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Showing 1 to 12 of 46 entries
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[Epidemiological aspects of ciprofloxacin-resistant Escherichia coli in a general hospital].

Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia

Serrano FJ, Muñoz RM, Vidal SS, Morán FG, García CB, Aznar AB.
PMID: 10878537
Rev Esp Quimioter. 2000 Mar;13(1):44-50.

The susceptibility to ciprofloxacin of 7288 Escherichia coli clinical isolates from 5667 patients was determined over a 4-year period (1995-1998). Information about the patients' age, sex, specimen type, date, origin and susceptibility to Escherichia coli isolates was studied, and...

Controlled release systems based on poly(lactic acid). An in vitro and in vivo study.

Journal of materials science. Materials in medicine

Andreopoulos AG, Hatzi EC, Doxastakis M.
PMID: 15348021
J Mater Sci Mater Med. 2000 Jun;11(6):393-7. doi: 10.1023/a:1008990109419.

A new biodegradable delivery system based on poly(lactic acid) has been formulated, with potential applications in sustained antibiotic release against bone infection. The in vitro release of a new quinolone (pefloxacin) from low molecular weight poly(D,L-lactic acid) Mw =...

Acid-base equilibria in substituted 4-quinolone carboxylic acid solutions.

Talanta

Jelikic M, Veselinovic D, Djurdjevic P.
PMID: 18965434
Talanta. 1992 Jun;39(6):665-70. doi: 10.1016/0039-9140(92)80078-r.

The protonation constants of some substituted 4-quinolone carboxylic acid anions (ofloxacin, pefloxacin and ciprofloxacin) were determined in lithium chloride solution of various concentrations at 293, 303 and 313 K using the pH-metric and spectrophotometric methods. The values of thermodynamic...

Quinolone pharmacokinetics.

International journal of antimicrobial agents

Robson RA.
PMID: 18611512
Int J Antimicrob Agents. 1992 Dec;2(1):3-10. doi: 10.1016/0924-8579(92)90020-r.

Fluoroquinolones have broad antibacterial spectra and are active against most Gram-negative and many Gram-positive species. They exhibit excellent oral bioavailability, extensive tissue penetration, low protein binding, and a long elimination half-life. This review compares and contrasts the pharmakonetics of...

1-Ethyl-6-fluoro-7-(4-methyl-piperazin-4-ium-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylate hexa-hydrate.

Acta crystallographica. Section E, Structure reports online

An Z, Liang QC.
PMID: 21201468
Acta Crystallogr Sect E Struct Rep Online. 2008 Jan 16;64:o441. doi: 10.1107/S1600536808000421.

In the title compound, C(17)H(20)FN(3)O(3)·6H(2)O, the pefloxacin (pef) neutral zwitterion is accompanied by six water mol-ecules of hydration. An extensive network of O-H⋯O and N-H⋯O hydrogen bonds help to establish the crystal packing.

Tetra-kis(dihydrogen pefloxacinium) di-μ(2)-chlorido-bis-[tetra-chloridobismuthate(III)] tetra-chloride octa-hydrate.

Acta crystallographica. Section E, Structure reports online

Polishchuk AV, Gerasimenko AV, Gayvoronskaya KA, Karaseva ET.
PMID: 21202786
Acta Crystallogr Sect E Struct Rep Online. 2008 Jun 19;64:m931-2. doi: 10.1107/S1600536808017674.

The title compound {systematic name: tetra-kis[4-(3-carb-oxy-1-ethyl-6-fluoro-4-hydroxonio-1,4-dihydro-7-quinol-yl)-1-meth-yl-piperazin-1-ium] di-μ(2)-chlorido-bis-[tetra-chlorido-bismuth-ate(III)] tetra-chloride octa-hydrate}, (C(17)H(22)FN(3)O(3))(4)[Bi(2)Cl(10)]Cl(4)·8H(2)O, is composed of edge-shared centrosymmetric dinuclear [Bi(2)Cl(10)](4-) anions, Cl(-) anions, dihydrogen pefloxacinium cations and water mol-ecules. The Bi(III) coordination polyhedron is a distorted octa-hedron. There are four short terminal...

Phenotypic and molecular characteristics of methicillin-resistant Staphylococcus aureus isolates from Ekiti State, Nigeria.

Infection and drug resistance

Olowe OA, Kukoyi OO, Taiwo SS, Ojurongbe O, Opaleye OO, Bolaji OS, Adegoke AA, Makanjuola OB, Ogbolu DO, Alli OT.
PMID: 23990730
Infect Drug Resist. 2013 Aug 20;6:87-92. doi: 10.2147/IDR.S48809. eCollection 2013.

INTRODUCTION: The characteristics and antimicrobial resistance profiles of Staphylococcus aureus differs according to geographical regions and in relation to antibiotic usage. The aim of this study was to determine the biochemical characteristics of the prevalent S. aureus from Ekiti...

Preparation and performance analysis of monodisperse glycidyl methacrylate modified restricted access media-imprinted materials.

Journal of separation science

Liu X, Pu J, Li J, Gong B.
PMID: 34933417
J Sep Sci. 2021 Dec 21; doi: 10.1002/jssc.202100746. Epub 2021 Dec 21.

Using monodisperse poly(glycidyl methacrylate-co-ethylene glycol dimethacrylate) as the matrix, and pefloxacin template molecules, a novel restricted-access medium molecularly imprinted polymers with Bovine serum albumin crosslinked on its surface was prepared through reversible addition-fragmentation chain-transfer polymerization. Then, the obtained material...

Early bacterial and inflammatory responses to antibiotic therapy in a model of polymicrobial peritonitis in rats.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

Montravers P, Mohler J, Maulin L, Carbon C.
PMID: 11864278
Clin Microbiol Infect. 1998 Feb;4(12):701-709. doi: 10.1111/j.1469-0691.1998.tb00655.x.

OBJECTIVE: To assess the consequences of different more or less selective treatments on the microbiological and inflammatory responses within the peritoneum. METHODS: The early effects of various antibiotic regimens were evaluated in a model of polymicrobial peritonitis with specifically...

Pefloxacin as a Surrogate Marker for Fluoroquinolone Susceptibility for Salmonella typhi: Problems and Prospects.

Journal of clinical and diagnostic research : JCDR

Veeraraghavan B, Anandan S, Sethuvel DP, Ragupathi NK.
PMID: 27656439
J Clin Diagn Res. 2016 Aug;10(8):DL01-2. doi: 10.7860/JCDR/2016/17022.8306. Epub 2016 Aug 01.

No abstract available.

Oral Bioavailability and Plasma Disposition of Pefloxacin in Healthy Broiler Chickens.

Frontiers in veterinary science

Martínez MA, Ares I, Rodríguez JL, Martínez M, Martínez-Larrañaga MR, Isea G, Anadón A.
PMID: 28596959
Front Vet Sci. 2017 May 24;4:77. doi: 10.3389/fvets.2017.00077. eCollection 2017.

The pharmacokinetics of pefloxacin after single 10 mg/kg BW intravenous (IV) and oral doses were studied in healthy broiler chickens. For 24 h, serial blood samples were obtained after IV and oral administration. Concentrations of pefloxacin and its major...

Effects of fluoroquinolones and glucocorticoids on cultivated tendon cells in vitro.

Toxicology in vitro : an international journal published in association with BIBRA

Kempka G, Ahr HJ, Rüther W, Schlüter G.
PMID: 20650258
Toxicol In Vitro. 1996 Dec;10(6):743-54. doi: 10.1016/s0887-2333(96)00050-1.

Achilles tendon rupture is known to occur after administration of various drugs to patients. It is also reported to occur after treatment with fluoroquinolone and glucocorticoids. To study potential cytotoxic effects of fluoroquinolones (ciprofloxacin, pefloxacin, sparfloxacin) and triamcinolonacetonide on...

Showing 1 to 12 of 46 entries