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Scott JM, Downs M, Buxton R, et al. Disuse-Induced Muscle Loss and Rehabilitation: The National Aeronautics and Space Administration Bed Rest Study. Crit Care Explor. 2020;2(12):e0269doi: 10.1097/CCE.0000000000000269.
Scott, J. M., Downs, M., Buxton, R., Goetchius, E., Crowell, B., Ploutz-Snyder, R., Hackney, K. J., Ryder, J., English, K., & Ploutz-Snyder, L. L. (2020). Disuse-Induced Muscle Loss and Rehabilitation: The National Aeronautics and Space Administration Bed Rest Study. Critical care explorations, 2(12), e0269. https://doi.org/10.1097/CCE.0000000000000269
Scott, Jessica M, et al. "Disuse-Induced Muscle Loss and Rehabilitation: The National Aeronautics and Space Administration Bed Rest Study." Critical care explorations vol. 2,12 (2020): e0269. doi: https://doi.org/10.1097/CCE.0000000000000269
Scott JM, Downs M, Buxton R, Goetchius E, Crowell B, Ploutz-Snyder R, Hackney KJ, Ryder J, English K, Ploutz-Snyder LL. Disuse-Induced Muscle Loss and Rehabilitation: The National Aeronautics and Space Administration Bed Rest Study. Crit Care Explor. 2020 Nov 24;2(12):e0269. doi: 10.1097/CCE.0000000000000269. eCollection 2020 Dec. PMID: 33251515; PMCID: PMC7688251.
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Crit Care Explor. 2020 Nov 24;2(12):e0269. doi: 10.1097/CCE.0000000000000269. eCollection 2020 Dec.

Disuse-Induced Muscle Loss and Rehabilitation: The National Aeronautics and Space Administration Bed Rest Study.

Critical care explorations

Jessica M Scott, Meghan Downs, Roxanne Buxton, Elizabeth Goetchius, Brent Crowell, Robert Ploutz-Snyder, Kyle J Hackney, Jeffrey Ryder, Kirk English, Lori L Ploutz-Snyder

Affiliations

  1. Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.
  2. Weill Cornell Medical College, New York, NY.
  3. Human Physiology, Performance, Protection and Operations, National Aeronautics and Space Administration (NASA), Houston, TX.
  4. Human Physiology, Performance, Protection and Operations, University of Houston, Houston, TX.
  5. Human Physiology, Performance, Protection and Operations, MEI Technologies, Houston, TX.
  6. Department of Systems, Populations and Leadership, University of Michigan, Ann Arbor, MI.
  7. Department of Health, Nutrition, and Exercise Sciences, North Dakota State University, Fargo, ND.
  8. Human Physiology, Performance, Protection and Operations, KBR, Houston, TX.
  9. Department of Clinical, Health and Applied Sciences, University of Houston-Clear Lake, Houston, TX.
  10. Exercise and Nutritional Health Institute, Houston, TX.

PMID: 33251515 PMCID: PMC7688251 DOI: 10.1097/CCE.0000000000000269

Abstract

OBJECTIVES: The time course and magnitude of atrophic remodeling and the effects of an acute rehabilitation program on muscle atrophy are unclear. We sought to characterize bed rest-induced leg muscle atrophy and evaluate the safety and efficacy of an acute rehabilitation program.

DESIGN: Prespecified analysis of a randomized controlled trial.

SETTING: Single-center urban hospital.

PATIENTS: Adults (24-55 yr) randomized to 70 days of sedentary bed rest.

INTERVENTIONS: The 11-day post-bed rest rehabilitation program consisted of low intensity exercise and progressed to increased aerobic exercise duration, plyometric exercises, and higher intensity resistance exercise.

MEASUREMENTS AND MAIN RESULTS: Upper (rectus femoris, vastus lateralis, quadriceps, hamstrings, adductors) and lower leg (medial gastrocnemius, lateral gastrocnemius, and soleus) MRI scans were obtained once before, nine times during, and three times after bed rest to assess muscle cross-sectional area. The magnitude and rate of muscle atrophy and recovery were determined for each muscle. Nine participants completed 70 days of sedentary bed rest and an 11-day rehabilitation program. A total of 11,588 muscle cross-sectional area images were quantified. Across all muscles except the rectus femoris (no change), there was a linear decline during bed rest, with the highest atrophic rate occurring in the soleus (-0.33%/d). Following rehabilitation, there was rapid recovery in all muscles; however, the quadriceps (-3.74 cm

CONCLUSIONS: Bed rest results in upper and lower leg muscle atrophy in a linear pattern, and an 11-day rehabilitation program was safe and effective in initiating a rapid trajectory of muscle recovery. These findings provide important information regarding the design and refinement of rehabilitation programs following bed rest.

Keywords: atrophy; exercise; magnetic resonance imaging

Conflict of interest statement

Dr. Scott is supported by research grants from AKTIV Against Cancer and the Memorial Sloan Kettering Cancer Center Support Grant/Core Grant (P30 CA008748). The remaining authors have disclosed that th

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