Display options
Cite
Shen LL, Jin Y. Effects of MTNR1B genetic variants on the risk of type 2 diabetes mellitus: A meta-analysis. Mol Genet Genomic Med. 2019;7(5):e611doi: 10.1002/mgg3.611.
Shen, L. L., & Jin, Y. (2019). Effects of MTNR1B genetic variants on the risk of type 2 diabetes mellitus: A meta-analysis. Molecular genetics & genomic medicine, 7(5), e611. https://doi.org/10.1002/mgg3.611
Shen, Ling-Long, and Jin, Yin. "Effects of MTNR1B genetic variants on the risk of type 2 diabetes mellitus: A meta-analysis." Molecular genetics & genomic medicine vol. 7,5 (2019): e611. doi: https://doi.org/10.1002/mgg3.611
Shen LL, Jin Y. Effects of MTNR1B genetic variants on the risk of type 2 diabetes mellitus: A meta-analysis. Mol Genet Genomic Med. 2019 May;7(5):e611. doi: 10.1002/mgg3.611. Epub 2019 Feb 27. PMID: 30811895; PMCID: PMC6503061.
Copy Download .nbib Format: NLM
Share it on

Mol Genet Genomic Med. 2019 May;7(5):e611. doi: 10.1002/mgg3.611. Epub 2019 Feb 27.

Effects of MTNR1B genetic variants on the risk of type 2 diabetes mellitus: A meta-analysis.

Molecular genetics & genomic medicine

Ling-Long Shen, Yin Jin

Affiliations

  1. Department of Clinical Laboratory, Huzhou Maternity and Child Health Care Hospital, Huzhou, China.
  2. Department of Clinical Laboratory, Huzhou Central Hospital, Huzhou, China.

PMID: 30811895 PMCID: PMC6503061 DOI: 10.1002/mgg3.611

Abstract

BACKGROUND: Whether melatonin receptor 1B (MTNR1B) variants are associated with type 2 diabetes mellitus (T2DM) remains unclear. Therefore, we performed this meta-analysis to better explore correlations between MTNR1B variants and T2DM.

METHODS: Literature research was performed in PubMed, Medline, and Embase. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated.

RESULTS: Totally 21 studies were enrolled to analyses. Pooled overall analyses showed that MTNR1B rs10830963 variant was significantly correlated with the susceptibility to T2DM (allele model: p = 0.02, OR = 0.97, 95% CI 0.95-1.00). Further subgroup analyses by ethnicity of participants revealed that rs10830963 variant was significantly correlated with the susceptibility to T2DM in South Asians, but not in Caucasians or East Asians. No any other positive results were found in overall and subgroup analyses.

CONCLUSIONS: Our findings indicated that MTNR1B rs10830963 variant might serve as a genetic biomarker of T2DM, especially in South Asians.

© 2019 The Authors. Molecular Genetics & Genomic Medicine published by Wiley Periodicals, Inc.

Keywords: genetic variants; melatonin receptor 1B (MTNR1B); meta-analysis; type 2 diabetes mellitus (T2DM)

References

  1. World J Diabetes. 2011 Jun 15;2(6):82-91 - PubMed
  2. Nat Rev Endocrinol. 2018 Feb;14(2):88-98 - PubMed
  3. Diabetes. 2016 Jun;65(6):1490-2 - PubMed
  4. Diabetes Care. 2014 Jan;37 Suppl 1:S81-90 - PubMed
  5. PLoS One. 2008;3(12):e3962 - PubMed
  6. Clin Exp Hypertens. 2017;39(2):175-182 - PubMed
  7. Eur J Pharmacol. 2014 Dec 5;744:220-3 - PubMed
  8. Scand J Immunol. 2017 Jul;86(1):50-58 - PubMed
  9. Neurochirurgie. 2015 Apr-Jun;61(2-3):77-84 - PubMed
  10. Mol Genet Genomic Med. 2019 May;7(5):e611 - PubMed
  11. Int J Mol Med. 2018 Feb;41(2):955-961 - PubMed
  12. Ann Intern Med. 2009 Aug 18;151(4):264-9, W64 - PubMed
  13. Curr Diabetes Rev. 2017;13(1):19-25 - PubMed
  14. Eur J Epidemiol. 2010 Sep;25(9):603-5 - PubMed
  15. Curr Diab Rep. 2017 Sep;17(9):72 - PubMed
  16. Drug Discov Today. 2014 Sep;19(9):1410-8 - PubMed
  17. Curr Pharm Des. 2014;20(30):4841-53 - PubMed
  18. J Obstet Gynaecol Res. 2016 Jul;42(7):844-54 - PubMed

Substances

MeSH terms

Publication Types