Display options
Cite
Bidulescu A, Choudhry S, Musani SK, et al. Associations of adiponectin with individual European ancestry in African Americans: the Jackson Heart Study. Front Genet. 2014;5:22doi: 10.3389/fgene.2014.00022.
Bidulescu, A., Choudhry, S., Musani, S. K., Buxbaum, S. G., Liu, J., Rotimi, C. N., Wilson, J. G., Taylor, H. A., & Gibbons, G. H. (2014). Associations of adiponectin with individual European ancestry in African Americans: the Jackson Heart Study. Frontiers in genetics, 522. https://doi.org/10.3389/fgene.2014.00022
Bidulescu, Aurelian, et al. "Associations of adiponectin with individual European ancestry in African Americans: the Jackson Heart Study." Frontiers in genetics vol. 5 (2014): 22. doi: https://doi.org/10.3389/fgene.2014.00022
Bidulescu A, Choudhry S, Musani SK, Buxbaum SG, Liu J, Rotimi CN, Wilson JG, Taylor HA, Gibbons GH. Associations of adiponectin with individual European ancestry in African Americans: the Jackson Heart Study. Front Genet. 2014 Feb 10;5:22. doi: 10.3389/fgene.2014.00022. eCollection 2014. PMID: 24575123; PMCID: PMC3918651.
Copy Download .nbib Format: NLM
Share it on

Front Genet. 2014 Feb 10;5:22. doi: 10.3389/fgene.2014.00022. eCollection 2014.

Associations of adiponectin with individual European ancestry in African Americans: the Jackson Heart Study.

Frontiers in genetics

Aurelian Bidulescu, Shweta Choudhry, Solomon K Musani, Sarah G Buxbaum, Jiankang Liu, Charles N Rotimi, James G Wilson, Herman A Taylor, Gary H Gibbons

Affiliations

  1. Department of Epidemiology and Biostatistics, Indiana University School of Public Health - Bloomington Bloomington, IN, USA.
  2. Department of Urology, University of California San Francisco, CA, USA.
  3. Jackson Heart Study, University of Mississippi Medical Center Jackson, MS, USA.
  4. Department of Health Sciences, Jackson State University Jackson, MS, USA.
  5. National Human Genome Research Institute, National Institutes of Health Bethesda, MD, USA.
  6. National Heart Lung and Blood Institute, National Institutes of Health Bethesda, MD, USA.

PMID: 24575123 PMCID: PMC3918651 DOI: 10.3389/fgene.2014.00022

Abstract

BACKGROUND: Compared with European Americans, African Americans (AAs) exhibit lower levels of the cardio-metabolically protective adiponectin even after accounting for adiposity measures. Because few studies have examined in AA the association between adiponectin and genetic admixture, a dense panel of ancestry informative markers (AIMs) was used to estimate the individual proportions of European ancestry (PEA) for the AAs enrolled in a large community-based cohort, the Jackson Heart Study (JHS). We tested the hypothesis that plasma adiponectin and PEA are directly associated and assessed the interaction with a series of cardio-metabolic risk factors.

METHODS: Plasma specimens from 1439 JHS participants were analyzed by ELISA for adiponectin levels. Using pseudo-ancestral population genotype data from the HapMap Consortium, PEA was estimated with a panel of up to 1447 genome-wide preselected AIMs by a maximum likelihood approach. Interaction assessment, stepwise linear and cubic multivariable-adjusted regression models were used to analyze the cross-sectional association between adiponectin and PEA.

RESULTS: Among the study participants (62% women; mean age 48 ± 12 years), the median (interquartile range) of PEA was 15.8 (9.3)%. Body mass index (BMI) (p = 0.04) and insulin resistance (p = 0.0001) modified the association between adiponectin and PEA. Adiponectin was directly and linearly associated with PEA (β = 0.62 ± 0.28, p = 0.03) among non-obese (n = 673) and insulin sensitive participants (n = 1141; β = 0.74 ± 0.23, p = 0.001), but not among those obese or with insulin resistance. No threshold point effect was detected for non-obese participants.

CONCLUSIONS: In a large AA population, the individual proportion of European ancestry was linearly and directly associated with plasma adiponectin among non-obese and non insulin-resistant participants, pointing to the interaction of genetic and metabolic factors influencing adiponectin levels.

Keywords: African Americans; adiponectin; cohort study; individual European ancestry; insulin resistance; minorities; obesity

References

  1. Am J Hum Genet. 2005 Feb;76(2):268-75 - PubMed
  2. Hum Genet. 2007 Jun;121(5):615-24 - PubMed
  3. Metabolism. 2004 Jan;53(1):1-3 - PubMed
  4. BMC Cardiovasc Disord. 2013 Feb 22;13:9 - PubMed
  5. Am J Hum Genet. 1998 Dec;63(6):1839-51 - PubMed
  6. Circ Cardiovasc Genet. 2009 Dec;2(6):629-36 - PubMed
  7. Diabetes Care. 2007 May;30(5):1200-5 - PubMed
  8. Ethn Dis. 2005 Autumn;15(4 Suppl 6):S6-1-3 - PubMed
  9. Diabetologia. 1985 Jul;28(7):412-9 - PubMed
  10. Am J Med Sci. 2004 Sep;328(3):131-44 - PubMed
  11. Vasc Med. 2010 Oct;15(5):351-9 - PubMed
  12. Metabolism. 2006 Nov;55(11):1551-7 - PubMed
  13. Trends Cardiovasc Med. 2006 Jul;16(5):141-6 - PubMed
  14. Am J Nephrol. 2010;31(3):202-8 - PubMed
  15. Ann Hum Genet. 2004 Mar;68(Pt 2):139-53 - PubMed
  16. J Clin Endocrinol Metab. 2005 Mar;90(3):1434-9 - PubMed
  17. Metabolism. 2007 Feb;56(2):234-8 - PubMed
  18. Genet Epidemiol. 1986;3(6):435-54 - PubMed
  19. Hum Genet. 2005 Dec;118(3-4):424-33 - PubMed
  20. Nat Genet. 2005 Aug;37(8):868-72 - PubMed
  21. N Engl J Med. 2003 Mar 20;348(12):1170-5 - PubMed
  22. Ethn Dis. 2005 Autumn;15(4 Suppl 6):S6-56-61 - PubMed
  23. Hum Genet. 2003 Apr;112(4):387-99 - PubMed
  24. Genetics. 1991 Feb;127(2):417-28 - PubMed
  25. Diabetes. 2013 Oct;62(10):3589-98 - PubMed
  26. Circ Heart Fail. 2011 Nov;4(6):747-53 - PubMed
  27. JAMA. 2009 Jul 8;302(2):179-88 - PubMed
  28. PLoS Genet. 2012;8(3):e1002607 - PubMed
  29. Eur J Endocrinol. 2004 May;150(5):715-8 - PubMed
  30. BMC Endocr Disord. 2013 Oct 16;13:47 - PubMed
  31. Diabetes. 2004 Sep;53(9):2473-8 - PubMed
  32. Ethn Dis. 2003 Fall;13(4):438-55 - PubMed
  33. Circulation. 2014 Jan 21;129(3):e28-e292 - PubMed
  34. Genome Biol. 2002 Jul 1;3(7):comment2007 - PubMed
  35. Front Public Health. 2013 May 24;1:16 - PubMed
  36. Am J Hum Genet. 2000 Jul;67(1):170-81 - PubMed
  37. Obesity (Silver Spring). 2007 May;15(5):1207-14 - PubMed
  38. Am J Hum Genet. 2008 Sep;83(3):322-36 - PubMed
  39. J Clin Endocrinol Metab. 2001 Sep;86(9):4321-5 - PubMed
  40. Circ Cardiovasc Genet. 2010 Jun;3(3):267-75 - PubMed
  41. Diabetes. 2007 May;56(5):1198-209 - PubMed
  42. Am J Phys Anthropol. 1986 Aug;70(4):433-41 - PubMed
  43. Aliment Pharmacol Ther. 2005 Nov;22 Suppl 2:3-10 - PubMed
  44. Diabetologia. 2003 Apr;46(4):459-69 - PubMed
  45. Am J Phys Anthropol. 2001 Jan;114(1):18-29 - PubMed
  46. Am J Hum Genet. 2004 May;74(5):1001-13 - PubMed
  47. Eur J Endocrinol. 2007 Aug;157(2):181-8 - PubMed
  48. Am J Phys Anthropol. 1986 Aug;70(4):489-503 - PubMed

Publication Types

Grant support