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Showing 1 to 12 of 645 entries
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Epidemiologic inquiry: observational studies.

Family medicine

Zweig SC, Blake RL.
PMID: 3060390
Fam Med. 1988 Jul-Aug;20(4):289-94.

A major objective of epidemiologic investigation is to determine whether or not an association between an exposure and a condition exists in a human population. The presence of such an association cna be explored using three distinct strategies, the...

Cadmium alters the formation of benzo[a]pyrene DNA adducts in the RPTEC/TERT1 human renal proximal tubule epithelial cell line.

Toxicology reports

Simon BR, Wilson MJ, Blake DA, Yu H, Wickliffe JK.
PMID: 25170436
Toxicol Rep. 2014 Jul 14;1:391-400. doi: 10.1016/j.toxrep.2014.07.003.

Previously, we demonstrated the sensitivity of RPTEC/TERT1 cells, an immortalized human renal proximal tubule epithelial cell line, to two common environmental carcinogens, cadmium (Cd) and benzo[a]pyrene (B[a]P). Here, we measured BPDE-DNA adducts using a competitive ELISA method after cells...

Triptolide and its prodrug minnelide suppress Hsp70 and inhibit in vivo growth in a xenograft model of mesothelioma.

Genes & cancer

Jacobson BA, Chen EZ, Tang S, Belgum HS, McCauley JA, Evenson KA, Etchison RG, Jay-Dixon J, Patel MR, Raza A, Saluja AK, D'Cunha J, Kratzke RA.
PMID: 26000097
Genes Cancer. 2015 Mar;6(3):144-52. doi: 10.18632/genesandcancer.55.

Malignant mesothelioma is a devastating disease with a poor prognosis for which there is a clear need for more successful therapeutic approaches. Triptolide, a diterpenoid triepoxide, is a highly effective agent against several cancer types in animal models. Owing...

Preservation of microbial communities enriched on lignocellulose under thermophilic and high-solid conditions.

Biotechnology for biofuels

Yu C, Reddy AP, Simmons CW, Simmons BA, Singer SW, VanderGheynst JS.
PMID: 26633993
Biotechnol Biofuels. 2015 Dec 02;8:206. doi: 10.1186/s13068-015-0392-y. eCollection 2015.

BACKGROUND: Microbial communities enriched from diverse environments have shown considerable promise for the targeted discovery of microorganisms and enzymes for bioconversion of lignocellulose to liquid fuels. While preservation of microbial communities is important for commercialization and research, few studies...

Discovery of the interstellar chiral molecule propylene oxide (CH₃CHCH₂O).

Science (New York, N.Y.)

McGuire BA, Carroll PB, Loomis RA, Finneran IA, Jewell PR, Remijan AJ, Blake GA.
PMID: 27303055
Science. 2016 Jun 17;352(6292):1449-52. doi: 10.1126/science.aae0328. Epub 2016 Jun 14.

Life on Earth relies on chiral molecules-that is, species not superimposable on their mirror images. This manifests itself in the selection of a single molecular handedness, or homochirality, across the biosphere. We present the astronomical detection of a chiral...

Ternary ionic liquid-water pretreatment systems of an agave bagasse and municipal solid waste blend.

Biotechnology for biofuels

Perez-Pimienta JA, Sathitsuksanoh N, Thompson VS, Tran K, Ponce-Noyola T, Stavila V, Singh S, Simmons BA.
PMID: 28344647
Biotechnol Biofuels. 2017 Mar 21;10:72. doi: 10.1186/s13068-017-0758-4. eCollection 2017.

BACKGROUND: Pretreatment is necessary to reduce biomass recalcitrance and enhance the efficiency of enzymatic saccharification for biofuel production. Ionic liquid (IL) pretreatment has gained a significant interest as a pretreatment process that can reduce cellulose crystallinity and remove lignin,...

Strong spontaneous tumor neoantigen responses induced by a natural human carcinogen.

Oncoimmunology

Creaney J, Ma S, Sneddon SA, Tourigny MR, Dick IM, Leon JS, Khong A, Fisher SA, Lake RA, Lesterhuis WJ, Nowak AK, Leary S, Watson MW, Robinson BW.
PMID: 26140232
Oncoimmunology. 2015 May 11;4(7):e1011492. doi: 10.1080/2162402X.2015.1011492. eCollection 2015 Jul.

A key to improving cancer immunotherapy will be the identification of tumor-specific "neoantigens" that arise from mutations and augment the resultant host immune response. In this study we identified single nucleotide variants (SNVs) by RNA sequencing of asbestos-induced murine...

An overview of selected current approaches to the characterization of aqueous inorganic clusters.

Dalton transactions (Cambridge, England : 2003)

Jackson MN, Kamunde-Devonish MK, Hammann BA, Wills LA, Fullmer LB, Hayes SE, Cheong PH, Casey WH, Nyman M, Johnson DW.
PMID: 26212049
Dalton Trans. 2015 Oct 21;44(39):16982-7006. doi: 10.1039/c5dt01268f. Epub 2015 Jul 27.

This Perspective article highlights some of the traditional and non-traditional analytical tools that are presently used to characterize aqueous inorganic nanoscale clusters and polyoxometalate ions. The techniques discussed in this article include nuclear magnetic resonance spectroscopy (NMR), small angle...

Halochromic coordination polymers based on a triarylmethane dye for reversible detection of acids.

Dalton transactions (Cambridge, England : 2003)

Zavakhina MS, Yushina IV, Samsonenko DG, Dybtsev DN, Fedin VP, Argent SP, Blake AJ, Schröder M.
PMID: 27957580
Dalton Trans. 2017 Jan 03;46(2):465-470. doi: 10.1039/c6dt03969c.

Chromeazurol B (Na

Hydrophobic resorufamine derivatives: potent and selective red fluorescent probes of the endoplasmic reticulum of mammalian cells.

Dyes and pigments : an international journal

Phaniraj S, Gao Z, Rane D, Peterson BR.
PMID: 27765999
Dyes Pigm. 2016 Dec;135:127-133. doi: 10.1016/j.dyepig.2016.05.007. Epub 2016 May 09.

The endoplasmic reticulum (ER) of eukaryotic cells plays critical roles in the processing of secreted and transmembrane proteins. Defects in these functions are associated with a wide range of pathologies. To image this organelle, cells are often treated with...

Combined Electron-Diffraction and Spectroscopic Determination of the Structure of Spiropentane, C.

The journal of physical chemistry. A

Sandwisch JW, Erickson BA, Hedberg K, Nibler JW.
PMID: 28609622
J Phys Chem A. 2017 Jul 06;121(26):4923-4929. doi: 10.1021/acs.jpca.7b04450. Epub 2017 Jun 26.

Gas-phase electron-diffraction (GED) data have been combined with recent spectroscopic rotational constants to determine the r

Digital health technology for use in patients with serious mental illness: a systematic review of the literature.

Medical devices (Auckland, N.Z.)

Batra S, Baker RA, Wang T, Forma F, DiBiasi F, Peters-Strickland T.
PMID: 29042823
Med Devices (Auckl). 2017 Oct 04;10:237-251. doi: 10.2147/MDER.S144158. eCollection 2017.

BACKGROUND: As the capabilities and reach of technology have expanded, there is an accompanying proliferation of digital technologies developed for use in the care of patients with mental illness. The objective of this review was to systematically search published...

Showing 1 to 12 of 645 entries