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Tabung FK, Wang W, Fung TT, et al. Development and validation of empirical indices to assess the insulinaemic potential of diet and lifestyle. Br J Nutr. 2016;1-12doi: 10.1017/S0007114516003755.
Tabung, F. K., Wang, W., Fung, T. T., Hu, F. B., Smith-Warner, S. A., Chavarro, J. E., Fuchs, C. S., Willett, W. C., & Giovannucci, E. L. (2016). Development and validation of empirical indices to assess the insulinaemic potential of diet and lifestyle. The British journal of nutrition, 1-12. https://doi.org/10.1017/S0007114516003755
Tabung, Fred K, et al. "Development and validation of empirical indices to assess the insulinaemic potential of diet and lifestyle." The British journal of nutrition vol. (2016): 1-12. doi: https://doi.org/10.1017/S0007114516003755
Tabung FK, Wang W, Fung TT, Hu FB, Smith-Warner SA, Chavarro JE, Fuchs CS, Willett WC, Giovannucci EL. Development and validation of empirical indices to assess the insulinaemic potential of diet and lifestyle. Br J Nutr. 2016 Nov 08;1-12. doi: 10.1017/S0007114516003755. Epub 2016 Nov 08. PMID: 27821188; PMCID: PMC5623113.
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Br J Nutr. 2016 Nov 08;1-12. doi: 10.1017/S0007114516003755. Epub 2016 Nov 08.

Development and validation of empirical indices to assess the insulinaemic potential of diet and lifestyle.

The British journal of nutrition

Fred K Tabung, Weike Wang, Teresa T Fung, Frank B Hu, Stephanie A Smith-Warner, Jorge E Chavarro, Charles S Fuchs, Walter C Willett, Edward L Giovannucci

Affiliations

  1. 1Department of Nutrition,Harvard T.H. Chan School of Public Health,Boston, MA 02115,USA.
  2. 4Channing Division of Network Medicine,Brigham and Women's Hospital,Boston, MA 02115,USA.

PMID: 27821188 PMCID: PMC5623113 DOI: 10.1017/S0007114516003755

Abstract

The glycaemic and insulin indices assess postprandial glycaemic and insulin response to foods, respectively, which may not reflect the long-term effects of diet on insulin response. We developed and evaluated the validity of four empirical indices to assess the insulinaemic potential of usual diets and lifestyles, using dietary, lifestyle and biomarker data from the Nurses' Health Study (NHS, n 5812 for hyperinsulinaemia, n 3929 for insulin resistance). The four indices were as follows: the empirical dietary index for hyperinsulinaemia (EDIH) and the empirical lifestyle index for hyperinsulinaemia (ELIH); the empirical dietary index for insulin resistance (EDIR) and the empirical lifestyle index for insulin resistance (ELIR). We entered thirty-nine FFQ-derived food groups in stepwise linear regression models, and defined indices as patterns most predictive of fasting plasma C-peptide, for the hyperinsulinaemia pathway (EDIH and ELIH), and of theTAG:HDL-cholesterol ratio, for the insulin-resistance pathway (EDIR and ELIR). We evaluated the validity of indices in two independent samples from NHS-II and Health Professionals Follow-up Study (HPFS) using multivariable-adjusted linear regression analyses to calculate relative concentrations of biomarkers. The EDIH is comprised of eighteen food groups; thirteen were positively associated with C-peptide and five were inversely associated. The EDIR is comprised of eighteen food groups; ten were positively associated with TAG:HDL-cholesterol and eight were inversely associated. Lifestyle indices had fewer dietary components, and included BMI and physical activity as components. In the validation samples, all indices significantly predicted biomarker concentrations - for example, the relative concentrations of the corresponding biomarkers comparing extreme index quintiles in the HPFS were EDIH, 1·29 (95 % CI 1·22, 1·37); ELIH, 1·78 (95 % CI 1·68, 1·88); EDIR, 1·44 (95 % CI 1·34, 1·55); and ELIR, 2·03 (95 % CI 1·89, 2·19); all P trend<0·0001. The robust associations of these novel hypothesis-driven indices with insulin response biomarker concentrations suggest their usefulness in assessing the ability of whole diets and lifestyles to stimulate and/or sustain insulin secretion.

Keywords: EDIH empirical dietary index for hyperinsulinaemia; EDIR empirical dietary index for insulin resistance; ELIH empirical lifestyle index for hyperinsulinaemia; ELIR empirical lifestyle index for insulin resistance; GI glycaemic index; HPFS Health Professionals Follow-up Study; NHS Nurses’ Health Study; PA physical activity; C-peptide; Dietary patterns; HDL; Hyperinsulinaemia; Hypothesis-driven indices; Insulin resistance; Lifestyle indices; TAG

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