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Yuan C, Zhang X, Babic A, et al. Preexisting Type 2 Diabetes and Survival among Patients with Colorectal Cancer. Cancer Epidemiol Biomarkers Prev. 2021;30(4):757-764doi: 10.1158/1055-9965.EPI-20-1083.
Yuan, C., Zhang, X., Babic, A., Morales-Oyarvide, V., Zhang, Y., Smith-Warner, S. A., Wu, K., Wang, M., Wolpin, B. M., Meyerhardt, J. A., Chan, A. T., Hu, F. B., Fuchs, C. S., Ogino, S., Giovannucci, E. L., & Ng, K. (2021). Preexisting Type 2 Diabetes and Survival among Patients with Colorectal Cancer. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 30(4), 757-764. https://doi.org/10.1158/1055-9965.EPI-20-1083
Yuan, Chen, et al. "Preexisting Type 2 Diabetes and Survival among Patients with Colorectal Cancer." Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology vol. 30,4 (2021): 757-764. doi: https://doi.org/10.1158/1055-9965.EPI-20-1083
Yuan C, Zhang X, Babic A, Morales-Oyarvide V, Zhang Y, Smith-Warner SA, Wu K, Wang M, Wolpin BM, Meyerhardt JA, Chan AT, Hu FB, Fuchs CS, Ogino S, Giovannucci EL, Ng K. Preexisting Type 2 Diabetes and Survival among Patients with Colorectal Cancer. Cancer Epidemiol Biomarkers Prev. 2021 Apr;30(4):757-764. doi: 10.1158/1055-9965.EPI-20-1083. Epub 2021 Feb 02. PMID: 33531435; PMCID: PMC8026573.
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Cancer Epidemiol Biomarkers Prev. 2021 Apr;30(4):757-764. doi: 10.1158/1055-9965.EPI-20-1083. Epub 2021 Feb 02.

Preexisting Type 2 Diabetes and Survival among Patients with Colorectal Cancer.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology

Chen Yuan, Xuehong Zhang, Ana Babic, Vicente Morales-Oyarvide, Yin Zhang, Stephanie A Smith-Warner, Kana Wu, Molin Wang, Brian M Wolpin, Jeffrey A Meyerhardt, Andrew T Chan, Frank B Hu, Charles S Fuchs, Shuji Ogino, Edward L Giovannucci, Kimmie Ng

Affiliations

  1. Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts. [email protected].
  2. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
  3. Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
  4. Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
  5. Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts.
  6. Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
  7. Clinical and Translational Epidemiology Unit and Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.
  8. Broad Institute of MIT and Harvard, Cambridge, Massachusetts.
  9. Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
  10. Yale Cancer Center, Smilow Cancer Hospital, New Haven, Connecticut.
  11. Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
  12. Department of Oncologic Pathology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts.

PMID: 33531435 PMCID: PMC8026573 DOI: 10.1158/1055-9965.EPI-20-1083

Abstract

BACKGROUND: Type 2 diabetes increases risk of developing colorectal cancer, but the association of preexisting diabetes with colorectal cancer survival remains unclear.

METHODS: We analyzed survival by diabetes status at cancer diagnosis among 4,038 patients with colorectal cancer from two prospective U.S. cohorts. Cox proportional hazards regression was used to calculate HRs and 95% confidence intervals (CI) for overall and cause-specific mortality, with adjustment for tumor characteristics and lifestyle factors.

RESULTS: In the first 5 years after colorectal cancer diagnosis, diabetes was associated with a modest increase in overall mortality in women (HR, 1.22; 95% CI, 1.00-1.49), but not in men (HR, 0.83; 95% CI, 0.62-1.12;

CONCLUSIONS: Among patients with colorectal cancer, preexisting diabetes was associated with increased risk of long-term mortality, particularly from other malignancies and cardiovascular disease.

IMPACT: Our findings highlight the importance of cardioprotection and cancer prevention to colorectal cancer survivors with diabetes.

©2021 American Association for Cancer Research.

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