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Showing 1 to 12 of 166 entries
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Acupuncture for visceral pain: neural substrates and potential mechanisms.

Evidence-based complementary and alternative medicine : eCAM

Chen S, Wang S, Rong P, Wang J, Qiao L, Feng X, Liu J, Zhang J.
PMID: 25614752
Evid Based Complement Alternat Med. 2014;2014:609594. doi: 10.1155/2014/609594. Epub 2014 Dec 29.

Visceral pain is the most common form of pain caused by varied diseases and a major reason for patients to seek medical consultation. Despite much advances, the pathophysiological mechanism is still poorly understood comparing with its somatic counterpart and,...

Maladaptive Behavior and Gastrointestinal Disorders in Children with Autism Spectrum Disorder.

Pediatric gastroenterology, hepatology & nutrition

Pusponegoro HD, Ismael S, Sastroasmoro S, Firmansyah A, Vandenplas Y.
PMID: 26770897
Pediatr Gastroenterol Hepatol Nutr. 2015 Dec;18(4):230-7. doi: 10.5223/pghn.2015.18.4.230. Epub 2015 Dec 23.

PURPOSE: Various gastrointestinal factors may contribute to maladaptive behavior in children with autism spectrum disorders (ASD). To determine the association between maladaptive behavior in children with ASD and gastrointestinal symptoms such as severity, intestinal microbiota, inflammation, enterocyte damage, permeability...

A high performance system to study the influence of temperature in on-line solid-phase extraction capillary electrophoresis.

Analytica chimica acta

Tascon M, Benavente F, Sanz-Nebot V, Gagliardi LG.
PMID: 25732315
Anal Chim Acta. 2015 Mar 10;863:78-85. doi: 10.1016/j.aca.2014.12.053. Epub 2014 Dec 31.

A novel high performance system to control the temperature of the microcartridge in on-line solid phase extraction capillary electrophoresis (SPE-CE) is introduced. The mini-device consists in a thermostatic bath that fits inside of the cassette of any commercial CE...

Lipid- and sugar-modified endomorphins: novel targets for the treatment of neuropathic pain.

Frontiers in pharmacology

Varamini P, Toth I.
PMID: 24379782
Front Pharmacol. 2013 Dec 13;4:155. doi: 10.3389/fphar.2013.00155.

Endomorphins are endogenous opioid peptides that cause potent antinociception in rodent models of acute and neuropathic pain with less undesirable side effects than opioid alkaloids. However, endomorphins are poorly suited to clinical applications because of low membrane permeability and...

Peptide transport and metabolism across the placenta.

Advanced drug delivery reviews

Chandorkar GA, Ampasavate C, Stobaugh JF, Audus KL.
PMID: 10837746
Adv Drug Deliv Rev. 1999 Jun 14;38(1):59-67. doi: 10.1016/s0169-409x(99)00006-x.

Advances made in the field of DNA and recombinant technology have led to the emergence of peptides and proteins as an important class of therapeutic compounds. While a significant amount of information exists regarding the transport and metabolism of...

Effect of naloxone on the plasma levels of LH, FSH, prolactin and testosterone in Beetal bucks.

Small ruminant research : the journal of the International Goat Association

Singh B, Dixit VD, Singh P, Georgie GC, Dixit VP.
PMID: 10818303
Small Rumin Res. 2000 Jul 01;37(1):51-55. doi: 10.1016/s0921-4488(99)00129-7.

Ten adult male Beetal goats were used for the study to elucidate the modulation of gonadotrophin, prolactin and testosterone secretion by endogenous opioid peptides. An indwelling catheter was placed in the jugular vein of each buck 20h before the...

Opioid receptors: from genes to mice.

The journal of pain

Kieffer BL.
PMID: 14622842
J Pain. 2000 Sep;1(3):45-50. doi: 10.1054/jpai.2000.9823.

Opiates produce their strong analgesic and addictive actions by activating mu-, delta-, and kappa-opioid receptors, which otherwise interact with endogenous opioid peptides to regulate nociception, mood, and responses to stress. The recent cloning of an opioid receptor gene family...

Pro-algesic versus analgesic actions of immune cells.

Current opinion in anaesthesiology

Rittner HL, Brack A, Stein C.
PMID: 17021507
Curr Opin Anaesthesiol. 2003 Oct;16(5):527-33. doi: 10.1097/00001503-200310000-00014.

PURPOSE OF REVIEW: When tissue is destroyed, pain arises. Tissue destruction is associated with an inflammatory reaction. This leads to activation of nociceptors. The following review will concentrate on pro-algesic and analgesic mediators, which arise from immune cells or...

[Peripheral opioid receptors and their role in postoperative pain management.].

Schmerz (Berlin, Germany)

Stein C.
PMID: 18415412
Schmerz. 1993 Mar;7(1):4-7. doi: 10.1007/BF02527631.

Animal experiments have unequivocally demonstrated peripheral antinociceptive effects of opioids in inflamed tissue. Exogenous mu-, delta- und kappa-agonists can produce such effects. Opioid receptors are present on peripheral terminals of primary afferent neurons and their endogenous ligands are produced...

Opioid analgesia: new information from gene knockout studies.

Current opinion in anaesthesiology

Clarke S, Kitchen I.
PMID: 17016257
Curr Opin Anaesthesiol. 1999 Oct;12(5):609-14. doi: 10.1097/00001503-199910000-00020.

The cloning of opioid peptides and receptors has led to the development of knockout mice deficient in a gene encoding for each peptide and each receptor. The major advantage of the knockout approach is the complete selectivity that the...

Endogenous opioid analgesia in peripheral tissues and the clinical implications for pain control.

Therapeutics and clinical risk management

Kapitzke D, Vetter I, Cabot PJ.
PMID: 18360571
Ther Clin Risk Manag. 2005 Dec;1(4):279-97.

Opioid receptors are widely expressed in the central and peripheral nervous system as well as in numerous nonneuronal tissues. Both animal models and human clinical data support the involvement of peripheral opioid receptors in analgesia, particularly in inflammation where...

Stereochemical basis for a unified structure activity theory of aromatic and heterocyclic rings in selected opioids and opioid peptides.

Perspectives in medicinal chemistry

Goldberg JS.
PMID: 20212915
Perspect Medicin Chem. 2010 Feb 18;4:1-10. doi: 10.4137/pmc.s3898.

This paper presents a novel unified theory of the structure activity relationship of opioids and opioid peptides. It is hypothesized that a virtual or known heterocyclic ring exists in all opioids which have activity in humans, and this ring...

Showing 1 to 12 of 166 entries