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Piroxicam confer neuroprotection in Cerebral Ischemia by inhibiting Cyclooxygenases, Acid- Sensing Ion Channel-1a and Aquaporin-4: an in silico comparison with Aspirin and Nimesulide.

Bioinformation

Mazumder MK, Borah A.
PMID: 26124563
Bioinformation. 2015 Apr 30;11(4):217-22. doi: 10.6026/97320630011217. eCollection 2015.

Cerebral ischemia (CI), caused by the deprivation of oxygen and glucose to the brain, is the leading cause of permanent disability. Neuronal demise in CI has been linked to several pathways which include cyclooxygenases (COX) - mediated production of...

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Mazumder MK, Borah A. Piroxicam confer neuroprotection in Cerebral Ischemia by inhibiting Cyclooxygenases, Acid- Sensing Ion Channel-1a and Aquaporin-4: an in silico comparison with Aspirin and Nimesulide. Bioinformation. 2015;11(4):217-22doi: 10.6026/97320630011217.
Mazumder, M. K., & Borah, A. (2015). Piroxicam confer neuroprotection in Cerebral Ischemia by inhibiting Cyclooxygenases, Acid- Sensing Ion Channel-1a and Aquaporin-4: an in silico comparison with Aspirin and Nimesulide. Bioinformation, 11(4), 217-22. https://doi.org/10.6026/97320630011217
Mazumder, Muhammed Khairujjaman, and Borah, Anupom. "Piroxicam confer neuroprotection in Cerebral Ischemia by inhibiting Cyclooxygenases, Acid- Sensing Ion Channel-1a and Aquaporin-4: an in silico comparison with Aspirin and Nimesulide." Bioinformation vol. 11,4 (2015): 217-22. doi: https://doi.org/10.6026/97320630011217
Mazumder MK, Borah A. Piroxicam confer neuroprotection in Cerebral Ischemia by inhibiting Cyclooxygenases, Acid- Sensing Ion Channel-1a and Aquaporin-4: an in silico comparison with Aspirin and Nimesulide. Bioinformation. 2015 Apr 30;11(4):217-22. doi: 10.6026/97320630011217. eCollection 2015. PMID: 26124563; PMCID: PMC4479049.
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Non-intubated Ambulatory Anaesthesia for Diagnostic gynaecological laparoscopy.

Journal of the West African College of Surgeons

Isamade E, Agbo D, Sagay A, Musa J, Egbodo C, Agbo D.
PMID: 25453009
J West Afr Coll Surg. 2013 Jan;3(1):14-24.

BACKGROUND: General endotracheal relaxant anaesthetic technique is favoured for laparoscopic gynaecological procedures, in order to prevent inadequate ventilation, regurgitation and aspiration resulting from pneumoperitoneum and steep trendelenburg position during the procedure. However, simple brief laparoscopic procedures have been performed...

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Isamade E, Agbo D, Sagay A, et al. Non-intubated Ambulatory Anaesthesia for Diagnostic gynaecological laparoscopy. J West Afr Coll Surg. 2013;3(1):14-24
Isamade, E., Agbo, D., Sagay, A., Musa, J., Egbodo, C., & Agbo, D. (2013). Non-intubated Ambulatory Anaesthesia for Diagnostic gynaecological laparoscopy. Journal of the West African College of Surgeons, 3(1), 14-24.
Isamade, Es, et al. "Non-intubated Ambulatory Anaesthesia for Diagnostic gynaecological laparoscopy." Journal of the West African College of Surgeons vol. 3,1 (2013): 14-24.
Isamade E, Agbo D, Sagay A, Musa J, Egbodo C, Agbo D. Non-intubated Ambulatory Anaesthesia for Diagnostic gynaecological laparoscopy. J West Afr Coll Surg. 2013 Jan;3(1):14-24. PMID: 25453009; PMCID: PMC4228810.
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Effects of Cyclooxygenase and Lipoxygenase Inhibitors on the Proliferation of Colon Cancer Cells and Their Production of Eicosanoids.

Cancer research and treatment

Lee HS, Kim EJ, Oh YS, Cho HJ, Park JH.
PMID: 26680815
Cancer Res Treat. 2001 Oct;33(5):404-13. doi: 10.4143/crt.2001.33.5.404.

PURPOSE: Epidemiological and laboratory studies suggest that nonsteroidal antiinflammatory drugs (NSAIDs) reduce the risk of colon cancer and that the inhibition of colon cancer is mediated through modulation of eicosanoid production. The present study examined the effect of cyclooxygenase...

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Lee HS, Kim EJ, Oh YS, et al. Effects of Cyclooxygenase and Lipoxygenase Inhibitors on the Proliferation of Colon Cancer Cells and Their Production of Eicosanoids. Cancer Res Treat. 2001;33(5):404-13doi: 10.4143/crt.2001.33.5.404.
Lee, H. S., Kim, E. J., Oh, Y. S., Cho, H. J., & Park, J. H. (2001). Effects of Cyclooxygenase and Lipoxygenase Inhibitors on the Proliferation of Colon Cancer Cells and Their Production of Eicosanoids. Cancer research and treatment, 33(5), 404-13. https://doi.org/10.4143/crt.2001.33.5.404
Lee, H S, et al. "Effects of Cyclooxygenase and Lipoxygenase Inhibitors on the Proliferation of Colon Cancer Cells and Their Production of Eicosanoids." Cancer research and treatment vol. 33,5 (2001): 404-13. doi: https://doi.org/10.4143/crt.2001.33.5.404
Lee HS, Kim EJ, Oh YS, Cho HJ, Park JH. Effects of Cyclooxygenase and Lipoxygenase Inhibitors on the Proliferation of Colon Cancer Cells and Their Production of Eicosanoids. Cancer Res Treat. 2001 Oct;33(5):404-13. doi: 10.4143/crt.2001.33.5.404. PMID: 26680815.
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In vitro and in vivo assessment of piroxicam incorporated Aloe vera transgel.

International journal of pharmaceutical investigation

Velam V, Yalavarthi PR, Sundaresan C, Vandana K, Dudala TB, Kodavatikanti H, Vadlamudi HC.
PMID: 24350041
Int J Pharm Investig. 2013 Oct;3(4):212-6. doi: 10.4103/2230-973X.121303.

BACKGROUND: The aim of the study was to develop piroxicam-Aloe vera gel (PAG) formulation and make a pharmacodynamic evaluation of the formulation.MATERIALS AND METHODS: The gel was prepared by using carbopol 934 as gelling agent and methyl paraben as...

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Velam V, Yalavarthi PR, Sundaresan C, et al. In vitro and in vivo assessment of piroxicam incorporated Aloe vera transgel. Int J Pharm Investig. 2013;3(4):212-6doi: 10.4103/2230-973X.121303.
Velam, V., Yalavarthi, P. R., Sundaresan, C., Vandana, K., Dudala, T. B., Kodavatikanti, H., & Vadlamudi, H. C. (2013). In vitro and in vivo assessment of piroxicam incorporated Aloe vera transgel. International journal of pharmaceutical investigation, 3(4), 212-6. https://doi.org/10.4103/2230-973X.121303
Velam, Vinesha, et al. "In vitro and in vivo assessment of piroxicam incorporated Aloe vera transgel." International journal of pharmaceutical investigation vol. 3,4 (2013): 212-6. doi: https://doi.org/10.4103/2230-973X.121303
Velam V, Yalavarthi PR, Sundaresan C, Vandana K, Dudala TB, Kodavatikanti H, Vadlamudi HC. In vitro and in vivo assessment of piroxicam incorporated Aloe vera transgel. Int J Pharm Investig. 2013 Oct;3(4):212-6. doi: 10.4103/2230-973X.121303. PMID: 24350041; PMCID: PMC3853761.
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Piroxicam and doxycycline treatment for an oral squamous cell carcinoma in an inshore bottlenose dolphin (Tursiops aduncus).

Australian veterinary journal

March DT, Blyde DJ, Bossart GD, Begg AP, Taylor DP, McClure V.
PMID: 27169383
Aust Vet J. 2016 Jun;94(6):203-207. doi: 10.1111/avj.12449. Epub 2016 May 11.

BACKGROUND: The virus family Papillomaviridae has been documented in a wide range of animal species and can cause benign and malignant proliferative lesions. The presence of concurrent lingual papillomas and squamous cell carcinomas (SCC) in cetaceans has also been...

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March DT, Blyde DJ, Bossart GD, et al. Piroxicam and doxycycline treatment for an oral squamous cell carcinoma in an inshore bottlenose dolphin (Tursiops aduncus). Aust Vet J. 2016;94(6):203-207doi: 10.1111/avj.12449.
March, D. T., Blyde, D. J., Bossart, G. D., Begg, A. P., Taylor, D. P., & McClure, V. (2016). Piroxicam and doxycycline treatment for an oral squamous cell carcinoma in an inshore bottlenose dolphin (Tursiops aduncus). Australian veterinary journal, 94(6), 203-207. https://doi.org/10.1111/avj.12449
March, D T, et al. "Piroxicam and doxycycline treatment for an oral squamous cell carcinoma in an inshore bottlenose dolphin (Tursiops aduncus)." Australian veterinary journal vol. 94,6 (2016): 203-207. doi: https://doi.org/10.1111/avj.12449
March DT, Blyde DJ, Bossart GD, Begg AP, Taylor DP, McClure V. Piroxicam and doxycycline treatment for an oral squamous cell carcinoma in an inshore bottlenose dolphin (Tursiops aduncus). Aust Vet J. 2016 Jun;94(6):203-207. doi: 10.1111/avj.12449. Epub 2016 May 11. PMID: 27169383.
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Enhanced Dissolution and Oral Bioavailability of Piroxicam Formulations: Modulating Effect of Phospholipids.

Pharmaceutics

Mirza S, Miroshnyk I, Habib MJ, Brausch JF, Hussain MD.
PMID: 27721361
Pharmaceutics. 2010 Oct 27;2(4):339-350. doi: 10.3390/pharmaceutics2040339.

Several biologically relevant phospholipids were assessed as potential carriers/additives for rapidly dissolving solid formulations of piroxicam (Biopharmaceutics Classification System Class II drug). On the basis of in vitro dissolution studies, dimyristoylphosphatidylglycerol (DMPG) was ranked as the first potent dissolution...

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Mirza S, Miroshnyk I, Habib MJ, et al. Enhanced Dissolution and Oral Bioavailability of Piroxicam Formulations: Modulating Effect of Phospholipids. Pharmaceutics. 2010;2(4):339-350doi: 10.3390/pharmaceutics2040339.
Mirza, S., Miroshnyk, I., Habib, M. J., Brausch, J. F., & Hussain, M. D. (2010). Enhanced Dissolution and Oral Bioavailability of Piroxicam Formulations: Modulating Effect of Phospholipids. Pharmaceutics, 2(4), 339-350. https://doi.org/10.3390/pharmaceutics2040339
Mirza, Sabiruddin, et al. "Enhanced Dissolution and Oral Bioavailability of Piroxicam Formulations: Modulating Effect of Phospholipids." Pharmaceutics vol. 2,4 (2010): 339-350. doi: https://doi.org/10.3390/pharmaceutics2040339
Mirza S, Miroshnyk I, Habib MJ, Brausch JF, Hussain MD. Enhanced Dissolution and Oral Bioavailability of Piroxicam Formulations: Modulating Effect of Phospholipids. Pharmaceutics. 2010 Oct 27;2(4):339-350. doi: 10.3390/pharmaceutics2040339. PMID: 27721361; PMCID: PMC3967142.
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Mechanisms Involved in Toxicity of Liver Caused by Piroxicam in Mice and Protective Effects of Leaf Extract of Hibiscus rosa-sinensis L.

Clinical medicine insights. Arthritis and musculoskeletal disorders

Sahu CR.
PMID: 26819562
Clin Med Insights Arthritis Musculoskelet Disord. 2016 Jan 19;9:9-13. doi: 10.4137/CMAMD.S29463. eCollection 2016.

Piroxicam is one of the important therapeutic nonsteroidal anti-inflammatory class of drugs used mainly to suppress pain and inflammation in arthritis and other musculoskeletal disorders. Besides being anti-inflammatory, these drugs are analgesic and antipyretic often used for the relief...

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Sahu CR. Mechanisms Involved in Toxicity of Liver Caused by Piroxicam in Mice and Protective Effects of Leaf Extract of Hibiscus rosa-sinensis L. Clin Med Insights Arthritis Musculoskelet Disord. 2016;9:9-13doi: 10.4137/CMAMD.S29463.
Sahu, C. R. (2016). Mechanisms Involved in Toxicity of Liver Caused by Piroxicam in Mice and Protective Effects of Leaf Extract of Hibiscus rosa-sinensis L. Clinical medicine insights. Arthritis and musculoskeletal disorders, 99-13. https://doi.org/10.4137/CMAMD.S29463
Sahu, C R. "Mechanisms Involved in Toxicity of Liver Caused by Piroxicam in Mice and Protective Effects of Leaf Extract of Hibiscus rosa-sinensis L." Clinical medicine insights. Arthritis and musculoskeletal disorders vol. 9 (2016): 9-13. doi: https://doi.org/10.4137/CMAMD.S29463
Sahu CR. Mechanisms Involved in Toxicity of Liver Caused by Piroxicam in Mice and Protective Effects of Leaf Extract of Hibiscus rosa-sinensis L. Clin Med Insights Arthritis Musculoskelet Disord. 2016 Jan 19;9:9-13. doi: 10.4137/CMAMD.S29463. eCollection 2016. PMID: 26819562; PMCID: PMC4720181.
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Synthesis and anti-inflammatory activity of N-substituted 2-oxo-2H-1-benzopyran-3-carboxamides and their 2-iminoanalogues.

European journal of medicinal chemistry

Bylov IE, Vasylyev MV, Bilokin YV.
PMID: 10889323
Eur J Med Chem. 1999 Nov 01;34(11):997-1001. doi: 10.1016/s0223-5234(99)00119-1.

Aseries of N-arylsubstituted 2-imino-2H-1-benzopyran-3-carboxamides 3a and b and 2-oxo-2H-1-benzopyran-3-carboxamides 4a-h were synthesized and evaluated for their anti-inflammatory activity in carrageenan-induced rat paw oedema assays and in acetic acid-induced peritonitis tests in albino rats. The resulting products were found to...

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Bylov IE, Vasylyev MV, Bilokin YV. Synthesis and anti-inflammatory activity of N-substituted 2-oxo-2H-1-benzopyran-3-carboxamides and their 2-iminoanalogues. Eur J Med Chem. 1999;34(11):997-1001doi: 10.1016/s0223-5234(99)00119-1.
Bylov, I. E., Vasylyev, M. V., & Bilokin, Y. V. (1999). Synthesis and anti-inflammatory activity of N-substituted 2-oxo-2H-1-benzopyran-3-carboxamides and their 2-iminoanalogues. European journal of medicinal chemistry, 34(11), 997-1001. https://doi.org/10.1016/s0223-5234(99)00119-1
Bylov, et al. "Synthesis and anti-inflammatory activity of N-substituted 2-oxo-2H-1-benzopyran-3-carboxamides and their 2-iminoanalogues." European journal of medicinal chemistry vol. 34,11 (1999): 997-1001. doi: https://doi.org/10.1016/s0223-5234(99)00119-1
Bylov IE, Vasylyev MV, Bilokin YV. Synthesis and anti-inflammatory activity of N-substituted 2-oxo-2H-1-benzopyran-3-carboxamides and their 2-iminoanalogues. Eur J Med Chem. 1999 Nov 01;34(11):997-1001. doi: 10.1016/s0223-5234(99)00119-1. PMID: 10889323.
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Nonsteroidal Anti-Inflammatory Drugs and Hypertension.

Journal of clinical hypertension (Greenwich, Conn.)

Brook RD, Kramer MB, Blaxall BC, Bisognano JD.
PMID: 11416668
J Clin Hypertens (Greenwich). 2000 Oct;2(5):319-323.

Nonsteroidal anti-inflammatory drugs are among the most widely prescribed medications. Their effect on blood pressure has been monitored, and many small studies have determined a potential relationship between their use and elevation of blood pressure. These drugs may affect...

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Brook RD, Kramer MB, Blaxall BC, et al. Nonsteroidal Anti-Inflammatory Drugs and Hypertension. J Clin Hypertens (Greenwich). 2000;2(5):319-323
Brook, R. D., Kramer, M. B., Blaxall, B. C., & Bisognano, J. D. (2000). Nonsteroidal Anti-Inflammatory Drugs and Hypertension. Journal of clinical hypertension (Greenwich, Conn.), 2(5), 319-323.
Brook, Robert D., et al. "Nonsteroidal Anti-Inflammatory Drugs and Hypertension." Journal of clinical hypertension (Greenwich, Conn.) vol. 2,5 (2000): 319-323.
Brook RD, Kramer MB, Blaxall BC, Bisognano JD. Nonsteroidal Anti-Inflammatory Drugs and Hypertension. J Clin Hypertens (Greenwich). 2000 Oct;2(5):319-323. PMID: 11416668.
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Two different strategies for the fluorimetric determination of piroxicam in serum.

Talanta

Arancibia JA, Escandar GM.
PMID: 18969137
Talanta. 2003 Aug 29;60(6):1113-21. doi: 10.1016/S0039-9140(03)00221-2.

Two different spectrofluorimetric methods for the determination of piroxicam (PX) in serum are presented and discussed. One of them is based on the use of three-way fluorescence data and multivariate calibration performed with parallel factor analysis (PARAFAC) and self-weighted...

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Arancibia JA, Escandar GM. Two different strategies for the fluorimetric determination of piroxicam in serum. Talanta. 2003;60(6):1113-21doi: 10.1016/S0039-9140(03)00221-2.
Arancibia, J. A., & Escandar, G. M. (2003). Two different strategies for the fluorimetric determination of piroxicam in serum. Talanta, 60(6), 1113-21. https://doi.org/10.1016/S0039-9140(03)00221-2
Arancibia, J A, and Escandar, G M. "Two different strategies for the fluorimetric determination of piroxicam in serum." Talanta vol. 60,6 (2003): 1113-21. doi: https://doi.org/10.1016/S0039-9140(03)00221-2
Arancibia JA, Escandar GM. Two different strategies for the fluorimetric determination of piroxicam in serum. Talanta. 2003 Aug 29;60(6):1113-21. doi: 10.1016/S0039-9140(03)00221-2. PMID: 18969137.
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Adverse drug reactions of nonsteroidal anti-inflammatory drugs in orthopedic patients.

Journal of pharmacology & pharmacotherapeutics

Gor AP, Saksena M.
PMID: 21701643
J Pharmacol Pharmacother. 2011 Jan;2(1):26-9. doi: 10.4103/0976-500X.77104.

OBJECTIVES: To identify the ADRs due to NSAIDs and to know how to monitor the drug's effect.MATERIALS AND METHODS: A descriptive study was undertaken in the Orthopedic Outpatients Department of a tertiary care teaching hospital. Hundred patients were enrolled...

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Gor AP, Saksena M. Adverse drug reactions of nonsteroidal anti-inflammatory drugs in orthopedic patients. J Pharmacol Pharmacother. 2011;2(1):26-9doi: 10.4103/0976-500X.77104.
Gor, A. P., & Saksena, M. (2011). Adverse drug reactions of nonsteroidal anti-inflammatory drugs in orthopedic patients. Journal of pharmacology & pharmacotherapeutics, 2(1), 26-9. https://doi.org/10.4103/0976-500X.77104
Gor, Alpa Pragnesh, and Saksena, Miti. "Adverse drug reactions of nonsteroidal anti-inflammatory drugs in orthopedic patients." Journal of pharmacology & pharmacotherapeutics vol. 2,1 (2011): 26-9. doi: https://doi.org/10.4103/0976-500X.77104
Gor AP, Saksena M. Adverse drug reactions of nonsteroidal anti-inflammatory drugs in orthopedic patients. J Pharmacol Pharmacother. 2011 Jan;2(1):26-9. doi: 10.4103/0976-500X.77104. PMID: 21701643; PMCID: PMC3117565.
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Current concepts of the actions of paracetamol (acetaminophen) and NSAIDs.

Inflammopharmacology

Graham GG, Day RO, Milligan MK, Ziegler JB, Kettle AJ.
PMID: 17638096
Inflammopharmacology. 1999;7(3):255-63. doi: 10.1007/s10787-999-0008-x.

There is much uncertainty about the mechanism of action of paracetamol (acetaminophen). It is commonly stated that, unlike the non-steroidal anti-inflammatory drugs (NSAIDs), it is a weak inhibitor of the synthesis of prostaglandins. This conclusion is made largely from...

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Graham GG, Day RO, Milligan MK, et al. Current concepts of the actions of paracetamol (acetaminophen) and NSAIDs. Inflammopharmacology. 1999;7(3):255-63doi: 10.1007/s10787-999-0008-x.
Graham, G. G., Day, R. O., Milligan, M. K., Ziegler, J. B., & Kettle, A. J. (1999). Current concepts of the actions of paracetamol (acetaminophen) and NSAIDs. Inflammopharmacology, 7(3), 255-63. https://doi.org/10.1007/s10787-999-0008-x
Graham, G G, et al. "Current concepts of the actions of paracetamol (acetaminophen) and NSAIDs." Inflammopharmacology vol. 7,3 (1999): 255-63. doi: https://doi.org/10.1007/s10787-999-0008-x
Graham GG, Day RO, Milligan MK, Ziegler JB, Kettle AJ. Current concepts of the actions of paracetamol (acetaminophen) and NSAIDs. Inflammopharmacology. 1999;7(3):255-63. doi: 10.1007/s10787-999-0008-x. PMID: 17638096.
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