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Zhang C, Li Y, Ma X, et al. Functional micro/nanobubbles for ultrasound medicine and visualizable guidance. Sci China Chem. 2021;1-16doi: 10.1007/s11426-020-9945-4.
Zhang, C., Li, Y., Ma, X., He, W., Liu, C., & Liu, Z. (2021). Functional micro/nanobubbles for ultrasound medicine and visualizable guidance. Science China. Chemistry, 1-16. https://doi.org/10.1007/s11426-020-9945-4
Zhang, Chen, et al. "Functional micro/nanobubbles for ultrasound medicine and visualizable guidance." Science China. Chemistry vol. (2021): 1-16. doi: https://doi.org/10.1007/s11426-020-9945-4
Zhang C, Li Y, Ma X, He W, Liu C, Liu Z. Functional micro/nanobubbles for ultrasound medicine and visualizable guidance. Sci China Chem. 2021 Feb 25;1-16. doi: 10.1007/s11426-020-9945-4. Epub 2021 Feb 25. PMID: 33679901; PMCID: PMC7921288.
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Sci China Chem. 2021 Feb 25;1-16. doi: 10.1007/s11426-020-9945-4. Epub 2021 Feb 25.

Functional micro/nanobubbles for ultrasound medicine and visualizable guidance.

Science China. Chemistry

Chen Zhang, Yihong Li, Xinyong Ma, Wenxin He, Chenxi Liu, Zhe Liu

Affiliations

  1. Academy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin, 300072 China.
  2. Tianjin Key Laboratory of Brain Science and Neural Engineering, Tianjin University, Tianjin, 300072 China.
  3. Division of Academic & Cultural Activities, Academic Divisions of the Chinese Academy of Sciences, Beijing, 100190 China.

PMID: 33679901 PMCID: PMC7921288 DOI: 10.1007/s11426-020-9945-4

Abstract

Chemically functionalized gas-filled bubbles with a versatile micro/nano-sized scale have witnessed a long history of developments and emerging applications in disease diagnosis and treatments. In combination with ultrasound and image-guidance, micro/nanobubbles have been endowed with the capabilities of biomedical imaging, drug delivery, gene transfection and disease-oriented therapy. As an external stimulus, ultrasound (US)-mediated targeting treatments have been achieving unprecedented efficiency. Nowadays, US is playing a crucial role in visualizing biological/pathological changes in lives as a reliable imaging technique and a powerful therapeutic tool. This review retrospects the history of ultrasound, the chemistry of functionalized agents and summarizes recent advancements of functional micro/nanobubbles as US contrast agents in preclinical and trans-clinical research. Latest ultrasound-based treatment modalities in association with functional micro/nanobubbles have been highlighted as their great potentials for disease precision therapy. It is believed that these state-of-the-art micro/nanobubbles will become a booster for ultrasound medicine and visualizable guidance to serve future human healthcare in a more comprehensive and practical manner.

© Science China Press and Springer-Verlag GmbH Germany, part of Springer Nature 2021.

Keywords: drug delivery; functional biomaterials; image guidance; ultrasound; visualizable medicine

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