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Showing 1 to 12 of 1059 entries
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Reprint of "Modeling the intracellular replication of influenza A virus in the presence of defective interfering RNAs.

Virus research

Laske T, Heldt FS, Hoffmann H, Frensing T, Reichl U.
PMID: 27208847
Virus Res. 2016 Jun 15;218:86-95. doi: 10.1016/j.virusres.2016.05.009.

Like many other viral pathogens, influenza A viruses can form defective interfering particles (DIPs). These particles carry a large internal deletion in at least one of their genome segments. Thus, their replication depends on the co-infection of cells by...

The NO stimulator, Catestatin, improves the Frank-Starling response in normotensive and hypertensive rat hearts.

Nitric oxide : biology and chemistry

Angelone T, Quintieri AM, Pasqua T, Filice E, Cantafio P, Scavello F, Rocca C, Mahata SK, Gattuso A, Cerra MC.
PMID: 26241941
Nitric Oxide. 2015 Nov 15;50:10-19. doi: 10.1016/j.niox.2015.07.004. Epub 2015 Aug 01.

The myocardial response to mechanical stretch (Frank-Starling law) is an important physiological cardiac determinant. Modulated by many endogenous substances, it is impaired in the presence of cardiovascular pathologies and during senescence. Catestatin (CST:hCgA352-372), a 21-amino-acid derivate of Chromogranin A...

Thrombin generation measured as thrombin-antithrombin complexes predicts clinical outcomes in patients with cirrhosis.

Hepatology research : the official journal of the Japan Society of Hepatology

Kalambokis GN, Oikonomou A, Baltayiannis G, Christou L, Kolaitis NI, Tsianos EV.
PMID: 25847196
Hepatol Res. 2016 Mar;46(3):E36-44. doi: 10.1111/hepr.12520. Epub 2015 May 22.

AIM: Hypercoagulability has been detected in patients with cirrhosis yet its clinical significance remains unclear. We investigated the association of hypercoagulability with clinical outcomes in patients with cirrhosis.METHODS: Thrombin-antithrombin (TAT) complexes as thrombin generation (TG) marker, D-dimer, antithrombin (AT),...

Age-related changes in expression and signaling of TAM receptor inflammatory regulators in monocytes.

Oncotarget

Wang X, Malawista A, Qian F, Ramsey C, Allore HG, Montgomery RR.
PMID: 29515754
Oncotarget. 2018 Jan 03;9(11):9572-9580. doi: 10.18632/oncotarget.23851. eCollection 2018 Feb 09.

The multifactorial immune deterioration in aging--termed "inflamm-aging"--is comprised of a state of low-grade, chronic inflammation and complex dysregulation of responses to immune stimulation. The TAM family (Tyro 3, Axl, and Mer) of receptor tyrosine kinases are negative regulators of...

Fungal Histidine Phosphotransferase Plays a Crucial Role in Photomorphogenesis and Pathogenesis in .

Frontiers in chemistry

Mohanan VC, Chandarana PM, Chattoo BB, Patkar RN, Manjrekar J.
PMID: 28580356
Front Chem. 2017 May 19;5:31. doi: 10.3389/fchem.2017.00031. eCollection 2017.

Two-component signal transduction (TCST) pathways play crucial roles in many cellular functions such as stress responses, biofilm formation, and sporulation. The histidine phosphotransferase (HPt), which is an intermediate phosphotransfer protein in a two-component system, transfers a phosphate group to...

PO-14 - Tumour expression of coagulation proteases of the aPC pathway - a role in the pathogenesis of gynaecological cancers?.

Thrombosis research

Martin F, Long JC, O'Toole SA, O'Leary JJ, Abu Saadeh F, Gleeson N, Norris LA.
PMID: 27161702
Thromb Res. 2016 Apr;140:S181. doi: 10.1016/S0049-3848(16)30147-5. Epub 2016 Apr 08.

INTRODUCTION: The close relationship between coagulation, thrombosis and cancer has long been established. Gynaecological cancers, in particular ovarian cancers, carry a high risk of thrombosis but coagulation activation is also thought to play a role in tumorigenesis and metastasis....

Natural Inhibitors and Lipids in Patients with Sickle Cell Disease.

Turkish journal of haematology : official journal of Turkish Society of Haematology

Canatan D, Oğuz N, Özsancak A, Aslan İ, Bengü A, Gürman A, Sarıca B.
PMID: 27263501
Turk J Haematol. 2000 Sep 05;17(3):119-22.

Microvascular occlusion in sickle cell disease (SCD) is a multifactorial process. Disordered coagulation may play a role in the pathogenesis of vaso occlusive crisis (VOC). The aim of this study was to evaluate the patients and to investigate their...

Haemostatic Profile in Patients of Myeloproliferative Neoplasms-A Tertiary Care Centre Experience.

Journal of clinical and diagnostic research : JCDR

Parashar Y, Kushwaha R, Kumar A, Agarwal K, Singh US, Jain M, Verma SP, Tripathi AK.
PMID: 28050371
J Clin Diagn Res. 2016 Nov;10(11):EC01-EC04. doi: 10.7860/JCDR/2016/19985.8840. Epub 2016 Nov 01.

INTRODUCTION: Patients of MPN commonly present with abnormalities in laboratory coagulation tests that are consistent with hypercoagulable state. Some individuals with MPN exhibit a pattern of exclusive bleeding or thrombotic events; many others have both bleeding and thrombosis during...

Sugar-Assisted Photogeneration of Didehydrotoluenes from Chlorobenzylphosphonic Acids.

The Journal of organic chemistry

Crespi S, Protti S, Ravelli D, Merli D, Fagnoni M.
PMID: 29019237
J Org Chem. 2017 Dec 01;82(23):12162-12172. doi: 10.1021/acs.joc.7b01963. Epub 2017 Nov 20.

Irradiation of the three isomeric chlorobenzylphophonic acids in aqueous buffer led to a pH-dependent photochemistry. Under acidic conditions (pH = 2.5), photocleavage of the Ar-Cl bond occurred and a phenyl cation chemistry resulted. Under basic conditions (pH = 11),...

Thrombophilia in East Asian countries: are there any genetic differences in these countries?.

Thrombosis journal

Miyata T, Maruyama K, Banno F, Neki R.
PMID: 27766051
Thromb J. 2016 Oct 04;14:25. doi: 10.1186/s12959-016-0109-x. eCollection 2016.

In recent years, genetic analyses of congenital deficiencies of three anticoagulant proteins, antithrombin, protein C (PC) and protein S (PS), in East Asian patients with venous thromboembolism (VTE) have greatly increased. The PS-K196E mutation is often identified in the...

Natural regulatory anticoagulants proteins among Sudanese patients with dengue virus infection.

International journal of health sciences

Bashir BA, Saeed OKA.
PMID: 28539856
Int J Health Sci (Qassim). 2017 Apr-Jun;11(2):3-8.

THE COAGULATION SYSTEM: Abnormalities in natural physiologic anticoagulants are observed in dengue infection. Laboratory values such as protein C (PC), protein S (PS), and antithrombin (AT) indicate this problem on the coagulation system in dengue. Recently, an interrelationship between...

Increased Level of Factor VIII and Physiological Inhibitors of Coagulation in Patients with Sickle Cell Disease.

Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion

Chekkal M, Rahal MCA, Moulasserdoun K, Seghier F.
PMID: 28596657
Indian J Hematol Blood Transfus. 2017 Jun;33(2):235-238. doi: 10.1007/s12288-016-0701-z. Epub 2016 Jun 25.

Sickle cell disease (SCD) is a hemoglobinopathy characterized by hemolysis, oxidative stress, and vaso-occlusive crises. Thromboembolism also remains a serious complication and probably underestimated in the SCD. Our objective was to seek the existence of hemostasis abnormalities that predispose...

Showing 1 to 12 of 1059 entries