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Showing 1 to 12 of 3152 entries
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The role of Peyer's patches in synchronizing gut IgA responses.

Frontiers in immunology

Lycke NY, Bemark M.
PMID: 23181060
Front Immunol. 2012 Nov 07;3:329. doi: 10.3389/fimmu.2012.00329. eCollection 2012.

Because Peyer's patches (PP) are the main inductive sites for gut IgA responses we have focused this review on what we know about the function of PP germinal centers (GC). The vast majority of IgA gene sequences in the...

Low levels of interleukin-10 in patients with transfusion-related acute lung injury.

Annals of translational medicine

Kapur R, Kim M, Rebetz J, Rondina MT, Porcelijn L, Semple JW.
PMID: 28861436
Ann Transl Med. 2017 Aug;5(16):339. doi: 10.21037/atm.2017.04.37.

No abstract available.

The Regulation of NF-κB Subunits by Phosphorylation.

Cells

Christian F, Smith EL, Carmody RJ.
PMID: 26999213
Cells. 2016 Mar 18;5(1). doi: 10.3390/cells5010012.

The NF-κB transcription factor is the master regulator of the inflammatory response and is essential for the homeostasis of the immune system. NF-κB regulates the transcription of genes that control inflammation, immune cell development, cell cycle, proliferation, and cell...

Cytokine and anti-cytokine therapies in prevention or treatment of fibrosis in IBD.

United European gastroenterology journal

Jacob N, Targan SR, Shih DQ.
PMID: 27536363
United European Gastroenterol J. 2016 Aug;4(4):531-40. doi: 10.1177/2050640616649356. Epub 2016 May 10.

The frequency of fibrosing Crohn's disease (CD) is significant, with approximately 40% of CD patients with ileal disease developing clinically apparent strictures throughout their lifetime. Although strictures may be subdivided into fibrotic, inflammatory, or mixed forms, despite immunosuppressive therapy...

Perivascular mast cells regulate vein graft neointimal formation and remodeling.

PeerJ

Wu J, Grassia G, Cambrook H, Ialenti A, MacRitchie N, Carberry J, Wadsworth RM, Lawrence C, Kennedy S, Maffia P.
PMID: 26312183
PeerJ. 2015 Aug 18;3:e1192. doi: 10.7717/peerj.1192. eCollection 2015.

Objective. Emerging evidence suggests an important role for mast cells in vein graft failure. This study addressed the hypothesis that perivascular mast cells regulate in situ vascular inflammatory and proliferative responses and subsequent vein graft neointimal lesion formation, using...

Immunological Functions of the Membrane Proximal Region of MHC Class II Molecules.

F1000Research

Harton J, Jin L, Hahn A, Drake J.
PMID: 27006762
F1000Res. 2016 Mar 17;5. doi: 10.12688/f1000research.7610.1. eCollection 2016.

Major histocompatibility complex (MHC) class II molecules present exogenously derived antigen peptides to CD4 T cells, driving activation of naïve T cells and supporting CD4-driven immune functions. However, MHC class II molecules are not inert protein pedestals that simply...

Characterization of candidate genes in inflammatory bowel disease-associated risk loci.

JCI insight

Peloquin JM, Goel G, Kong L, Huang H, Haritunians T, Sartor RB, Daly MJ, Newberry RD, McGovern DP, Yajnik V, Lira SA, Xavier RJ.
PMID: 27668286
JCI Insight. 2016 Aug 18;1(13):e87899. doi: 10.1172/jci.insight.87899.

GWAS have linked SNPs to risk of inflammatory bowel disease (IBD), but a systematic characterization of disease-associated genes has been lacking. Prior studies utilized microarrays that did not capture many genes encoded within risk loci or defined expression quantitative...

Autoantibody Repertoire in APECED Patients Targets Two Distinct Subgroups of Proteins.

Frontiers in immunology

Fishman D, Kisand K, Hertel C, Rothe M, Remm A, Pihlap M, Adler P, Vilo J, Peet A, Meloni A, Podkrajsek KT, Battelino T, Bruserud Ø, Wolff ASB, Husebye ES, Kluger N, Krohn K, Ranki A, Peterson H, Hayday A, Peterson P.
PMID: 28861084
Front Immunol. 2017 Aug 16;8:976. doi: 10.3389/fimmu.2017.00976. eCollection 2017.

High titer autoantibodies produced by B lymphocytes are clinically important features of many common autoimmune diseases. APECED patients with deficient autoimmune regulator (AIRE) gene collectively display a broad repertoire of high titer autoantibodies, including some which are pathognomonic for...

Autoimmune Aspects of Neurodegenerative and Psychiatric Diseases: A Template for Innovative Therapy.

Frontiers in psychiatry

de Haan P, Klein HC, 't Hart BA.
PMID: 28421005
Front Psychiatry. 2017 Apr 04;8:46. doi: 10.3389/fpsyt.2017.00046. eCollection 2017.

Neurodegenerative and psychiatric diseases (NPDs) are today's most important group of diseases, surpassing both atherosclerotic cardiovascular disease and cancer in morbidity incidence. Although NPDs have a dramatic impact on our society because of their high incidence, mortality, and severe...

How to Verify Plagiarism of the Paper Written in Macedonian and Translated in Foreign Language?.

Open access Macedonian journal of medical sciences

Spiroski M.
PMID: 27275319
Open Access Maced J Med Sci. 2016 Mar 15;4(1):1-4. doi: 10.3889/oamjms.2016.035. Epub 2016 Feb 29.

AIM: The aim of this study was to show how to verify plagiarism of the paper written in Macedonian and translated in foreign language.MATERIAL AND METHODS: Original article "Ethics in Medical Research Involving Human Subjects", written in Macedonian, was...

Human Mesenchymal Stromal Cells Transplantation May Enhance or Inhibit 4T1 Murine Breast Adenocarcinoma through Different Approaches.

Stem cells international

Jazedje T, Ribeiro AL, Pellati M, de Siqueira Bueno HM, Nagata G, Trierveiler M, Rodrigues EG, Zatz M.
PMID: 26000020
Stem Cells Int. 2015;2015:796215. doi: 10.1155/2015/796215. Epub 2015 Apr 27.

The use of Mesenchymal Stromal Cells (MSCs) aiming to treat cancer has shown very contradictory results. In an attempt to clarify the contradictory results reported in the literature and the possible role of human fallopian tube Mesenchymal Stromal Cells...

β-lapachone-Induced Apoptosis of Human Gastric Carcinoma AGS Cells Is Caspase-Dependent and Regulated by the PI3K/Akt Pathway.

Biomolecules & therapeutics

Yu HY, Kim SO, Jin CY, Kim GY, Kim WJ, Yoo YH, Choi YH.
PMID: 25009698
Biomol Ther (Seoul). 2014 May;22(3):184-92. doi: 10.4062/biomolther.2014.026.

β-lapachone is a naturally occurring quinone that selectively induces apoptotic cell death in a variety of human cancer cells in vitro and in vivo; however, its mechanism of action needs to be further elaborated. In this study, we investigated...

Showing 1 to 12 of 3152 entries