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Showing 1 to 12 of 1910 entries
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Immunomodulatory effects of the botanical compound LCS101: implications for cancer treatment.

OncoTargets and therapy

Rachmut IH, Samuels N, Melnick SJ, Ramachandran C, Sharabi Y, Pavlovsky A, Maimon Y, Shoham J.
PMID: 23637542
Onco Targets Ther. 2013 Apr 24;6:437-45. doi: 10.2147/OTT.S42038. Print 2013.

OBJECTIVE: To examine the effects of LSC101, a botanical compound, on adaptive and innate immunity.MATERIALS AND METHODS: LCS101 preparations were tested for batch-to-batch consistency using high-performance liquid chromatography. T-cell activation was quantified in murine spleen cells using 3H-thymidine incorporation,...

Feasibility of the Interferon-γ Release Assay for the Diagnosis of Genitourinary Tuberculosis in an Endemic Area.

Korean journal of urology

Kim JK, Bang WJ, Oh CY, Yoo C, Cho JS.
PMID: 23550219
Korean J Urol. 2013 Feb;54(2):123-6. doi: 10.4111/kju.2013.54.2.123. Epub 2013 Feb 18.

PURPOSE: To evaluate the feasibility of the interferon-gamma release assay (IGRA) as a supplementary diagnostic tool for the diagnosis of genitourinary tuberculosis (GUTB).MATERIALS AND METHODS: Fifty-seven patients who were tested with the IGRA to diagnose GUTB were included. All...

Biomarkers in kidney transplantation: From bench to bedside.

World journal of nephrology

Townamchai N, Eiam-Ong S.
PMID: 26558185
World J Nephrol. 2015 Nov 06;4(5):487-91. doi: 10.5527/wjn.v4.i5.487.

Immunosuppressive drug level monitoring and serum creatinine are widely used for kidney transplantation (KT) monitoring. Monitoring of drug level is not the direct measurement of the immune response while the rising of creatinine is too late for detection of...

Ginsenoside fractions regulate the action of monocytes and their differentiation into dendritic cells.

Journal of ginseng research

Lee YJ, Son YM, Gu MJ, Song KD, Park SM, Song HJ, Kang JS, Woo JS, Jung JH, Yang DC, Han SH, Yun CH.
PMID: 25535474
J Ginseng Res. 2015 Jan;39(1):29-37. doi: 10.1016/j.jgr.2014.07.003. Epub 2014 Aug 07.

BACKGROUND: Panax ginseng (i.e., ginseng) root is extensively used in traditional oriental medicine. It is a modern pharmaceutical reagent for preventing various human diseases such as cancer. Ginsenosides-the major active components of ginseng-exhibit immunomodulatory effects. However, the mechanism and...

The High-Risk Human Papillomavirus E6 Oncogene Exacerbates the Negative Effect of Tryptophan Starvation on the Development of Chlamydia trachomatis.

PloS one

Sherchand SP, Ibana JA, Zea AH, Quayle AJ, Aiyar A.
PMID: 27658027
PLoS One. 2016 Sep 22;11(9):e0163174. doi: 10.1371/journal.pone.0163174. eCollection 2016.

Chlamydia trachomatis is an obligate intracellular pathogen that requires specific essential nutrients from the host cell, one of which is the amino acid tryptophan. In this context interferon gamma (IFNγ) is the major host protective cytokine against chlamydial infections...

A single nucleotide polymorphism in the interferon-γ gene (.

Oncotarget

Wei Z, Wenhao S, Yuanyuan M, Yang L, Daming Z, Jiangchun X, Jijun J.
PMID: 28881572
Oncotarget. 2017 Apr 20;8(31):50415-50429. doi: 10.18632/oncotarget.17304. eCollection 2017 Aug 01.

Interferon-γ (Interferon gamma, IFNG) is an important cytokine involved in providing resistance to mycobacterial diseases. Common variants of

Performance of a rapid strip test for the serologic diagnosis of latent tuberculosis in children.

Journal of clinical and diagnostic research : JCDR

Kasempimolporn S, Thaveekarn W, Kerdpanich P, Skulpichetrat U, Saekhow O, Boonchang S, Bharnthong T, Sitprija V.
PMID: 25737986
J Clin Diagn Res. 2015 Jan;9(1):DC11-4. doi: 10.7860/JCDR/2015/10989.5403. Epub 2015 Jan 01.

BACKGROUND: The serodiagnostic tests for tuberculosis (TB) present a high variability in terms of sensitivity and specificity. Data on patients with latent TB infection (LTBI) and children in high prevalence settings are still limited. The present study aimed to...

Restoring Lost Anti-HER-2 Th1 Immunity in Breast Cancer: A Crucial Role for Th1 Cytokines in Therapy and Prevention.

Frontiers in pharmacology

Nocera NF, Lee MC, De La Cruz LM, Rosemblit C, Czerniecki BJ.
PMID: 27766079
Front Pharmacol. 2016 Oct 06;7:356. doi: 10.3389/fphar.2016.00356. eCollection 2016.

The ErbB/B2 (HER-2/neu) oncogene family plays a critical role in the development and metastatic spread of several tumor types including breast, ovarian and gastric cancer. In breast cancer, HER-2/neu is expressed in early disease development in a large percentage...

Utility of a Mouse Model of Osteoarthritis to Demonstrate Cartilage Protection by IFNγ-Primed Equine Mesenchymal Stem Cells.

Frontiers in immunology

Maumus M, Roussignol G, Toupet K, Penarier G, Bentz I, Teixeira S, Oustric D, Jung M, Lepage O, Steinberg R, Jorgensen C, Noel D.
PMID: 27729913
Front Immunol. 2016 Sep 27;7:392. doi: 10.3389/fimmu.2016.00392. eCollection 2016.

OBJECTIVE: Mesenchymal stem cells isolated from adipose tissue (ASC) have been shown to influence the course of osteoarthritis (OA) in different animal models and are promising in veterinary medicine for horses involved in competitive sport. The aim of this...

Exoenzyme T Plays a Pivotal Role in the IFN-γ Production after .

Frontiers in immunology

Vourc'h M, Roquilly A, Broquet A, David G, Hulin P, Jacqueline C, Caillon J, Retiere C, Asehnoune K.
PMID: 29067027
Front Immunol. 2017 Oct 10;8:1283. doi: 10.3389/fimmu.2017.01283. eCollection 2017.

No abstract available.

The importance of single nucleotide polymorphisms in interferon gamma receptor-1 gene in pulmonary patients infected with rapid grower mycobacterium.

International journal of mycobacteriology

Farnia P, Ghanavi J, Tabasri P, Saif S, Velayati AA.
PMID: 28043560
Int J Mycobacteriol. 2016 Dec;5:S210-S211. doi: 10.1016/j.ijmyco.2016.09.040. Epub 2016 Nov 11.

OBJECTIVE/BACKGROUND: Interferon gamma (IFN-γ) plays a key role in protective immune response against Mycobacterial infection. IFN-γ excretes its antimycobacterial effectors mechanisms by activation of macrophages and dendritic cells via interaction with its receptor complex, that is, a ligand-binding subunit...

Induction of Fas-Mediated Apoptosis by Interferon-γ is Dependent on Granulosa Cell Differentiation and Follicular Maturation in the Rat Ovary.

Development & reproduction

Lee HJ, Kim JY, Park JE, Yoon YD, Tsang BK, Kim JM.
PMID: 28144637
Dev Reprod. 2016 Dec;20(4):315-329. doi: 10.12717/DR.2016.20.4.315. Epub 2016 Dec 31.

Fas ligand (FasL) and its receptor Fas have been implicated in granulosa cell apoptosis during follicular atresia. Although interferon-gamma (IFN-γ) is believed to be involved in the regulation Fas expression in differentiated granulosa or granulosa-luteal cells, the expression of...

Showing 1 to 12 of 1910 entries