Display options
Cite
Constantinescu SN, Ghaffari S, Lodish HF. The Erythropoietin Receptor: Structure, Activation and Intracellular Signal Transduction. Trends Endocrinol Metab. 1999;10(1):18-23doi: 10.1016/s1043-2760(98)00101-5.
Constantinescu, S. N., Ghaffari, S., & Lodish, H. F. (1999). The Erythropoietin Receptor: Structure, Activation and Intracellular Signal Transduction. Trends in endocrinology and metabolism: TEM, 10(1), 18-23. https://doi.org/10.1016/s1043-2760(98)00101-5
Constantinescu, et al. "The Erythropoietin Receptor: Structure, Activation and Intracellular Signal Transduction." Trends in endocrinology and metabolism: TEM vol. 10,1 (1999): 18-23. doi: https://doi.org/10.1016/s1043-2760(98)00101-5
Constantinescu SN, Ghaffari S, Lodish HF. The Erythropoietin Receptor: Structure, Activation and Intracellular Signal Transduction. Trends Endocrinol Metab. 1999 Dec;10(1):18-23. doi: 10.1016/s1043-2760(98)00101-5. PMID: 10322390.
Copy Download .nbib Format: NLM
Share it on
Full text links
Elsevier Science

Trends Endocrinol Metab. 1999 Dec;10(1):18-23. doi: 10.1016/s1043-2760(98)00101-5.

The Erythropoietin Receptor: Structure, Activation and Intracellular Signal Transduction.

Trends in endocrinology and metabolism: TEM

Constantinescu, Ghaffari, Lodish

Affiliations

  1. Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA.

PMID: 10322390 DOI: 10.1016/s1043-2760(98)00101-5

Abstract

Erythropoietin (Epo) and its receptor (EpoR) are essential for proliferation, differentiation and survival of erythroid progenitors. Here, we review several mechanisms by which the EpoR can be activated. We also describe the many intracellular signal transduction pathways activated by the EpoR. None are unique to the EpoR and mutant receptors able to activate only a subset of these pathways can support erythropoiesis in EpoR-/- fetal liver cells. Furthermore, normal erythroid differentiation occurs when the EpoR is replaced by the prolactin receptor or the myeloid oncoprotein Bcr-abl. Epo and probably other growth factors are required merely to ensure the survival and proliferation of already committed progenitors.

Cited by

Publication Types

LinkOut - more resources