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Adams KF. Systems biology and heart failure: concepts, methods, and potential research applications. Heart Fail Rev. 2010;15(4):371-98doi: 10.1007/s10741-009-9138-x.
Adams, K. F. (2010). Systems biology and heart failure: concepts, methods, and potential research applications. Heart failure reviews, 15(4), 371-98. https://doi.org/10.1007/s10741-009-9138-x
Adams, Kirkwood F. "Systems biology and heart failure: concepts, methods, and potential research applications." Heart failure reviews vol. 15,4 (2010): 371-98. doi: https://doi.org/10.1007/s10741-009-9138-x
Adams KF. Systems biology and heart failure: concepts, methods, and potential research applications. Heart Fail Rev. 2010 Jul;15(4):371-98. doi: 10.1007/s10741-009-9138-x. PMID: 19396630.
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Heart Fail Rev. 2010 Jul;15(4):371-98. doi: 10.1007/s10741-009-9138-x.

Systems biology and heart failure: concepts, methods, and potential research applications.

Heart failure reviews

Kirkwood F Adams

Affiliations

  1. UNC Heart Failure Program, Department of Medicine, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA. [email protected]

PMID: 19396630 DOI: 10.1007/s10741-009-9138-x

Abstract

Dramatic advances in molecular biology dominated twentieth century biomedical science and delineated the function of individual genes and molecules in exquisite detail. However, biological processes cannot be fully understood based on the properties of individual genes and molecules alone, since these elements act in concert to enable the specific functions that make for living cells and organisms. The discipline of systems biology provides a novel conceptual framework for understanding biological phenomenon. Systems biology synthesizes information concerning the interactions of genes and molecules and allows characterization of the supramolecular networks and functional modules that represent the most essential aspects of cell organization and physiology.

References

  1. Curr Opin Mol Ther. 2005 Dec;7(6):577-82 - PubMed
  2. Circulation. 2007 Oct 9;116(15):1714-24 - PubMed
  3. Pediatr Nephrol. 2006 Feb;21(2):169-76 - PubMed
  4. J Mol Med (Berl). 2007 Dec;85(12):1291-2 - PubMed
  5. J Am Coll Cardiol. 2006 Nov 7;48(9):1733-41 - PubMed
  6. Heart Fail Rev. 2007 Mar;12(1):1-11 - PubMed
  7. J Lipid Res. 2006 Nov;47(11):2355-66 - PubMed
  8. Circulation. 2005 Oct 18;112(16):2403-10 - PubMed
  9. Nat Genet. 2003 Sep;35(1):57-64 - PubMed
  10. Symp Soc Exp Biol. 1958;12:138-63 - PubMed
  11. J Clin Invest. 2005 Mar;115(3):495-9 - PubMed
  12. Circulation. 2004 Nov 30;110(22):3444-51 - PubMed
  13. Nature. 1997 Jun 12;387(6634):657 - PubMed
  14. Hist Philos Life Sci. 2006;28(4):491-512 - PubMed
  15. J Hypertens. 2008 Jul;26(7):1367-72 - PubMed
  16. Nat Rev Genet. 2006 Nov;7(11):829-40 - PubMed
  17. Nature. 1992 Oct 15;359(6396):641-4 - PubMed
  18. Nature. 2008 Apr 17;452(7189):872-6 - PubMed
  19. Genetics. 2003 Aug;164(4):1607-14 - PubMed
  20. Science. 2007 Jun 8;316(5830):1488-91 - PubMed
  21. Science. 2002 Apr 26;296(5568):752-5 - PubMed
  22. Lancet. 2005 Sep 24-30;366(9491):1121-31 - PubMed
  23. Diabetes. 2004 Jul;53(7):1884-9 - PubMed
  24. J Mol Med (Berl). 2008 Jun;86(6):637-41 - PubMed
  25. J Clin Invest. 1990 Oct;86(4):1343-6 - PubMed
  26. J Am Coll Cardiol. 2007 Mar 20;49(11):1193-202 - PubMed
  27. Science. 2006 Oct 20;314(5798):475-8 - PubMed
  28. Physiol Rev. 2008 Oct;88(4):1567-651 - PubMed
  29. Nat Genet. 2006 Jun;38(6):644-51 - PubMed
  30. Trends Microbiol. 2007 Jan;15(1):45-50 - PubMed
  31. Nature. 1970 Aug 8;227(5258):561-3 - PubMed
  32. Clin Res Cardiol. 2008 Jul;97(7):418-31 - PubMed
  33. Nature. 2004 Aug 12;430(7001):743-7 - PubMed
  34. Hypertens Res. 2007 Nov;30(11):1129-37 - PubMed
  35. Nat Rev Genet. 2005 Apr;6(4):271-86 - PubMed
  36. Kidney Int. 2009 Jan;75(2):142-6 - PubMed
  37. Nature. 2000 Jul 27;406(6794):378-82 - PubMed
  38. Nat Genet. 2006 Jun;38(6):659-62 - PubMed
  39. Am J Physiol Heart Circ Physiol. 2006 Jan;290(1):H17-29 - PubMed
  40. Nat Rev Mol Cell Biol. 2006 Mar;7(3):198-210 - PubMed
  41. Nature. 2003 Jan 23;421(6921):409-12 - PubMed
  42. Peptides. 2005 Jun;26(6):944-56 - PubMed
  43. Nat Genet. 2007 Feb;39(2):226-31 - PubMed
  44. Nat Genet. 2007 Jul;39(7 Suppl):S3-5 - PubMed
  45. Hum Mol Genet. 2008 Oct 15;17(R2):R135-42 - PubMed
  46. N Engl J Med. 2007 Aug 2;357(5):443-53 - PubMed
  47. Genes Immun. 2007 Jan;8(1):57-68 - PubMed
  48. Mamm Genome. 2006 Jun;17(6):466-79 - PubMed
  49. Am J Respir Crit Care Med. 1997 Oct;156(4 Pt 2):S103-9 - PubMed
  50. J Am Soc Nephrol. 1999 Jul;10(7):1598-605 - PubMed
  51. Circulation. 2008 Jul 15;118(3):238-46 - PubMed
  52. Genomics. 2008 Nov;92(5):265-72 - PubMed
  53. Nature. 1995 May 11;375(6527):146-8 - PubMed
  54. J Am Coll Cardiol. 2006 Aug 1;48(3):499-505 - PubMed
  55. RNA. 2001 Aug;7(8):1055-67 - PubMed
  56. Nature. 1985 Sep 19-25;317(6034):230-4 - PubMed
  57. Am J Hum Genet. 1998 Apr;62(4):950-61 - PubMed
  58. J Am Coll Cardiol. 2007 Mar 13;49(10):1071-8 - PubMed
  59. Genetics. 2008 Aug;179(4):1741-56 - PubMed
  60. Circ Res. 2008 Aug 29;103(5):502-8 - PubMed
  61. Angew Chem Int Ed Engl. 2005 Dec 1;44(45):7342-72 - PubMed
  62. Science. 2004 Jul 23;305(5683):525-8 - PubMed
  63. Nat Rev Genet. 2008 Jun;9(6):477-85 - PubMed
  64. Nat Rev Genet. 2002 Nov;3(11):862-71 - PubMed
  65. Med Hypotheses. 2007;68(3):697-704 - PubMed
  66. J Mol Cell Cardiol. 2002 Jul;34(7):689-93 - PubMed
  67. Clin Chim Acta. 2003 Aug;334(1-2):233-9 - PubMed
  68. Hypertension. 1997 Jan;29(1 Pt 2):150-7 - PubMed
  69. Nat Genet. 2002 Dec;32 Suppl:522-5 - PubMed
  70. Nature. 2005 Oct 27;437(7063):1365-9 - PubMed
  71. Trends Genet. 2004 Mar;20(3):136-45 - PubMed
  72. Lancet. 2003 Feb 15;361(9357):598-604 - PubMed
  73. Science. 2002 Aug 16;297(5584):1143 - PubMed
  74. Clin Chem. 2006 Jan;52(1):82-7 - PubMed
  75. FEBS J. 2008 May;275(9):1949-59 - PubMed
  76. Trends Genet. 2002 Feb;18(2):74-82 - PubMed
  77. Curr Mol Med. 2006 Sep;6(6):695-701 - PubMed
  78. Am J Hum Genet. 2009 Feb;84(2):148-61 - PubMed
  79. Curr Opin Nephrol Hypertens. 2006 Mar;15(2):145-51 - PubMed
  80. Proc Natl Acad Sci U S A. 2002 Apr 2;99(7):4602-7 - PubMed
  81. Nat Rev Genet. 2007 Dec;8(12):921-31 - PubMed
  82. Am J Physiol Regul Integr Comp Physiol. 2007 Feb;292(2):R897-901 - PubMed
  83. Am J Hum Genet. 1998 Dec;63(6):1886-97 - PubMed
  84. Proc Natl Acad Sci U S A. 2005 Nov 29;102(48):17442-7 - PubMed
  85. Science. 2007 Jun 1;316(5829):1331-6 - PubMed
  86. Nat Genet. 2007 Oct;39(10):1217-24 - PubMed
  87. Science. 1997 Oct 24;278(5338):605-7 - PubMed
  88. Int J Cardiol. 2000 Jan 15;72(2):151-61 - PubMed
  89. N Engl J Med. 2007 Aug 2;357(5):436-9 - PubMed
  90. Hypertens Res. 2008 Jan;31(1):89-96 - PubMed
  91. Hypertension. 2007 Apr;49(4):857-64 - PubMed
  92. Genomics. 2009 Jan;93(1):22-6 - PubMed
  93. Trends Cardiovasc Med. 2005 May;15(4):130-8 - PubMed
  94. Nature. 1989 Jul 20;340(6230):245-6 - PubMed
  95. Endocrinology. 2003 Jun;144(6):2184-90 - PubMed
  96. Curr Biol. 2002 Nov 19;12(22):1952-8 - PubMed
  97. Nat Rev Genet. 2005 Feb;6(2):109-18 - PubMed
  98. Curr Biol. 2001 Jul 24;11(14):R576-9 - PubMed
  99. Nature. 1987 Dec 10-16;330(6148):576-8 - PubMed
  100. PLoS Genet. 2006 Oct 6;2(10):e150 - PubMed
  101. Am J Hum Genet. 2003 Dec;73(6):1402-22 - PubMed
  102. Chembiochem. 2008 Jun 16;9(9):1342-59 - PubMed
  103. Eur J Heart Fail. 2008 Jan;10(1):3-13 - PubMed
  104. Curr Opin Biotechnol. 2008 Oct;19(5):482-91 - PubMed
  105. Hypertension. 2007 May;49(5):1114-9 - PubMed
  106. Ann Hum Genet. 2002 Nov;66(Pt 5-6):393-405 - PubMed
  107. Nat Rev Genet. 2005 Feb;6(2):95-108 - PubMed
  108. Hypertension. 1997 Dec;30(6):1318-24 - PubMed
  109. Nat Rev Genet. 2005 May;6(5):419-25 - PubMed
  110. Nature. 1999 Dec 2;402(6761 Suppl):C47-52 - PubMed
  111. Hist Philos Life Sci. 2006;28(4):567-93 - PubMed
  112. Nature. 2000 Oct 5;407(6804):651-4 - PubMed
  113. Nature. 2007 Oct 18;449(7164):851-61 - PubMed
  114. J Am Coll Cardiol. 2006 Oct 3;48(7):1289-98 - PubMed
  115. Curr Opin Nephrol Hypertens. 2004 Jan;13(1):101-6 - PubMed
  116. Nature. 2004 Jul 1;430(6995):88-93 - PubMed
  117. J Clin Endocrinol Metab. 1993 Apr;76(4):832-8 - PubMed
  118. Mol Syst Biol. 2008;4:161 - PubMed
  119. Cell Res. 2008 Feb;18(2):224-37 - PubMed
  120. Cell. 2005 Feb 25;120(4):533-44 - PubMed
  121. Nat Biotechnol. 2008 Oct;26(10):1090-2 - PubMed
  122. Cell Mol Life Sci. 2007 Jul;64(14):1752-62 - PubMed
  123. J Biol Chem. 2002 May 10;277(19):16900-5 - PubMed
  124. J Am Coll Cardiol. 2004 Nov 16;44(10):2019-26 - PubMed
  125. Trends Genet. 2003 Nov;19(11):615-22 - PubMed
  126. J Am Coll Cardiol. 2007 Mar 13;49(10):1079-88 - PubMed
  127. Nat Genet. 2007 Jul;39(7 Suppl):S37-42 - PubMed
  128. Science. 2002 Jan 4;295(5552):127-31 - PubMed
  129. Thromb Haemost. 2008 Nov;100(5):738-46 - PubMed
  130. Biomol Eng. 2007 Jun;24(2):169-77 - PubMed
  131. Trends Cardiovasc Med. 2006 Feb;16(2):35-8 - PubMed
  132. Nature. 2001 May 3;411(6833):41-2 - PubMed
  133. Lancet. 2005 Sep 17-23;366(9490):1036-44 - PubMed
  134. JAMA. 2008 Mar 19;299(11):1351-2 - PubMed
  135. Annu Rev Genomics Hum Genet. 2001;2:343-72 - PubMed
  136. PLoS Genet. 2008 May 09;4(5):e1000070 - PubMed
  137. Diabetes. 1999 Dec;48(12):2475-9 - PubMed
  138. Am J Hum Genet. 2007 Jan;80(1):126-39 - PubMed
  139. Nature. 2004 Oct 21;431(7011):931-45 - PubMed
  140. J Lipid Res. 2006 Dec;47(12):2601-13 - PubMed
  141. Trends Genet. 2001 Jul;17(7):388-91 - PubMed
  142. Hum Mol Genet. 2006 Apr 15;15 Spec No 1:R57-66 - PubMed
  143. Proc Natl Acad Sci U S A. 1998 Sep 15;95(19):11389-93 - PubMed
  144. Biochem Biophys Res Commun. 1990 Mar 16;167(2):693-700 - PubMed
  145. Am J Hum Genet. 2002 Aug;71(2):304-11 - PubMed
  146. J Am Coll Cardiol. 2007 Sep 18;50(12):1115-22 - PubMed
  147. Proc Natl Acad Sci U S A. 1991 Nov 1;88(21):9578-82 - PubMed
  148. J Muscle Res Cell Motil. 2003;24(4-6):251-60 - PubMed
  149. Mol Cell. 2007 Dec 14;28(5):730-8 - PubMed
  150. Am J Respir Cell Mol Biol. 2008 Mar;38(3):324-36 - PubMed
  151. Nat Genet. 2005 Jul;37(7):710-7 - PubMed
  152. Nature. 1953 Apr 25;171(4356):737-8 - PubMed
  153. Mamm Genome. 2007 Jul;18(6-7):389-401 - PubMed
  154. Nat Biotechnol. 2004 Oct;22(10):1249-52 - PubMed
  155. Circulation. 2005 May 31;111(21):2837-49 - PubMed
  156. Curr Heart Fail Rep. 2008 Jun;5(2):97-104 - PubMed
  157. J R Soc Interface. 2005 Sep 22;2(4):267-80 - PubMed
  158. J Biosci. 2008 Jun;33(2):171-5 - PubMed
  159. Trends Genet. 2005 Jun;21(6):315-7 - PubMed
  160. Nat Rev Mol Cell Biol. 2005 Feb;6(2):99-111 - PubMed
  161. Cardiol Clin. 2008 Feb;26(1):127-35, viii - PubMed
  162. Nature. 2001 May 10;411(6834):199-204 - PubMed
  163. Nature. 2002 Nov 14;420(6912):206-10 - PubMed
  164. J Pharmacol Exp Ther. 2008 Aug;326(2):380-7 - PubMed
  165. Nat Genet. 2004 May;36(5):512-7 - PubMed
  166. Curr Pharm Des. 2007;13(36):3726-34 - PubMed
  167. Nat Genet. 2009 Jan;41(1):18-24 - PubMed
  168. J Nat Prod. 2005 Dec;68(12):1813-20 - PubMed
  169. Am J Hum Genet. 1996 Nov;59(5):983-9 - PubMed
  170. Am J Hum Genet. 1998 Feb;62(2):450-8 - PubMed
  171. Trends Genet. 2003 Oct;19(10):551-60 - PubMed
  172. Clin Chem. 2006 Jun;52(6):1054-61 - PubMed
  173. Nature. 2006 Nov 23;444(7118):444-54 - PubMed
  174. Am J Hum Genet. 2000 Jul;67(1):146-54 - PubMed
  175. Science. 2007 Apr 27;316(5824):550-1 - PubMed

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