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Showing 1 to 12 of 96 entries
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Roles of Rap1 signaling in tumor cell migration and invasion.

Cancer biology & medicine

Zhang YL, Wang RC, Cheng K, Ring BZ, Su L.
PMID: 28443208
Cancer Biol Med. 2017 Feb;14(1):90-99. doi: 10.20892/j.issn.2095-3941.2016.0086.

Ras-associated protein-1 (Rap1), a small GTPase in the Ras-related protein family, is an important regulator of basic cellular functions (e.g., formation and control of cell adhesions and junctions), cellular migration, and polarization. Through its interaction with other proteins, Rap1...

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Zhang YL, Wang RC, Cheng K, et al. Roles of Rap1 signaling in tumor cell migration and invasion. Cancer Biol Med. 2017;14(1):90-99doi: 10.20892/j.issn.2095-3941.2016.0086.
Zhang, Y. L., Wang, R. C., Cheng, K., Ring, B. Z., & Su, L. (2017). Roles of Rap1 signaling in tumor cell migration and invasion. Cancer biology & medicine, 14(1), 90-99. https://doi.org/10.20892/j.issn.2095-3941.2016.0086
Zhang, Yi-Lei, et al. "Roles of Rap1 signaling in tumor cell migration and invasion." Cancer biology & medicine vol. 14,1 (2017): 90-99. doi: https://doi.org/10.20892/j.issn.2095-3941.2016.0086
Zhang YL, Wang RC, Cheng K, Ring BZ, Su L. Roles of Rap1 signaling in tumor cell migration and invasion. Cancer Biol Med. 2017 Feb;14(1):90-99. doi: 10.20892/j.issn.2095-3941.2016.0086. PMID: 28443208; PMCID: PMC5365179.
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Feeding and fasting controls liver expression of a regulator of G protein signaling (Rgs16) in periportal hepatocytes.

Comparative hepatology

Huang J, Pashkov V, Kurrasch DM, Yu K, Gold SJ, Wilkie TM.
PMID: 17123436
Comp Hepatol. 2006 Nov 23;5:8. doi: 10.1186/1476-5926-5-8.

BACKGROUND: Heterotrimeric G protein signaling in liver helps maintain carbohydrate and lipid homeostasis. G protein signaling is activated by binding of extracellular ligands to G protein coupled receptors and inhibited inside cells by regulators of G protein signaling (RGS)...

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Huang J, Pashkov V, Kurrasch DM, et al. Feeding and fasting controls liver expression of a regulator of G protein signaling (Rgs16) in periportal hepatocytes. Comp Hepatol. 2006;5:8doi: 10.1186/1476-5926-5-8.
Huang, J., Pashkov, V., Kurrasch, D. M., Yu, K., Gold, S. J., & Wilkie, T. M. (2006). Feeding and fasting controls liver expression of a regulator of G protein signaling (Rgs16) in periportal hepatocytes. Comparative hepatology, 58. https://doi.org/10.1186/1476-5926-5-8
Huang, Jie, et al. "Feeding and fasting controls liver expression of a regulator of G protein signaling (Rgs16) in periportal hepatocytes." Comparative hepatology vol. 5 (2006): 8. doi: https://doi.org/10.1186/1476-5926-5-8
Huang J, Pashkov V, Kurrasch DM, Yu K, Gold SJ, Wilkie TM. Feeding and fasting controls liver expression of a regulator of G protein signaling (Rgs16) in periportal hepatocytes. Comp Hepatol. 2006 Nov 23;5:8. doi: 10.1186/1476-5926-5-8. PMID: 17123436; PMCID: PMC1687201.
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Grhl3 and GEF19 in the front rho.

Small GTPases

Darido C, Jane SM.
PMID: 21686262
Small GTPases. 2010 Sep;1(2):104-107. doi: 10.4161/sgtp.1.2.13620.

Directional migration is a critical component of cell motility is observed in many diverse processes including embryogenesis, immune surveillance and wound repair. A central aspect of directional migration is cellular polarity, which is established through several signaling pathways that...

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Darido C, Jane SM. Grhl3 and GEF19 in the front rho. Small GTPases. 2010;1(2):104-107doi: 10.4161/sgtp.1.2.13620.
Darido, C., & Jane, S. M. (2010). Grhl3 and GEF19 in the front rho. Small GTPases, 1(2), 104-107. https://doi.org/10.4161/sgtp.1.2.13620
Darido, Charbel, and Jane, Stephen M. "Grhl3 and GEF19 in the front rho." Small GTPases vol. 1,2 (2010): 104-107. doi: https://doi.org/10.4161/sgtp.1.2.13620
Darido C, Jane SM. Grhl3 and GEF19 in the front rho. Small GTPases. 2010 Sep;1(2):104-107. doi: 10.4161/sgtp.1.2.13620. PMID: 21686262; PMCID: PMC3116594.
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CaM interaction and Ser181 phosphorylation as new K-Ras signaling modulators.

Small GTPases

Alvarez-Moya B, Barceló C, Tebar F, Jaumot M, Agell N.
PMID: 21776410
Small GTPases. 2011 Mar;2(2):99-103. doi: 10.4161/sgtp.2.2.15555.

The small G-protein Ras was the first oncogene to be identified and has a very important contribution to human cancer development (20-23% prevalence). K-RasB, one of the members of the Ras family, is the one that is most mutated...

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Alvarez-Moya B, Barceló C, Tebar F, et al. CaM interaction and Ser181 phosphorylation as new K-Ras signaling modulators. Small GTPases. 2011;2(2):99-103doi: 10.4161/sgtp.2.2.15555.
Alvarez-Moya, B., Barceló, C., Tebar, F., Jaumot, M., & Agell, N. (2011). CaM interaction and Ser181 phosphorylation as new K-Ras signaling modulators. Small GTPases, 2(2), 99-103. https://doi.org/10.4161/sgtp.2.2.15555
Alvarez-Moya, Blanca, et al. "CaM interaction and Ser181 phosphorylation as new K-Ras signaling modulators." Small GTPases vol. 2,2 (2011): 99-103. doi: https://doi.org/10.4161/sgtp.2.2.15555
Alvarez-Moya B, Barceló C, Tebar F, Jaumot M, Agell N. CaM interaction and Ser181 phosphorylation as new K-Ras signaling modulators. Small GTPases. 2011 Mar;2(2):99-103. doi: 10.4161/sgtp.2.2.15555. PMID: 21776410; PMCID: PMC3136912.
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RGS Proteins in Heart: Brakes on the Vagus.

Frontiers in physiology

Stewart A, Huang J, Fisher RA.
PMID: 22685433
Front Physiol. 2012 Apr 13;3:95. doi: 10.3389/fphys.2012.00095. eCollection 2012.

It has been nearly a century since Otto Loewi discovered that acetylcholine (ACh) release from the vagus produces bradycardia and reduced cardiac contractility. It is now known that parasympathetic control of the heart is mediated by ACh stimulation of...

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Stewart A, Huang J, Fisher RA. RGS Proteins in Heart: Brakes on the Vagus. Front Physiol. 2012;3:95doi: 10.3389/fphys.2012.00095.
Stewart, A., Huang, J., & Fisher, R. A. (2012). RGS Proteins in Heart: Brakes on the Vagus. Frontiers in physiology, 395. https://doi.org/10.3389/fphys.2012.00095
Stewart, Adele, et al. "RGS Proteins in Heart: Brakes on the Vagus." Frontiers in physiology vol. 3 (2012): 95. doi: https://doi.org/10.3389/fphys.2012.00095
Stewart A, Huang J, Fisher RA. RGS Proteins in Heart: Brakes on the Vagus. Front Physiol. 2012 Apr 13;3:95. doi: 10.3389/fphys.2012.00095. eCollection 2012. PMID: 22685433; PMCID: PMC3368389.
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Rga4, a Rho-GAP from fission yeast: Finding specificity within promiscuity.

Communicative & integrative biology

Cansado J, Soto T, Gacto M, Pérez P.
PMID: 21057634
Commun Integr Biol. 2010 Sep;3(5):436-9. doi: 10.4161/cib.3.5.12284.

Regulation by signaling molecules of pathways involved in determining cell size and shape is fundamental to understand morphogenesis. In eukaryotic cells, Rho GTPases modulate cellular events by acting as molecular switches. GTPase Activating Proteins (GAPs) control the fine-tuning of...

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Cansado J, Soto T, Gacto M, et al. Rga4, a Rho-GAP from fission yeast: Finding specificity within promiscuity. Commun Integr Biol. 2010;3(5):436-9doi: 10.4161/cib.3.5.12284.
Cansado, J., Soto, T., Gacto, M., & Pérez, P. (2010). Rga4, a Rho-GAP from fission yeast: Finding specificity within promiscuity. Communicative & integrative biology, 3(5), 436-9. https://doi.org/10.4161/cib.3.5.12284
Cansado, José, et al. "Rga4, a Rho-GAP from fission yeast: Finding specificity within promiscuity." Communicative & integrative biology vol. 3,5 (2010): 436-9. doi: https://doi.org/10.4161/cib.3.5.12284
Cansado J, Soto T, Gacto M, Pérez P. Rga4, a Rho-GAP from fission yeast: Finding specificity within promiscuity. Commun Integr Biol. 2010 Sep;3(5):436-9. doi: 10.4161/cib.3.5.12284. PMID: 21057634; PMCID: PMC2974074.
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Cdc42 activation state affects its localization and protein levels in fission yeast.

Microbiology (Reading, England)

Estravís M, Rincón SA, Portales E, Pérez P, Santos B.
PMID: 28742002
Microbiology (Reading). 2017 Aug;163(8):1156-1166. doi: 10.1099/mic.0.000503.

Rho GTPases control polarized cell growth and are well-known regulators of exocytic and endocytic processes. Cdc42 is an essential GTPase, conserved from yeast to humans, that is critical for cell polarization. Cdc42 is negatively regulated by the GTPase-activating proteins...

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Estravís M, Rincón SA, Portales E, et al. Cdc42 activation state affects its localization and protein levels in fission yeast. Microbiology (Reading). 2017;163(8):1156-1166doi: 10.1099/mic.0.000503.
Estravís, M., Rincón, S. A., Portales, E., Pérez, P., & Santos, B. (2017). Cdc42 activation state affects its localization and protein levels in fission yeast. Microbiology (Reading, England), 163(8), 1156-1166. https://doi.org/10.1099/mic.0.000503
Estravís, Miguel, et al. "Cdc42 activation state affects its localization and protein levels in fission yeast." Microbiology (Reading, England) vol. 163,8 (2017): 1156-1166. doi: https://doi.org/10.1099/mic.0.000503
Estravís M, Rincón SA, Portales E, Pérez P, Santos B. Cdc42 activation state affects its localization and protein levels in fission yeast. Microbiology (Reading). 2017 Aug;163(8):1156-1166. doi: 10.1099/mic.0.000503. PMID: 28742002.
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The dynamics of spatio-temporal Rho GTPase signaling: formation of signaling patterns.

F1000Research

Fritz RD, Pertz O.
PMID: 27158467
F1000Res. 2016 Apr 26;5. doi: 10.12688/f1000research.7370.1. eCollection 2016.

Rho GTPases are crucial signaling molecules that regulate a plethora of biological functions. Traditional biochemical, cell biological, and genetic approaches have founded the basis of Rho GTPase biology. The development of biosensors then allowed measuring Rho GTPase activity with...

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Fritz RD, Pertz O. The dynamics of spatio-temporal Rho GTPase signaling: formation of signaling patterns. F1000Res. 2016;5doi: 10.12688/f1000research.7370.1.
Fritz, R. D., & Pertz, O. (2016). The dynamics of spatio-temporal Rho GTPase signaling: formation of signaling patterns. F1000Research, 5. https://doi.org/10.12688/f1000research.7370.1
Fritz, Rafael Dominik, and Pertz, Olivier. "The dynamics of spatio-temporal Rho GTPase signaling: formation of signaling patterns." F1000Research vol. 5 (2016). doi: https://doi.org/10.12688/f1000research.7370.1
Fritz RD, Pertz O. The dynamics of spatio-temporal Rho GTPase signaling: formation of signaling patterns. F1000Res. 2016 Apr 26;5. doi: 10.12688/f1000research.7370.1. eCollection 2016. PMID: 27158467; PMCID: PMC4847568.
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ARHGAP24 regulates cell ability and apoptosis of colorectal cancer cells via the regulation of P53.

Oncology letters

Zhang S, Sui L, Zhuang J, He S, Song Y, Ye Y, Xia W.
PMID: 30127956
Oncol Lett. 2018 Sep;16(3):3517-3524. doi: 10.3892/ol.2018.9075. Epub 2018 Jul 04.

Colorectal cancer is a human malignancy ranked the third highest of the global incidence of malignant tumors. Rho GTPase-activating proteins (RHOGAPs) were identified functional in several processes of tumors. In the present study, through reverse transcription-quantitative PCR (RT-qPCR) and...

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Zhang S, Sui L, Zhuang J, et al. ARHGAP24 regulates cell ability and apoptosis of colorectal cancer cells via the regulation of P53. Oncol Lett. 2018;16(3):3517-3524doi: 10.3892/ol.2018.9075.
Zhang, S., Sui, L., Zhuang, J., He, S., Song, Y., Ye, Y., & Xia, W. (2018). ARHGAP24 regulates cell ability and apoptosis of colorectal cancer cells via the regulation of P53. Oncology letters, 16(3), 3517-3524. https://doi.org/10.3892/ol.2018.9075
Zhang, Suiliang, et al. "ARHGAP24 regulates cell ability and apoptosis of colorectal cancer cells via the regulation of P53." Oncology letters vol. 16,3 (2018): 3517-3524. doi: https://doi.org/10.3892/ol.2018.9075
Zhang S, Sui L, Zhuang J, He S, Song Y, Ye Y, Xia W. ARHGAP24 regulates cell ability and apoptosis of colorectal cancer cells via the regulation of P53. Oncol Lett. 2018 Sep;16(3):3517-3524. doi: 10.3892/ol.2018.9075. Epub 2018 Jul 04. PMID: 30127956; PMCID: PMC6096278.
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Hormones Secretion and Rho GTPases in Neuroendocrine Tumors.

Cancers

Streit L, Brunaud L, Vitale N, Ory S, Gasman S.
PMID: 32664294
Cancers (Basel). 2020 Jul 10;12(7). doi: 10.3390/cancers12071859.

Neuroendocrine tumors (NETs) belong to a heterogeneous group of neoplasms arising from hormone secreting cells. These tumors are often associated with a dysfunction of their secretory activity. Neuroendocrine secretion occurs through calcium-regulated exocytosis, a process that is tightly controlled...

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Streit L, Brunaud L, Vitale N, et al. Hormones Secretion and Rho GTPases in Neuroendocrine Tumors. Cancers (Basel). 2020;12(7)doi: 10.3390/cancers12071859.
Streit, L., Brunaud, L., Vitale, N., Ory, S., & Gasman, S. (2020). Hormones Secretion and Rho GTPases in Neuroendocrine Tumors. Cancers, 12(7), . https://doi.org/10.3390/cancers12071859
Streit, Laura, et al. "Hormones Secretion and Rho GTPases in Neuroendocrine Tumors." Cancers vol. 12,7 (2020). doi: https://doi.org/10.3390/cancers12071859
Streit L, Brunaud L, Vitale N, Ory S, Gasman S. Hormones Secretion and Rho GTPases in Neuroendocrine Tumors. Cancers (Basel). 2020 Jul 10;12(7). doi: 10.3390/cancers12071859. PMID: 32664294; PMCID: PMC7408961.
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Underappreciated roles for Rho GDP dissociation inhibitors (RhoGDIs) in cell function: Lessons learned from the pancreatic islet β-cell.

Biochemical pharmacology

Kowluru A, Gleason NF.
PMID: 34968495
Biochem Pharmacol. 2021 Dec 28;197:114886. doi: 10.1016/j.bcp.2021.114886. Epub 2021 Dec 28.

Rho subfamily of G proteins (e.g., Rac1) have been implicated in glucose-stimulated insulin secretion from the pancreatic β-cell. Interestingly, metabolic stress (e.g., chronic exposure to high glucose) results in sustained activation of Rac1 leading to increased oxidative stress, impaired...

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Kowluru A, Gleason NF. Underappreciated roles for Rho GDP dissociation inhibitors (RhoGDIs) in cell function: Lessons learned from the pancreatic islet β-cell. Biochem Pharmacol. 2021;197:114886doi: 10.1016/j.bcp.2021.114886.
Kowluru, A., & Gleason, N. F. (2021). Underappreciated roles for Rho GDP dissociation inhibitors (RhoGDIs) in cell function: Lessons learned from the pancreatic islet β-cell. Biochemical pharmacology, 197114886. https://doi.org/10.1016/j.bcp.2021.114886
Kowluru, Anjaneyulu, and Gleason, Noah F. "Underappreciated roles for Rho GDP dissociation inhibitors (RhoGDIs) in cell function: Lessons learned from the pancreatic islet β-cell." Biochemical pharmacology vol. 197 (2021): 114886. doi: https://doi.org/10.1016/j.bcp.2021.114886
Kowluru A, Gleason NF. Underappreciated roles for Rho GDP dissociation inhibitors (RhoGDIs) in cell function: Lessons learned from the pancreatic islet β-cell. Biochem Pharmacol. 2021 Dec 28;197:114886. doi: 10.1016/j.bcp.2021.114886. Epub 2021 Dec 28. PMID: 34968495.
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The emerging roles of srGAPs in cancer.

Molecular biology reports

Ji V, Kishore C.
PMID: 34825319
Mol Biol Rep. 2022 Jan;49(1):755-759. doi: 10.1007/s11033-021-06872-2. Epub 2021 Nov 25.

GTPase activating proteins (GAPs) were initially considered as the inhibitors of cell signaling pathways because of their nature to activate the intrinsic GTPase activity of the RhoGTPases. But recent studies of dysregulated GAPs in many cancers such as glioblastoma,...

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Ji V, Kishore C. The emerging roles of srGAPs in cancer. Mol Biol Rep. 2021;49(1):755-759doi: 10.1007/s11033-021-06872-2.
Ji, V., & Kishore, C. (2022). The emerging roles of srGAPs in cancer. Molecular biology reports, 49(1), 755-759. https://doi.org/10.1007/s11033-021-06872-2
Ji, Vaishali, and Kishore, Chandra. "The emerging roles of srGAPs in cancer." Molecular biology reports vol. 49,1 (2022): 755-759. doi: https://doi.org/10.1007/s11033-021-06872-2
Ji V, Kishore C. The emerging roles of srGAPs in cancer. Mol Biol Rep. 2022 Jan;49(1):755-759. doi: 10.1007/s11033-021-06872-2. Epub 2021 Nov 25. PMID: 34825319.
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Showing 1 to 12 of 96 entries