Advanced Search
Display options
Filter resources
Text Availability
Article type
Publication date
Species
Language
Sex
Age
Showing 1 to 12 of 2368 entries
Sorted by: Best Match Show Resources per page
Diversification of Antisense Research and Development: Review of the Ringberg Meeting, April 1994: Mechanisms of Antisense-Mediated Gene Silencing

STEM and diversification

[No authors listed]
GSID: KOIKOkf1eEgJ
JW HAWKINS, W NELLEN - Antisense research and development, 1994 - liebertpub.com

… Much of antisense technology and our conceptual under¬ standing of antisense effects stem from experiments with oligonucleotides. Indeed, the advent of biologically stable …

Cite
HAWKINS, JAMES W. et NELLEN, WOLFGANG. Diversification of Antisense Research and Development: Review of the Ringberg Meeting, April 1994: Mechanisms of Antisense-Mediated Gene Silencing. Antisense research and development, 1994, vol. 4, no 2, p. 127-129.
HAWKINS, J. W., & NELLEN, W. (1994). Diversification of Antisense Research and Development: Review of the Ringberg Meeting, April 1994: Mechanisms of Antisense-Mediated Gene Silencing. Antisense research and development, 4(2), 127-129.
Copy Download .nbib Format: MLA
Architecture with GIDEON, a program for design in structural DNA nanotechnology

program design

[No authors listed]
GSID: ord-kyPhudsJ
JJ Birac, WB Sherman, J Kopatsch… - Journal of Molecular …, 2006 - Elsevier

We present geometry based design strategies for DNA nanostructures. The strategies have been implemented with GIDEON—a graphical integrated development environment for oligonucleotides. GIDEON has a highly flexible graphical user interface that facilitates the …

Cite
Birac, J. J., Sherman, W. B., Kopatsch, J., Constantinou, P. E., & Seeman, N. C. (2006). Architecture with GIDEON, a program for design in structural DNA nanotechnology. Journal of Molecular Graphics and Modelling, 25(4), 470-480.
Birac, Jeffrey J., et al. "Architecture with GIDEON, a program for design in structural DNA nanotechnology." Journal of Molecular Graphics and Modelling 25.4 (2006): 470-480.
Copy Download .nbib Format: MLA
Rolling-Circle RNA Synthesis: Circular Oligonucleotides as Efficient Substrates for T7 RNA Polymerase.

Journal of the American Chemical Society

Daubendiek SL, Ryan K, Kool ET.
PMID: 27524830
J Am Chem Soc. 1995 Jul 01;117(29):7818-7819. doi: 10.1021/ja00134a032.

No abstract available.

Cite
Daubendiek SL, Ryan K, Kool ET. Rolling-Circle RNA Synthesis: Circular Oligonucleotides as Efficient Substrates for T7 RNA Polymerase. J Am Chem Soc. 1995;117(29):7818-7819doi: 10.1021/ja00134a032.
Daubendiek, S. L., Ryan, K., & Kool, E. T. (1995). Rolling-Circle RNA Synthesis: Circular Oligonucleotides as Efficient Substrates for T7 RNA Polymerase. Journal of the American Chemical Society, 117(29), 7818-7819. https://doi.org/10.1021/ja00134a032
Daubendiek, Sarah L, et al. "Rolling-Circle RNA Synthesis: Circular Oligonucleotides as Efficient Substrates for T7 RNA Polymerase." Journal of the American Chemical Society vol. 117,29 (1995): 7818-7819. doi: https://doi.org/10.1021/ja00134a032
Daubendiek SL, Ryan K, Kool ET. Rolling-Circle RNA Synthesis: Circular Oligonucleotides as Efficient Substrates for T7 RNA Polymerase. J Am Chem Soc. 1995 Jul 01;117(29):7818-7819. doi: 10.1021/ja00134a032. PMID: 27524830; PMCID: PMC4982548.
Copy Download .nbib Format: NLM
Self-Amplifying Replicon RNA Vaccine Delivery to Dendritic Cells by Synthetic Nanoparticles.

Vaccines

McCullough KC, Milona P, Thomann-Harwood L, Démoulins T, Englezou P, Suter R, Ruggli N.
PMID: 26344889
Vaccines (Basel). 2014 Oct 16;2(4):735-54. doi: 10.3390/vaccines2040735.

Dendritic cells (DC) play essential roles determining efficacy of vaccine delivery with respect to immune defence development and regulation. This renders DCs important targets for vaccine delivery, particularly RNA vaccines. While delivery of interfering RNA oligonucleotides to the appropriate...

Cite
McCullough KC, Milona P, Thomann-Harwood L, et al. Self-Amplifying Replicon RNA Vaccine Delivery to Dendritic Cells by Synthetic Nanoparticles. Vaccines (Basel). 2014;2(4):735-54doi: 10.3390/vaccines2040735.
McCullough, K. C., Milona, P., Thomann-Harwood, L., Démoulins, T., Englezou, P., Suter, R., & Ruggli, N. (2014). Self-Amplifying Replicon RNA Vaccine Delivery to Dendritic Cells by Synthetic Nanoparticles. Vaccines, 2(4), 735-54. https://doi.org/10.3390/vaccines2040735
McCullough, Kenneth C, et al. "Self-Amplifying Replicon RNA Vaccine Delivery to Dendritic Cells by Synthetic Nanoparticles." Vaccines vol. 2,4 (2014): 735-54. doi: https://doi.org/10.3390/vaccines2040735
McCullough KC, Milona P, Thomann-Harwood L, Démoulins T, Englezou P, Suter R, Ruggli N. Self-Amplifying Replicon RNA Vaccine Delivery to Dendritic Cells by Synthetic Nanoparticles. Vaccines (Basel). 2014 Oct 16;2(4):735-54. doi: 10.3390/vaccines2040735. PMID: 26344889; PMCID: PMC4494254.
Copy Download .nbib Format: NLM
Differences and Variations among Anguilla japonica, Muraenesox cinereus and Conger myriaster from the Yellow Sea.

Development & reproduction

Yoon JM.
PMID: 27004273
Dev Reprod. 2015 Sep;19(3):163-6. doi: 10.12717/DR.2015.19.3.163.

Genomic DNAs were extracted from the muscle of twenty-one specimens of three eel species collected in Anguilla japonica (AJ), Muraenesox cinereus (MC) and Conger myriaster (CM) from the Yellow Sea, respectively. In the present study, 7 oligonucleotides primers generated...

Cite
Yoon JM. Differences and Variations among Anguilla japonica, Muraenesox cinereus and Conger myriaster from the Yellow Sea. Dev Reprod. 2015;19(3):163-6doi: 10.12717/DR.2015.19.3.163.
Yoon, J. M. (2015). Differences and Variations among Anguilla japonica, Muraenesox cinereus and Conger myriaster from the Yellow Sea. Development & reproduction, 19(3), 163-6. https://doi.org/10.12717/DR.2015.19.3.163
Yoon, Jong-Man. "Differences and Variations among Anguilla japonica, Muraenesox cinereus and Conger myriaster from the Yellow Sea." Development & reproduction vol. 19,3 (2015): 163-6. doi: https://doi.org/10.12717/DR.2015.19.3.163
Yoon JM. Differences and Variations among Anguilla japonica, Muraenesox cinereus and Conger myriaster from the Yellow Sea. Dev Reprod. 2015 Sep;19(3):163-6. doi: 10.12717/DR.2015.19.3.163. PMID: 27004273; PMCID: PMC4801043.
Copy Download .nbib Format: NLM
Options for Synthetic DNA Order Screening, Revisited.

mSphere

DiEuliis D, Carter SR, Gronvall GK.
PMID: 28861521
mSphere. 2017 Aug 23;2(4). doi: 10.1128/mSphere.00319-17. eCollection 2017.

Gene synthesis providers affiliated with the International Gene Synthesis Consortium (IGSC) voluntarily screen double-stranded DNA (dsDNA) synthesis orders over 200 bp to check for matches to regulated pathogens and to screen customers. Questions have been raised, however, about the...

Cite
DiEuliis D, Carter SR, Gronvall GK. Options for Synthetic DNA Order Screening, Revisited. mSphere. 2017;2(4)doi: 10.1128/mSphere.00319-17.
DiEuliis, D., Carter, S. R., & Gronvall, G. K. (2017). Options for Synthetic DNA Order Screening, Revisited. mSphere, 2(4), . https://doi.org/10.1128/mSphere.00319-17
DiEuliis, Diane, et al. "Options for Synthetic DNA Order Screening, Revisited." mSphere vol. 2,4 (2017). doi: https://doi.org/10.1128/mSphere.00319-17
DiEuliis D, Carter SR, Gronvall GK. Options for Synthetic DNA Order Screening, Revisited. mSphere. 2017 Aug 23;2(4). doi: 10.1128/mSphere.00319-17. eCollection 2017. PMID: 28861521; PMCID: PMC5566836.
Copy Download .nbib Format: NLM
Pigmy MicroRNA: surveillance cops in Therapies kingdom.

Molecular medicine (Cambridge, Mass.)

Bhadra U, Patra P, Chhatai J, Pal-Bhadra M.
PMID: 27704139
Mol Med. 2016 Dec;22:759-775. doi: 10.2119/molmed.2016.00136. Epub 2016 Sep 28.

MicroRNAs (miRNAs) are well preserved in every animal. These pigmy sized non-coding RNAs (21-23 nt), scattered in genome, are responsible for micromanaging the versatile gene regulations. Involvement of miRNAs was surveillance cops in all human diseases including cardiovascular defects,...

Cite
Bhadra U, Patra P, Chhatai J, et al. Pigmy MicroRNA: surveillance cops in Therapies kingdom. Mol Med. 2016;22:759-775doi: 10.2119/molmed.2016.00136.
Bhadra, U., Patra, P., Chhatai, J., & Pal-Bhadra, M. (2016). Pigmy MicroRNA: surveillance cops in Therapies kingdom. Molecular medicine (Cambridge, Mass.), 22759-775. https://doi.org/10.2119/molmed.2016.00136
Bhadra, Utpal, et al. "Pigmy MicroRNA: surveillance cops in Therapies kingdom." Molecular medicine (Cambridge, Mass.) vol. 22 (2016): 759-775. doi: https://doi.org/10.2119/molmed.2016.00136
Bhadra U, Patra P, Chhatai J, Pal-Bhadra M. Pigmy MicroRNA: surveillance cops in Therapies kingdom. Mol Med. 2016 Dec;22:759-775. doi: 10.2119/molmed.2016.00136. Epub 2016 Sep 28. PMID: 27704139; PMCID: PMC5193465.
Copy Download .nbib Format: NLM
Image-Guided Hydrodynamic Gene Delivery: Current Status and Future Directions.

Pharmaceutics

Kamimura K, Yokoo T, Abe H, Kobayashi Y, Ogawa K, Shinagawa Y, Inoue R, Terai S.
PMID: 26308044
Pharmaceutics. 2015 Aug 21;7(3):213-23. doi: 10.3390/pharmaceutics7030213.

Hydrodynamics-based delivery has been used as an experimental tool to express transgene in small animals. This in vivo gene transfer method is useful for functional analysis of genetic elements, therapeutic effect of oligonucleotides, and cancer cells to establish the...

Cite
Kamimura K, Yokoo T, Abe H, et al. Image-Guided Hydrodynamic Gene Delivery: Current Status and Future Directions. Pharmaceutics. 2015;7(3):213-23doi: 10.3390/pharmaceutics7030213.
Kamimura, K., Yokoo, T., Abe, H., Kobayashi, Y., Ogawa, K., Shinagawa, Y., Inoue, R., & Terai, S. (2015). Image-Guided Hydrodynamic Gene Delivery: Current Status and Future Directions. Pharmaceutics, 7(3), 213-23. https://doi.org/10.3390/pharmaceutics7030213
Kamimura, Kenya, et al. "Image-Guided Hydrodynamic Gene Delivery: Current Status and Future Directions." Pharmaceutics vol. 7,3 (2015): 213-23. doi: https://doi.org/10.3390/pharmaceutics7030213
Kamimura K, Yokoo T, Abe H, Kobayashi Y, Ogawa K, Shinagawa Y, Inoue R, Terai S. Image-Guided Hydrodynamic Gene Delivery: Current Status and Future Directions. Pharmaceutics. 2015 Aug 21;7(3):213-23. doi: 10.3390/pharmaceutics7030213. PMID: 26308044; PMCID: PMC4588196.
Copy Download .nbib Format: NLM
Hydrophobically Modified siRNAs Silence Huntingtin mRNA in Primary Neurons and Mouse Brain.

Molecular therapy. Nucleic acids

Alterman JF, Hall LM, Coles AH, Hassler MR, Didiot MC, Chase K, Abraham J, Sottosanti E, Johnson E, Sapp E, Osborn MF, Difiglia M, Aronin N, Khvorova A.
PMID: 26623938
Mol Ther Nucleic Acids. 2015 Dec 01;4:e266. doi: 10.1038/mtna.2015.38.

Applications of RNA interference for neuroscience research have been limited by a lack of simple and efficient methods to deliver oligonucleotides to primary neurons in culture and to the brain. Here, we show that primary neurons rapidly internalize hydrophobically...

Cite
Alterman JF, Hall LM, Coles AH, et al. Hydrophobically Modified siRNAs Silence Huntingtin mRNA in Primary Neurons and Mouse Brain. Mol Ther Nucleic Acids. 2015;4:e266doi: 10.1038/mtna.2015.38.
Alterman, J. F., Hall, L. M., Coles, A. H., Hassler, M. R., Didiot, M. C., Chase, K., Abraham, J., Sottosanti, E., Johnson, E., Sapp, E., Osborn, M. F., Difiglia, M., Aronin, N., & Khvorova, A. (2015). Hydrophobically Modified siRNAs Silence Huntingtin mRNA in Primary Neurons and Mouse Brain. Molecular therapy. Nucleic acids, 4e266. https://doi.org/10.1038/mtna.2015.38
Alterman, Julia F, et al. "Hydrophobically Modified siRNAs Silence Huntingtin mRNA in Primary Neurons and Mouse Brain." Molecular therapy. Nucleic acids vol. 4 (2015): e266. doi: https://doi.org/10.1038/mtna.2015.38
Alterman JF, Hall LM, Coles AH, Hassler MR, Didiot MC, Chase K, Abraham J, Sottosanti E, Johnson E, Sapp E, Osborn MF, Difiglia M, Aronin N, Khvorova A. Hydrophobically Modified siRNAs Silence Huntingtin mRNA in Primary Neurons and Mouse Brain. Mol Ther Nucleic Acids. 2015 Dec 01;4:e266. doi: 10.1038/mtna.2015.38. PMID: 26623938; PMCID: PMC5014532.
Copy Download .nbib Format: NLM
Predictive dose-based estimation of systemic exposure multiples in mouse and monkey relative to human for antisense oligonucleotides with 2'-o-(2-methoxyethyl) modifications.

Molecular therapy. Nucleic acids

Yu RZ, Grundy JS, Henry SP, Kim TW, Norris DA, Burkey J, Wang Y, Vick A, Geary RS.
PMID: 25602582
Mol Ther Nucleic Acids. 2015 Jan 20;4:e218. doi: 10.1038/mtna.2014.69.

Evaluation of species differences and systemic exposure multiples (or ratios) in toxicological animal species versus human is an ongoing exercise during the course of drug development. The systemic exposure ratios are best estimated by directly comparing area under the...

Cite
Yu RZ, Grundy JS, Henry SP, et al. Predictive dose-based estimation of systemic exposure multiples in mouse and monkey relative to human for antisense oligonucleotides with 2'-o-(2-methoxyethyl) modifications. Mol Ther Nucleic Acids. 2015;4:e218doi: 10.1038/mtna.2014.69.
Yu, R. Z., Grundy, J. S., Henry, S. P., Kim, T. W., Norris, D. A., Burkey, J., Wang, Y., Vick, A., & Geary, R. S. (2015). Predictive dose-based estimation of systemic exposure multiples in mouse and monkey relative to human for antisense oligonucleotides with 2'-o-(2-methoxyethyl) modifications. Molecular therapy. Nucleic acids, 4e218. https://doi.org/10.1038/mtna.2014.69
Yu, Rosie Z, et al. "Predictive dose-based estimation of systemic exposure multiples in mouse and monkey relative to human for antisense oligonucleotides with 2'-o-(2-methoxyethyl) modifications." Molecular therapy. Nucleic acids vol. 4 (2015): e218. doi: https://doi.org/10.1038/mtna.2014.69
Yu RZ, Grundy JS, Henry SP, Kim TW, Norris DA, Burkey J, Wang Y, Vick A, Geary RS. Predictive dose-based estimation of systemic exposure multiples in mouse and monkey relative to human for antisense oligonucleotides with 2'-o-(2-methoxyethyl) modifications. Mol Ther Nucleic Acids. 2015 Jan 20;4:e218. doi: 10.1038/mtna.2014.69. PMID: 25602582; PMCID: PMC4345302.
Copy Download .nbib Format: NLM
Synthesis of dinucleoside acylphosphonites by phosphonodiamidite chemistry and investigation of phosphorus epimerization.

Beilstein journal of organic chemistry

Hersh WH.
PMID: 25815068
Beilstein J Org Chem. 2015 Jan 30;11:184-91. doi: 10.3762/bjoc.11.19. eCollection 2015.

The reaction of the diamidite, (iPr2N)2PH, with acyl chlorides proceeds with the loss of HCl to give the corresponding acyl diamidites, RC(O)P(N(iPr)2)2 (R = Me (7), Ph (9)), without the intervention of sodium to give a phosphorus anion. The...

Cite
Hersh WH. Synthesis of dinucleoside acylphosphonites by phosphonodiamidite chemistry and investigation of phosphorus epimerization. Beilstein J Org Chem. 2015;11:184-91doi: 10.3762/bjoc.11.19.
Hersh, W. H. (2015). Synthesis of dinucleoside acylphosphonites by phosphonodiamidite chemistry and investigation of phosphorus epimerization. Beilstein journal of organic chemistry, 11184-91. https://doi.org/10.3762/bjoc.11.19
Hersh, William H. "Synthesis of dinucleoside acylphosphonites by phosphonodiamidite chemistry and investigation of phosphorus epimerization." Beilstein journal of organic chemistry vol. 11 (2015): 184-91. doi: https://doi.org/10.3762/bjoc.11.19
Hersh WH. Synthesis of dinucleoside acylphosphonites by phosphonodiamidite chemistry and investigation of phosphorus epimerization. Beilstein J Org Chem. 2015 Jan 30;11:184-91. doi: 10.3762/bjoc.11.19. eCollection 2015. PMID: 25815068; PMCID: PMC4362088.
Copy Download .nbib Format: NLM
Hairpin Ribozyme Genes Curtail Alcohol Drinking: from Rational Design to in vivo Effects in the Rat.

Molecular therapy. Nucleic acids

Sapag A, Irrazábal T, Lobos-González L, Muñoz-Brauning CR, Quintanilla ME, Tampier L.
PMID: 27404720
Mol Ther Nucleic Acids. 2016 Jul 12;5(7):e335. doi: 10.1038/mtna.2016.41.

Ribozyme genes were designed to reduce voluntary alcohol drinking in a rat model of alcohol dependence. Acetaldehyde generated from alcohol in the liver is metabolized by the mitochondrial aldehyde dehydrogenase (ALDH2) such that diminishing ALDH2 activity leads to the...

Cite
Sapag A, Irrazábal T, Lobos-González L, et al. Hairpin Ribozyme Genes Curtail Alcohol Drinking: from Rational Design to in vivo Effects in the Rat. Mol Ther Nucleic Acids. 2016;5(7):e335doi: 10.1038/mtna.2016.41.
Sapag, A., Irrazábal, T., Lobos-González, L., Muñoz-Brauning, C. R., Quintanilla, M. E., & Tampier, L. (2016). Hairpin Ribozyme Genes Curtail Alcohol Drinking: from Rational Design to in vivo Effects in the Rat. Molecular therapy. Nucleic acids, 5(7), e335. https://doi.org/10.1038/mtna.2016.41
Sapag, Amalia, et al. "Hairpin Ribozyme Genes Curtail Alcohol Drinking: from Rational Design to in vivo Effects in the Rat." Molecular therapy. Nucleic acids vol. 5,7 (2016): e335. doi: https://doi.org/10.1038/mtna.2016.41
Sapag A, Irrazábal T, Lobos-González L, Muñoz-Brauning CR, Quintanilla ME, Tampier L. Hairpin Ribozyme Genes Curtail Alcohol Drinking: from Rational Design to in vivo Effects in the Rat. Mol Ther Nucleic Acids. 2016 Jul 12;5(7):e335. doi: 10.1038/mtna.2016.41. PMID: 27404720; PMCID: PMC5330938.
Copy Download .nbib Format: NLM
Showing 1 to 12 of 2368 entries