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Sun Y, Zeng X, Xiao Y, et al. Novel dual-function near-infrared II fluorescence and PET probe for tumor delineation and image-guided surgery. Chem Sci. 2018;9(8):2092-2097doi: 10.1039/c7sc04774f.
Sun, Y., Zeng, X., Xiao, Y., Liu, C., Zhu, H., Zhou, H., Chen, Z., Xu, F., Wang, J., Zhu, M., Wu, J., Tian, M., Zhang, H., Deng, Z., Cheng, Z., & Hong, X. (2018). Novel dual-function near-infrared II fluorescence and PET probe for tumor delineation and image-guided surgery. Chemical science, 9(8), 2092-2097. https://doi.org/10.1039/c7sc04774f
Sun, Yao, et al. "Novel dual-function near-infrared II fluorescence and PET probe for tumor delineation and image-guided surgery." Chemical science vol. 9,8 (2018): 2092-2097. doi: https://doi.org/10.1039/c7sc04774f
Sun Y, Zeng X, Xiao Y, Liu C, Zhu H, Zhou H, Chen Z, Xu F, Wang J, Zhu M, Wu J, Tian M, Zhang H, Deng Z, Cheng Z, Hong X. Novel dual-function near-infrared II fluorescence and PET probe for tumor delineation and image-guided surgery. Chem Sci. 2018 Jan 08;9(8):2092-2097. doi: 10.1039/c7sc04774f. eCollection 2018 Feb 28. PMID: 29675250; PMCID: PMC5892408.
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Chem Sci. 2018 Jan 08;9(8):2092-2097. doi: 10.1039/c7sc04774f. eCollection 2018 Feb 28.

Novel dual-function near-infrared II fluorescence and PET probe for tumor delineation and image-guided surgery.

Chemical science

Yao Sun, Xiaodong Zeng, Yuling Xiao, Changhao Liu, Hua Zhu, Hui Zhou, Ziyang Chen, Fuchun Xu, Jule Wang, Mengyue Zhu, Junzhu Wu, Mei Tian, Hong Zhang, Zixin Deng, Zhen Cheng, Xuechuan Hong

Affiliations

  1. State Key Laboratory of Virology , Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (MOE) and Hubei Province Engineering and Technology Research Center for Fluorinated Pharmaceuticals , Wuhan University School of Pharmaceutical Sciences , Wuhan 430071 , China . Email: [email protected].
  2. Key Laboratory of Pesticides and Chemical Biology , Ministry of Education , College of Chemistry , Central China Normal University , Wuhan 430079 , China.
  3. Molecular Imaging Program at Stanford (MIPS) , Bio-X Program , Department of Radiology , Stanford University , CA 94305 , USA . Email: [email protected].
  4. Medical College , Tibet University , Lasa , 850000 , China.
  5. Hubei Provincial Key Laboratory of Developmentally Originated Disease , Center for Experimental Basic Medical Education , Wuhan University , Wuhan 430071 , China.
  6. Department of Nuclear Medicine , The Second Hospital of Zhejiang University School of Medicine , 88 Jiefang Road , Hangzhou , 310009 , China . Email: [email protected].

PMID: 29675250 PMCID: PMC5892408 DOI: 10.1039/c7sc04774f

Abstract

Accurate tumor identification is essential in cancer management. Incomplete excision of tumor tissue, however, negatively affects the prognosis of the patient. To accomplish radical excision of tumor tissue, radiotracers can be used that target tumor tissue and can be detected using a gamma probe during surgery. Intraoperative fluorescence imaging could allow accurate real-time tumor delineation. Herein, a novel dual-modal imaging platform using base-catalyzed double addition of thiols into a propiolamide scaffold has been developed, allowing for the highly efficient and selective assembly of various thiol units in a protecting-group-free manner. The first small-molecule based αvβ

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