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Showing 1 to 12 of 52 entries
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Correction: Worldwide trends in volume and quality of published protocols of randomized controlled trials.

PloS one

van Rosmalen BV, Alldinger I, Cieslak KP, Wennink R, Clarke M, Ali UA, Besselink MGH.
PMID: 29073285
PLoS One. 2017 Oct 26;12(10):e0187389. doi: 10.1371/journal.pone.0187389. eCollection 2017.

[This corrects the article DOI: 10.1371/journal.pone.0173042.].

Does mixing acute medical admissions with burn patients increase infective complications from paediatric thermal injuries?.

JRSM short reports

Shaban F, Stewart K, Kalima P.
PMID: 21103093
JRSM Short Rep. 2010 Jun 30;1(1):1. doi: 10.1258/shorts.2009.090026.

In the winter of 2005-2006, the management at our children's hospital elected to admit 'overspill' acute medical admissions to the ward used for plastic surgery and burns for logistical reasons. This study was conducted to assess the effects of...

Molecular Application of Aptamers in the Diagnosis and Treatment of Cancer and Communicable Diseases.

Pharmaceuticals (Basel, Switzerland)

Molefe PF, Masamba P, Oyinloye BE, Mbatha LS, Meyer M, Kappo AP.
PMID: 30274155
Pharmaceuticals (Basel). 2018 Sep 28;11(4). doi: 10.3390/ph11040093.

Cancer and infectious diseases such as Ebola, HIV, tuberculosis, Zika, hepatitis, measles and human schistosomiasis are serious global health hazards. The increasing annual morbidities and mortalities of these diseases have been blamed on drug resistance and the inefficacy of...

Microscale thermophoresis analysis of the molecular interaction between small nuclear ribonucleoprotein polypeptide G and the RING finger domain of RBBP6 towards anti-cancer drug discovery.

American journal of translational research

Mabonga L, Masamba P, Basson AK, Kappo AP.
PMID: 34956492
Am J Transl Res. 2021 Nov 15;13(11):12775-12785. eCollection 2021.

Regulatory core-splicing proteins are now becoming highly promising therapeutic targets for the development of anti-cancer drugs. SNRPG and RBBP6 are two good examples of regulatory core-splicing proteins involved in tumorigenesis and tumor development whose multi-functional role is primarily mediated...

Current Biochemical Applications and Future Prospects of Chlorotoxin in Cancer Diagnostics and Therapeutics.

Advanced pharmaceutical bulletin

Khanyile S, Masamba P, Oyinloye BE, Mbatha LS, Kappo AP.
PMID: 31857956
Adv Pharm Bull. 2019 Oct;9(4):510-520. doi: 10.15171/apb.2019.061. Epub 2019 Oct 24.

Chlorotoxin (CTX) is a minute 4 kDa protein made up of 36 amino acid residues, commonly known for its binding affinity to chloride channels and matrix metalloproteinase-2 (MMP-2) of glioma tumors of the spine and brain. This property and...

Evaluating the Safety of Performing Flexible Cystoscopy When Urinalysis Suggests Presence of "Infection": Results of a Prospective Clinical Study in 2350 patients.

European urology open science

Trail M, Cullen J, Fulton E, Clayton F, McGregor E, McWilliam F, Dick L, Kalima P, Donat R, Mariappan P.
PMID: 34467238
Eur Urol Open Sci. 2021 Jul 26;31:28-36. doi: 10.1016/j.euros.2021.06.014. eCollection 2021 Sep.

BACKGROUND: There is significant underutilisation of allocated health service resources when a scheduled flexible cystoscopy (FC) is cancelled because a pre-cystoscopy urinalysis (PCU) suggests "infection", despite patients being asymptomatic for urinary tract infection (UTI).OBJECTIVE: To evaluate the risk of...

Anaerobic Digestion of Tetracycline Spiked Livestock Manure and Poultry Litter Increased the Abundances of Antibiotic and Heavy Metal Resistance Genes.

Frontiers in microbiology

Agga GE, Kasumba J, Loughrin JH, Conte ED.
PMID: 33391245
Front Microbiol. 2020 Dec 18;11:614424. doi: 10.3389/fmicb.2020.614424. eCollection 2020.

Anaerobic digestion is used for the treatment of animal manure by generating biogas. Heavy metals cause environmental pollutions and co-select for antimicrobial resistance. We evaluated the impact of mesophilic anaerobic digestion of cattle manure (CM), swine manure (SM) and...

A case of cutaneous toxigenic .

Access microbiology

Othieno R, Mark K, Etherson M, Foster G, Murray S, Kalima P, Fry NK, Cameron C, Strachan J.
PMID: 32974539
Access Microbiol. 2019 May 30;1(7):e000025. doi: 10.1099/acmi.0.000025. eCollection 2019.

CASE PRESENTATION: A 60-year-old female presented with a slow-healing finger-burn wound. A skin swab cultured CONCLUSION: This was a rare case of cutaneous diphtheria secondary to

Ethics of DNA research on human remains: five globally applicable guidelines.

Nature

Alpaslan-Roodenberg S, Anthony D, Babiker H, Bánffy E, Booth T, Capone P, Deshpande-Mukherjee A, Eisenmann S, Fehren-Schmitz L, Frachetti M, Fujita R, Frieman CJ, Fu Q, Gibbon V, Haak W, Hajdinjak M, Hofmann KP, Holguin B, Inomata T, Kanzawa-Kiriyama H, Keegan W, Kelso J, Krause J, Kumaresan G, Kusimba C, Kusimba S, Lalueza-Fox C, Llamas B, MacEachern S, Mallick S, Matsumura H, Morales-Arce AY, Matuzeviciute GM, Mushrif-Tripathy V, Nakatsuka N, Nores R, Ogola C, Okumura M, Patterson N, Pinhasi R, Prasad SPR, Prendergast ME, Punzo JL, Reich D, Sawafuji R, Sawchuk E, Schiffels S, Sedig J, Shnaider S, Sirak K, Skoglund P, Slon V, Snow M, Soressi M, Spriggs M, Stockhammer PW, Szécsényi-Nagy A, Thangaraj K, Tiesler V, Tobler R, Wang CC, Warinner C, Yasawardene S, Zahir M.
PMID: 34671160
Nature. 2021 Nov;599(7883):41-46. doi: 10.1038/s41586-021-04008-x. Epub 2021 Oct 20.

We are a group of archaeologists, anthropologists, curators and geneticists representing diverse global communities and 31 countries. All of us met in a virtual workshop dedicated to ethics in ancient DNA research held in November 2020. There was widespread...

Propulsion by stiff elastic filaments in viscous fluids.

Physical review. E

Katsamba P, Lauga E.
PMID: 31212530
Phys Rev E. 2019 May;99(5):053107. doi: 10.1103/PhysRevE.99.053107.

Flexible filaments moving in viscous fluids are ubiquitous in the natural microscopic world. For example, the swimming of bacteria and spermatozoa as well as important physiological functions at organ level, such as the cilia-induced motion of mucus in the...

Structural Analysis and Epitope Prediction of MHC Class-1-Chain Related Protein-A for Cancer Vaccine Development.

Vaccines

Adekiya TA, Aruleba RT, Khanyile S, Masamba P, Oyinloye BE, Kappo AP.
PMID: 29295563
Vaccines (Basel). 2017 Dec 25;6(1). doi: 10.3390/vaccines6010001.

Major histocompatibility complex class 1 chain-related gene sequence A is a polymorphic gene found at about 46.6 kb centromeric to HLA-B. It encodes a transmembrane protein, which is a non-classical human leukocyte antigen whose expression is normally induced by...

Roles of Heat Shock Proteins in Apoptosis, Oxidative Stress, Human Inflammatory Diseases, and Cancer.

Pharmaceuticals (Basel, Switzerland)

Ikwegbue PC, Masamba P, Oyinloye BE, Kappo AP.
PMID: 29295496
Pharmaceuticals (Basel). 2017 Dec 23;11(1). doi: 10.3390/ph11010002.

Heat shock proteins (HSPs) play cytoprotective activities under pathological conditions through the initiation of protein folding, repair, refolding of misfolded peptides, and possible degradation of irreparable proteins. Excessive apoptosis, resulting from increased reactive oxygen species (ROS) cellular levels and...

Showing 1 to 12 of 52 entries