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Showing 25 to 36 of 664 entries
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In vitro inhibitory effects of plumbagin, the promising antimalarial candidate, on human cytochrome P450 enzymes.

Asian Pacific journal of tropical medicine

Sumsakul W, Chaijaroenkul W, Na-Bangchang K.
PMID: 26614990
Asian Pac J Trop Med. 2015 Nov;8(11):914-918. doi: 10.1016/j.apjtm.2015.10.016. Epub 2015 Oct 09.

OBJECTIVE: To investigate the propensity of plumbagin to inhibit the three isoforms of human cytochrome P450 (CYP), i.e., CYP1A2, CYP2C19, and CYP3A4 using human liver microsomes in vitro.METHODS: Inhibitory effects of plumbagin on the three human CYP isoforms were...

Combination Use of Clopidogrel and Proton Pump Inhibitors Increases Major Adverse Cardiovascular Events in Patients With Coronary Artery Disease: A Meta-Analysis.

Journal of cardiovascular pharmacology and therapeutics

Niu Q, Wang Z, Zhang Y, Wang J, Zhang P, Wang C, Yin X, Hou Y.
PMID: 27512080
J Cardiovasc Pharmacol Ther. 2017 Mar;22(2):142-152. doi: 10.1177/1074248416663647. Epub 2016 Aug 20.

BACKGROUND: Published data indicated that combination use of clopidogrel and proton pump inhibitors (PPIs) may increase the incidence of major adverse cardiovascular events (MACEs). This has been a highly controversial topic for years.DESIGN: The present study was performed to...

Evaluation of the impact of Flos Daturae on rat hepatic cytochrome P450 enzymes by cocktail probe drugs.

International journal of clinical and experimental medicine

Geng P, Wang S, Wang C, Chen J, Zhang L, Yang S, Wen C, Zhou Y, Zhang M.
PMID: 26885208
Int J Clin Exp Med. 2015 Dec 15;8(12):22310-8. eCollection 2015.

Flos Daturae, known as "baimantuoluo" or "yangjinhua" in China, has been used for centuries in Traditional Chinese Medicine for the treatment of asthma, convulsions, pain, and rheumatism. To investigate the influences of Flos Daturae on the activities of rat...

Proton pump inhibitor-induced exfoliative dermatitis: A case report.

Experimental and therapeutic medicine

Qiu Z, Liu H, He L, Ma Y, Song H, Bai W, Yu M.
PMID: 26893644
Exp Ther Med. 2016 Feb;11(2):543-546. doi: 10.3892/etm.2015.2926. Epub 2015 Dec 08.

A 74-year-old female patient was admitted to hospital following a road accident with pains in the chest, abdomen, waist, back, nose, left wrist and lower limbs. After 1 week, the patient presented with gastrointestinal bleeding, and thus was treated...

The Association between Helicobacter pylori Infection and Body Weight among Children.

Pediatric gastroenterology, hepatology & nutrition

Choi JS, Ko KO, Lim JW, Cheon EJ, Lee GM, Yoon JM.
PMID: 27437187
Pediatr Gastroenterol Hepatol Nutr. 2016 Jun;19(2):110-5. doi: 10.5223/pghn.2016.19.2.110. Epub 2016 Jun 28.

PURPOSE: We performed to reveal the association between the Helicobacter pylori infection and body weight among children.METHODS: Out retrospective study included patients who underwent the H. pylori immunoglobulin G testing at Konyang University Hospital between March 2011 and June...

Protective effect of hydro-alcoholic extract of Ruta graveolens Linn. leaves on indomethacin and pylorus ligation-induced gastric ulcer in rats.

Journal of Ayurveda and integrative medicine

Tarique M, Siddiqui HH, Khushtar M, Rahman MA.
PMID: 27297508
J Ayurveda Integr Med. 2016 Mar;7(1):38-43. doi: 10.1016/j.jaim.2015.09.002. Epub 2016 May 24.

BACKGROUND: The search for an ideal and new antiulcer drug has been extended to herbals for novel molecules that decrease the incidence of relapse and afford better protection.OBJECTIVE: The present study was designed to investigate the protective effect of...

Inadequate drug prescription and the rise in drug-induced acute tubulointerstitial nephritis incidence.

NDT plus

Garcia M, Saracho R, Jaio N, Vrotsoukanari K, Aguirre C.
PMID: 25949466
NDT Plus. 2010 Dec;3(6):555-7. doi: 10.1093/ndtplus/sfq146. Epub 2010 Aug 09.

Drugs are a frequent cause of acute tubulointerstitial nephritis (ATIN). Antibiotics, non-steroidal anti-inflammatory drugs and recently proton pump inhibitors stand among the most commonly responsible ones. However, their respective responsibility is not well known. This study reports 33 cases...

Evaluation of the benefit of addition of clidinium C to a Helicobacter pylori eradication regimen.

Gastroenterology and hepatology from bed to bench

Chorami M, Zojaji H, Naderi N, Moghimi-Dehkordi B, Mirsattari D, Shalmani HM.
PMID: 24834261
Gastroenterol Hepatol Bed Bench. 2013;6(3):141-5.

AIM: This study aimed to evaluate the success of H.pylori eradication therapy in patients with dyspepsia by therapeutics regimes with and without clidinium C.BACKGROUND: Helicobacter pylori infections are reported in all parts of the world. Appropriate antibiotic therapy can...

The cost-effectiveness of celecoxib versus non-steroidal anti-inflammatory drugs plus proton-pump inhibitors in the treatment of osteoarthritis in Saudi Arabia.

Health economics review

Nasef SA, Shaaban AA, Mould-Quevedo J, Ismail TA.
PMID: 26061682
Health Econ Rev. 2015 Dec;5(1):53. doi: 10.1186/s13561-015-0053-7. Epub 2015 Jun 11.

BACKGROUND: Cyclooxygenase (COX)-2 inhibitors including celecoxib are as effective as non-selective non-steroidal anti-inflammatory drugs (ns-NSAIDs) in the treatment of osteoarthritis (OA) and have less gastrointestinal toxicity. Although they are associated with higher treatment costs, COX-2 inhibitors may simultaneously reduce...

Antiulcer properties of Glycyrrhiza glabra L. extract on experimental models of gastric ulcer in mice.

Iranian journal of pharmaceutical research : IJPR

Jalilzadeh-Amin G, Najarnezhad V, Anassori E, Mostafavi M, Keshipour H.
PMID: 26664383
Iran J Pharm Res. 2015;14(4):1163-70.

Glycyrrhiza glabra L. is used in folk medicine for treatment of stomach disorders including peptic ulcers. The hydroalcoholic extract of Glycyrrhiza glabra L. (HEGG) was evaluated for antiulcerogenic activity and acute toxicity profile in mice. Various doses of HEGG...

Effects of long-term administration of omeprazole on bone mineral density and the mechanical properties of the bone.

Revista brasileira de ortopedia

Yanagihara GR, de Paiva AG, Neto MP, Torres LH, Shimano AC, Louzada MJ, Annoni R, de Oliveira Penoni ÁC.
PMID: 26229922
Rev Bras Ortop. 2015 Mar 14;50(2):232-8. doi: 10.1016/j.rboe.2015.03.002. eCollection 2015.

OBJECTIVES: Epidemiological studies have shown a relationship between long-term use of proton pump inhibitors and bone metabolism. However, this relationship has not yet become established. The aim of the present study was to analyze the mechanical properties and bone...

Gateways to clinical trials.

Methods and findings in experimental and clinical pharmacology

Bayes M, Rabasseda X, Prous JR.
PMID: 11980386
Methods Find Exp Clin Pharmacol. 2002 Jan-Feb;24(1):37-55.

Gateways to Clinical Trials is a guide to the most recent clinical trials in current literature and congresses, which has been retrieved from the Clinical Studies knowledge area of Prous Science Integrity, the world's first drug discovery and development...

Showing 25 to 36 of 664 entries