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Importance of Including Non-European Populations in Large Human Genetic Studies to Enhance Precision Medicine

Science and underrepresentation

Hui D, Ju D, Wonkam A.
GSID: BNeRO23M0SkJ
D Ju, D Hui, DA Hammond, A Wonkam… - … Data Science, 2022 - annualreviews.org

One goal of genomic medicine is to uncover an individual's genetic risk for disease, which generally requires data connecting genotype to phenotype, as done in genome-wide association studies (GWAS). While there may be clinical promise to employing prediction tools...

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Ju, D., Hui, D., Hammond, D. A., Wonkam, A., & Tishkoff, S. A. (2022). Importance of Including Non-European Populations in Large Human Genetic Studies to Enhance Precision Medicine. Annual Review of Biomedical Data Science, 5.
Ju, Dan, et al. "Importance of Including Non-European Populations in Large Human Genetic Studies to Enhance Precision Medicine." Annual Review of Biomedical Data Science 5 (2022).
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Weakening density dependence from climate change and agricultural intensification triggers pest outbreaks: a 37-year observation of cotton bollworms.

Ecology and evolution

Ouyang F, Hui C, Ge S, Men XY, Zhao ZH, Shi PJ, Zhang YS, Li BL.
PMID: 25535553
Ecol Evol. 2014 Sep;4(17):3362-74. doi: 10.1002/ece3.1190. Epub 2014 Aug 12.

Understanding drivers of population fluctuation, especially for agricultural pests, is central to the provision of agro-ecosystem services. Here, we examine the role of endogenous density dependence and exogenous factors of climate and human activity in regulating the 37-year population...

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Ouyang F, Hui C, Ge S, et al. Weakening density dependence from climate change and agricultural intensification triggers pest outbreaks: a 37-year observation of cotton bollworms. Ecol Evol. 2014;4(17):3362-74doi: 10.1002/ece3.1190.
Ouyang, F., Hui, C., Ge, S., Men, X. Y., Zhao, Z. H., Shi, P. J., Zhang, Y. S., & Li, B. L. (2014). Weakening density dependence from climate change and agricultural intensification triggers pest outbreaks: a 37-year observation of cotton bollworms. Ecology and evolution, 4(17), 3362-74. https://doi.org/10.1002/ece3.1190
Ouyang, Fang, et al. "Weakening density dependence from climate change and agricultural intensification triggers pest outbreaks: a 37-year observation of cotton bollworms." Ecology and evolution vol. 4,17 (2014): 3362-74. doi: https://doi.org/10.1002/ece3.1190
Ouyang F, Hui C, Ge S, Men XY, Zhao ZH, Shi PJ, Zhang YS, Li BL. Weakening density dependence from climate change and agricultural intensification triggers pest outbreaks: a 37-year observation of cotton bollworms. Ecol Evol. 2014 Sep;4(17):3362-74. doi: 10.1002/ece3.1190. Epub 2014 Aug 12. PMID: 25535553; PMCID: PMC4228611.
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Embedded optical waveguides fabricated in SF10 glass by low-repetition-rate ultrafast laser.

Applied optics

Bai J, Long X, Liu X, Huo G, Zhao W, Stoian R, Hui R, Cheng G.
PMID: 24216582
Appl Opt. 2013 Oct 20;52(30):7288-94. doi: 10.1364/AO.52.007288.

Symmetric embedded waveguides were fabricated in heavy metal oxide SF10 glass using slit-shaped infrared femtosecond laser writing in the low-repetition frequency regime. The impact of the writing parameters on the waveguide formation in the transverse writing scheme was systemically...

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Bai J, Long X, Liu X, et al. Embedded optical waveguides fabricated in SF10 glass by low-repetition-rate ultrafast laser. Appl Opt. 2013;52(30):7288-94doi: 10.1364/AO.52.007288.
Bai, J., Long, X., Liu, X., Huo, G., Zhao, W., Stoian, R., Hui, R., & Cheng, G. (2013). Embedded optical waveguides fabricated in SF10 glass by low-repetition-rate ultrafast laser. Applied optics, 52(30), 7288-94. https://doi.org/10.1364/AO.52.007288
Bai, Jing, et al. "Embedded optical waveguides fabricated in SF10 glass by low-repetition-rate ultrafast laser." Applied optics vol. 52,30 (2013): 7288-94. doi: https://doi.org/10.1364/AO.52.007288
Bai J, Long X, Liu X, Huo G, Zhao W, Stoian R, Hui R, Cheng G. Embedded optical waveguides fabricated in SF10 glass by low-repetition-rate ultrafast laser. Appl Opt. 2013 Oct 20;52(30):7288-94. doi: 10.1364/AO.52.007288. PMID: 24216582.
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A novel lncRNA, LL22NC03-N64E9.1, represses KLF2 transcription through binding with EZH2 in colorectal cancer.

Oncotarget

Lian Y, Yan C, Ding J, Xia R, Ma Z, Hui B, Ji H, Zhou J, Wang K.
PMID: 28938648
Oncotarget. 2017 Jul 31;8(35):59435-59445. doi: 10.18632/oncotarget.19738. eCollection 2017 Aug 29.

Long noncoding RNAs (lncRNA) have been implicated in variety human cancer but their mechanisms of function are mainly undocumented. In the present study, we investigated lncRNAs alteration that contributed to colorectal cancer (CRC) by utilizing TCGA RNA sequencing data...

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Lian Y, Yan C, Ding J, et al. A novel lncRNA, LL22NC03-N64E9.1, represses KLF2 transcription through binding with EZH2 in colorectal cancer. Oncotarget. 2017;8(35):59435-59445doi: 10.18632/oncotarget.19738.
Lian, Y., Yan, C., Ding, J., Xia, R., Ma, Z., Hui, B., Ji, H., Zhou, J., & Wang, K. (2017). A novel lncRNA, LL22NC03-N64E9.1, represses KLF2 transcription through binding with EZH2 in colorectal cancer. Oncotarget, 8(35), 59435-59445. https://doi.org/10.18632/oncotarget.19738
Lian, Yifan, et al. "A novel lncRNA, LL22NC03-N64E9.1, represses KLF2 transcription through binding with EZH2 in colorectal cancer." Oncotarget vol. 8,35 (2017): 59435-59445. doi: https://doi.org/10.18632/oncotarget.19738
Lian Y, Yan C, Ding J, Xia R, Ma Z, Hui B, Ji H, Zhou J, Wang K. A novel lncRNA, LL22NC03-N64E9.1, represses KLF2 transcription through binding with EZH2 in colorectal cancer. Oncotarget. 2017 Jul 31;8(35):59435-59445. doi: 10.18632/oncotarget.19738. eCollection 2017 Aug 29. PMID: 28938648; PMCID: PMC5601744.
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Hybrid Monoterpenoid Indole Alkaloids Obtained as Artifacts from Rauvolfia tetraphylla.

Natural products and bioprospecting

Gao Y, Zhou DS, Hai P, Li Y, Wang F.
PMID: 26416155
Nat Prod Bioprospect. 2015 Oct;5(5):247-53. doi: 10.1007/s13659-015-0074-2. Epub 2015 Sep 29.

Five new hybrid monoterpenoid indole alkaloids bearing an unusual 2,2-dimethyl-4-oxopiperidin-6-yl moiety, namely rauvotetraphyllines F-H (1, 3, 4), 17-epi-rauvotetraphylline F (2) and 21-epi-rauvotetraphylline H (5), were isolated from the aerial parts of Rauvolfia tetraphylla. Their structures were established by extensive...

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Gao Y, Zhou DS, Hai P, et al. Hybrid Monoterpenoid Indole Alkaloids Obtained as Artifacts from Rauvolfia tetraphylla. Nat Prod Bioprospect. 2015;5(5):247-53doi: 10.1007/s13659-015-0074-2.
Gao, Y., Zhou, D. S., Hai, P., Li, Y., & Wang, F. (2015). Hybrid Monoterpenoid Indole Alkaloids Obtained as Artifacts from Rauvolfia tetraphylla. Natural products and bioprospecting, 5(5), 247-53. https://doi.org/10.1007/s13659-015-0074-2
Gao, Yuan, et al. "Hybrid Monoterpenoid Indole Alkaloids Obtained as Artifacts from Rauvolfia tetraphylla." Natural products and bioprospecting vol. 5,5 (2015): 247-53. doi: https://doi.org/10.1007/s13659-015-0074-2
Gao Y, Zhou DS, Hai P, Li Y, Wang F. Hybrid Monoterpenoid Indole Alkaloids Obtained as Artifacts from Rauvolfia tetraphylla. Nat Prod Bioprospect. 2015 Oct;5(5):247-53. doi: 10.1007/s13659-015-0074-2. Epub 2015 Sep 29. PMID: 26416155; PMCID: PMC4607677.
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Ethanol-Induced Neurodegeneration and Glial Activation in the Developing Brain.

Brain sciences

Saito M, Chakraborty G, Hui M, Masiello K, Saito M.
PMID: 27537918
Brain Sci. 2016 Aug 16;6(3). doi: 10.3390/brainsci6030031.

Ethanol induces neurodegeneration in the developing brain, which may partially explain the long-lasting adverse effects of prenatal ethanol exposure in fetal alcohol spectrum disorders (FASD). While animal models of FASD show that ethanol-induced neurodegeneration is associated with glial activation,...

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Saito M, Chakraborty G, Hui M, et al. Ethanol-Induced Neurodegeneration and Glial Activation in the Developing Brain. Brain Sci. 2016;6(3)doi: 10.3390/brainsci6030031.
Saito, M., Chakraborty, G., Hui, M., Masiello, K., & Saito, M. (2016). Ethanol-Induced Neurodegeneration and Glial Activation in the Developing Brain. Brain sciences, 6(3), . https://doi.org/10.3390/brainsci6030031
Saito, Mariko, et al. "Ethanol-Induced Neurodegeneration and Glial Activation in the Developing Brain." Brain sciences vol. 6,3 (2016). doi: https://doi.org/10.3390/brainsci6030031
Saito M, Chakraborty G, Hui M, Masiello K, Saito M. Ethanol-Induced Neurodegeneration and Glial Activation in the Developing Brain. Brain Sci. 2016 Aug 16;6(3). doi: 10.3390/brainsci6030031. PMID: 27537918; PMCID: PMC5039460.
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Layer Number Dependence of Li(+) Intercalation on Few-Layer Graphene and Electrochemical Imaging of Its Solid-Electrolyte Interphase Evolution.

ACS nano

Hui J, Burgess M, Zhang J, Rodríguez-López J.
PMID: 26943950
ACS Nano. 2016 Apr 26;10(4):4248-57. doi: 10.1021/acsnano.5b07692. Epub 2016 Mar 14.

A fundamental question facing electrodes made out of few layers of graphene (FLG) is if they display chemical properties that are different to their bulk graphite counterpart. Here, we show evidence that suggests that lithium ion intercalation on FLG,...

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Hui J, Burgess M, Zhang J, et al. Layer Number Dependence of Li(+) Intercalation on Few-Layer Graphene and Electrochemical Imaging of Its Solid-Electrolyte Interphase Evolution. ACS Nano. 2016;10(4):4248-57doi: 10.1021/acsnano.5b07692.
Hui, J., Burgess, M., Zhang, J., & Rodríguez-López, J. (2016). Layer Number Dependence of Li(+) Intercalation on Few-Layer Graphene and Electrochemical Imaging of Its Solid-Electrolyte Interphase Evolution. ACS nano, 10(4), 4248-57. https://doi.org/10.1021/acsnano.5b07692
Hui, Jingshu, et al. "Layer Number Dependence of Li(+) Intercalation on Few-Layer Graphene and Electrochemical Imaging of Its Solid-Electrolyte Interphase Evolution." ACS nano vol. 10,4 (2016): 4248-57. doi: https://doi.org/10.1021/acsnano.5b07692
Hui J, Burgess M, Zhang J, Rodríguez-López J. Layer Number Dependence of Li(+) Intercalation on Few-Layer Graphene and Electrochemical Imaging of Its Solid-Electrolyte Interphase Evolution. ACS Nano. 2016 Apr 26;10(4):4248-57. doi: 10.1021/acsnano.5b07692. Epub 2016 Mar 14. PMID: 26943950.
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The role and significance of VEGFR2.

OncoTargets and therapy

Zhu P, Hu C, Hui K, Jiang X.
PMID: 28919780
Onco Targets Ther. 2017 Sep 01;10:4315-4319. doi: 10.2147/OTT.S142085. eCollection 2017.

Tumor development is closely related to angiogenesis, and VEGFR2 plays an important role in tumor angiogenesis. It is broadly expressed in the blood vessels, especially in the microvessels of tumor tissues. Furthermore, VEGFR2 is detected on the surface of...

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Zhu P, Hu C, Hui K, et al. The role and significance of VEGFR2. Onco Targets Ther. 2017;10:4315-4319doi: 10.2147/OTT.S142085.
Zhu, P., Hu, C., Hui, K., & Jiang, X. (2017). The role and significance of VEGFR2. OncoTargets and therapy, 104315-4319. https://doi.org/10.2147/OTT.S142085
Zhu, Panrong, et al. "The role and significance of VEGFR2." OncoTargets and therapy vol. 10 (2017): 4315-4319. doi: https://doi.org/10.2147/OTT.S142085
Zhu P, Hu C, Hui K, Jiang X. The role and significance of VEGFR2. Onco Targets Ther. 2017 Sep 01;10:4315-4319. doi: 10.2147/OTT.S142085. eCollection 2017. PMID: 28919780; PMCID: PMC5590762.
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Identification of hub genes and pathways associated with hepatocellular carcinoma based on network strategy.

Experimental and therapeutic medicine

Liu J, Hua P, Hui L, Zhang LL, Hu Z, Zhu YW.
PMID: 27703495
Exp Ther Med. 2016 Oct;12(4):2109-2119. doi: 10.3892/etm.2016.3599. Epub 2016 Aug 12.

The objective of this study was to identify hub genes and pathways associated with hepatocellular carcinoma (HCC) by centrality analysis of a co-expression network. A co-expression network based on differentially expressed (DE) genes of HCC was constructed using the...

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Liu J, Hua P, Hui L, et al. Identification of hub genes and pathways associated with hepatocellular carcinoma based on network strategy. Exp Ther Med. 2016;12(4):2109-2119doi: 10.3892/etm.2016.3599.
Liu, J., Hua, P., Hui, L., Zhang, L. L., Hu, Z., & Zhu, Y. W. (2016). Identification of hub genes and pathways associated with hepatocellular carcinoma based on network strategy. Experimental and therapeutic medicine, 12(4), 2109-2119. https://doi.org/10.3892/etm.2016.3599
Liu, Jun, et al. "Identification of hub genes and pathways associated with hepatocellular carcinoma based on network strategy." Experimental and therapeutic medicine vol. 12,4 (2016): 2109-2119. doi: https://doi.org/10.3892/etm.2016.3599
Liu J, Hua P, Hui L, Zhang LL, Hu Z, Zhu YW. Identification of hub genes and pathways associated with hepatocellular carcinoma based on network strategy. Exp Ther Med. 2016 Oct;12(4):2109-2119. doi: 10.3892/etm.2016.3599. Epub 2016 Aug 12. PMID: 27703495; PMCID: PMC5039750.
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Small Molecules Facilitate Single Factor-Mediated Hepatic Reprogramming.

Cell reports

Lim KT, Lee SC, Gao Y, Kim KP, Song G, An SY, Adachi K, Jang YJ, Kim J, Oh KJ, Kwak TH, Hwang SI, You JS, Ko K, Koo SH, Sharma AD, Kim JH, Hui L, Cantz T, Schöler HR, Han DW.
PMID: 27149847
Cell Rep. 2016 Apr 26;15(4):814-829. doi: 10.1016/j.celrep.2016.03.071. Epub 2016 Apr 14.

Recent studies have shown that defined factors could lead to the direct conversion of fibroblasts into induced hepatocyte-like cells (iHeps). However, reported conversion efficiencies are very low, and the underlying mechanism of the direct hepatic reprogramming is largely unknown....

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Lim KT, Lee SC, Gao Y, et al. Small Molecules Facilitate Single Factor-Mediated Hepatic Reprogramming. Cell Rep. 2016;15(4):814-829doi: 10.1016/j.celrep.2016.03.071.
Lim, K. T., Lee, S. C., Gao, Y., Kim, K. P., Song, G., An, S. Y., Adachi, K., Jang, Y. J., Kim, J., Oh, K. J., Kwak, T. H., Hwang, S. I., You, J. S., Ko, K., Koo, S. H., Sharma, A. D., Kim, J. H., Hui, L., Cantz, T., Schöler, H. R., & Han, D. W. (2016). Small Molecules Facilitate Single Factor-Mediated Hepatic Reprogramming. Cell reports, 15(4), 814-829. https://doi.org/10.1016/j.celrep.2016.03.071
Lim, Kyung Tae, et al. "Small Molecules Facilitate Single Factor-Mediated Hepatic Reprogramming." Cell reports vol. 15,4 (2016): 814-829. doi: https://doi.org/10.1016/j.celrep.2016.03.071
Lim KT, Lee SC, Gao Y, Kim KP, Song G, An SY, Adachi K, Jang YJ, Kim J, Oh KJ, Kwak TH, Hwang SI, You JS, Ko K, Koo SH, Sharma AD, Kim JH, Hui L, Cantz T, Schöler HR, Han DW. Small Molecules Facilitate Single Factor-Mediated Hepatic Reprogramming. Cell Rep. 2016 Apr 26;15(4):814-829. doi: 10.1016/j.celrep.2016.03.071. Epub 2016 Apr 14. PMID: 27149847.
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Polymer Nanocomposite Electrode Consisting of Polyaniline and Modified Multi-Walled Carbon Nanotube for Rechargeable Battery.

Journal of nanoscience and nanotechnology

Ha JS, Lee JM, Lee HR, Huh P, Jo NJ.
PMID: 26726628
J Nanosci Nanotechnol. 2015 Nov;15(11):8977-83. doi: 10.1166/jnn.2015.11569.

In this study, PANI nanocomposite with modified multi-walled carbon nanotube (mMWCNT) was prepared. Herein MWCNT was modified by Friedel-Crafts acylation reaction. The dc conductivity of PANI nanocomposite according to the content of mMWCNT was measured by four-point probe. The...

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Ha JS, Lee JM, Lee HR, et al. Polymer Nanocomposite Electrode Consisting of Polyaniline and Modified Multi-Walled Carbon Nanotube for Rechargeable Battery. J Nanosci Nanotechnol. 2015;15(11):8977-83doi: 10.1166/jnn.2015.11569.
Ha, J. S., Lee, J. M., Lee, H. R., Huh, P., & Jo, N. J. (2015). Polymer Nanocomposite Electrode Consisting of Polyaniline and Modified Multi-Walled Carbon Nanotube for Rechargeable Battery. Journal of nanoscience and nanotechnology, 15(11), 8977-83. https://doi.org/10.1166/jnn.2015.11569
Ha, Jeong-Seon, et al. "Polymer Nanocomposite Electrode Consisting of Polyaniline and Modified Multi-Walled Carbon Nanotube for Rechargeable Battery." Journal of nanoscience and nanotechnology vol. 15,11 (2015): 8977-83. doi: https://doi.org/10.1166/jnn.2015.11569
Ha JS, Lee JM, Lee HR, Huh P, Jo NJ. Polymer Nanocomposite Electrode Consisting of Polyaniline and Modified Multi-Walled Carbon Nanotube for Rechargeable Battery. J Nanosci Nanotechnol. 2015 Nov;15(11):8977-83. doi: 10.1166/jnn.2015.11569. PMID: 26726628.
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Hypermetabolism and symptom burden in advanced cancer patients evaluated in a cachexia clinic.

Journal of cachexia, sarcopenia and muscle

Dev R, Hui D, Chisholm G, Delgado-Guay M, Dalal S, Del Fabbro E, Bruera E.
PMID: 26136416
J Cachexia Sarcopenia Muscle. 2015 Mar;6(1):95-8. doi: 10.1002/jcsm.12014. Epub 2015 Mar 31.

BACKGROUND: Elevated resting energy expenditure (REE) may contribute to weight loss and symptom burden in cancer patients.AIMS: The aim of this study was to compare the velocity of weight loss, symptom burden (fatigue, insomnia, anxiety, and anorexia-combined score as...

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Dev R, Hui D, Chisholm G, et al. Hypermetabolism and symptom burden in advanced cancer patients evaluated in a cachexia clinic. J Cachexia Sarcopenia Muscle. 2015;6(1):95-8doi: 10.1002/jcsm.12014.
Dev, R., Hui, D., Chisholm, G., Delgado-Guay, M., Dalal, S., Del Fabbro, E., & Bruera, E. (2015). Hypermetabolism and symptom burden in advanced cancer patients evaluated in a cachexia clinic. Journal of cachexia, sarcopenia and muscle, 6(1), 95-8. https://doi.org/10.1002/jcsm.12014
Dev, Rony, et al. "Hypermetabolism and symptom burden in advanced cancer patients evaluated in a cachexia clinic." Journal of cachexia, sarcopenia and muscle vol. 6,1 (2015): 95-8. doi: https://doi.org/10.1002/jcsm.12014
Dev R, Hui D, Chisholm G, Delgado-Guay M, Dalal S, Del Fabbro E, Bruera E. Hypermetabolism and symptom burden in advanced cancer patients evaluated in a cachexia clinic. J Cachexia Sarcopenia Muscle. 2015 Mar;6(1):95-8. doi: 10.1002/jcsm.12014. Epub 2015 Mar 31. PMID: 26136416; PMCID: PMC4435101.
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Showing 1 to 12 of 2062 entries