ahn Y, Cho JG, Park JC.
PMID: 26730363
Chonnam Med J. 2015 Dec;51(3):120-8. doi: 10.4068/cmj.2015.51.3.120. Epub 2015 Dec 11.

We evaluated the impact of achieved low-density lipoprotein cholesterol (LDL-C) concentrations

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Hong YJ, Jeong MH, Kim MC, et al. Predictors of Plaque Progression in Hypertensive Angina Patients with Achieved Low-Density Lipoprotein Cholesterol Less Than 70 mg/dL after Rosuvastatin Treatment. Chonnam Med J. 2015;51(3):120-8doi: 10.4068/cmj.2015.51.3.120.
Hong, Y. J., Jeong, M. H., Kim, M. C., Kim, W. J., Kim, H. K., Park, K. H., Sim, D. S., Kim, J. H., Ahn, Y., Cho, J. G., & Park, J. C. (2015). Predictors of Plaque Progression in Hypertensive Angina Patients with Achieved Low-Density Lipoprotein Cholesterol Less Than 70 mg/dL after Rosuvastatin Treatment. Chonnam medical journal, 51(3), 120-8. https://doi.org/10.4068/cmj.2015.51.3.120
Hong, Young Joon, et al. "Predictors of Plaque Progression in Hypertensive Angina Patients with Achieved Low-Density Lipoprotein Cholesterol Less Than 70 mg/dL after Rosuvastatin Treatment." Chonnam medical journal vol. 51,3 (2015): 120-8. doi: https://doi.org/10.4068/cmj.2015.51.3.120
Hong YJ, Jeong MH, Kim MC, Kim WJ, Kim HK, Park KH, Sim DS, Kim JH, Ahn Y, Cho JG, Park JC. Predictors of Plaque Progression in Hypertensive Angina Patients with Achieved Low-Density Lipoprotein Cholesterol Less Than 70 mg/dL after Rosuvastatin Treatment. Chonnam Med J. 2015 Dec;51(3):120-8. doi: 10.4068/cmj.2015.51.3.120. Epub 2015 Dec 11. PMID: 26730363; PMCID: PMC4697112.
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The relationship between apolipoprotein CIII gene polymorphism and serum lipid levels in Han Chinese males.

Meta gene

Su S, Tang M, Zhang M, Cheng C, Tang X.
PMID: 25606375
Meta Gene. 2013 Nov 15;1:58-64. doi: 10.1016/j.mgene.2013.09.005. eCollection 2013 Dec.

BACKGROUND: Although apolipoprotein (apo) CIII gene polymorphisms have proved to be related to the increased serum lipid level in foreign studies, the results have not always been consistent among diverse populations. In addition, the research focuses on the impact...

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Su S, Tang M, Zhang M, et al. The relationship between apolipoprotein CIII gene polymorphism and serum lipid levels in Han Chinese males. Meta Gene. 2013;1:58-64doi: 10.1016/j.mgene.2013.09.005.
Su, S., Tang, M., Zhang, M., Cheng, C., & Tang, X. (2013). The relationship between apolipoprotein CIII gene polymorphism and serum lipid levels in Han Chinese males. Meta gene, 158-64. https://doi.org/10.1016/j.mgene.2013.09.005
Su, Shu, et al. "The relationship between apolipoprotein CIII gene polymorphism and serum lipid levels in Han Chinese males." Meta gene vol. 1 (2013): 58-64. doi: https://doi.org/10.1016/j.mgene.2013.09.005
Su S, Tang M, Zhang M, Cheng C, Tang X. The relationship between apolipoprotein CIII gene polymorphism and serum lipid levels in Han Chinese males. Meta Gene. 2013 Nov 15;1:58-64. doi: 10.1016/j.mgene.2013.09.005. eCollection 2013 Dec. PMID: 25606375; PMCID: PMC4205029.
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Serum lipid profiles, the prevalence of dyslipidemia and the risk factors in two isolated Chinese minorities.

International journal of clinical and experimental medicine

Liao PJ, Xie RB, Yin RX, Wei DX, Huang J, Huang F, Li H, Lin WX, Wu JZ, Pan SL.
PMID: 26770556
Int J Clin Exp Med. 2015 Oct 15;8(10):19200-11. eCollection 2015.

Both Jing and Mulao nationalities are the isolated minorities in China. Little is known about the prevalence of dyslipidemia between the two ethnic groups. Therefore, the aim of this study was to compare the differences in serum lipid profiles,...

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Liao PJ, Xie RB, Yin RX, et al. Serum lipid profiles, the prevalence of dyslipidemia and the risk factors in two isolated Chinese minorities. Int J Clin Exp Med. 2015;8(10):19200-11
Liao, P. J., Xie, R. B., Yin, R. X., Wei, D. X., Huang, J., Huang, F., Li, H., Lin, W. X., Wu, J. Z., & Pan, S. L. (2015). Serum lipid profiles, the prevalence of dyslipidemia and the risk factors in two isolated Chinese minorities. International journal of clinical and experimental medicine, 8(10), 19200-11.
Liao, Pei-Juan, et al. "Serum lipid profiles, the prevalence of dyslipidemia and the risk factors in two isolated Chinese minorities." International journal of clinical and experimental medicine vol. 8,10 (2015): 19200-11.
Liao PJ, Xie RB, Yin RX, Wei DX, Huang J, Huang F, Li H, Lin WX, Wu JZ, Pan SL. Serum lipid profiles, the prevalence of dyslipidemia and the risk factors in two isolated Chinese minorities. Int J Clin Exp Med. 2015 Oct 15;8(10):19200-11. eCollection 2015. PMID: 26770556; PMCID: PMC4694456.
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The APOB insertion/deletion polymorphism (rs17240441) influences postprandial lipaemia in healthy adults.

Nutrition & metabolism

Vimaleswaran KS, Minihane AM, Li Y, Gill R, Lovegrove JA, Williams CM, Jackson KG.
PMID: 25793007
Nutr Metab (Lond). 2015 Mar 08;12:7. doi: 10.1186/s12986-015-0002-9. eCollection 2015.

BACKGROUND: Apolipoprotein (apo)B is the structural apoprotein of intestinally- and liver- derived lipoproteins and plays an important role in the transport of triacylglycerol (TAG) and cholesterol. Previous studies have examined the association between the APOB insertion/deletion (ins/del) polymorphism (rs17240441)...

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Vimaleswaran KS, Minihane AM, Li Y, et al. The APOB insertion/deletion polymorphism (rs17240441) influences postprandial lipaemia in healthy adults. Nutr Metab (Lond). 2015;12:7doi: 10.1186/s12986-015-0002-9.
Vimaleswaran, K. S., Minihane, A. M., Li, Y., Gill, R., Lovegrove, J. A., Williams, C. M., & Jackson, K. G. (2015). The APOB insertion/deletion polymorphism (rs17240441) influences postprandial lipaemia in healthy adults. Nutrition & metabolism, 127. https://doi.org/10.1186/s12986-015-0002-9
Vimaleswaran, Karani Santhanakrishnan, et al. "The APOB insertion/deletion polymorphism (rs17240441) influences postprandial lipaemia in healthy adults." Nutrition & metabolism vol. 12 (2015): 7. doi: https://doi.org/10.1186/s12986-015-0002-9
Vimaleswaran KS, Minihane AM, Li Y, Gill R, Lovegrove JA, Williams CM, Jackson KG. The APOB insertion/deletion polymorphism (rs17240441) influences postprandial lipaemia in healthy adults. Nutr Metab (Lond). 2015 Mar 08;12:7. doi: 10.1186/s12986-015-0002-9. eCollection 2015. PMID: 25793007; PMCID: PMC4365815.
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Showing 1 to 12 of 2475 entries