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Kehm RD, MacInnis RJ, John EM, et al. Recreational Physical Activity and Outcomes After Breast Cancer in Women at High Familial Risk. JNCI Cancer Spectr. 2021;5(6):pkab090doi: 10.1093/jncics/pkab090.
Kehm, R. D., MacInnis, R. J., John, E. M., Liao, Y., Kurian, A. W., Genkinger, J. M., Knight, J. A., Colonna, S. V., Chung, W. K., Milne, R., Zeinomar, N., Dite, G. S., Southey, M. C., Giles, G. G., McLachlan, S. A., Whitaker, K. D., Friedlander, M. L., Weideman, P. C., Glendon, G., Nesci, S., Phillips, K. A., Andrulis, I. L., Buys, S. S., Daly, M. B., Hopper, J. L., & Terry, M. B. (2021). Recreational Physical Activity and Outcomes After Breast Cancer in Women at High Familial Risk. JNCI cancer spectrum, 5(6), pkab090. https://doi.org/10.1093/jncics/pkab090
Kehm, Rebecca D, et al. "Recreational Physical Activity and Outcomes After Breast Cancer in Women at High Familial Risk." JNCI cancer spectrum vol. 5,6 (2021): pkab090. doi: https://doi.org/10.1093/jncics/pkab090
Kehm RD, MacInnis RJ, John EM, Liao Y, Kurian AW, Genkinger JM, Knight JA, Colonna SV, Chung WK, Milne R, Zeinomar N, Dite GS, Southey MC, Giles GG, McLachlan SA, Whitaker KD, Friedlander ML, Weideman PC, Glendon G, Nesci S, Phillips KA, Andrulis IL, Buys SS, Daly MB, Hopper JL, Terry MB. Recreational Physical Activity and Outcomes After Breast Cancer in Women at High Familial Risk. JNCI Cancer Spectr. 2021 Dec 08;5(6):pkab090. doi: 10.1093/jncics/pkab090. eCollection 2021 Dec. PMID: 34950851; PMCID: PMC8692829.
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JNCI Cancer Spectr. 2021 Dec 08;5(6):pkab090. doi: 10.1093/jncics/pkab090. eCollection 2021 Dec.

Recreational Physical Activity and Outcomes After Breast Cancer in Women at High Familial Risk.

JNCI cancer spectrum

Rebecca D Kehm, Robert J MacInnis, Esther M John, Yuyan Liao, Allison W Kurian, Jeanine M Genkinger, Julia A Knight, Sarah V Colonna, Wendy K Chung, Roger Milne, Nur Zeinomar, Gillian S Dite, Melissa C Southey, Graham G Giles, Sue-Anne McLachlan, Kristen D Whitaker, Michael L Friedlander, Prue C Weideman, Gord Glendon, Stephanie Nesci, Kelly-Anne Phillips, Irene L Andrulis, Saundra S Buys, Mary B Daly, John L Hopper, Mary Beth Terry

Affiliations

  1. Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA.
  2. Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.
  3. Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, Australia.
  4. Department of Medicine and Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA.
  5. Division of Medical Oncology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
  6. Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY, USA.
  7. Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada.
  8. Epidemiology Division, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.
  9. Division of Medical Oncology, Huntsman Cancer Institute, Salt Lake City, UT, USA.
  10. Departments of Pediatrics and Medicine, Columbia University Medical Center, New York, NY, USA.
  11. Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia.
  12. Cancer Epidemiology and Health Outcomes, Rutgers Cancer Institute of New Jersey, Robert Wood Johnson Medical School, New Brunswick, NJ, USA.
  13. Department of Clinical Pathology, The University of Melbourne, Melbourne, Victoria, Australia.
  14. Department of Medicine, St Vincent's Hospital, The University of Melbourne, Melbourne, Victoria, Australia.
  15. Department of Medical Oncology, St Vincent's Hospital, Fitzroy, Melbourne, Victoria, Australia.
  16. Department of Clinical Genetics, Fox Chase Cancer Center, Philadelphia, PA, USA.
  17. Prince of Wales Clinical School, University of New South Wales, Sydney, New South Wales, Australia.
  18. Department of Medical Oncology, Prince of Wales Hospital, Sydney, New South Wales, Australia.
  19. Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
  20. Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Victoria, Australia.
  21. Departments of Molecular Genetics and Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.
  22. Department of Medicine and Huntsman Cancer Institute, University of Utah Health, Salt Lake City, UT, USA.

PMID: 34950851 PMCID: PMC8692829 DOI: 10.1093/jncics/pkab090

Abstract

BACKGROUND: Recreational physical activity (RPA) is associated with improved survival after breast cancer (BC) in average-risk women, but evidence is limited for women who are at increased familial risk because of a BC family history or

METHODS: We estimated associations of RPA (self-reported average hours per week within 3 years of BC diagnosis) with all-cause mortality and second BC events (recurrence or new primary) after first invasive BC in women in the Prospective Family Study Cohort (n = 4610, diagnosed 1993-2011, aged 22-79 years at diagnosis). We fitted Cox proportional hazards regression models adjusted for age at diagnosis, demographics, and lifestyle factors. We tested for multiplicative interactions (Wald test statistic for cross-product terms) and additive interactions (relative excess risk due to interaction) by age at diagnosis, body mass index, estrogen receptor status, stage at diagnosis,

RESULTS: We observed 1212 deaths and 473 second BC events over a median follow-up from study enrollment of 11.0 and 10.5 years, respectively. After adjusting for covariates, RPA (any vs none) was associated with lower all-cause mortality of 16.1% (95% confidence interval [CI] = 2.4% to 27.9%) overall, 11.8% (95% CI = -3.6% to 24.9%) in women without

CONCLUSION: Findings support that RPA is associated with lower all-cause mortality in women with BC, particularly in women with

© The Author(s) 2021. Published by Oxford University Press.

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