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Showing 1 to 12 of 19 entries
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Effects of secretin on TCDCA- or TDCA-induced cholestatic liver injury in the rat.

Hepatology research : the official journal of the Japan Society of Hepatology

Fukumoto Y, Murakami F, Tateishi A, Itoh Y, Sakaida I, Okita K.
PMID: 11882418
Hepatol Res. 2002 Mar;22(3):214-222. doi: 10.1016/s1386-6346(01)00141-3.

Secretin, a gastrointestinal hormone, is known to act on bile duct epithelial cells and has been thought to have no effects on the bile acid transport in the liver. However, secretin was proved recently to stimulate biliary secretion of...

Vectorial transport of bile acids in immortalized mouse bile duct cells.

Hepatology research : the official journal of the Japan Society of Hepatology

Kida M, Mano Y, Ueno Y, Kobayashi K, Goto J, Ishii M, Shimosegawa T.
PMID: 14563430
Hepatol Res. 2003 Oct;27(2):151-157. doi: 10.1016/s1386-6346(03)00201-8.

In ileal epithelial cells, apical sodium-dependent bile acid transporter (ASBT) is responsible for the uptake of bile acids from the lumen. Furthermore, ASBT is expressed in the apical plasma membrane of intrahepatic bile duct cells (BECs). Using cultured immortalized...

A systematic review of preclinical studies on the efficacy of taurine for the treatment of rheumatoid arthritis.

Amino acids

Malek Mahdavi A, Javadivala Z.
PMID: 33929638
Amino Acids. 2021 Jun;53(6):783-800. doi: 10.1007/s00726-021-02988-8. Epub 2021 Apr 30.

Due to the undesirable effects of conventional medical therapies prescribed for rheumatoid arthritis (RA), complementary therapies, especially nutritional agents, have recently gained great attention. Recent animal and in vitro researches have shown benefits of taurine (Tau), a sulfur-containing amino...

Taurochenodeoxycholic Acid Increases cAMP Content via Specially Interacting with Bile Acid Receptor TGR5.

Molecules (Basel, Switzerland)

Qi Y, Shi L, Duan G, Ma Y, Li P.
PMID: 34885648
Molecules. 2021 Nov 23;26(23). doi: 10.3390/molecules26237066.

Taurochenodeoxycholic acid (TCDCA) is one of the main components of bile acids (BAs). TCDCA has been reported as a signaling molecule, exerting anti-inflammatory and immunomodulatory functions. However, it is not well known whether those effects are mediated by TGR5....

Taurochenodeoxycholic Acid Increases cAMP Content via Specially Interacting with Bile Acid Receptor TGR5.

Molecules (Basel, Switzerland)

Qi Y, Shi L, Duan G, Ma Y, Li P.
PMID: 34885648
Molecules. 2021 Nov 23;26(23). doi: 10.3390/molecules26237066.

Taurochenodeoxycholic acid (TCDCA) is one of the main components of bile acids (BAs). TCDCA has been reported as a signaling molecule, exerting anti-inflammatory and immunomodulatory functions. However, it is not well known whether those effects are mediated by TGR5....

Bile acid profiles in bile and feces of obese mice by a high-performance liquid chromatography-tandem mass spectrometry.

Biotechnology and applied biochemistry

Zheng J, Ye C, Hu B, Yang H, Yao Q, Ma J, Liu Y, Liu H.
PMID: 33140486
Biotechnol Appl Biochem. 2021 Dec;68(6):1332-1341. doi: 10.1002/bab.2055. Epub 2020 Nov 02.

Bile acids (BAs) play a pivotal role in manipulating the development of metabolic diseases. However, due to the compositional complexity and functional variation of BAs, it remains unclear about the changes in BA pool for individuals with obesity or...

Transcriptome investigation of anti-inflammation and immuno-regulation mechanism of taurochenodeoxycholic acid.

BMC pharmacology & toxicology

Bao L, Hao D, Wang X, He X, Mao W, Li P.
PMID: 33926569
BMC Pharmacol Toxicol. 2021 Apr 29;22(1):23. doi: 10.1186/s40360-021-00491-0.

BACKGROUND: Taurochenodeoxycholic acid (TCDCA) is one of the major active components in bile acid. It was proven to have inhibitory activities on inflammation and also participate in host immuno-regulation. TCDCA exerts anti-inflammatory and immuno-regulatory effects through the glucocorticoid receptor...

Taurochenodeoxycholic acid inhibits the proliferation and invasion of gastric cancer and induces its apoptosis.

Journal of food biochemistry

Zhang D, Zhu Y, Su Y, Yu M, Xu X, Wang C, Zhang S, Xia L.
PMID: 34278593
J Food Biochem. 2021 Jul 18;e13866. doi: 10.1111/jfbc.13866. Epub 2021 Jul 18.

Taurochenodeoxycholic acid (TCDCA) is the principal ingredient of Compound Shougong Powder. Despite traditional Chinese medicine (TCM) research demonstrates that Compound Shougong Powder can restrict tumor growth, whether TCDCA exerts a role in suppressing cancer as the major ingredient of...

Bile acid profiles in bile and feces of obese mice by a high-performance liquid chromatography-tandem mass spectrometry.

Biotechnology and applied biochemistry

Zheng J, Ye C, Hu B, Yang H, Yao Q, Ma J, Liu Y, Liu H.
PMID: 33140486
Biotechnol Appl Biochem. 2020 Nov 02; doi: 10.1002/bab.2055. Epub 2020 Nov 02.

Bile acids (BAs) play a pivotal role in manipulating the development of metabolic diseases. However, due to the compositional complexity and functional variation of BAs, it remains unclear about the changes in BA pool for individuals with obesity or...

Semi-Preparative Isolation and Purification of Three Tauro-Conjugated Cholic Acids from Pulvis Fellis Suis by HSCCC Coupled with ELSD Detection.

Chromatographia

He J, Zhang Y, Ito Y, Sun W.
PMID: 21442029
Chromatographia. 2011;73(3):361-365. doi: 10.1007/s10337-010-1893-2.

Coupled with evaporative light scattering detection, a high-speed counter-current chromatography (HSCCC) method was applied to the separation and purification of three tauro-conjugated cholic acids of taurochenodeoxycholic acid (TCDCA), taurohyodeoxycholic acid (THDCA) and taurohyocholic acid (THCA) from Pulvis Fellis Suis...

FXR in the dorsal vagal complex is sufficient and necessary for upper small intestinal microbiome-mediated changes of TCDCA to alter insulin action in rats.

Gut

Zhang SY, Li RJW, Lim YM, Batchuluun B, Liu H, Waise TMZ, Lam TKT.
PMID: 33087489
Gut. 2021 Sep;70(9):1675-1683. doi: 10.1136/gutjnl-2020-321757. Epub 2020 Oct 21.

OBJECTIVE: Conjugated bile acids are metabolised by upper small intestinal microbiota, and serum levels of taurine-conjugated bile acids are elevated and correlated with insulin resistance in people with type 2 diabetes. However, whether changes in taurine-conjugated bile acids are...

Serum Metabolomic Profiling Identifies Key Metabolic Signatures Associated With Pathogenesis of Alcoholic Liver Disease in Humans.

Hepatology communications

Yang Z, Kusumanchi P, Ross RA, Heathers L, Chandler K, Oshodi A, Thoudam T, Li F, Wang L, Liangpunsakul S.
PMID: 30976744
Hepatol Commun. 2019 Feb 20;3(4):542-557. doi: 10.1002/hep4.1322. eCollection 2019 Apr.

Alcoholic liver disease (ALD) develops in a subset of heavy drinkers (HDs). The goals of our study were to (1) characterize the global serum metabolomic changes in well-characterized cohorts of controls (Cs), HDs, and those with alcoholic cirrhosis (AC);...

Showing 1 to 12 of 19 entries