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Showing 13 to 24 of 3591 entries
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Two lessons from the empiric management of a combined overdose of liraglutide and amitriptyline.

A & A case reports

Bowler M, Nethercott DR.
PMID: 25611153
A A Case Rep. 2014 Feb 01;2(3):28-30. doi: 10.1097/ACC.0b013e3182a526fa.

We report the case of a 52-year-old man with a combined liraglutide and amitriptyline overdose who presented with a seizure and then pulseless electrical activity cardiac arrest. This is the largest reported overdose of liraglutide (36 mg), a novel...

Alveolar Rhabdomyosarcoma in a 69-Year-Old Woman Receiving Glucagon-Like Peptide-2 Therapy.

Case reports in oncological medicine

Zyczynski LE, McHugh JB, Gribbin TE, Schuetze SM.
PMID: 26266067
Case Rep Oncol Med. 2015;2015:107479. doi: 10.1155/2015/107479. Epub 2015 Jul 22.

A 69-year-old woman was diagnosed with alveolar rhabdomyosarcoma (ARMS) of the nasopharynx. She has a history of catastrophic thromboembolic event in the abdomen that caused short-gut syndrome and dependence on total parenteral nutrition (TPN) twelve hours per day. She...

The Investigation of Plasma Glucagon-like Peptide-1 Levels in Newly Diagnosed Type 1 Diabetic Children.

The West Indian medical journal

Uslu B, Gurbuz F, Temiz F, Yuksel B, Mungan N, Topaloglu AK.
PMID: 26901603
West Indian Med J. 2015 Sep 03;65(1):141-146. doi: 10.7727/wimj.2014.134.

OBJECTIVE: To reveal the possible role of glucagon-like peptide-1 (GLP-1) in newly diagnosed Type 1 diabetic children.METHODS: Twenty-five newly diagnosed children and 22 healthy children were included in the study.RESULTS: In oral glucose tolerance tests, no correlation was observed...

Umbilical Cord Derived Mesenchymal Stem Cells Useful in Insulin Production - Another Opportunity in Cell Therapy.

International journal of stem cells

Sarang S, Viswanathan C.
PMID: 27426087
Int J Stem Cells. 2016 May 30;9(1):60-9. doi: 10.15283/ijsc.2016.9.1.60.

BACKGROUND AND OBJECTIVES: Type 1 Diabetes Mellitus (T1DM) is an autoimmune disorder resulting out of T cell mediated destruction of pancreatic beta cells. Immunomodulatory properties of mesenchymal stem cells may help to regenerate beta cells and/or prevent further destruction...

Specific appetite, energetic and metabolomics responses to fat overfeeding in resistant-to-bodyweight-gain constitutional thinness.

Nutrition & diabetes

Germain N, Galusca B, Caron-Dorval D, Martin JF, Pujos-Guillot E, Boirie Y, Khalfallah Y, Ling Y, Minnion JS, Bloom SR, Epelbaum J, Estour B.
PMID: 25027794
Nutr Diabetes. 2014 Jul 14;4:e126. doi: 10.1038/nutd.2014.17.

BACKGROUND: Contrasting with obesity, constitutional thinness (CT) is a rare condition of natural low bodyweight. CT exhibits preserved menstruation in females, no biological marker of undernutrition, no eating disorders but a bodyweight gain desire. Anorexigenic hormonal profile with high...

Inflammation Meets Metabolic Disease: Gut Feeling Mediated by GLP-1.

Frontiers in immunology

Zietek T, Rath E.
PMID: 27148273
Front Immunol. 2016 Apr 22;7:154. doi: 10.3389/fimmu.2016.00154. eCollection 2016.

Chronic diseases, such as obesity and diabetes, cardiovascular, and inflammatory bowel diseases (IBD) share common features in their pathology. Metabolic disorders exhibit strong inflammatory underpinnings and vice versa, inflammation is associated with metabolic alterations. Next to cytokines and cellular...

Leptin recruits Creb-regulated transcriptional coactivator 1 to improve hyperglycemia in insulin-deficient diabetes.

Molecular metabolism

Kim GH, Szabo A, King EM, Ayala J, Ayala JE, Altarejos JY.
PMID: 25737949
Mol Metab. 2014 Dec 19;4(3):227-36. doi: 10.1016/j.molmet.2014.12.006. eCollection 2015 Mar.

OBJECTIVE: Leptin alleviates hyperglycemia in rodent models of Type 1 diabetes by activating leptin receptors within the central nervous system. Here we delineate whether non-canonical leptin signaling through the Creb-regulated transcriptional coactivator 1 (Crtc1) contributes to leptin-dependent improvements in...

Case of aniridia with a heterozygous PAX6 mutation in which the glucagon response to arginine was evaluated.

Journal of diabetes investigation

Osawa S, Yasuda T, Kaneto H, Shimo N, Yamamoto Y, Kawamori D, Miyatsuka T, Matsuoka TA, Shimomura I.
PMID: 25621140
J Diabetes Investig. 2015 Jan;6(1):105-6. doi: 10.1111/jdi.12251. Epub 2015 Jan 01.

No abstract available.

Injectable Coformulations in Diabetology.

Diabetes therapy : research, treatment and education of diabetes and related disorders

Kalra S, Gupta Y.
PMID: 25801349
Diabetes Ther. 2015 Jun;6(2):101-11. doi: 10.1007/s13300-015-0106-2. Epub 2015 Mar 24.

Coformulations are a novel pharmaceutical development in diabetology. They are composed of two medicinal products, both of which maintain their distinct pharmacokinetic and pharmacodynamic properties. Currently available coformulations include combinations of basal and rapid-acting insulin, and basal and glucagon-like...

Interpretation of cardiovascular outcome trials in type 2 diabetes needs a multiaxial approach.

World journal of diabetes

Johansen OE.
PMID: 26265995
World J Diabetes. 2015 Aug 10;6(9):1092-6. doi: 10.4239/wjd.v6.i9.1092.

In cardiovascular (CV) diabetology a "one-size fits-all" approach needs caution as vasculopathy and CV manifestations in patients with type 2 diabetes (T2D) with short disease duration are different as compared to those with longer duration. This is of relevance...

GLP1 and glucagon co-secreting pancreatic neuroendocrine tumor presenting as hypoglycemia after gastric bypass.

Endocrinology, diabetes & metabolism case reports

Guimarães M, Rodrigues P, Pereira SS, Nora M, Gonçalves G, Albrechtsen NW, Hartmann B, Holst JJ, Monteiro MP.
PMID: 26266036
Endocrinol Diabetes Metab Case Rep. 2015;2015:150049. doi: 10.1530/EDM-15-0049. Epub 2015 Jul 15.

UNLABELLED: Post-prandial hypoglycemia is frequently found after bariatric surgery. Although rare, pancreatic neuroendocrine tumors (pNET), which occasionally are mixed hormone secreting, can lead to atypical clinical manifestations, including reactive hypoglycemia. Two years after gastric bypass surgery for the treatment...

Glucose intolerance induced by blockade of central FGF receptors is linked to an acute stress response.

Molecular metabolism

Rojas JM, Matsen ME, Mundinger TO, Morton GJ, Stefanovski D, Bergman RN, Kaiyala KJ, Taborsky GJ, Schwartz MW.
PMID: 26266088
Mol Metab. 2015 Jun 04;4(8):561-8. doi: 10.1016/j.molmet.2015.05.005. eCollection 2015 Aug.

OBJECTIVE: Central administration of ligands for fibroblast growth factor receptors (FGFRs) such as fibroblast growth factor-19 (FGF19) and FGF21 exert glucose-lowering effects in rodent models of obesity and type 2 diabetes (T2D). Conversely, intracerebroventricular (icv) administration of the non-selective...

Showing 13 to 24 of 3591 entries