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Showing 1 to 12 of 2266 entries
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Acitretin : A Review of its Pharmacology and Therapeutic Use.

Drugs

Pilkington T, Brogden RN.
PMID: 28421560
Drugs. 1992 Apr;43(4):597-627. doi: 10.2165/00003495-199243040-00010.

SYNOPSIS: Acitretin (etretin), a second generation monoaromatic retinoid for use in the treatment of severe psoriasis and other dermatoses, is the major active metabolite of etretinate and possesses a similar therapeutic index; i.e. a similar ratio of clinical efficacy...

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Pilkington T, Brogden RN. Acitretin : A Review of its Pharmacology and Therapeutic Use. Drugs. 1992;43(4):597-627doi: 10.2165/00003495-199243040-00010.
Pilkington, T., & Brogden, R. N. (1992). Acitretin : A Review of its Pharmacology and Therapeutic Use. Drugs, 43(4), 597-627. https://doi.org/10.2165/00003495-199243040-00010
Pilkington, Tania, and Brogden, Rex N. "Acitretin : A Review of its Pharmacology and Therapeutic Use." Drugs vol. 43,4 (1992): 597-627. doi: https://doi.org/10.2165/00003495-199243040-00010
Pilkington T, Brogden RN. Acitretin : A Review of its Pharmacology and Therapeutic Use. Drugs. 1992 Apr;43(4):597-627. doi: 10.2165/00003495-199243040-00010. PMID: 28421560.
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Role of Mitogen-Activated Protein Kinases, Early Response Protooncogenes, and Activator Protein-1 in Cell Signaling by Asbestos.

Inhalation toxicology

Mossman B, Hubbard A, Shukla A, Timblin CR.
PMID: 26368630
Inhal Toxicol. 2000 Jan;12:307-16. doi: 10.1080/08958378.2000.11463240.

Cell signaling by pathogenic minerals may initiate the transactivation of genes that are critical to carcinogenesis and fibroproliferative diseases of the lung and pleura. We have shown previously that stimulation of the mitogen-activated protein kinase (MAPK) cascade by asbestos...

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Mossman B, Hubbard A, Shukla A, et al. Role of Mitogen-Activated Protein Kinases, Early Response Protooncogenes, and Activator Protein-1 in Cell Signaling by Asbestos. Inhal Toxicol. 2000;12:307-16doi: 10.1080/08958378.2000.11463240.
Mossman, B., Hubbard, A., Shukla, A., & Timblin, C. R. (2000). Role of Mitogen-Activated Protein Kinases, Early Response Protooncogenes, and Activator Protein-1 in Cell Signaling by Asbestos. Inhalation toxicology, 12307-16. https://doi.org/10.1080/08958378.2000.11463240
Mossman, B, et al. "Role of Mitogen-Activated Protein Kinases, Early Response Protooncogenes, and Activator Protein-1 in Cell Signaling by Asbestos." Inhalation toxicology vol. 12 (2000): 307-16. doi: https://doi.org/10.1080/08958378.2000.11463240
Mossman B, Hubbard A, Shukla A, Timblin CR. Role of Mitogen-Activated Protein Kinases, Early Response Protooncogenes, and Activator Protein-1 in Cell Signaling by Asbestos. Inhal Toxicol. 2000 Jan;12:307-16. doi: 10.1080/08958378.2000.11463240. PMID: 26368630.
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Tampering with springs: phosphorylation of titin affecting the mechanical function of cardiomyocytes.

Biophysical reviews

Hamdani N, Herwig M, Linke WA.
PMID: 28510118
Biophys Rev. 2017 Jun;9(3):225-237. doi: 10.1007/s12551-017-0263-9. Epub 2017 Apr 10.

Reversible post-translational modifications of various cardiac proteins regulate the mechanical properties of the cardiomyocytes and thus modulate the contractile performance of the heart. The giant protein titin forms a continuous filament network in the sarcomeres of striated muscle cells,...

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Hamdani N, Herwig M, Linke WA. Tampering with springs: phosphorylation of titin affecting the mechanical function of cardiomyocytes. Biophys Rev. 2017;9(3):225-237doi: 10.1007/s12551-017-0263-9.
Hamdani, N., Herwig, M., & Linke, W. A. (2017). Tampering with springs: phosphorylation of titin affecting the mechanical function of cardiomyocytes. Biophysical reviews, 9(3), 225-237. https://doi.org/10.1007/s12551-017-0263-9
Hamdani, Nazha, et al. "Tampering with springs: phosphorylation of titin affecting the mechanical function of cardiomyocytes." Biophysical reviews vol. 9,3 (2017): 225-237. doi: https://doi.org/10.1007/s12551-017-0263-9
Hamdani N, Herwig M, Linke WA. Tampering with springs: phosphorylation of titin affecting the mechanical function of cardiomyocytes. Biophys Rev. 2017 Jun;9(3):225-237. doi: 10.1007/s12551-017-0263-9. Epub 2017 Apr 10. PMID: 28510118; PMCID: PMC5498327.
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The Mitogen-Activated Protein Kinase (MAPK) Pathway: Role in Immune Evasion by Trypanosomatids.

Frontiers in microbiology

Soares-Silva M, Diniz FF, Gomes GN, Bahia D.
PMID: 26941717
Front Microbiol. 2016 Feb 24;7:183. doi: 10.3389/fmicb.2016.00183. eCollection 2016.

Leishmania spp. and Trypanosoma cruzi are the causative agents of leishmaniasis and Chagas disease, respectively, two neglected tropical diseases that affect about 25 million people worldwide. These parasites belong to the family Trypanosomatidae, and are both obligate intracellular parasites...

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Soares-Silva M, Diniz FF, Gomes GN, et al. The Mitogen-Activated Protein Kinase (MAPK) Pathway: Role in Immune Evasion by Trypanosomatids. Front Microbiol. 2016;7:183doi: 10.3389/fmicb.2016.00183.
Soares-Silva, M., Diniz, F. F., Gomes, G. N., & Bahia, D. (2016). The Mitogen-Activated Protein Kinase (MAPK) Pathway: Role in Immune Evasion by Trypanosomatids. Frontiers in microbiology, 7183. https://doi.org/10.3389/fmicb.2016.00183
Soares-Silva, Mercedes, et al. "The Mitogen-Activated Protein Kinase (MAPK) Pathway: Role in Immune Evasion by Trypanosomatids." Frontiers in microbiology vol. 7 (2016): 183. doi: https://doi.org/10.3389/fmicb.2016.00183
Soares-Silva M, Diniz FF, Gomes GN, Bahia D. The Mitogen-Activated Protein Kinase (MAPK) Pathway: Role in Immune Evasion by Trypanosomatids. Front Microbiol. 2016 Feb 24;7:183. doi: 10.3389/fmicb.2016.00183. eCollection 2016. PMID: 26941717; PMCID: PMC4764696.
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Bone morphogenetic protein-4 modulates proliferation and terminal differentiation of fetal hepatic stem/progenitor cells.

Hepatology research : the official journal of the Japan Society of Hepatology

Goto F, Kakinuma S, Miyoshi M, Tsunoda T, Kaneko S, Sato A, Asano Y, Otani S, Azuma S, Nagata H, Kawai-Kitahata F, Murakawa M, Nitta S, Itsui Y, Nakagawa M, Asahina Y, Watanabe M.
PMID: 27670640
Hepatol Res. 2017 Aug;47(9):941-952. doi: 10.1111/hepr.12823. Epub 2016 Oct 31.

Fetal hepatic stem/progenitor cells, called hepatoblasts, play central roles in liver organogenesis; however, molecular mechanisms regulating proliferation and terminal differentiation of such cells have not been completely elucidated. Bone morphogenetic protein-4 (BMP-4) is essential for the development of stem...

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Goto F, Kakinuma S, Miyoshi M, et al. Bone morphogenetic protein-4 modulates proliferation and terminal differentiation of fetal hepatic stem/progenitor cells. Hepatol Res. 2016;47(9):941-952doi: 10.1111/hepr.12823.
Goto, F., Kakinuma, S., Miyoshi, M., Tsunoda, T., Kaneko, S., Sato, A., Asano, Y., Otani, S., Azuma, S., Nagata, H., Kawai-Kitahata, F., Murakawa, M., Nitta, S., Itsui, Y., Nakagawa, M., Asahina, Y., & Watanabe, M. (2017). Bone morphogenetic protein-4 modulates proliferation and terminal differentiation of fetal hepatic stem/progenitor cells. Hepatology research : the official journal of the Japan Society of Hepatology, 47(9), 941-952. https://doi.org/10.1111/hepr.12823
Goto, Fumio, et al. "Bone morphogenetic protein-4 modulates proliferation and terminal differentiation of fetal hepatic stem/progenitor cells." Hepatology research : the official journal of the Japan Society of Hepatology vol. 47,9 (2017): 941-952. doi: https://doi.org/10.1111/hepr.12823
Goto F, Kakinuma S, Miyoshi M, Tsunoda T, Kaneko S, Sato A, Asano Y, Otani S, Azuma S, Nagata H, Kawai-Kitahata F, Murakawa M, Nitta S, Itsui Y, Nakagawa M, Asahina Y, Watanabe M. Bone morphogenetic protein-4 modulates proliferation and terminal differentiation of fetal hepatic stem/progenitor cells. Hepatol Res. 2017 Aug;47(9):941-952. doi: 10.1111/hepr.12823. Epub 2016 Oct 31. PMID: 27670640.
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Quantification of a Pharmacodynamic ERK End Point in Melanoma Cell Lysates: Toward Personalized Precision Medicine.

ACS medicinal chemistry letters

Warthaka M, Adelmann CH, Kaoud TS, Edupuganti R, Yan C, Johnson WH, Ferguson S, Tavares CD, Pence LJ, Anslyn EV, Ren P, Tsai KY, Dalby KN.
PMID: 25589929
ACS Med Chem Lett. 2014 Oct 17;6(1):47-52. doi: 10.1021/ml500198b. eCollection 2015 Jan 08.

Protein kinases are mutated or otherwise rendered constitutively active in numerous cancers where they are attractive therapeutic targets with well over a dozen kinase inhibitors now being used in therapy. While fluorescent sensors have capacity to measure changes in...

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Warthaka M, Adelmann CH, Kaoud TS, et al. Quantification of a Pharmacodynamic ERK End Point in Melanoma Cell Lysates: Toward Personalized Precision Medicine. ACS Med Chem Lett. 2014;6(1):47-52doi: 10.1021/ml500198b.
Warthaka, M., Adelmann, C. H., Kaoud, T. S., Edupuganti, R., Yan, C., Johnson, W. H., Ferguson, S., Tavares, C. D., Pence, L. J., Anslyn, E. V., Ren, P., Tsai, K. Y., & Dalby, K. N. (2015). Quantification of a Pharmacodynamic ERK End Point in Melanoma Cell Lysates: Toward Personalized Precision Medicine. ACS medicinal chemistry letters, 6(1), 47-52. https://doi.org/10.1021/ml500198b
Warthaka, Mangalika, et al. "Quantification of a Pharmacodynamic ERK End Point in Melanoma Cell Lysates: Toward Personalized Precision Medicine." ACS medicinal chemistry letters vol. 6,1 (2015): 47-52. doi: https://doi.org/10.1021/ml500198b
Warthaka M, Adelmann CH, Kaoud TS, Edupuganti R, Yan C, Johnson WH, Ferguson S, Tavares CD, Pence LJ, Anslyn EV, Ren P, Tsai KY, Dalby KN. Quantification of a Pharmacodynamic ERK End Point in Melanoma Cell Lysates: Toward Personalized Precision Medicine. ACS Med Chem Lett. 2014 Oct 17;6(1):47-52. doi: 10.1021/ml500198b. eCollection 2015 Jan 08. PMID: 25589929; PMCID: PMC4291693.
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Identification of New Resistance Loci to African Stem Rust Race TTKSK in Tetraploid Wheats Based on Linkage and Genome-Wide Association Mapping.

Frontiers in plant science

Laidò G, Panio G, Marone D, Russo MA, Ficco DB, Giovanniello V, Cattivelli L, Steffenson B, de Vita P, Mastrangelo AM.
PMID: 26697025
Front Plant Sci. 2015 Dec 09;6:1033. doi: 10.3389/fpls.2015.01033. eCollection 2015.

Stem rust, caused by Puccinia graminis Pers. f. sp. tritici Eriks. and E. Henn. (Pgt), is one of the most destructive diseases of wheat. Races of the pathogen in the "Ug99 lineage" are of international concern due to their...

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Laidò G, Panio G, Marone D, et al. Identification of New Resistance Loci to African Stem Rust Race TTKSK in Tetraploid Wheats Based on Linkage and Genome-Wide Association Mapping. Front Plant Sci. 2015;6:1033doi: 10.3389/fpls.2015.01033.
Laidò, G., Panio, G., Marone, D., Russo, M. A., Ficco, D. B., Giovanniello, V., Cattivelli, L., Steffenson, B., de Vita, P., & Mastrangelo, A. M. (2015). Identification of New Resistance Loci to African Stem Rust Race TTKSK in Tetraploid Wheats Based on Linkage and Genome-Wide Association Mapping. Frontiers in plant science, 61033. https://doi.org/10.3389/fpls.2015.01033
Laidò, Giovanni, et al. "Identification of New Resistance Loci to African Stem Rust Race TTKSK in Tetraploid Wheats Based on Linkage and Genome-Wide Association Mapping." Frontiers in plant science vol. 6 (2015): 1033. doi: https://doi.org/10.3389/fpls.2015.01033
Laidò G, Panio G, Marone D, Russo MA, Ficco DB, Giovanniello V, Cattivelli L, Steffenson B, de Vita P, Mastrangelo AM. Identification of New Resistance Loci to African Stem Rust Race TTKSK in Tetraploid Wheats Based on Linkage and Genome-Wide Association Mapping. Front Plant Sci. 2015 Dec 09;6:1033. doi: 10.3389/fpls.2015.01033. eCollection 2015. PMID: 26697025; PMCID: PMC4673868.
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The Emerging Role of Protein Phosphorylation as a Critical Regulatory Mechanism Controlling Cellulose Biosynthesis.

Frontiers in plant science

Jones DM, Murray CM, Ketelaar KJ, Thomas JJ, Villalobos JA, Wallace IS.
PMID: 27252710
Front Plant Sci. 2016 May 24;7:684. doi: 10.3389/fpls.2016.00684. eCollection 2016.

Plant cell walls are extracellular matrices that surround plant cells and critically influence basic cellular processes, such as cell division and expansion. Cellulose is a major constituent of plant cell walls, and this paracrystalline polysaccharide is synthesized at the...

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Jones DM, Murray CM, Ketelaar KJ, et al. The Emerging Role of Protein Phosphorylation as a Critical Regulatory Mechanism Controlling Cellulose Biosynthesis. Front Plant Sci. 2016;7:684doi: 10.3389/fpls.2016.00684.
Jones, D. M., Murray, C. M., Ketelaar, K. J., Thomas, J. J., Villalobos, J. A., & Wallace, I. S. (2016). The Emerging Role of Protein Phosphorylation as a Critical Regulatory Mechanism Controlling Cellulose Biosynthesis. Frontiers in plant science, 7684. https://doi.org/10.3389/fpls.2016.00684
Jones, Danielle M, et al. "The Emerging Role of Protein Phosphorylation as a Critical Regulatory Mechanism Controlling Cellulose Biosynthesis." Frontiers in plant science vol. 7 (2016): 684. doi: https://doi.org/10.3389/fpls.2016.00684
Jones DM, Murray CM, Ketelaar KJ, Thomas JJ, Villalobos JA, Wallace IS. The Emerging Role of Protein Phosphorylation as a Critical Regulatory Mechanism Controlling Cellulose Biosynthesis. Front Plant Sci. 2016 May 24;7:684. doi: 10.3389/fpls.2016.00684. eCollection 2016. PMID: 27252710; PMCID: PMC4877384.
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Isocryptotanshinone Induced Apoptosis and Activated MAPK Signaling in Human Breast Cancer MCF-7 Cells.

Journal of breast cancer

Zhang X, Luo W, Zhao W, Lu J, Chen X.
PMID: 26155286
J Breast Cancer. 2015 Jun;18(2):112-8. doi: 10.4048/jbc.2015.18.2.112. Epub 2015 Jun 26.

PURPOSE: Isocryptotanshinone (ICTS) is a natural bioactive product that is isolated from the roots of the widely used medical herb Salvia miltiorrhiza. However, few reports exist on the mechanisms underlying the therapeutic effects of ICTS. Here, we report that...

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Zhang X, Luo W, Zhao W, et al. Isocryptotanshinone Induced Apoptosis and Activated MAPK Signaling in Human Breast Cancer MCF-7 Cells. J Breast Cancer. 2015;18(2):112-8doi: 10.4048/jbc.2015.18.2.112.
Zhang, X., Luo, W., Zhao, W., Lu, J., & Chen, X. (2015). Isocryptotanshinone Induced Apoptosis and Activated MAPK Signaling in Human Breast Cancer MCF-7 Cells. Journal of breast cancer, 18(2), 112-8. https://doi.org/10.4048/jbc.2015.18.2.112
Zhang, Xuenong, et al. "Isocryptotanshinone Induced Apoptosis and Activated MAPK Signaling in Human Breast Cancer MCF-7 Cells." Journal of breast cancer vol. 18,2 (2015): 112-8. doi: https://doi.org/10.4048/jbc.2015.18.2.112
Zhang X, Luo W, Zhao W, Lu J, Chen X. Isocryptotanshinone Induced Apoptosis and Activated MAPK Signaling in Human Breast Cancer MCF-7 Cells. J Breast Cancer. 2015 Jun;18(2):112-8. doi: 10.4048/jbc.2015.18.2.112. Epub 2015 Jun 26. PMID: 26155286; PMCID: PMC4490259.
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Effect of Orexin-A on Cortisol Secretion in H295R Cells via p70S6K/4EBP1 Signaling Pathway.

International journal of endocrinology

Chang X, Zhao Y, Guo L.
PMID: 26064108
Int J Endocrinol. 2015;2015:405157. doi: 10.1155/2015/405157. Epub 2015 May 10.

Orexin-A is a neuropeptide that orchestrates diverse central and peripheral processes. It is now clear that orexin system plays a central role in the regulation of endocrine, paracrine, and neurocrine. It is involved in the regulation of growth hormone,...

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Chang X, Zhao Y, Guo L. Effect of Orexin-A on Cortisol Secretion in H295R Cells via p70S6K/4EBP1 Signaling Pathway. Int J Endocrinol. 2015;2015:405157doi: 10.1155/2015/405157.
Chang, X., Zhao, Y., & Guo, L. (2015). Effect of Orexin-A on Cortisol Secretion in H295R Cells via p70S6K/4EBP1 Signaling Pathway. International journal of endocrinology, 2015405157. https://doi.org/10.1155/2015/405157
Chang, Xiaocen, et al. "Effect of Orexin-A on Cortisol Secretion in H295R Cells via p70S6K/4EBP1 Signaling Pathway." International journal of endocrinology vol. 2015 (2015): 405157. doi: https://doi.org/10.1155/2015/405157
Chang X, Zhao Y, Guo L. Effect of Orexin-A on Cortisol Secretion in H295R Cells via p70S6K/4EBP1 Signaling Pathway. Int J Endocrinol. 2015;2015:405157. doi: 10.1155/2015/405157. Epub 2015 May 10. PMID: 26064108; PMCID: PMC4441985.
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KCl Mediates K(+) Channel-Activated Mitogen-Activated Protein Kinases Signaling in Wound Healing.

Archives of plastic surgery

Shim JH, Lim JW, Kim BK, Park SJ, Kim SW, Choi TH.
PMID: 25606484
Arch Plast Surg. 2015 Jan;42(1):11-9. doi: 10.5999/aps.2015.42.1.11. Epub 2015 Jan 14.

BACKGROUND: Wound healing is an interaction of a complex signaling cascade of cellular events, including inflammation, proliferation, and maturation. K(+) channels modulate the mitogen-activated protein kinase (MAPK) signaling pathway. Here, we investigated whether K(+) channel-activated MAPK signaling directs collagen...

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Shim JH, Lim JW, Kim BK, et al. KCl Mediates K(+) Channel-Activated Mitogen-Activated Protein Kinases Signaling in Wound Healing. Arch Plast Surg. 2015;42(1):11-9doi: 10.5999/aps.2015.42.1.11.
Shim, J. H., Lim, J. W., Kim, B. K., Park, S. J., Kim, S. W., & Choi, T. H. (2015). KCl Mediates K(+) Channel-Activated Mitogen-Activated Protein Kinases Signaling in Wound Healing. Archives of plastic surgery, 42(1), 11-9. https://doi.org/10.5999/aps.2015.42.1.11
Shim, Jung Hee, et al. "KCl Mediates K(+) Channel-Activated Mitogen-Activated Protein Kinases Signaling in Wound Healing." Archives of plastic surgery vol. 42,1 (2015): 11-9. doi: https://doi.org/10.5999/aps.2015.42.1.11
Shim JH, Lim JW, Kim BK, Park SJ, Kim SW, Choi TH. KCl Mediates K(+) Channel-Activated Mitogen-Activated Protein Kinases Signaling in Wound Healing. Arch Plast Surg. 2015 Jan;42(1):11-9. doi: 10.5999/aps.2015.42.1.11. Epub 2015 Jan 14. PMID: 25606484; PMCID: PMC4297800.
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Bioorthogonal Chemical Activation of Kinases in Living Systems.

ACS central science

Zhang G, Li J, Xie R, Fan X, Liu Y, Zheng S, Ge Y, Chen PR.
PMID: 27280167
ACS Cent Sci. 2016 May 25;2(5):325-31. doi: 10.1021/acscentsci.6b00024. Epub 2016 Apr 27.

Selective manipulation of protein kinases under living conditions is highly desirable yet extremely challenging, particularly in a gain-of-function fashion. Here we employ our recently developed bioorthogonal cleavage reaction as a general strategy for intracellular activation of individual kinases. Site-specific...

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Zhang G, Li J, Xie R, et al. Bioorthogonal Chemical Activation of Kinases in Living Systems. ACS Cent Sci. 2016;2(5):325-31doi: 10.1021/acscentsci.6b00024.
Zhang, G., Li, J., Xie, R., Fan, X., Liu, Y., Zheng, S., Ge, Y., & Chen, P. R. (2016). Bioorthogonal Chemical Activation of Kinases in Living Systems. ACS central science, 2(5), 325-31. https://doi.org/10.1021/acscentsci.6b00024
Zhang, Gong, et al. "Bioorthogonal Chemical Activation of Kinases in Living Systems." ACS central science vol. 2,5 (2016): 325-31. doi: https://doi.org/10.1021/acscentsci.6b00024
Zhang G, Li J, Xie R, Fan X, Liu Y, Zheng S, Ge Y, Chen PR. Bioorthogonal Chemical Activation of Kinases in Living Systems. ACS Cent Sci. 2016 May 25;2(5):325-31. doi: 10.1021/acscentsci.6b00024. Epub 2016 Apr 27. PMID: 27280167; PMCID: PMC4882735.
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Showing 1 to 12 of 2266 entries