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Parsa A, Kanetsky PA, Xiao R, et al. Genome-Wide Association of CKD Progression: The Chronic Renal Insufficiency Cohort Study. J Am Soc Nephrol. 2016;28(3):923-934doi: 10.1681/ASN.2015101152.
Parsa, A., Kanetsky, P. A., Xiao, R., Gupta, J., Mitra, N., Limou, S., Xie, D., Xu, H., Anderson, A. H., Ojo, A., Kusek, J. W., Lora, C. M., Hamm, L. L., He, J., Sandholm, N., Jeff, J., Raj, D. E., Böger, C. A., Bottinger, E., Salimi, S., Parekh, R. S., Adler, S. G., Langefeld, C. D., Bowden, D. W., Groop, P. H., Forsblom, C., Freedman, B. I., Lipkowitz, M., Fox, C. S., Winkler, C. A., Feldman, H. I. (2017). Genome-Wide Association of CKD Progression: The Chronic Renal Insufficiency Cohort Study. Journal of the American Society of Nephrology : JASN, 28(3), 923-934. https://doi.org/10.1681/ASN.2015101152
Parsa, Afshin, et al. "Genome-Wide Association of CKD Progression: The Chronic Renal Insufficiency Cohort Study." Journal of the American Society of Nephrology : JASN vol. 28,3 (2017): 923-934. doi: https://doi.org/10.1681/ASN.2015101152
Parsa A, Kanetsky PA, Xiao R, Gupta J, Mitra N, Limou S, Xie D, Xu H, Anderson AH, Ojo A, Kusek JW, Lora CM, Hamm LL, He J, Sandholm N, Jeff J, Raj DE, Böger CA, Bottinger E, Salimi S, Parekh RS, Adler SG, Langefeld CD, Bowden DW, Groop PH, Forsblom C, Freedman BI, Lipkowitz M, Fox CS, Winkler CA, Feldman HI. Genome-Wide Association of CKD Progression: The Chronic Renal Insufficiency Cohort Study. J Am Soc Nephrol. 2017 Mar;28(3):923-934. doi: 10.1681/ASN.2015101152. Epub 2016 Oct 11. PMID: 27729571; PMCID: PMC5328149.
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J Am Soc Nephrol. 2017 Mar;28(3):923-934. doi: 10.1681/ASN.2015101152. Epub 2016 Oct 11.

Genome-Wide Association of CKD Progression: The Chronic Renal Insufficiency Cohort Study.

Journal of the American Society of Nephrology : JASN

Afshin Parsa, Peter A Kanetsky, Rui Xiao, Jayanta Gupta, Nandita Mitra, Sophie Limou, Dawei Xie, Huichun Xu, Amanda Hyre Anderson, Akinlolu Ojo, John W Kusek, Claudia M Lora, L Lee Hamm, Jiang He, Niina Sandholm, Janina Jeff, Dominic E Raj, Carsten A Böger, Erwin Bottinger, Shabnam Salimi, Rulan S Parekh, Sharon G Adler, Carl D Langefeld, Donald W Bowden, Per-Henrik Groop, Carol Forsblom, Barry I Freedman, Michael Lipkowitz, Caroline S Fox, Cheryl A Winkler, Harold I Feldman,

Affiliations

  1. Division of Nephrology and [email protected].
  2. Department of Medicine, Baltimore Veterans Affairs Medical Center, Baltimore, Maryland.
  3. Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.
  4. Department of Biostatistics and Epidemiology and.
  5. Department of Health Sciences, College of Health Professions and Social Work, Florida Gulf Coast University, Fort Myers, FL.
  6. Molecular Genetic Epidemiology Section, Basic Research Laboratory, Center for Cancer Research, National Cancer Institute and Basic Science Program, Leidos Biomedical Research, Inc., Frederick National Laboratory, Frederick, Maryland.
  7. Departments of Medicine and.
  8. Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania.
  9. Division of Nephrology, University of Michigan, Ann Arbor, Michigan.
  10. Division of Kidney, Urologic and Hematologic Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland.
  11. Department of Medicine, Division of Nephrology, University of Illinois at Chicago, Chicago, Illinois.
  12. Department of Medicine, Section of Nephrology, Tulane University, New Orleans, Louisiana.
  13. Folkhälsan Institute of Genetics, Folkhälsan Research Center, Helsinki, Finland.
  14. Abdominal Center Nephrology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
  15. Research Programs Unit, Diabetes and Obesity, University of Helsinki, Helsinki, Finland.
  16. Department of Medicine, The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine Mount Sinai, New York, New York.
  17. Department of Medicine, The George Washington University School of Medicine, Washington, DC.
  18. Department of Nephrology, University Hospital Regensburg, Regensburg, Germany.
  19. Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland.
  20. Division of Nephrology, Department of Pediatrics and Medicine, Hospital for Sick Children, University Health Network and the University of Toronto, Toronto, Ontario, Canada.
  21. Department of Medicine, Division of Nephrology and Hypertension, Harbor-University of California, Los Angeles Medical Center, Los Angeles, California.
  22. Departments of Biostatistical Sciences and.
  23. Biochemistry and.
  24. Department of Internal Medicine, Section on Nephrology, Wake Forest School of Medicine, Winston-Salem, North Carolina.
  25. Department of Medicine, Georgetown University Medical Center, Washington, DC; and.
  26. Division of Intramural Research, National Heart, Lung and Blood Institute's Framingham Heart Study, National Heart, Lung and Blood Institute, Framingham, Massachusetts.

PMID: 27729571 PMCID: PMC5328149 DOI: 10.1681/ASN.2015101152

Abstract

The rate of decline of renal function varies significantly among individuals with CKD. To understand better the contribution of genetics to CKD progression, we performed a genome-wide association study among participants in the Chronic Renal Insufficiency Cohort Study. Our outcome of interest was CKD progression measured as change in eGFR over time among 1331 blacks and 1476 whites with CKD. We stratified all analyses by race and subsequently, diabetes status. Single-nucleotide polymorphisms (SNPs) that surpassed a significance threshold of

Copyright © 2017 by the American Society of Nephrology.

Keywords: chronic kidney disease; human genetics; polymorphisms; progression of chronic renal failure

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