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Showing 1 to 12 of 20 entries
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Integrating subpathway analysis to identify candidate agents for hepatocellular carcinoma.

OncoTargets and therapy

Wang J, Li M, Wang Y, Liu X.
PMID: 27022281
Onco Targets Ther. 2016 Mar 07;9:1221-30. doi: 10.2147/OTT.S97211. eCollection 2016.

Hepatocellular carcinoma (HCC) is the second most common cause of cancer-associated death worldwide, characterized by a high invasiveness and resistance to normal anticancer treatments. The need to develop new therapeutic agents for HCC is urgent. Here, we developed a...

Regulation of intracellular calcium in dispersed fat body trophocytes of the cockroach, Periplaneta americana, by hypertrehalosemic hormone.

Journal of insect physiology

Sun D, Steele JE.
PMID: 12770146
J Insect Physiol. 2001 Dec;47(12):1399-1408. doi: 10.1016/s0022-1910(01)00130-5.

Incubation of trophocytes from dissaggregated fat body of Periplaneta americana with either of the hypertrehalosemic hormones, HTH-I or HTH-II, leads to an increase in the cytosolic concentration of Ca(2+) from approximately 80 to approximately 310nM with a rise time...

Expression of the Proenkephalin A Gene and [Met(5)]enkephalin Secretion Induced by Prostaglandin E(2) in Bovine Adrenal Medullary Chromaffin Cells: Involvement of Second Messengers.

Molecular and cellular neurosciences

Suh HH, McMillian MK, Hudson PM, Pennypacker KR, Hong JS.
PMID: 19912914
Mol Cell Neurosci. 1993 Feb;4(1):113-20. doi: 10.1006/mcne.1993.1013.

We have reported that prostaglandin E(2) (PGE(2)) increases the long-term secretion of [Met(5)]enkephalin (ME) and the expression of proenkephalin A (proENK) mRNA in bovine adrenal medullary chromaffin (BAMC) cells. In order to characterize the underlying mechanisms for the PGE(2)-induced...

Molecular mechanisms of large-conductance ca (2+) -activated potassium channel activation by ginseng gintonin.

Evidence-based complementary and alternative medicine : eCAM

Choi SH, Lee BH, Hwang SH, Kim HJ, Lee SM, Kim HC, Rhim HW, Nah SY.
PMID: 23662129
Evid Based Complement Alternat Med. 2013;2013:323709. doi: 10.1155/2013/323709. Epub 2013 Apr 04.

Gintonin is a unique lysophosphatidic acid (LPA) receptor ligand found in Panax ginseng. Gintonin induces transient [Ca(2+)]i through G protein-coupled LPA receptors. Large-conductance Ca(2+)-activated K(+) (BKCa) channels are expressed in blood vessels and neurons and play important roles in...

Voltage-gated calcium channels contribute to spontaneous glutamate release directly via nanodomain coupling or indirectly via calmodulin.

Progress in neurobiology

Lee BJ, Yang CH, Lee SY, Lee SH, Kim Y, Ho WK.
PMID: 34695543
Prog Neurobiol. 2022 Jan;208:102182. doi: 10.1016/j.pneurobio.2021.102182. Epub 2021 Oct 22.

Neurotransmitter release occurs either synchronously with action potentials (evoked release) or spontaneously (spontaneous release). Whether the molecular mechanisms underlying evoked and spontaneous release are identical, especially whether voltage-gated calcium channels (VGCCs) can trigger spontaneous events, is still a matter...

Pharmacological properties of voltage-gated Na+ currents in motor neurones from a hydrozoan jellyfish Polyorchis penicillatus.

The Journal of experimental biology

Spafford J, Grigoriev N, Spencer A.
PMID: 9318735
J Exp Biol. 1996;199:941-8.

The Na+ current of 'swimming motor neurones' in the hydromedusan Polyorchis penicillatus was tetrodotoxin-insensitive. The local anaesthetics lidocaine and procainamide caused partial, non use-dependent blockade of the Na+ channel. Veratridine produced partial blockade of the Na+ channel without affecting...

Plasma Membrane Ca-ATPase of Radish Seedlings : II. Regulation by Calmodulin.

Plant physiology

Rasi-Caldogno F, Carnelli A, De Michelis MI.
PMID: 16668747
Plant Physiol. 1992 Mar;98(3):1202-6. doi: 10.1104/pp.98.3.1202.

The effect of calmodulin on the activity of the plasma membrane Ca-ATPase was investigated on plasma membranes purified from radish (Raphanus sativus L.) seedlings. Calmodulin stimulated the hydrolytic activity and the transport activity of the plasma membrane Ca-ATPase to...

Regulation of proenkephalin gene expression by angiotensin in bovine adrenal medullary cells: Molecular mechanisms and nature of the second messenger systems.

Molecular and cellular neurosciences

Stachowiak MK, Poisner A, Jiang HK, Hudson PH, Hong JS.
PMID: 19912801
Mol Cell Neurosci. 1991 Jun;2(3):213-20. doi: 10.1016/1044-7431(91)90047-r.

The purpose of this study was to examine the effects of angiotensin on the release of enkephalin peptides and the expression of the proenkephalin (pEK) gene. Incubation of cultured bovine adrenal medullary (AM) cells in serum-free medium resulted in...

Activation of eNOS by D-pinitol Induces an Endothelium-Dependent Vasodilatation in Mouse Mesenteric Artery.

Frontiers in pharmacology

Moreira LN, Silva JF, Silva GC, Lemos VS, Cortes SF.
PMID: 29872397
Front Pharmacol. 2018 May 22;9:528. doi: 10.3389/fphar.2018.00528. eCollection 2018.

D-pinitol is a cyclitol present in several edible plant species and extensively investigated for the treatment of metabolic diseases in humans, as food supplement, and demonstrated protective effects in the cardiovascular system. For these reasons, the present work aimed...

Voltage-gated calcium channels contribute to spontaneous glutamate release directly via nanodomain coupling or indirectly via calmodulin.

Progress in neurobiology

Lee BJ, Yang CH, Lee SY, Lee SH, Kim Y, Ho WK.
PMID: 34695543
Prog Neurobiol. 2021 Oct 22;102182. doi: 10.1016/j.pneurobio.2021.102182. Epub 2021 Oct 22.

Neurotransmitter release occurs either synchronously with action potentials (evoked release) or spontaneously (spontaneous release). Whether the molecular mechanisms underlying evoked and spontaneous release are identical, especially whether voltage-gated calcium channels (VGCCs) can trigger spontaneous events, is still a matter...

Performance of a scalable RNA extraction-free transcriptome profiling method for adherent cultured human cells.

Scientific reports

Ghimire S, Stewart CG, Thurman AL, Pezzulo AA.
PMID: 34593905
Sci Rep. 2021 Sep 30;11(1):19438. doi: 10.1038/s41598-021-98912-x.

RNA sequencing enables high-content/high-complexity measurements in small molecule screens. Whereas the costs of DNA sequencing and RNA-seq library preparation have decreased consistently, RNA extraction remains a significant bottleneck to scalability. We evaluate the performance of a bulk RNA-seq library...

Calcium Transport in Membrane Vesicles Isolated from Maize Coleoptiles (Effect of Indoleacetic Acid and Fusicoccin).

Plant physiology

Zocchi G, Rabotti G.
PMID: 12231672
Plant Physiol. 1993 Jan;101(1):135-139. doi: 10.1104/pp.101.1.135.

Maize (Zea mays L.) coleoptile segments loaded with 45Ca released about 50% of the ion after 1 h when treated with indoleacetic acid (IAA). In contrast, fusicoccin (FC) had no effect. The same relation was found when ATP-dependent Ca2+...

Showing 1 to 12 of 20 entries