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Nova Regulates GABAA Receptor γ2 Alternative Splicing via a Distal Downstream UCAU-Rich Intronic Splicing Enhancer

STEM and diversify

Darnell RB.
GSID: 9u3ATHcGOPoJ
BK Dredge, RB Darnell - Molecular and cellular biology, 2003 - Am Soc Microbiol

… , acting at multiple levels to regulate and diversify gene expression, and such functions are … characterized by loss of inhibitory control of motor neurons in the spinal cord and brainstem. …

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Dredge, B. K., & Darnell, R. B. (2003). Nova regulates GABAA receptor γ2 alternative splicing via a distal downstream UCAU-rich intronic splicing enhancer. Molecular and cellular biology, 23(13), 4687-4700.
Dredge, B. Kate, and Robert B. Darnell. "Nova regulates GABAA receptor γ2 alternative splicing via a distal downstream UCAU-rich intronic splicing enhancer." Molecular and cellular biology 23.13 (2003): 4687-4700.
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Quasi-Experimental Study of Functional Family Therapy Effectiveness for Juvenile Justice Aftercare in a Racially and Ethnically Diverse Community Sample.

Children and youth services review

Darnell AJ, Schuler MS.
PMID: 25767310
Child Youth Serv Rev. 2015 Mar;50:75-82. doi: 10.1016/j.childyouth.2015.01.013.

Functional Family Therapy (FFT) is an intensive community-based treatment program designed to reduce youth behavior problems such as violence, drug use, and other delinquency. Although there is evidence of FFT efficacy and effectiveness with predominantly White samples, there is...

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Darnell AJ, Schuler MS. Quasi-Experimental Study of Functional Family Therapy Effectiveness for Juvenile Justice Aftercare in a Racially and Ethnically Diverse Community Sample. Child Youth Serv Rev. 2015;50:75-82doi: 10.1016/j.childyouth.2015.01.013.
Darnell, A. J., & Schuler, M. S. (2015). Quasi-Experimental Study of Functional Family Therapy Effectiveness for Juvenile Justice Aftercare in a Racially and Ethnically Diverse Community Sample. Children and youth services review, 5075-82. https://doi.org/10.1016/j.childyouth.2015.01.013
Darnell, Adam J, and Schuler, Megan S. "Quasi-Experimental Study of Functional Family Therapy Effectiveness for Juvenile Justice Aftercare in a Racially and Ethnically Diverse Community Sample." Children and youth services review vol. 50 (2015): 75-82. doi: https://doi.org/10.1016/j.childyouth.2015.01.013
Darnell AJ, Schuler MS. Quasi-Experimental Study of Functional Family Therapy Effectiveness for Juvenile Justice Aftercare in a Racially and Ethnically Diverse Community Sample. Child Youth Serv Rev. 2015 Mar;50:75-82. doi: 10.1016/j.childyouth.2015.01.013. PMID: 25767310; PMCID: PMC4354807.
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Disease variants in genomes of 44 centenarians.

Molecular genetics & genomic medicine

Freudenberg-Hua Y, Freudenberg J, Vacic V, Abhyankar A, Emde AK, Ben-Avraham D, Barzilai N, Oschwald D, Christen E, Koppel J, Greenwald B, Darnell RB, Germer S, Atzmon G, Davies P.
PMID: 25333069
Mol Genet Genomic Med. 2014 Sep;2(5):438-50. doi: 10.1002/mgg3.86. Epub 2014 Jun 15.

To identify previously reported disease mutations that are compatible with extraordinary longevity, we screened the coding regions of the genomes of 44 Ashkenazi Jewish centenarians. Individual genome sequences were generated with 30× coverage on the Illumina HiSeq 2000 and...

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Freudenberg-Hua Y, Freudenberg J, Vacic V, et al. Disease variants in genomes of 44 centenarians. Mol Genet Genomic Med. 2014;2(5):438-50doi: 10.1002/mgg3.86.
Freudenberg-Hua, Y., Freudenberg, J., Vacic, V., Abhyankar, A., Emde, A. K., Ben-Avraham, D., Barzilai, N., Oschwald, D., Christen, E., Koppel, J., Greenwald, B., Darnell, R. B., Germer, S., Atzmon, G., & Davies, P. (2014). Disease variants in genomes of 44 centenarians. Molecular genetics & genomic medicine, 2(5), 438-50. https://doi.org/10.1002/mgg3.86
Freudenberg-Hua, Yun, et al. "Disease variants in genomes of 44 centenarians." Molecular genetics & genomic medicine vol. 2,5 (2014): 438-50. doi: https://doi.org/10.1002/mgg3.86
Freudenberg-Hua Y, Freudenberg J, Vacic V, Abhyankar A, Emde AK, Ben-Avraham D, Barzilai N, Oschwald D, Christen E, Koppel J, Greenwald B, Darnell RB, Germer S, Atzmon G, Davies P. Disease variants in genomes of 44 centenarians. Mol Genet Genomic Med. 2014 Sep;2(5):438-50. doi: 10.1002/mgg3.86. Epub 2014 Jun 15. PMID: 25333069; PMCID: PMC4190879.
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THE LANGUAGE OF CLERGYMEN.

Science (New York, N.Y.)

Darnell TW, Allen ES.
PMID: 17735347
Science. 1931 Jan 16;73(1881):68. doi: 10.1126/science.73.1881.68.

No abstract available.

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Darnell TW, Allen ES. THE LANGUAGE OF CLERGYMEN. Science. 1931;73(1881):68doi: 10.1126/science.73.1881.68.
Darnell, T. W., & Allen, E. S. (1931). THE LANGUAGE OF CLERGYMEN. Science (New York, N.Y.), 73(1881), 68. https://doi.org/10.1126/science.73.1881.68
Darnell, T W, and Allen, E S. "THE LANGUAGE OF CLERGYMEN." Science (New York, N.Y.) vol. 73,1881 (1931): 68. doi: https://doi.org/10.1126/science.73.1881.68
Darnell TW, Allen ES. THE LANGUAGE OF CLERGYMEN. Science. 1931 Jan 16;73(1881):68. doi: 10.1126/science.73.1881.68. PMID: 17735347.
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Latest developments at GANIL for stable and radioactive ion beam production.

The Review of scientific instruments

Jardin P, Barué C, Bajeat O, Canet C, Clément E, Cornell JC, Delahaye P, Dubois M, Dupuis M, Flambard JL, Frånberg H, Frigot R, Leboucher C, Lecesne N, Lecomte P, Lehérissier P, Lemagnen F, Leroy R, Maunoury L, Méry A, De Oliveira F, Pichard A, Pacquet JY, Saint-Laurent MG, Thomas JC.
PMID: 20192406
Rev Sci Instrum. 2010 Feb;81(2):02A909. doi: 10.1063/1.3267296.

In the frame of the SPIRAL II (Système de Production d'Ions Radioactifs Accélérés en Ligne Partie II) project, several developments of stable and radioactive ion production systems have been started up. In parallel, GANIL has the ambition to preserve...

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Jardin P, Barué C, Bajeat O, et al. Latest developments at GANIL for stable and radioactive ion beam production. Rev Sci Instrum. 2010;81(2):02A909doi: 10.1063/1.3267296.
Jardin, P., Barué, C., Bajeat, O., Canet, C., Clément, E., Cornell, J. C., Delahaye, P., Dubois, M., Dupuis, M., Flambard, J. L., Frånberg, H., Frigot, R., Leboucher, C., Lecesne, N., Lecomte, P., Lehérissier, P., Lemagnen, F., Leroy, R., Maunoury, L., Méry, A., De Oliveira, F., Pichard, A., Pacquet, J. Y., Saint-Laurent, M. G., & Thomas, J. C. (2010). Latest developments at GANIL for stable and radioactive ion beam production. The Review of scientific instruments, 81(2), 02A909. https://doi.org/10.1063/1.3267296
Jardin, P, et al. "Latest developments at GANIL for stable and radioactive ion beam production." The Review of scientific instruments vol. 81,2 (2010): 02A909. doi: https://doi.org/10.1063/1.3267296
Jardin P, Barué C, Bajeat O, Canet C, Clément E, Cornell JC, Delahaye P, Dubois M, Dupuis M, Flambard JL, Frånberg H, Frigot R, Leboucher C, Lecesne N, Lecomte P, Lehérissier P, Lemagnen F, Leroy R, Maunoury L, Méry A, De Oliveira F, Pichard A, Pacquet JY, Saint-Laurent MG, Thomas JC. Latest developments at GANIL for stable and radioactive ion beam production. Rev Sci Instrum. 2010 Feb;81(2):02A909. doi: 10.1063/1.3267296. PMID: 20192406.
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Vitamin D intake is associated with insulin sensitivity in African American, but not European American, women.

Nutrition & metabolism

Alvarez JA, Bush NC, Choquette SS, Hunter GR, Darnell BE, Oster RA, Gower BA.
PMID: 20398267
Nutr Metab (Lond). 2010 Apr 14;7:28. doi: 10.1186/1743-7075-7-28.

BACKGROUND: The prevalence of type 2 diabetes is higher among African Americans (AA) vs European Americans (EA), independent of obesity and other known confounders. Although the reason for this disparity is not known, it is possible that relatively low...

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Alvarez JA, Bush NC, Choquette SS, et al. Vitamin D intake is associated with insulin sensitivity in African American, but not European American, women. Nutr Metab (Lond). 2010;7:28doi: 10.1186/1743-7075-7-28.
Alvarez, J. A., Bush, N. C., Choquette, S. S., Hunter, G. R., Darnell, B. E., Oster, R. A., & Gower, B. A. (2010). Vitamin D intake is associated with insulin sensitivity in African American, but not European American, women. Nutrition & metabolism, 728. https://doi.org/10.1186/1743-7075-7-28
Alvarez, Jessica A, et al. "Vitamin D intake is associated with insulin sensitivity in African American, but not European American, women." Nutrition & metabolism vol. 7 (2010): 28. doi: https://doi.org/10.1186/1743-7075-7-28
Alvarez JA, Bush NC, Choquette SS, Hunter GR, Darnell BE, Oster RA, Gower BA. Vitamin D intake is associated with insulin sensitivity in African American, but not European American, women. Nutr Metab (Lond). 2010 Apr 14;7:28. doi: 10.1186/1743-7075-7-28. PMID: 20398267; PMCID: PMC2868016.
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The Neuronal Splicing Factor Nova Co-Localizes with Target RNAs in the Dendrite.

Frontiers in neural circuits

Racca C, Gardiol A, Eom T, Ule J, Triller A, Darnell RB.
PMID: 20407637
Front Neural Circuits. 2010 Mar 03;4:5. doi: 10.3389/neuro.04.005.2010. eCollection 2010.

Nova proteins are neuron-specific RNA binding proteins targeted by autoantibodies in a disorder manifest by failure of motor inhibition, and they regulate splicing and alternative 3' processing. Nova regulates splicing of RNAs encoding synaptic proteins, including the inhibitory glycine...

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Racca C, Gardiol A, Eom T, et al. The Neuronal Splicing Factor Nova Co-Localizes with Target RNAs in the Dendrite. Front Neural Circuits. 2010;4:5doi: 10.3389/neuro.04.005.2010.
Racca, C., Gardiol, A., Eom, T., Ule, J., Triller, A., & Darnell, R. B. (2010). The Neuronal Splicing Factor Nova Co-Localizes with Target RNAs in the Dendrite. Frontiers in neural circuits, 45. https://doi.org/10.3389/neuro.04.005.2010
Racca, Claudia, et al. "The Neuronal Splicing Factor Nova Co-Localizes with Target RNAs in the Dendrite." Frontiers in neural circuits vol. 4 (2010): 5. doi: https://doi.org/10.3389/neuro.04.005.2010
Racca C, Gardiol A, Eom T, Ule J, Triller A, Darnell RB. The Neuronal Splicing Factor Nova Co-Localizes with Target RNAs in the Dendrite. Front Neural Circuits. 2010 Mar 03;4:5. doi: 10.3389/neuro.04.005.2010. eCollection 2010. PMID: 20407637; PMCID: PMC2856630.
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RNA regulation in neurologic disease and cancer.

Cancer research and treatment

Darnell RB.
PMID: 20948916
Cancer Res Treat. 2010 Sep;42(3):125-9. doi: 10.4143/crt.2010.42.3.125. Epub 2010 Sep 30.

The paraneoplastic neurologic diseases (PNDs) are brain degenerations that develop in the setting of clinically inapparent cancers. PNDs arise when common cancers express brain proteins, triggering an anti-tumor immune response and tumor immunity. Research on these brain-cancer proteins has...

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Darnell RB. RNA regulation in neurologic disease and cancer. Cancer Res Treat. 2010;42(3):125-9doi: 10.4143/crt.2010.42.3.125.
Darnell, R. B. (2010). RNA regulation in neurologic disease and cancer. Cancer research and treatment, 42(3), 125-9. https://doi.org/10.4143/crt.2010.42.3.125
Darnell, Robert B. "RNA regulation in neurologic disease and cancer." Cancer research and treatment vol. 42,3 (2010): 125-9. doi: https://doi.org/10.4143/crt.2010.42.3.125
Darnell RB. RNA regulation in neurologic disease and cancer. Cancer Res Treat. 2010 Sep;42(3):125-9. doi: 10.4143/crt.2010.42.3.125. Epub 2010 Sep 30. PMID: 20948916; PMCID: PMC2953774.
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Erratum: Mapping Argonaute and conventional RNA-binding protein interactions with RNA at single-nucleotide resolution using HITS-CLIP and CIMS analysis.

Nature protocols

Moore MJ, Zhang C, Gantman EC, Mele A, Darnell JC, Darnell RB.
PMID: 26914319
Nat Protoc. 2016 Mar;11(3):616. doi: 10.1038/nprot0316-616c. Epub 2016 Feb 25.

No abstract available.

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Moore MJ, Zhang C, Gantman EC, et al. Erratum: Mapping Argonaute and conventional RNA-binding protein interactions with RNA at single-nucleotide resolution using HITS-CLIP and CIMS analysis. Nat Protoc. 2016;11(3):616doi: 10.1038/nprot0316-616c.
Moore, M. J., Zhang, C., Gantman, E. C., Mele, A., Darnell, J. C., & Darnell, R. B. (2016). Erratum: Mapping Argonaute and conventional RNA-binding protein interactions with RNA at single-nucleotide resolution using HITS-CLIP and CIMS analysis. Nature protocols, 11(3), 616. https://doi.org/10.1038/nprot0316-616c
Moore, Michael J, et al. "Erratum: Mapping Argonaute and conventional RNA-binding protein interactions with RNA at single-nucleotide resolution using HITS-CLIP and CIMS analysis." Nature protocols vol. 11,3 (2016): 616. doi: https://doi.org/10.1038/nprot0316-616c
Moore MJ, Zhang C, Gantman EC, Mele A, Darnell JC, Darnell RB. Erratum: Mapping Argonaute and conventional RNA-binding protein interactions with RNA at single-nucleotide resolution using HITS-CLIP and CIMS analysis. Nat Protoc. 2016 Mar;11(3):616. doi: 10.1038/nprot0316-616c. Epub 2016 Feb 25. PMID: 26914319.
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Mental health service utilization following a campus mass shooting: The role of preshooting emotion dysregulation and posttraumatic cognitions.

Psychological trauma : theory, research, practice and policy

Reffi AN, Ellis RA, Darnell BC, Orcutt HK.
PMID: 34197171
Psychol Trauma. 2022 Jan;14(1):151-160. doi: 10.1037/tra0001036. Epub 2021 Jul 01.

OBJECTIVE: This study investigated preshooting emotion dysregulation and posttraumatic cognitions as predictors of mental health service utilization ([MHU]; i.e., therapy/medication) among undergraduate women following a campus mass shooting, controlling for time, age, and postshooting posttraumatic stress (PTS) and depressive...

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Reffi AN, Ellis RA, Darnell BC, et al. Mental health service utilization following a campus mass shooting: The role of preshooting emotion dysregulation and posttraumatic cognitions. Psychol Trauma. 2021;14(1):151-160doi: 10.1037/tra0001036.
Reffi, A. N., Ellis, R. A., Darnell, B. C., & Orcutt, H. K. (2022). Mental health service utilization following a campus mass shooting: The role of preshooting emotion dysregulation and posttraumatic cognitions. Psychological trauma : theory, research, practice and policy, 14(1), 151-160. https://doi.org/10.1037/tra0001036
Reffi, Anthony N, et al. "Mental health service utilization following a campus mass shooting: The role of preshooting emotion dysregulation and posttraumatic cognitions." Psychological trauma : theory, research, practice and policy vol. 14,1 (2022): 151-160. doi: https://doi.org/10.1037/tra0001036
Reffi AN, Ellis RA, Darnell BC, Orcutt HK. Mental health service utilization following a campus mass shooting: The role of preshooting emotion dysregulation and posttraumatic cognitions. Psychol Trauma. 2022 Jan;14(1):151-160. doi: 10.1037/tra0001036. Epub 2021 Jul 01. PMID: 34197171; PMCID: PMC8720105.
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Acute Beet Juice Supplementation Does Not Improve 30- or 60-second Maximal Intensity Performance in Anaerobically Trained Athletes.

International journal of exercise science

Conger SA, Zamzow CM, Darnell ME.
PMID: 34055148
Int J Exerc Sci. 2021 Apr 01;14(2):60-75. eCollection 2021.

Research suggests that beet juice is beneficial during aerobic exercise. However, the impact of beet juice during primarily anaerobic exercise is equivocal. The purpose of this study was to determine the effects of acute beet juice supplementation on maximal...

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Conger SA, Zamzow CM, Darnell ME. Acute Beet Juice Supplementation Does Not Improve 30- or 60-second Maximal Intensity Performance in Anaerobically Trained Athletes. Int J Exerc Sci. 2021;14(2):60-75
Conger, S. A., Zamzow, C. M., & Darnell, M. E. (2021). Acute Beet Juice Supplementation Does Not Improve 30- or 60-second Maximal Intensity Performance in Anaerobically Trained Athletes. International journal of exercise science, 14(2), 60-75.
Conger, Scott A, et al. "Acute Beet Juice Supplementation Does Not Improve 30- or 60-second Maximal Intensity Performance in Anaerobically Trained Athletes." International journal of exercise science vol. 14,2 (2021): 60-75.
Conger SA, Zamzow CM, Darnell ME. Acute Beet Juice Supplementation Does Not Improve 30- or 60-second Maximal Intensity Performance in Anaerobically Trained Athletes. Int J Exerc Sci. 2021 Apr 01;14(2):60-75. eCollection 2021. PMID: 34055148; PMCID: PMC8136611.
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FMRP regulates mRNAs encoding distinct functions in the cell body and dendrites of CA1 pyramidal neurons.

eLife

Hale CR, Sawicka K, Mora K, Fak JJ, Kang JJ, Cutrim P, Cialowicz K, Carroll TS, Darnell RB.
PMID: 34939924
Elife. 2021 Dec 23;10. doi: 10.7554/eLife.71892. Epub 2021 Dec 23.

Neurons rely on translation of synaptic mRNAs in order to generate activity-dependent changes in plasticity. Here we develop a strategy combining compartment-specific CLIP and TRAP in conditionally tagged mice to precisely define the ribosome-bound dendritic transcriptome of CA1 pyramidal...

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Hale CR, Sawicka K, Mora K, et al. FMRP regulates mRNAs encoding distinct functions in the cell body and dendrites of CA1 pyramidal neurons. Elife. 2021;10doi: 10.7554/eLife.71892.
Hale, C. R., Sawicka, K., Mora, K., Fak, J. J., Kang, J. J., Cutrim, P., Cialowicz, K., Carroll, T. S., & Darnell, R. B. (2021). FMRP regulates mRNAs encoding distinct functions in the cell body and dendrites of CA1 pyramidal neurons. eLife, 10. https://doi.org/10.7554/eLife.71892
Hale, Caryn R, et al. "FMRP regulates mRNAs encoding distinct functions in the cell body and dendrites of CA1 pyramidal neurons." eLife vol. 10 (2021). doi: https://doi.org/10.7554/eLife.71892
Hale CR, Sawicka K, Mora K, Fak JJ, Kang JJ, Cutrim P, Cialowicz K, Carroll TS, Darnell RB. FMRP regulates mRNAs encoding distinct functions in the cell body and dendrites of CA1 pyramidal neurons. Elife. 2021 Dec 23;10. doi: 10.7554/eLife.71892. Epub 2021 Dec 23. PMID: 34939924.
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Showing 1 to 12 of 65 entries