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Showing 1 to 12 of 24 entries
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Post-marketing surveillance data of thrombomodulin alfa: sub-analysis in patients with sepsis-induced disseminated intravascular coagulation.

Journal of intensive care

Eguchi Y, Gando S, Ishikura H, Saitoh D, Mimuro J, Takahashi H, Kitajima I, Tsuji H, Matsushita T, Tsujita R, Nagao O, Sakata Y.
PMID: 25520842
J Intensive Care. 2014 Apr 30;2(1):30. doi: 10.1186/2052-0492-2-30. eCollection 2014.

BACKGROUND: Thrombomodulin alfa (TM-α, recombinant thrombomodulin) significantly improved disseminated intravascular coagulation (DIC) when compared with heparin therapy in a phase III study. Post-marketing surveillance of TM-α was performed to evaluate the effects and safety in patients with sepsis-induced DIC.METHODS:...

DIAGNOSING DISSEMINATED INTRAVASCULAR COAGULATION IN ACUTE INFECTION : CAN WE DO WITHOUT FDP & D-DIMER.

Medical journal, Armed Forces India

Arora MM, Mishra KB, Nair V, Bhardwaj JR, Bhalwar R, Somani BL.
PMID: 27365652
Med J Armed Forces India. 2002 Jan;58(1):13-7. doi: 10.1016/S0377-1237(02)80005-3. Epub 2011 Jul 21.

Alterations in coagulation profile viz. platelet count, prothrombin time (PT), partial thromboplastin time with kaolin (PTTK), thrombin time (TT) and fibrinogen were studied in 96 patients (73 males and 23 females) of acute infections. Fibrin/fibrinogen degradation products (FDP) level...

Deposition of immunoreactants in a cutaneous allergic drug reaction.

North American journal of medical sciences

Abreu-Velez AM, Jackson BL, Howard MS.
PMID: 22666692
N Am J Med Sci. 2009 Sep;1(4):180-3. doi: 10.4297/najms.2009.4180.

CONTEXT: The analysis of allergic drug reaction pathology may be difficult, especially if multiple histological reaction patterns are detected on review of hematoxylin and eosin (H&E) stained sections. In this case, we emphasize the value of adding immunohistochemistry (IHC)...

Age adjusted D-dimer cutoffs for pulmonary embolism in a geriatric population utilizing a D-dimer unit assay.

The American journal of emergency medicine

Khan M, Alter SM, Clayton LM, Hughes PG, Shih RD, Solano JJ.
PMID: 34735966
Am J Emerg Med. 2022 Jan;51:103-107. doi: 10.1016/j.ajem.2021.10.009. Epub 2021 Oct 22.

BACKGROUND: Age adjusted serum d-dimer (AADD) with clinical decision rules have been utilized to rule out pulmonary embolism (PE) in low-risk patients; however, its use in the geriatric population has been questioned and the use of d-dimer unit (DDU)...

Development of a delirium predictive model for adult trauma patients in an emergency and critical care center: a retrospective study.

Trauma surgery & acute care open

Matsuoka A, Miike T, Miyazaki M, Goto T, Sasaki A, Yamazaki H, Komaki M, Higuchi M, Mori K, Shinada K, Nakayama K, Sakurai R, Asahi M, Futami A, Yoshitake K, Narumi S, Koba M, Koami H, Kawaguchi A, Murakawa TH, Monji A, Sakamoto Y.
PMID: 34901468
Trauma Surg Acute Care Open. 2021 Nov 29;6(1):e000827. doi: 10.1136/tsaco-2021-000827. eCollection 2021.

BACKGROUND: Delirium has been shown to prolong the length of intensive care unit stay, hospitalization, and duration of ventilatory control, in addition to increasing the use of sedatives and increasing the medical costs. Although there have been a number...

Effect of Recombinant Human Soluble Thrombomodulin on Coagulation-Related Variables in Patients With Sepsis-Induced Disseminated Intravascular Coagulation: A Retrospective Observational Study.

Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis

Mitaka C, Kawagoe I, Satoh D, Hayashida M.
PMID: 34859680
Clin Appl Thromb Hemost. 2021 Jan-Dec;27:10760296211050356. doi: 10.1177/10760296211050356.

To evaluate associations among coagulation-related variables, resolution of disseminated intravascular coagulation (DIC) and mortality, we retrospectively investigated 123 patients with sepsis-induced DIC treated with recombinant human soluble thrombomodulin (rTM). Changes in coagulation-related variables before and after treatment with rTM...

Efficacy of recombinant human soluble thrombomodulin in patients with sepsis and disseminated intravascular coagulation in the gastroenterology field.

Biomedical reports

Ito T, Nagahara A, Osada T, Kato J, Ueyama H, Saito H, Taniki N, Kanazawa R, Shimizu R, Sai J, Shiina S, Watanabe S.
PMID: 26171148
Biomed Rep. 2015 Jul;3(4):457-460. doi: 10.3892/br.2015.464. Epub 2015 May 13.

Recombinant human soluble thrombomodulin (rTM) was approved recently and has been used for treatment of disseminated intravascular coagulation (DIC). The aim of the present study was to evaluate the efficacy of rTM for DIC. The data of 53 inpatients...

Comparison of multidetector computed tomography findings with clinical and laboratory data in pulmonary thromboembolism.

Polish journal of radiology

Gülşen Z, Koşar PN, Gökharman FD.
PMID: 26029288
Pol J Radiol. 2015 May 13;80:252-8. doi: 10.12659/PJR.893793. eCollection 2015.

BACKGROUND: Pulmonary thromboembolism (PTE) is a common disease with a high mortality rate that is difficult to diagnose and treat. Because of the variety of clinical symptoms and signs, it is difficult to diagnose. Therefore, the diagnosis of PTE...

Age adjusted D-dimer cutoffs for pulmonary embolism in a geriatric population utilizing a D-dimer unit assay.

The American journal of emergency medicine

Khan M, Alter SM, Clayton LM, Hughes PG, Shih RD, Solano JJ.
PMID: 34735966
Am J Emerg Med. 2022 Jan;51:103-107. doi: 10.1016/j.ajem.2021.10.009. Epub 2021 Oct 22.

BACKGROUND: Age adjusted serum d-dimer (AADD) with clinical decision rules have been utilized to rule out pulmonary embolism (PE) in low-risk patients; however, its use in the geriatric population has been questioned and the use of d-dimer unit (DDU)...

Diagnostic accuracy of D-dimer in patients at high-risk for splanchnic vein thrombosis: A systematic review and meta-analysis.

Thrombosis research

Riva N, Attard LM, Vella K, Squizzato A, Gatt A, Calleja-Agius J.
PMID: 34600286
Thromb Res. 2021 Sep 27;207:102-112. doi: 10.1016/j.thromres.2021.09.016. Epub 2021 Sep 27.

BACKGROUND: D-dimer is included in the diagnostic algorithm for deep vein thrombosis and pulmonary embolism. However, its role in the diagnosis of splanchnic vein thrombosis (SVT) is still controversial. The aim of this study was to evaluate the diagnostic...

Time course of coagulation and fibrinolytic parameters in pediatric traumatic brain injury.

Journal of neurosurgery. Pediatrics

Nakae R, Fujiki Y, Takayama Y, Kanaya T, Igarashi Y, Suzuki G, Naoe Y, Yokobori S.
PMID: 34416724
J Neurosurg Pediatr. 2021 Aug 20;28(5):526-532. doi: 10.3171/2021.5.PEDS21125.

OBJECTIVE: Coagulopathy is a well-recognized risk factor for poor outcomes in patients with traumatic brain injury (TBI). Differences in the time courses of coagulation and fibrinolytic parameters between pediatric and adult patients with TBI have not been defined.METHODS: Patients...

Development of a delirium predictive model for adult trauma patients in an emergency and critical care center: a retrospective study.

Trauma surgery & acute care open

Matsuoka A, Miike T, Miyazaki M, Goto T, Sasaki A, Yamazaki H, Komaki M, Higuchi M, Mori K, Shinada K, Nakayama K, Sakurai R, Asahi M, Futami A, Yoshitake K, Narumi S, Koba M, Koami H, Kawaguchi A, Murakawa TH, Monji A, Sakamoto Y.
PMID: 34901468
Trauma Surg Acute Care Open. 2021 Nov 29;6(1):e000827. doi: 10.1136/tsaco-2021-000827. eCollection 2021.

BACKGROUND: Delirium has been shown to prolong the length of intensive care unit stay, hospitalization, and duration of ventilatory control, in addition to increasing the use of sedatives and increasing the medical costs. Although there have been a number...

Showing 1 to 12 of 24 entries