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Tissue Biomarkers in Hepatocellular Tumors: Which, When, and How.

Frontiers in medicine

Di Tommaso L, Roncalli M.
PMID: 28280721
Front Med (Lausanne). 2017 Feb 23;4:10. doi: 10.3389/fmed.2017.00010. eCollection 2017.

Few tissue markers are currently available to pathologists in the study of hepatocellular tumors. These markers should be used carefully taking into consideration not only morphology but also, and sometimes even more important, the clinical setting where the lesion...

Eosinophil recruitment and activation: the role of lipid mediators.

Frontiers in pharmacology

Luna-Gomes T, Bozza PT, Bandeira-Melo C.
PMID: 23525348
Front Pharmacol. 2013 Mar 22;4:27. doi: 10.3389/fphar.2013.00027. eCollection 2013.

Eosinophils are effector cells that migrate toward several mediators released at inflammatory sites to perform their multiple functions. The mechanisms driving eosinophil selective accumulation in sites of allergic inflammation are well-established and involve several steps controlled by adhesion molecules,...

Imperatorin Suppresses Degranulation and Eicosanoid Generation in Activated Bone Marrow-Derived Mast Cells.

Biomolecules & therapeutics

Jeong KT, Lee E, Park NY, Kim SG, Park HH, Lee J, Lee YJ, Lee E.
PMID: 26336581
Biomol Ther (Seoul). 2015 Sep;23(5):421-7. doi: 10.4062/biomolther.2015.023. Epub 2015 Sep 01.

Imperatorin has been known to exert many biological functions including anti-inflammatory activity. In this study, we investigated the inhibitory effects of imperatorin on the production of inflammatory mediators in mouse bone marrow-derived mast cells (BMMC). Imperatorin inhibited degranulation and...

Detection of allergic reactions during oral food challenge using noninvasive urinary prostaglandin D2 metabolites.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology

Inuzuka Y, Yamamoto-Hanada K, Nakamura T, Shimosawa T, Murata T, Ohya Y.
PMID: 34460978
Clin Exp Allergy. 2022 Jan;52(1):176-179. doi: 10.1111/cea.14006. Epub 2021 Sep 05.

No abstract available.

Protective Effect of Low-Dose Alcohol Consumption against Post-Ischemic Neuronal Apoptosis: Role of L-PGDS.

International journal of molecular sciences

Li C, Li J, Loreno EG, Miriyala S, Panchatcharam M, Sun H.
PMID: 35008575
Int J Mol Sci. 2021 Dec 23;23(1). doi: 10.3390/ijms23010133.

Ischemic stroke is one of the leading causes of permanent disability and death in adults worldwide. Apoptosis is a major element contributing to post-ischemic neuronal death. We previously found that low-dose alcohol consumption (LAC) protects against neuronal apoptosis in...

Protective Effect of Low-Dose Alcohol Consumption against Post-Ischemic Neuronal Apoptosis: Role of L-PGDS.

International journal of molecular sciences

Li C, Li J, Loreno EG, Miriyala S, Panchatcharam M, Sun H.
PMID: 35008575
Int J Mol Sci. 2021 Dec 23;23(1). doi: 10.3390/ijms23010133.

Ischemic stroke is one of the leading causes of permanent disability and death in adults worldwide. Apoptosis is a major element contributing to post-ischemic neuronal death. We previously found that low-dose alcohol consumption (LAC) protects against neuronal apoptosis in...

Correction to "Absorption, Distribution, Metabolism, and Excretion of the Oral Prostaglandin D2 Receptor 2 Antagonist Fevipiprant (QAW039) in Healthy Volunteers and In Vitro".

Drug metabolism and disposition: the biological fate of chemicals

[No authors listed]
PMID: 33593806
Drug Metab Dispos. 2021 Mar;49(3):287-288. doi: 10.1124/dmd.117.075358err.

No abstract available.

Catalysis-Enabled Concise and Stereoselective Total Synthesis of the Tricyclic Prostaglandin D2 Metabolite Methyl Ester.

Angewandte Chemie (International ed. in English)

Dai M, Sims HS, de Andrade Horn P, Isshiki R, Lim M, Xu Y, Grubbs RH.
PMID: 34870881
Angew Chem Int Ed Engl. 2021 Dec 06; doi: 10.1002/anie.202115633. Epub 2021 Dec 06.

A concise and stereoselective total synthesis of the clinically relevant tricyclic prostaglandin D 2 metabolite (tricyclic-PGDM) methyl ester in racemic form was accomplished in 8 steps from a readily available known cyclopentene-diol derivative. The synthesis features a nickel-catalyzed Ueno-Stork-type...

Label-Free, Novel Electrofluidic Capacitor Biosensor for Prostaglandin E2 Detection toward Early and Rapid Urinary Tract Infection Diagnosis.

ACS sensors

Ganguly A, Ebrahimzadeh T, Zimmern P, De Nisco NJ, Prasad S.
PMID: 34928577
ACS Sens. 2021 Dec 20; doi: 10.1021/acssensors.1c01951. Epub 2021 Dec 20.

Urine Prostaglandin E2 (PGE2) has been identified as an attractive diagnostic and prognostic biomarker for urinary tract infection (UTI). This work demonstrates the use of PGE2 as a biomarker for rapid and label-free testing for UTI. In this work,...

DP1 prostanoid receptor activation increases the severity of an acute lower respiratory viral infection in mice via TNF-α-induced immunopathology.

Mucosal immunology

Ullah MA, Rittchen S, Li J, Hasnain SZ, Phipps S.
PMID: 33879829
Mucosal Immunol. 2021 Jul;14(4):963-972. doi: 10.1038/s41385-021-00405-7. Epub 2021 Apr 20.

Respiratory syncytial virus (RSV) bronchiolitis is a leading cause of infant hospitalization and mortality. We previously identified that prostaglandin D2 (PGD2), released following RSV infection of primary human airway epithelial cells or pneumonia virus of mice (PVM) infection of...

Plant Sterol-Poor Diet Is Associated with Pro-Inflammatory Lipid Mediators in the Murine Brain.

International journal of molecular sciences

Reinicke M, Leyh J, Zimmermann S, Chey S, Brkovic IB, Wassermann C, Landmann J, Lütjohann D, Isermann B, Bechmann I, Ceglarek U.
PMID: 34948003
Int J Mol Sci. 2021 Dec 08;22(24). doi: 10.3390/ijms222413207.

Plant sterols (PSs) cannot be synthesized in mammals and are exclusively diet-derived. PSs cross the blood-brain barrier and may have anti-neuroinflammatory effects. Obesity is linked to lower intestinal uptake and blood levels of PSs, but its effects in terms...

Molecular basis for lipid recognition by the prostaglandin D.

Proceedings of the National Academy of Sciences of the United States of America

Liu H, Deepak RNVK, Shiriaeva A, Gati C, Batyuk A, Hu H, Weierstall U, Liu W, Wang L, Cherezov V, Fan H, Zhang C.
PMID: 34341104
Proc Natl Acad Sci U S A. 2021 Aug 10;118(32). doi: 10.1073/pnas.2102813118.

Prostaglandin D

Showing 1 to 12 of 90 entries