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Showing 1 to 12 of 38 entries
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Association of mitochondrial deoxyribonucleic acid mutation with polymorphism in CYP2E1 gene in oral carcinogenesis.

Journal of oral biology and craniofacial research

Pandey R, Mehrotra D, Catapano C, Choubey V, Sarin R, Mahdi AA, Singh S.
PMID: 25756024
J Oral Biol Craniofac Res. 2012 Jan-Apr;2(1):4-9. doi: 10.1016/S2212-4268(12)60003-7.

BACKGROUND: Oral carcinogenesis is a complex process affected by genetic as well as environmental factors. CYP2E1 gene is involved in metabolism of number of compounds and carcinogens. Its normal functioning is required for homeostasis of free radical. Mitochondrial deoxyribonucleic...

Assessment of DNA Extracted from Forensic Samples Prior to Genotyping.

Forensic science review

Barbisin M, Shewale JG.
PMID: 26242597
Forensic Sci Rev. 2010 Jul;22(2):199-214.

Quantification of human DNA has been an integral part of forensic DNA analysis. Hybridizationbased methods such as Quantiblot® kits were used extensively in the 1990s. These methods fulfilled the need at the time, since their sensitivity range was similar...

mtDNA Mutations and Their Role in Aging, Diseases and Forensic Sciences.

Aging and disease

Zapico SC, Ubelaker DH.
PMID: 24307969
Aging Dis. 2013 Oct 03;4(6):364-80. doi: 10.14336/AD.2013.0400364.

Mitochondria are independent organelles with their own DNA. As a primary function, mitochondria produce the energy for the cell through Oxidative Phosphorylation (OXPHOS) in the Electron Transport Chain (ETC). One of the toxic products of this process is Reactive...

A rapid, simple method for nuclei isolation from plant protoplasts.

Plant physiology

Ohyama K, Pelcher LE, Horn D.
PMID: 16660054
Plant Physiol. 1977 Aug;60(2):179-81. doi: 10.1104/pp.60.2.179.

A rapid, simple method for nuclei isolation and purification from soybean (Glycine max L. Merr.) protoplasts is described. The isolated nuclei exhibited active amino acid incorporation and RNA synthesis, but DNA synthesis was not detectable. Analysis by CsCl density...

Extracellular Tuning of Mitochondrial Respiration Leads to Aortic Aneurysm.

Circulation

Oller J, Gabandé-Rodríguez E, Ruiz-Rodríguez MJ, Desdín-Micó G, Aranda JF, Rodrigues-Diez R, Ballesteros-Martínez C, Blanco EM, Roldan-Montero R, Acuña P, Forteza Gil A, Martín-López CE, Nistal JF, Lino Cardenas CL, Lindsay ME, Martín-Ventura JL, Briones AM, Redondo JM, Mittelbrunn M.
PMID: 33709773
Circulation. 2021 May 25;143(21):2091-2109. doi: 10.1161/CIRCULATIONAHA.120.051171. Epub 2021 Mar 12.

BACKGROUND: Marfan syndrome (MFS) is an autosomal dominant disorder of the connective tissue caused by mutations in the METHODS: Combining transcriptomics and metabolic analysis of aortas from an MFS mouse model (RESULTS: The main canonical pathways highlighted in the...

Next-Generation Sequencing-Based Analysis of Urine Cell-Free mtDNA Reveals Aberrant Fragmentation and Mutation Profile in Cancer Patients.

Clinical chemistry

Zhou K, Liu Y, Yuan Q, Lai D, Guo S, Wang Z, Su L, Zhang H, Wang X, Guo W, Ji X, Gu X, Huang Q, Guo X, Xing J.
PMID: 34993545
Clin Chem. 2022 Jan 05; doi: 10.1093/clinchem/hvab268. Epub 2022 Jan 05.

BACKGROUND: Many studies have demonstrated the high efficacy of cell-free nuclear DNA in cancer diagnostics. Compared to nuclear DNA, mitochondrial DNA (mtDNA) exhibits distinct characteristics, including multiple copies per cell and higher mutation frequency. However, the potential applicability of...

Identification of mitochondrial RNA polymerase as a potential therapeutic target of osteosarcoma.

Cell death discovery

Han QC, Zhang XY, Yan PH, Chen SF, Liu FF, Zhu YR, Tian Q.
PMID: 34907167
Cell Death Discov. 2021 Dec 14;7(1):393. doi: 10.1038/s41420-021-00780-x.

POLRMT (RNA polymerase mitochondrial) is essential for transcription of mitochondrial genome encoding components of oxidative phosphorylation process. The current study tested POLRMT expression and its potential function in osteosarcoma (OS). The Cancer Genome Atlas (TCGA) cohorts and Gene Expression...

Primary mitochondrial myopathies in childhood.

Neuromuscular disorders : NMD

Olimpio C, Tiet MY, Horvath R.
PMID: 34736635
Neuromuscul Disord. 2021 Oct;31(10):978-987. doi: 10.1016/j.nmd.2021.08.005.

Primary mitochondrial myopathies are genetic metabolic disorders of mitochondrial dysfunction affecting mainly, but not exclusively, skeletal muscle. Although individually rare, they are the most common inherited metabolic disorders in childhood. They can be similar to other childhood muscle diseases...

Extracellular Tuning of Mitochondrial Respiration Leads to Aortic Aneurysm.

Circulation

Oller J, Gabandé-Rodríguez E, Ruiz-Rodríguez MJ, Desdín-Micó G, Aranda JF, Rodrigues-Diez R, Ballesteros-Martínez C, Blanco EM, Roldan-Montero R, Acuña P, Forteza Gil A, Martín-López CE, Nistal JF, Lino Cardenas CL, Lindsay ME, Martín-Ventura JL, Briones AM, Redondo JM, Mittelbrunn M.
PMID: 33709773
Circulation. 2021 May 25;143(21):2091-2109. doi: 10.1161/CIRCULATIONAHA.120.051171. Epub 2021 Mar 12.

BACKGROUND: Marfan syndrome (MFS) is an autosomal dominant disorder of the connective tissue caused by mutations in the METHODS: Combining transcriptomics and metabolic analysis of aortas from an MFS mouse model (RESULTS: The main canonical pathways highlighted in the...

There and back again - ancient genes reveal early migrations.

Nature reviews. Genetics

Willson J.
PMID: 32099103
Nat Rev Genet. 2020 Apr;21(4):205. doi: 10.1038/s41576-020-0222-3.

No abstract available.

CRISPR-Free Mitochondrial DNA Base Editing.

The CRISPR journal

Wallace DC.
PMID: 32833534
CRISPR J. 2020 Aug;3(4):228-230. doi: 10.1089/crispr.2020.29101.dwa.

No abstract available.

Combination therapy with extracorporeal shock wave and melatonin markedly attenuated neuropathic pain in rat.

American journal of translational research

Chen KH, Yang CH, Wallace CG, Lin CR, Liu CK, Yin TC, Huang TH, Chen YL, Sun CK, Yip HK.
PMID: 29118920
Am J Transl Res. 2017 Oct 15;9(10):4593-4606. eCollection 2017.

This study tested the hypothesis that combination therapy using extracorporeal shock wave (ECSW)-melatonin (Mel) was superior to either alone at ameliorating neuropathic pain (NP). NP was induced by chronic constriction injury (CCI) to the left sciatic nerve in rats....

Showing 1 to 12 of 38 entries