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Showing 1 to 12 of 17 entries
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Optimal labeling dose, labeling time, and magnetic resonance imaging detection limits of ultrasmall superparamagnetic iron-oxide nanoparticle labeled mesenchymal stromal cells.

Stem cells international

Mathiasen AB, Hansen L, Friis T, Thomsen C, Bhakoo K, Kastrup J.
PMID: 23577035
Stem Cells Int. 2013;2013:353105. doi: 10.1155/2013/353105. Epub 2013 Mar 19.

Background. Regenerative therapy is an emerging treatment modality. To determine migration and retention of implanted cells, it is crucial to develop noninvasive tracking methods. The aim was to determine ex vivo magnetic resonance imaging (MRI) detection limits of ultrasmall...

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Mathiasen AB, Hansen L, Friis T, et al. Optimal labeling dose, labeling time, and magnetic resonance imaging detection limits of ultrasmall superparamagnetic iron-oxide nanoparticle labeled mesenchymal stromal cells. Stem Cells Int. 2013;2013:353105doi: 10.1155/2013/353105.
Mathiasen, A. B., Hansen, L., Friis, T., Thomsen, C., Bhakoo, K., & Kastrup, J. (2013). Optimal labeling dose, labeling time, and magnetic resonance imaging detection limits of ultrasmall superparamagnetic iron-oxide nanoparticle labeled mesenchymal stromal cells. Stem cells international, 2013353105. https://doi.org/10.1155/2013/353105
Mathiasen, Anders Bruun, et al. "Optimal labeling dose, labeling time, and magnetic resonance imaging detection limits of ultrasmall superparamagnetic iron-oxide nanoparticle labeled mesenchymal stromal cells." Stem cells international vol. 2013 (2013): 353105. doi: https://doi.org/10.1155/2013/353105
Mathiasen AB, Hansen L, Friis T, Thomsen C, Bhakoo K, Kastrup J. Optimal labeling dose, labeling time, and magnetic resonance imaging detection limits of ultrasmall superparamagnetic iron-oxide nanoparticle labeled mesenchymal stromal cells. Stem Cells Int. 2013;2013:353105. doi: 10.1155/2013/353105. Epub 2013 Mar 19. PMID: 23577035; PMCID: PMC3614076.
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MRI detection of endothelial cell inflammation using targeted superparamagnetic particles of iron oxide (SPIO).

Clinical and translational medicine

Chan JMS, Cheung MSH, Gibbs RGJ, Bhakoo KK.
PMID: 28044245
Clin Transl Med. 2017 Dec;6(1):1. doi: 10.1186/s40169-016-0134-1. Epub 2017 Jan 02.

BACKGROUND: There is currently no clinical imaging technique available to assess the degree of inflammation associated with atherosclerotic plaques. This study aims to develop targeted superparamagnetic particles of iron oxide (SPIO) as a magnetic resonance imaging (MRI) probe for...

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Chan JMS, Cheung MSH, Gibbs RGJ, et al. MRI detection of endothelial cell inflammation using targeted superparamagnetic particles of iron oxide (SPIO). Clin Transl Med. 2017;6(1):1doi: 10.1186/s40169-016-0134-1.
Chan, J. M. S., Cheung, M. S. H., Gibbs, R. G. J., & Bhakoo, K. K. (2017). MRI detection of endothelial cell inflammation using targeted superparamagnetic particles of iron oxide (SPIO). Clinical and translational medicine, 6(1), 1. https://doi.org/10.1186/s40169-016-0134-1
Chan, Joyce M S, et al. "MRI detection of endothelial cell inflammation using targeted superparamagnetic particles of iron oxide (SPIO)." Clinical and translational medicine vol. 6,1 (2017): 1. doi: https://doi.org/10.1186/s40169-016-0134-1
Chan JMS, Cheung MSH, Gibbs RGJ, Bhakoo KK. MRI detection of endothelial cell inflammation using targeted superparamagnetic particles of iron oxide (SPIO). Clin Transl Med. 2017 Dec;6(1):1. doi: 10.1186/s40169-016-0134-1. Epub 2017 Jan 02. PMID: 28044245; PMCID: PMC5206220.
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Design, synthesis and in vitro characterization of fluorescent and paramagnetic CXCR4-targeted imaging agents.

American journal of nuclear medicine and molecular imaging

Tietz O, Kamaly N, Smith G, Shamsaei E, Bhakoo KK, Long NJ, Aboagye EO.
PMID: 23901361
Am J Nucl Med Mol Imaging. 2013 Jul 10;3(4):372-83. Print 2013.

The G-protein coupled C-X-C chemokine receptor type 4 (CXCR4) is highly overexpressed in a range of cancers and is therefore an excellent biomarker for cancer imaging. To this end targeted iron oxide nanoparticles were developed and utilised for in...

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Tietz O, Kamaly N, Smith G, et al. Design, synthesis and in vitro characterization of fluorescent and paramagnetic CXCR4-targeted imaging agents. Am J Nucl Med Mol Imaging. 2013;3(4):372-83
Tietz, O., Kamaly, N., Smith, G., Shamsaei, E., Bhakoo, K. K., Long, N. J., & Aboagye, E. O. (2013). Design, synthesis and in vitro characterization of fluorescent and paramagnetic CXCR4-targeted imaging agents. American journal of nuclear medicine and molecular imaging, 3(4), 372-83.
Tietz, Ole, et al. "Design, synthesis and in vitro characterization of fluorescent and paramagnetic CXCR4-targeted imaging agents." American journal of nuclear medicine and molecular imaging vol. 3,4 (2013): 372-83.
Tietz O, Kamaly N, Smith G, Shamsaei E, Bhakoo KK, Long NJ, Aboagye EO. Design, synthesis and in vitro characterization of fluorescent and paramagnetic CXCR4-targeted imaging agents. Am J Nucl Med Mol Imaging. 2013 Jul 10;3(4):372-83. Print 2013. PMID: 23901361; PMCID: PMC3715781.
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nCP:Fe-A Biomineral Magnetic Nanocontrast Agent for Tracking Implanted Stem Cells in Brain Using MRI.

ACS applied bio materials

Anna IM, Sathy BN, Ashokan A, Gowd GS, Ramachandran R, Kochugovindan Unni AK, Manohar M, Chulliyath D, Nair S, Bhakoo K, Koyakutty M.
PMID: 35021538
ACS Appl Bio Mater. 2019 Dec 16;2(12):5390-5403. doi: 10.1021/acsabm.9b00709. Epub 2019 Oct 28.

No abstract available.

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Anna IM, Sathy BN, Ashokan A, et al. nCP:Fe-A Biomineral Magnetic Nanocontrast Agent for Tracking Implanted Stem Cells in Brain Using MRI. ACS Appl Bio Mater. 2019;2(12):5390-5403doi: 10.1021/acsabm.9b00709.
Anna, I. M., Sathy, B. N., Ashokan, A., Gowd, G. S., Ramachandran, R., Kochugovindan Unni, A. K., Manohar, M., Chulliyath, D., Nair, S., Bhakoo, K., & Koyakutty, M. (2019). nCP:Fe-A Biomineral Magnetic Nanocontrast Agent for Tracking Implanted Stem Cells in Brain Using MRI. ACS applied bio materials, 2(12), 5390-5403. https://doi.org/10.1021/acsabm.9b00709
Anna, Ida M, et al. "nCP:Fe-A Biomineral Magnetic Nanocontrast Agent for Tracking Implanted Stem Cells in Brain Using MRI." ACS applied bio materials vol. 2,12 (2019): 5390-5403. doi: https://doi.org/10.1021/acsabm.9b00709
Anna IM, Sathy BN, Ashokan A, Gowd GS, Ramachandran R, Kochugovindan Unni AK, Manohar M, Chulliyath D, Nair S, Bhakoo K, Koyakutty M. nCP:Fe-A Biomineral Magnetic Nanocontrast Agent for Tracking Implanted Stem Cells in Brain Using MRI. ACS Appl Bio Mater. 2019 Dec 16;2(12):5390-5403. doi: 10.1021/acsabm.9b00709. Epub 2019 Oct 28. PMID: 35021538.
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Bone marrow mesenchymal stem cells with low dose bone morphogenetic protein 2 enhances scaffold-based spinal fusion in a porcine model.

Journal of tissue engineering and regenerative medicine

Hu T, Liu L, Lam RWM, Toh SY, Abbah SA, Wang M, Ramruttun AK, Bhakoo K, Cool S, Li J, Cho-Hong Goh J, Wong HK.
PMID: 34687157
J Tissue Eng Regen Med. 2022 Jan;16(1):63-75. doi: 10.1002/term.3260. Epub 2021 Nov 01.

High doses bone morphogenetic protein 2 (BMP-2) have resulted in a series of complications in spinal fusion. We previously established a polyelectrolyte complex (PEC) carrier system that reduces the therapeutic dose of BMP-2 in both rodent and porcine spinal...

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Hu T, Liu L, Lam RWM, et al. Bone marrow mesenchymal stem cells with low dose bone morphogenetic protein 2 enhances scaffold-based spinal fusion in a porcine model. J Tissue Eng Regen Med. 2021;16(1):63-75doi: 10.1002/term.3260.
Hu, T., Liu, L., Lam, R. W. M., Toh, S. Y., Abbah, S. A., Wang, M., Ramruttun, A. K., Bhakoo, K., Cool, S., Li, J., Cho-Hong Goh, J., & Wong, H. K. (2022). Bone marrow mesenchymal stem cells with low dose bone morphogenetic protein 2 enhances scaffold-based spinal fusion in a porcine model. Journal of tissue engineering and regenerative medicine, 16(1), 63-75. https://doi.org/10.1002/term.3260
Hu, Tao, et al. "Bone marrow mesenchymal stem cells with low dose bone morphogenetic protein 2 enhances scaffold-based spinal fusion in a porcine model." Journal of tissue engineering and regenerative medicine vol. 16,1 (2022): 63-75. doi: https://doi.org/10.1002/term.3260
Hu T, Liu L, Lam RWM, Toh SY, Abbah SA, Wang M, Ramruttun AK, Bhakoo K, Cool S, Li J, Cho-Hong Goh J, Wong HK. Bone marrow mesenchymal stem cells with low dose bone morphogenetic protein 2 enhances scaffold-based spinal fusion in a porcine model. J Tissue Eng Regen Med. 2022 Jan;16(1):63-75. doi: 10.1002/term.3260. Epub 2021 Nov 01. PMID: 34687157.
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A comparison of PET imaging agents for the assessment of therapy efficacy in a rodent model of glioma.

American journal of nuclear medicine and molecular imaging

Moonshi SS, Bejot R, Atcha Z, Vijayaragavan V, Bhakoo KK, Goggi JL.
PMID: 24116348
Am J Nucl Med Mol Imaging. 2013 Sep 19;3(5):397-407. eCollection 2013.

The aim of the current study was to assess the ability of PET imaging agents to detect early response to therapy in an orthotopic experimental rodent model of glioma. Clinically, MRI and [(18)F]FDG PET are routinely used but their...

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Moonshi SS, Bejot R, Atcha Z, et al. A comparison of PET imaging agents for the assessment of therapy efficacy in a rodent model of glioma. Am J Nucl Med Mol Imaging. 2013;3(5):397-407
Moonshi, S. S., Bejot, R., Atcha, Z., Vijayaragavan, V., Bhakoo, K. K., & Goggi, J. L. (2013). A comparison of PET imaging agents for the assessment of therapy efficacy in a rodent model of glioma. American journal of nuclear medicine and molecular imaging, 3(5), 397-407.
Moonshi, Shehzahdi S, et al. "A comparison of PET imaging agents for the assessment of therapy efficacy in a rodent model of glioma." American journal of nuclear medicine and molecular imaging vol. 3,5 (2013): 397-407.
Moonshi SS, Bejot R, Atcha Z, Vijayaragavan V, Bhakoo KK, Goggi JL. A comparison of PET imaging agents for the assessment of therapy efficacy in a rodent model of glioma. Am J Nucl Med Mol Imaging. 2013 Sep 19;3(5):397-407. eCollection 2013. PMID: 24116348; PMCID: PMC3784803.
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Tuning sub-10 nm single-phase NaMnF3 nanocrystals as ultrasensitive hosts for pure intense fluorescence and excellent T1 magnetic resonance imaging.

Chemical communications (Cambridge, England)

Zhang Y, Lin JD, Vijayaragavan V, Bhakoo KK, Tan TT.
PMID: 22936349
Chem Commun (Camb). 2012 Oct 25;48(83):10322-4. doi: 10.1039/c2cc34858f.

We report ultrasensitive sub-10 nm NaMnF(3) nanocrystals codoped with Yb(3+), Er(3+)/Tm(3+) ions, and their intense pure red and near-infrared upconversion emissions in the presence of Mn(2+). The nanocrystals showed excellent T(1) contrast in 7 T MRI, implying their potential...

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Zhang Y, Lin JD, Vijayaragavan V, et al. Tuning sub-10 nm single-phase NaMnF3 nanocrystals as ultrasensitive hosts for pure intense fluorescence and excellent T1 magnetic resonance imaging. Chem Commun (Camb). 2012;48(83):10322-4doi: 10.1039/c2cc34858f.
Zhang, Y., Lin, J. D., Vijayaragavan, V., Bhakoo, K. K., & Tan, T. T. (2012). Tuning sub-10 nm single-phase NaMnF3 nanocrystals as ultrasensitive hosts for pure intense fluorescence and excellent T1 magnetic resonance imaging. Chemical communications (Cambridge, England), 48(83), 10322-4. https://doi.org/10.1039/c2cc34858f
Zhang, Yan, et al. "Tuning sub-10 nm single-phase NaMnF3 nanocrystals as ultrasensitive hosts for pure intense fluorescence and excellent T1 magnetic resonance imaging." Chemical communications (Cambridge, England) vol. 48,83 (2012): 10322-4. doi: https://doi.org/10.1039/c2cc34858f
Zhang Y, Lin JD, Vijayaragavan V, Bhakoo KK, Tan TT. Tuning sub-10 nm single-phase NaMnF3 nanocrystals as ultrasensitive hosts for pure intense fluorescence and excellent T1 magnetic resonance imaging. Chem Commun (Camb). 2012 Oct 25;48(83):10322-4. doi: 10.1039/c2cc34858f. PMID: 22936349.
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[No title available]

Stem cells international

Mathiasen AB, Qayyum AA, Jørgensen E, Helqvist S, Ekblond A, Ng M, Bhakoo K, Kastrup J.
PMID: 31814830
Stem Cells Int. 2019 Nov 14;2019:2754927. doi: 10.1155/2019/2754927. eCollection 2019.

BACKGROUND: While regenerative stem cell therapy for ischemic heart disease has moved into phase 3 studies, little is still known about retention and migration of cell posttransplantation. In human studies, the ability to track transplanted cells has been limited...

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Mathiasen AB, Qayyum AA, Jørgensen E, et al. . Stem Cells Int. 2019;2019:2754927doi: 10.1155/2019/2754927.
Mathiasen, A. B., Qayyum, A. A., Jørgensen, E., Helqvist, S., Ekblond, A., Ng, M., Bhakoo, K., & Kastrup, J. (2019). . Stem cells international, 20192754927. https://doi.org/10.1155/2019/2754927
Mathiasen, Anders Bruun, et al. "." Stem cells international vol. 2019 (2019): 2754927. doi: https://doi.org/10.1155/2019/2754927
Mathiasen AB, Qayyum AA, Jørgensen E, Helqvist S, Ekblond A, Ng M, Bhakoo K, Kastrup J. . Stem Cells Int. 2019 Nov 14;2019:2754927. doi: 10.1155/2019/2754927. eCollection 2019. PMID: 31814830; PMCID: PMC6877937.
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Predictive mouse model reflects distinct stages of human atheroma in a single carotid artery.

Translational research : the journal of laboratory and clinical medicine

Chan JM, Park SJ, Ng M, Chen WC, Garnell J, Bhakoo K.
PMID: 34478893
Transl Res. 2021 Aug 31; doi: 10.1016/j.trsl.2021.08.007. Epub 2021 Aug 31.

Identification of patients with high-risk asymptomatic atherosclerotic plaques remains an elusive but essential step in preventing stroke. However, there is a lack of animal model that provides a reproducible method to predict where, when and what types of plaque...

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Chan JM, Park SJ, Ng M, et al. Predictive mouse model reflects distinct stages of human atheroma in a single carotid artery. Transl Res. 2021;doi: 10.1016/j.trsl.2021.08.007.
Chan, J. M., Park, S. J., Ng, M., Chen, W. C., Garnell, J., & Bhakoo, K. (2021). Predictive mouse model reflects distinct stages of human atheroma in a single carotid artery. Translational research : the journal of laboratory and clinical medicine, . https://doi.org/10.1016/j.trsl.2021.08.007
Chan, Joyce Ms, et al. "Predictive mouse model reflects distinct stages of human atheroma in a single carotid artery." Translational research : the journal of laboratory and clinical medicine vol. (2021). doi: https://doi.org/10.1016/j.trsl.2021.08.007
Chan JM, Park SJ, Ng M, Chen WC, Garnell J, Bhakoo K. Predictive mouse model reflects distinct stages of human atheroma in a single carotid artery. Transl Res. 2021 Aug 31; doi: 10.1016/j.trsl.2021.08.007. Epub 2021 Aug 31. PMID: 34478893.
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Bone marrow mesenchymal stem cells with low dose bone morphogenetic protein 2 enhances scaffold-based spinal fusion in a porcine model.

Journal of tissue engineering and regenerative medicine

Hu T, Liu L, Lam RWM, Toh SY, Abbah SA, Wang M, Ramruttun AK, Bhakoo K, Cool S, Li J, Cho-Hong Goh J, Wong HK.
PMID: 34687157
J Tissue Eng Regen Med. 2021 Oct 22; doi: 10.1002/term.3260. Epub 2021 Oct 22.

High doses bone morphogenetic protein 2 (BMP-2) have resulted in a series of complications in spinal fusion. We previously established a polyelectrolyte complex (PEC) carrier system that reduces the therapeutic dose of BMP-2 in both rodent and porcine spinal...

Cite
Hu T, Liu L, Lam RWM, et al. Bone marrow mesenchymal stem cells with low dose bone morphogenetic protein 2 enhances scaffold-based spinal fusion in a porcine model. J Tissue Eng Regen Med. 2021;doi: 10.1002/term.3260.
Hu, T., Liu, L., Lam, R. W. M., Toh, S. Y., Abbah, S. A., Wang, M., Ramruttun, A. K., Bhakoo, K., Cool, S., Li, J., Cho-Hong Goh, J., & Wong, H. K. (2021). Bone marrow mesenchymal stem cells with low dose bone morphogenetic protein 2 enhances scaffold-based spinal fusion in a porcine model. Journal of tissue engineering and regenerative medicine, . https://doi.org/10.1002/term.3260
Hu, Tao, et al. "Bone marrow mesenchymal stem cells with low dose bone morphogenetic protein 2 enhances scaffold-based spinal fusion in a porcine model." Journal of tissue engineering and regenerative medicine vol. (2021). doi: https://doi.org/10.1002/term.3260
Hu T, Liu L, Lam RWM, Toh SY, Abbah SA, Wang M, Ramruttun AK, Bhakoo K, Cool S, Li J, Cho-Hong Goh J, Wong HK. Bone marrow mesenchymal stem cells with low dose bone morphogenetic protein 2 enhances scaffold-based spinal fusion in a porcine model. J Tissue Eng Regen Med. 2021 Oct 22; doi: 10.1002/term.3260. Epub 2021 Oct 22. PMID: 34687157.
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Predictive mouse model reflects distinct stages of human atheroma in a single carotid artery.

Translational research : the journal of laboratory and clinical medicine

Chan JM, Park SJ, Ng M, Chen WC, Garnell J, Bhakoo K.
PMID: 34478893
Transl Res. 2022 Feb;240:33-49. doi: 10.1016/j.trsl.2021.08.007. Epub 2021 Aug 31.

Identification of patients with high-risk asymptomatic atherosclerotic plaques remains an elusive but essential step in preventing stroke. However, there is a lack of animal model that provides a reproducible method to predict where, when and what types of plaque...

Cite
Chan JM, Park SJ, Ng M, et al. Predictive mouse model reflects distinct stages of human atheroma in a single carotid artery. Transl Res. 2021;240:33-49doi: 10.1016/j.trsl.2021.08.007.
Chan, J. M., Park, S. J., Ng, M., Chen, W. C., Garnell, J., & Bhakoo, K. (2022). Predictive mouse model reflects distinct stages of human atheroma in a single carotid artery. Translational research : the journal of laboratory and clinical medicine, 24033-49. https://doi.org/10.1016/j.trsl.2021.08.007
Chan, Joyce Ms, et al. "Predictive mouse model reflects distinct stages of human atheroma in a single carotid artery." Translational research : the journal of laboratory and clinical medicine vol. 240 (2022): 33-49. doi: https://doi.org/10.1016/j.trsl.2021.08.007
Chan JM, Park SJ, Ng M, Chen WC, Garnell J, Bhakoo K. Predictive mouse model reflects distinct stages of human atheroma in a single carotid artery. Transl Res. 2022 Feb;240:33-49. doi: 10.1016/j.trsl.2021.08.007. Epub 2021 Aug 31. PMID: 34478893.
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Development of Molecular Magnetic Resonance Imaging Tools for Risk Stratification of Carotid Atherosclerotic Disease Using Dual-Targeted Microparticles of Iron Oxide.

Translational stroke research

Chan JMS, Jin PS, Ng M, Garnell J, Ying CW, Tec CT, Bhakoo K.
PMID: 34304360
Transl Stroke Res. 2021 Jul 25; doi: 10.1007/s12975-021-00931-3. Epub 2021 Jul 25.

Identification of patients with high-risk asymptomatic carotid plaques remains a challenging but crucial step in stroke prevention. Inflammation is the key factor that drives plaque instability. Currently, there is no imaging tool in routine clinical practice to assess the...

Cite
Chan JMS, Jin PS, Ng M, et al. Development of Molecular Magnetic Resonance Imaging Tools for Risk Stratification of Carotid Atherosclerotic Disease Using Dual-Targeted Microparticles of Iron Oxide. Transl Stroke Res. 2021;doi: 10.1007/s12975-021-00931-3.
Chan, J. M. S., Jin, P. S., Ng, M., Garnell, J., Ying, C. W., Tec, C. T., & Bhakoo, K. (2021). Development of Molecular Magnetic Resonance Imaging Tools for Risk Stratification of Carotid Atherosclerotic Disease Using Dual-Targeted Microparticles of Iron Oxide. Translational stroke research, . https://doi.org/10.1007/s12975-021-00931-3
Chan, Joyce M S, et al. "Development of Molecular Magnetic Resonance Imaging Tools for Risk Stratification of Carotid Atherosclerotic Disease Using Dual-Targeted Microparticles of Iron Oxide." Translational stroke research vol. (2021). doi: https://doi.org/10.1007/s12975-021-00931-3
Chan JMS, Jin PS, Ng M, Garnell J, Ying CW, Tec CT, Bhakoo K. Development of Molecular Magnetic Resonance Imaging Tools for Risk Stratification of Carotid Atherosclerotic Disease Using Dual-Targeted Microparticles of Iron Oxide. Transl Stroke Res. 2021 Jul 25; doi: 10.1007/s12975-021-00931-3. Epub 2021 Jul 25. PMID: 34304360.
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Showing 1 to 12 of 17 entries