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Efficacy and Safety of G2013 as a Novel Immunosuppressive Agent on Differentiation, Maturation and Function of Human Dendritic Cells.

Iranian journal of public health

Arjomand Fard N, Tabrizian N, Mirzaei R, Hadjati J, Tofighi Zavareh F, Salehi Nodeh AR, Mirshafiey A.
PMID: 28451557
Iran J Public Health. 2017 Feb;46(2):216-221.

BACKGROUND: The expanse of dendritic cells (DC) differentiation plays an important role in determining immune response. DC-based immunosuppressive drugs have notable side effects in increasing the risk of infectious diseases and cancers. G2013, as a novel anti-inflammatory and immunosuppressive...

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Arjomand Fard N, Tabrizian N, Mirzaei R, et al. Efficacy and Safety of G2013 as a Novel Immunosuppressive Agent on Differentiation, Maturation and Function of Human Dendritic Cells. Iran J Public Health. 2017;46(2):216-221
Arjomand Fard, N., Tabrizian, N., Mirzaei, R., Hadjati, J., Tofighi Zavareh, F., Salehi Nodeh, A. R., & Mirshafiey, A. (2017). Efficacy and Safety of G2013 as a Novel Immunosuppressive Agent on Differentiation, Maturation and Function of Human Dendritic Cells. Iranian journal of public health, 46(2), 216-221.
Arjomand Fard, Nazanin, et al. "Efficacy and Safety of G2013 as a Novel Immunosuppressive Agent on Differentiation, Maturation and Function of Human Dendritic Cells." Iranian journal of public health vol. 46,2 (2017): 216-221.
Arjomand Fard N, Tabrizian N, Mirzaei R, Hadjati J, Tofighi Zavareh F, Salehi Nodeh AR, Mirshafiey A. Efficacy and Safety of G2013 as a Novel Immunosuppressive Agent on Differentiation, Maturation and Function of Human Dendritic Cells. Iran J Public Health. 2017 Feb;46(2):216-221. PMID: 28451557; PMCID: PMC5402780.
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High baseline levels of interleukin-8 in leukocytes and urine predict tumor recurrence in non-muscle invasive bladder cancer patients receiving bacillus Calmette-Guerin therapy: A long-term survival analysis.

Oncoimmunology

Qu K, Gu J, Ye Y, Williams SB, Dinney CP, Wu X, Kamat A.
PMID: 28344874
Oncoimmunology. 2017 Jan 03;6(2):e1265719. doi: 10.1080/2162402X.2016.1265719. eCollection 2017.

Bacillus Calmette-Guerin (BCG) therapy for non-muscle invasive bladder cancer (NMIBC) can significantly reduce the risk of recurrence and progression. However, BCG therapy may fail in up to a half of treated patients and may also cause toxicities. Biomarkers to...

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Qu K, Gu J, Ye Y, et al. High baseline levels of interleukin-8 in leukocytes and urine predict tumor recurrence in non-muscle invasive bladder cancer patients receiving bacillus Calmette-Guerin therapy: A long-term survival analysis. Oncoimmunology. 2017;6(2):e1265719doi: 10.1080/2162402X.2016.1265719.
Qu, K., Gu, J., Ye, Y., Williams, S. B., Dinney, C. P., Wu, X., & Kamat, A. (2017). High baseline levels of interleukin-8 in leukocytes and urine predict tumor recurrence in non-muscle invasive bladder cancer patients receiving bacillus Calmette-Guerin therapy: A long-term survival analysis. Oncoimmunology, 6(2), e1265719. https://doi.org/10.1080/2162402X.2016.1265719
Qu, Kai, et al. "High baseline levels of interleukin-8 in leukocytes and urine predict tumor recurrence in non-muscle invasive bladder cancer patients receiving bacillus Calmette-Guerin therapy: A long-term survival analysis." Oncoimmunology vol. 6,2 (2017): e1265719. doi: https://doi.org/10.1080/2162402X.2016.1265719
Qu K, Gu J, Ye Y, Williams SB, Dinney CP, Wu X, Kamat A. High baseline levels of interleukin-8 in leukocytes and urine predict tumor recurrence in non-muscle invasive bladder cancer patients receiving bacillus Calmette-Guerin therapy: A long-term survival analysis. Oncoimmunology. 2017 Jan 03;6(2):e1265719. doi: 10.1080/2162402X.2016.1265719. eCollection 2017. PMID: 28344874; PMCID: PMC5353920.
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Repeated intratumoral administration of ONCOS-102 leads to systemic antitumor CD8.

Oncoimmunology

Vassilev L, Ranki T, Joensuu T, Jäger E, Karbach J, Wahle C, Partanen K, Kairemo K, Alanko T, Turkki R, Linder N, Lundin J, Ristimäki A, Kankainen M, Hemminki A, Backman C, Dienel K, von Euler M, Haavisto E, Hakonen T, Juhila J, Jäderberg M, Priha P, Vuolanto A, Pesonen S.
PMID: 26140248
Oncoimmunology. 2015 Apr 01;4(7):e1017702. doi: 10.1080/2162402X.2015.1017702. eCollection 2015 Jul.

Adenoviruses are excellent immunotherapeutic agents with a unique ability to prime and boost immune responses. Recombinant adenoviruses cause immunogenic cancer cell death and subsequent release of tumor antigens for antigen presenting cells, resulting in the priming of potent tumor-specific...

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Vassilev L, Ranki T, Joensuu T, et al. Repeated intratumoral administration of ONCOS-102 leads to systemic antitumor CD8. Oncoimmunology. 2015;4(7):e1017702doi: 10.1080/2162402X.2015.1017702.
Vassilev, L., Ranki, T., Joensuu, T., Jäger, E., Karbach, J., Wahle, C., Partanen, K., Kairemo, K., Alanko, T., Turkki, R., Linder, N., Lundin, J., Ristimäki, A., Kankainen, M., Hemminki, A., Backman, C., Dienel, K., von Euler, M., Haavisto, E., Hakonen, T., Juhila, J., Jäderberg, M., Priha, P., Vuolanto, A., & Pesonen, S. (2015). Repeated intratumoral administration of ONCOS-102 leads to systemic antitumor CD8. Oncoimmunology, 4(7), e1017702. https://doi.org/10.1080/2162402X.2015.1017702
Vassilev, L, et al. "Repeated intratumoral administration of ONCOS-102 leads to systemic antitumor CD8." Oncoimmunology vol. 4,7 (2015): e1017702. doi: https://doi.org/10.1080/2162402X.2015.1017702
Vassilev L, Ranki T, Joensuu T, Jäger E, Karbach J, Wahle C, Partanen K, Kairemo K, Alanko T, Turkki R, Linder N, Lundin J, Ristimäki A, Kankainen M, Hemminki A, Backman C, Dienel K, von Euler M, Haavisto E, Hakonen T, Juhila J, Jäderberg M, Priha P, Vuolanto A, Pesonen S. Repeated intratumoral administration of ONCOS-102 leads to systemic antitumor CD8. Oncoimmunology. 2015 Apr 01;4(7):e1017702. doi: 10.1080/2162402X.2015.1017702. eCollection 2015 Jul. PMID: 26140248; PMCID: PMC4485730.
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Rapid transient expression of human granulocyte-macrophage colony-stimulating factor in two industrial cultivars of tobacco (.

Biotechnology reports (Amsterdam, Netherlands)

Vojta L, Ljuma-Skupnjak L, Budimir A, Vukičević S, Fulgosi H.
PMID: 28626718
Biotechnol Rep (Amst). 2015 May 30;7:81-86. doi: 10.1016/j.btre.2015.05.006. eCollection 2015 Sep.

We report the production of hGM-CSF cytokine in leaves of industrial tobacco cultivars DH-17 and DH-27 by using

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Vojta L, Ljuma-Skupnjak L, Budimir A, et al. Rapid transient expression of human granulocyte-macrophage colony-stimulating factor in two industrial cultivars of tobacco (. Biotechnol Rep (Amst). 2015;7:81-86doi: 10.1016/j.btre.2015.05.006.
Vojta, L., Ljuma-Skupnjak, L., Budimir, A., Vukičević, S., & Fulgosi, H. (2015). Rapid transient expression of human granulocyte-macrophage colony-stimulating factor in two industrial cultivars of tobacco (. Biotechnology reports (Amsterdam, Netherlands), 781-86. https://doi.org/10.1016/j.btre.2015.05.006
Vojta, Lea, et al. "Rapid transient expression of human granulocyte-macrophage colony-stimulating factor in two industrial cultivars of tobacco (." Biotechnology reports (Amsterdam, Netherlands) vol. 7 (2015): 81-86. doi: https://doi.org/10.1016/j.btre.2015.05.006
Vojta L, Ljuma-Skupnjak L, Budimir A, Vukičević S, Fulgosi H. Rapid transient expression of human granulocyte-macrophage colony-stimulating factor in two industrial cultivars of tobacco (. Biotechnol Rep (Amst). 2015 May 30;7:81-86. doi: 10.1016/j.btre.2015.05.006. eCollection 2015 Sep. PMID: 28626718; PMCID: PMC5466047.
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miR-148a-3p Mediates Notch Signaling to Promote the Differentiation and M1 Activation of Macrophages.

Frontiers in immunology

Huang F, Zhao JL, Wang L, Gao CC, Liang SQ, An DJ, Bai J, Chen Y, Han H, Qin HY.
PMID: 29085372
Front Immunol. 2017 Oct 16;8:1327. doi: 10.3389/fimmu.2017.01327. eCollection 2017.

The Notch pathway plays critical roles in the differentiation and polarized activation of macrophages; however, the downstream molecular mechanisms underlying Notch activity in macrophages remain elusive. Our previous study has identified a group of microRNAs that mediate Notch signaling...

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Huang F, Zhao JL, Wang L, et al. miR-148a-3p Mediates Notch Signaling to Promote the Differentiation and M1 Activation of Macrophages. Front Immunol. 2017;8:1327doi: 10.3389/fimmu.2017.01327.
Huang, F., Zhao, J. L., Wang, L., Gao, C. C., Liang, S. Q., An, D. J., Bai, J., Chen, Y., Han, H., & Qin, H. Y. (2017). miR-148a-3p Mediates Notch Signaling to Promote the Differentiation and M1 Activation of Macrophages. Frontiers in immunology, 81327. https://doi.org/10.3389/fimmu.2017.01327
Huang, Fei, et al. "miR-148a-3p Mediates Notch Signaling to Promote the Differentiation and M1 Activation of Macrophages." Frontiers in immunology vol. 8 (2017): 1327. doi: https://doi.org/10.3389/fimmu.2017.01327
Huang F, Zhao JL, Wang L, Gao CC, Liang SQ, An DJ, Bai J, Chen Y, Han H, Qin HY. miR-148a-3p Mediates Notch Signaling to Promote the Differentiation and M1 Activation of Macrophages. Front Immunol. 2017 Oct 16;8:1327. doi: 10.3389/fimmu.2017.01327. eCollection 2017. PMID: 29085372; PMCID: PMC5650608.
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Monocyte chemoattractant protein 1 and fractalkine play opposite roles in angiogenesis .

International journal of ophthalmology

Chen L, Liu GQ, Wu HY, Jin J, Yin X, Li D, Lu PR.
PMID: 29487809
Int J Ophthalmol. 2018 Feb 18;11(2):216-222. doi: 10.18240/ijo.2018.02.06. eCollection 2018.

AIM: To explore the interaction between macrophages and chemokines [monocyte chemoattractant protein 1 (MCP-1/CCL2) and fractalkine/CX3CL1] and the effects of their interaction on neovascularization.METHODS: Human peripheral blood mononuclear cells, donated by healthy volunteers, were separated and cultured in RPMI-1640...

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Chen L, Liu GQ, Wu HY, et al. Monocyte chemoattractant protein 1 and fractalkine play opposite roles in angiogenesis . Int J Ophthalmol. 2018;11(2):216-222doi: 10.18240/ijo.2018.02.06.
Chen, L., Liu, G. Q., Wu, H. Y., Jin, J., Yin, X., Li, D., & Lu, P. R. (2018). Monocyte chemoattractant protein 1 and fractalkine play opposite roles in angiogenesis . International journal of ophthalmology, 11(2), 216-222. https://doi.org/10.18240/ijo.2018.02.06
Chen, Lei, et al. "Monocyte chemoattractant protein 1 and fractalkine play opposite roles in angiogenesis ." International journal of ophthalmology vol. 11,2 (2018): 216-222. doi: https://doi.org/10.18240/ijo.2018.02.06
Chen L, Liu GQ, Wu HY, Jin J, Yin X, Li D, Lu PR. Monocyte chemoattractant protein 1 and fractalkine play opposite roles in angiogenesis . Int J Ophthalmol. 2018 Feb 18;11(2):216-222. doi: 10.18240/ijo.2018.02.06. eCollection 2018. PMID: 29487809; PMCID: PMC5824074.
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Potential association between membranous nephropathy and sargramostim therapy for pulmonary alveolar proteinosis.

Clinical nephrology. Case studies

Sewaralthahab K, Rennke H, Sewaralthahab S, Madias NE, Jaber BL.
PMID: 29043131
Clin Nephrol Case Stud. 2014 Dec 15;3:31-36. doi: 10.5414/CNCS108420. eCollection 2015.

We present the case of a 43-year-old woman with a diagnosis of pulmonary alveolar proteinosis, on chronic treatment with sargramostim, a recombinant granulocyte-macrophage colony-stimulating factor, who presented with the nephrotic syndrome secondary to biopsy-proven membranous nephropathy. We discuss potential...

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Sewaralthahab K, Rennke H, Sewaralthahab S, et al. Potential association between membranous nephropathy and sargramostim therapy for pulmonary alveolar proteinosis. Clin Nephrol Case Stud. 2014;3:31-36doi: 10.5414/CNCS108420.
Sewaralthahab, K., Rennke, H., Sewaralthahab, S., Madias, N. E., & Jaber, B. L. (2015). Potential association between membranous nephropathy and sargramostim therapy for pulmonary alveolar proteinosis. Clinical nephrology. Case studies, 331-36. https://doi.org/10.5414/CNCS108420
Sewaralthahab, Kamal, et al. "Potential association between membranous nephropathy and sargramostim therapy for pulmonary alveolar proteinosis." Clinical nephrology. Case studies vol. 3 (2015): 31-36. doi: https://doi.org/10.5414/CNCS108420
Sewaralthahab K, Rennke H, Sewaralthahab S, Madias NE, Jaber BL. Potential association between membranous nephropathy and sargramostim therapy for pulmonary alveolar proteinosis. Clin Nephrol Case Stud. 2014 Dec 15;3:31-36. doi: 10.5414/CNCS108420. eCollection 2015. PMID: 29043131; PMCID: PMC5437997.
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Therapeutic improvement of colonic anastomotic healing under complicated conditions: A systematic review.

World journal of gastrointestinal surgery

Nerstrøm M, Krarup PM, Jorgensen LN, Ågren MS.
PMID: 27231518
World J Gastrointest Surg. 2016 May 27;8(5):389-401. doi: 10.4240/wjgs.v8.i5.389.

AIM: To identify therapeutic agents for the prophylaxis of gastrointestinal anastomotic leakage (AL) under complicated conditions.METHODS: The PubMed and EMBASE databases were searched for English articles published between January 1975 and September 2014. Studies with the primary purpose of...

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Nerstrøm M, Krarup PM, Jorgensen LN, et al. Therapeutic improvement of colonic anastomotic healing under complicated conditions: A systematic review. World J Gastrointest Surg. 2016;8(5):389-401doi: 10.4240/wjgs.v8.i5.389.
Nerstrøm, M., Krarup, P. M., Jorgensen, L. N., & Ågren, M. S. (2016). Therapeutic improvement of colonic anastomotic healing under complicated conditions: A systematic review. World journal of gastrointestinal surgery, 8(5), 389-401. https://doi.org/10.4240/wjgs.v8.i5.389
Nerstrøm, Malene, et al. "Therapeutic improvement of colonic anastomotic healing under complicated conditions: A systematic review." World journal of gastrointestinal surgery vol. 8,5 (2016): 389-401. doi: https://doi.org/10.4240/wjgs.v8.i5.389
Nerstrøm M, Krarup PM, Jorgensen LN, Ågren MS. Therapeutic improvement of colonic anastomotic healing under complicated conditions: A systematic review. World J Gastrointest Surg. 2016 May 27;8(5):389-401. doi: 10.4240/wjgs.v8.i5.389. PMID: 27231518; PMCID: PMC4872068.
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Cytokine-induced killer cell therapy for modulating regulatory T cells in patients with non-small cell lung cancer.

Experimental and therapeutic medicine

Yu B, Wang J, He C, Wang W, Tang J, Zheng R, Zhou C, Zhang H, Fu Z, Li Q, Xu J.
PMID: 28673007
Exp Ther Med. 2017 Jul;14(1):831-840. doi: 10.3892/etm.2017.4562. Epub 2017 Jun 08.

Previous studies have reported that regulatory T cells (Tregs), which are physiologically engaged in the maintenance of immunological self-tolerance, have a critical role in the regulation of the antitumor immune response. Targeting Tregs has the potential to augment cancer...

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Yu B, Wang J, He C, et al. Cytokine-induced killer cell therapy for modulating regulatory T cells in patients with non-small cell lung cancer. Exp Ther Med. 2017;14(1):831-840doi: 10.3892/etm.2017.4562.
Yu, B., Wang, J., He, C., Wang, W., Tang, J., Zheng, R., Zhou, C., Zhang, H., Fu, Z., Li, Q., & Xu, J. (2017). Cytokine-induced killer cell therapy for modulating regulatory T cells in patients with non-small cell lung cancer. Experimental and therapeutic medicine, 14(1), 831-840. https://doi.org/10.3892/etm.2017.4562
Yu, Baodan, et al. "Cytokine-induced killer cell therapy for modulating regulatory T cells in patients with non-small cell lung cancer." Experimental and therapeutic medicine vol. 14,1 (2017): 831-840. doi: https://doi.org/10.3892/etm.2017.4562
Yu B, Wang J, He C, Wang W, Tang J, Zheng R, Zhou C, Zhang H, Fu Z, Li Q, Xu J. Cytokine-induced killer cell therapy for modulating regulatory T cells in patients with non-small cell lung cancer. Exp Ther Med. 2017 Jul;14(1):831-840. doi: 10.3892/etm.2017.4562. Epub 2017 Jun 08. PMID: 28673007; PMCID: PMC5488714.
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Immunotherapeutic intervention with oncolytic adenovirus in mouse mammary tumors.

Oncoimmunology

Gibson H, Munns S, Freytag S, Barton K, Veenstra J, Bettahi I, Bissonette J, Wei WZ.
PMID: 25949865
Oncoimmunology. 2015 Feb 03;4(1):e984523. doi: 10.4161/2162402X.2014.984523. eCollection 2015 Jan.

The goal is to elucidate the immune modulating activity of an adenovirus (Adv) vector which showed therapeutic activity in human clinical trials. The oncolytic adenovirus (Adv/CD-TK) expressing two suicide genes was tested in two HER2/neu positive BALB/c mouse mammary...

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Gibson H, Munns S, Freytag S, et al. Immunotherapeutic intervention with oncolytic adenovirus in mouse mammary tumors. Oncoimmunology. 2015;4(1):e984523doi: 10.4161/2162402X.2014.984523.
Gibson, H., Munns, S., Freytag, S., Barton, K., Veenstra, J., Bettahi, I., Bissonette, J., & Wei, W. Z. (2015). Immunotherapeutic intervention with oncolytic adenovirus in mouse mammary tumors. Oncoimmunology, 4(1), e984523. https://doi.org/10.4161/2162402X.2014.984523
Gibson, Heather, et al. "Immunotherapeutic intervention with oncolytic adenovirus in mouse mammary tumors." Oncoimmunology vol. 4,1 (2015): e984523. doi: https://doi.org/10.4161/2162402X.2014.984523
Gibson H, Munns S, Freytag S, Barton K, Veenstra J, Bettahi I, Bissonette J, Wei WZ. Immunotherapeutic intervention with oncolytic adenovirus in mouse mammary tumors. Oncoimmunology. 2015 Feb 03;4(1):e984523. doi: 10.4161/2162402X.2014.984523. eCollection 2015 Jan. PMID: 25949865; PMCID: PMC4368120.
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Clinical Development of the E75 Vaccine in Breast Cancer.

Breast care (Basel, Switzerland)

Clifton GT, Gall V, Peoples GE, Mittendorf EA.
PMID: 27239173
Breast Care (Basel). 2016 Apr;11(2):116-21. doi: 10.1159/000446097. Epub 2016 Apr 26.

E75 is an immunogenic peptide derived from the human epidermal growth factor receptor 2 (HER2) protein. A large amount of preclinical work evaluated the immunogenicity of E75, after which phase I trials investigated using E75 mixed with an immunoadjuvant...

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Clifton GT, Gall V, Peoples GE, et al. Clinical Development of the E75 Vaccine in Breast Cancer. Breast Care (Basel). 2016;11(2):116-21doi: 10.1159/000446097.
Clifton, G. T., Gall, V., Peoples, G. E., & Mittendorf, E. A. (2016). Clinical Development of the E75 Vaccine in Breast Cancer. Breast care (Basel, Switzerland), 11(2), 116-21. https://doi.org/10.1159/000446097
Clifton, Guy T, et al. "Clinical Development of the E75 Vaccine in Breast Cancer." Breast care (Basel, Switzerland) vol. 11,2 (2016): 116-21. doi: https://doi.org/10.1159/000446097
Clifton GT, Gall V, Peoples GE, Mittendorf EA. Clinical Development of the E75 Vaccine in Breast Cancer. Breast Care (Basel). 2016 Apr;11(2):116-21. doi: 10.1159/000446097. Epub 2016 Apr 26. PMID: 27239173; PMCID: PMC4881244.
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Hematopoietic cytokines as therapeutic players in early stages Parkinson's disease.

Frontiers in aging neuroscience

Farmer K, Rudyk C, Prowse NA, Hayley S.
PMID: 26191001
Front Aging Neurosci. 2015 Jul 03;7:126. doi: 10.3389/fnagi.2015.00126. eCollection 2015.

Parkinson's disease (PD) is a devastating age related neurodegenerative disease that is believed to have a lengthy prodromal state. It is critical to find methods to harness compensatory recovery processes in order to slow or prevent the eventual progression...

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Farmer K, Rudyk C, Prowse NA, et al. Hematopoietic cytokines as therapeutic players in early stages Parkinson's disease. Front Aging Neurosci. 2015;7:126doi: 10.3389/fnagi.2015.00126.
Farmer, K., Rudyk, C., Prowse, N. A., & Hayley, S. (2015). Hematopoietic cytokines as therapeutic players in early stages Parkinson's disease. Frontiers in aging neuroscience, 7126. https://doi.org/10.3389/fnagi.2015.00126
Farmer, Kyle, et al. "Hematopoietic cytokines as therapeutic players in early stages Parkinson's disease." Frontiers in aging neuroscience vol. 7 (2015): 126. doi: https://doi.org/10.3389/fnagi.2015.00126
Farmer K, Rudyk C, Prowse NA, Hayley S. Hematopoietic cytokines as therapeutic players in early stages Parkinson's disease. Front Aging Neurosci. 2015 Jul 03;7:126. doi: 10.3389/fnagi.2015.00126. eCollection 2015. PMID: 26191001; PMCID: PMC4490238.
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Showing 1 to 12 of 764 entries