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The hypergraph regularity method and its applications.

Proceedings of the National Academy of Sciences of the United States of America

Rödl V, Nagle B, Skokan J, Schacht M, Kohayakawa Y.
PMID: 15919821
Proc Natl Acad Sci U S A. 2005 Jun 07;102(23):8109-13. doi: 10.1073/pnas.0502771102. Epub 2005 May 26.

Szemeredi's regularity lemma asserts that every graph can be decomposed into relatively few random-like subgraphs. This random-like behavior enables one to find and enumerate subgraphs of a given isomorphism type, yielding the so-called counting lemma for graphs. The combined...

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Rödl V, Nagle B, Skokan J, et al. The hypergraph regularity method and its applications. Proc Natl Acad Sci U S A. 2005;102(23):8109-13doi: 10.1073/pnas.0502771102.
Rödl, V., Nagle, B., Skokan, J., Schacht, M., & Kohayakawa, Y. (2005). The hypergraph regularity method and its applications. Proceedings of the National Academy of Sciences of the United States of America, 102(23), 8109-13. https://doi.org/10.1073/pnas.0502771102
Rödl, V, et al. "The hypergraph regularity method and its applications." Proceedings of the National Academy of Sciences of the United States of America vol. 102,23 (2005): 8109-13. doi: https://doi.org/10.1073/pnas.0502771102
Rödl V, Nagle B, Skokan J, Schacht M, Kohayakawa Y. The hypergraph regularity method and its applications. Proc Natl Acad Sci U S A. 2005 Jun 07;102(23):8109-13. doi: 10.1073/pnas.0502771102. Epub 2005 May 26. PMID: 15919821; PMCID: PMC1149431.
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Cytomegalovirus esophagitis developing during chemoradiotherapy for esophageal cancer: two case reports.

Journal of medical case reports

Umemoto K, Kojima Y, Nagata N, Yokoi C, Sakurai T, Kobayakawa M, Iizuka T, Igari T, Yanase M, Akiyama J.
PMID: 27655584
J Med Case Rep. 2016 Sep 21;10(1):259. doi: 10.1186/s13256-016-0947-y.

BACKGROUND: It is well known that cytomegalovirus esophagitis occurs in immunosuppressed patients. However, few reports have described cytomegalovirus esophagitis occurring during chemoradiotherapy for esophageal cancer.CASE PRESENTATION: We report two cases of patients with cytomegalovirus esophagitis that developed during chemoradiotherapy...

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Umemoto K, Kojima Y, Nagata N, et al. Cytomegalovirus esophagitis developing during chemoradiotherapy for esophageal cancer: two case reports. J Med Case Rep. 2016;10(1):259doi: 10.1186/s13256-016-0947-y.
Umemoto, K., Kojima, Y., Nagata, N., Yokoi, C., Sakurai, T., Kobayakawa, M., Iizuka, T., Igari, T., Yanase, M., & Akiyama, J. (2016). Cytomegalovirus esophagitis developing during chemoradiotherapy for esophageal cancer: two case reports. Journal of medical case reports, 10(1), 259. https://doi.org/10.1186/s13256-016-0947-y
Umemoto, Kumiko, et al. "Cytomegalovirus esophagitis developing during chemoradiotherapy for esophageal cancer: two case reports." Journal of medical case reports vol. 10,1 (2016): 259. doi: https://doi.org/10.1186/s13256-016-0947-y
Umemoto K, Kojima Y, Nagata N, Yokoi C, Sakurai T, Kobayakawa M, Iizuka T, Igari T, Yanase M, Akiyama J. Cytomegalovirus esophagitis developing during chemoradiotherapy for esophageal cancer: two case reports. J Med Case Rep. 2016 Sep 21;10(1):259. doi: 10.1186/s13256-016-0947-y. PMID: 27655584; PMCID: PMC5031298.
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A Therapeutic Strategy to Combat HIV-1 Latently Infected Cells With a Combination of Latency-Reversing Agents Containing DAG-Lactone PKC Activators.

Frontiers in microbiology

Matsuda K, Kobayakawa T, Kariya R, Tsuchiya K, Ryu S, Tsuji K, Ishii T, Gatanaga H, Yoshimura K, Okada S, Hamada A, Mitsuya H, Tamamura H, Maeda K.
PMID: 33815322
Front Microbiol. 2021 Mar 17;12:636276. doi: 10.3389/fmicb.2021.636276. eCollection 2021.

Advances in antiviral therapy have dramatically improved the therapeutic effects on HIV type 1 (HIV-1) infection. However, even with potent combined antiretroviral therapy, HIV-1 latently infected cells cannot be fully eradicated. Latency-reversing agents (LRAs) are considered a potential tool...

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Matsuda K, Kobayakawa T, Kariya R, et al. A Therapeutic Strategy to Combat HIV-1 Latently Infected Cells With a Combination of Latency-Reversing Agents Containing DAG-Lactone PKC Activators. Front Microbiol. 2021;12:636276doi: 10.3389/fmicb.2021.636276.
Matsuda, K., Kobayakawa, T., Kariya, R., Tsuchiya, K., Ryu, S., Tsuji, K., Ishii, T., Gatanaga, H., Yoshimura, K., Okada, S., Hamada, A., Mitsuya, H., Tamamura, H., & Maeda, K. (2021). A Therapeutic Strategy to Combat HIV-1 Latently Infected Cells With a Combination of Latency-Reversing Agents Containing DAG-Lactone PKC Activators. Frontiers in microbiology, 12636276. https://doi.org/10.3389/fmicb.2021.636276
Matsuda, Kouki, et al. "A Therapeutic Strategy to Combat HIV-1 Latently Infected Cells With a Combination of Latency-Reversing Agents Containing DAG-Lactone PKC Activators." Frontiers in microbiology vol. 12 (2021): 636276. doi: https://doi.org/10.3389/fmicb.2021.636276
Matsuda K, Kobayakawa T, Kariya R, Tsuchiya K, Ryu S, Tsuji K, Ishii T, Gatanaga H, Yoshimura K, Okada S, Hamada A, Mitsuya H, Tamamura H, Maeda K. A Therapeutic Strategy to Combat HIV-1 Latently Infected Cells With a Combination of Latency-Reversing Agents Containing DAG-Lactone PKC Activators. Front Microbiol. 2021 Mar 17;12:636276. doi: 10.3389/fmicb.2021.636276. eCollection 2021. PMID: 33815322; PMCID: PMC8010149.
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Efficacy and Safety of Peroral Endoscopic Myotomy for Esophageal Achalasia and Achalasia-Related Diseases in Patients Aged 75 Years and Over.

Healthcare (Basel, Switzerland)

Nakamura J, Hikichi T, Hashimoto M, Takasumi M, Kato T, Kobashi R, Yanagita T, Suzuki R, Sugimoto M, Sato Y, Irie H, Takagi T, Kobayakawa M, Ohira H.
PMID: 34946392
Healthcare (Basel). 2021 Dec 01;9(12). doi: 10.3390/healthcare9121668.

Peroral endoscopic myotomy (POEM) has become a popular treatment for esophageal achalasia and other esophageal motility disorders. However, its efficacy and safety in elderly patients are unclear. To clarify that, we reviewed the medical records of patients who underwent...

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Nakamura J, Hikichi T, Hashimoto M, et al. Efficacy and Safety of Peroral Endoscopic Myotomy for Esophageal Achalasia and Achalasia-Related Diseases in Patients Aged 75 Years and Over. Healthcare (Basel). 2021;9(12)doi: 10.3390/healthcare9121668.
Nakamura, J., Hikichi, T., Hashimoto, M., Takasumi, M., Kato, T., Kobashi, R., Yanagita, T., Suzuki, R., Sugimoto, M., Sato, Y., Irie, H., Takagi, T., Kobayakawa, M., & Ohira, H. (2021). Efficacy and Safety of Peroral Endoscopic Myotomy for Esophageal Achalasia and Achalasia-Related Diseases in Patients Aged 75 Years and Over. Healthcare (Basel, Switzerland), 9(12), . https://doi.org/10.3390/healthcare9121668
Nakamura, Jun, et al. "Efficacy and Safety of Peroral Endoscopic Myotomy for Esophageal Achalasia and Achalasia-Related Diseases in Patients Aged 75 Years and Over." Healthcare (Basel, Switzerland) vol. 9,12 (2021). doi: https://doi.org/10.3390/healthcare9121668
Nakamura J, Hikichi T, Hashimoto M, Takasumi M, Kato T, Kobashi R, Yanagita T, Suzuki R, Sugimoto M, Sato Y, Irie H, Takagi T, Kobayakawa M, Ohira H. Efficacy and Safety of Peroral Endoscopic Myotomy for Esophageal Achalasia and Achalasia-Related Diseases in Patients Aged 75 Years and Over. Healthcare (Basel). 2021 Dec 01;9(12). doi: 10.3390/healthcare9121668. PMID: 34946392; PMCID: PMC8700855.
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Downregulation of Neuronal and Dendritic Connexin36-Made Electrical Synapses Without Glutamatergic Axon Terminals in Spinal Anterior Horn Cells From the Early Stage of Amyotrophic Lateral Sclerosis.

Frontiers in neuroscience

Kobayakawa Y, Masaki K, Yamasaki R, Shiraishi W, Hayashida S, Hayashi S, Okamoto K, Matsushita T, Kira JI.
PMID: 30546295
Front Neurosci. 2018 Nov 28;12:894. doi: 10.3389/fnins.2018.00894. eCollection 2018.

Connexin36 (Cx36) forms gap junctions between neurons, which are called electrical synapses, enabling adjacent neurons to communicate directly. The participation of chemical synapses in neurodegeneration in amyotrophic lateral sclerosis (ALS) has long been indicated, but it remains unclear whether...

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Kobayakawa Y, Masaki K, Yamasaki R, et al. Downregulation of Neuronal and Dendritic Connexin36-Made Electrical Synapses Without Glutamatergic Axon Terminals in Spinal Anterior Horn Cells From the Early Stage of Amyotrophic Lateral Sclerosis. Front Neurosci. 2018;12:894doi: 10.3389/fnins.2018.00894.
Kobayakawa, Y., Masaki, K., Yamasaki, R., Shiraishi, W., Hayashida, S., Hayashi, S., Okamoto, K., Matsushita, T., & Kira, J. I. (2018). Downregulation of Neuronal and Dendritic Connexin36-Made Electrical Synapses Without Glutamatergic Axon Terminals in Spinal Anterior Horn Cells From the Early Stage of Amyotrophic Lateral Sclerosis. Frontiers in neuroscience, 12894. https://doi.org/10.3389/fnins.2018.00894
Kobayakawa, Yuko, et al. "Downregulation of Neuronal and Dendritic Connexin36-Made Electrical Synapses Without Glutamatergic Axon Terminals in Spinal Anterior Horn Cells From the Early Stage of Amyotrophic Lateral Sclerosis." Frontiers in neuroscience vol. 12 (2018): 894. doi: https://doi.org/10.3389/fnins.2018.00894
Kobayakawa Y, Masaki K, Yamasaki R, Shiraishi W, Hayashida S, Hayashi S, Okamoto K, Matsushita T, Kira JI. Downregulation of Neuronal and Dendritic Connexin36-Made Electrical Synapses Without Glutamatergic Axon Terminals in Spinal Anterior Horn Cells From the Early Stage of Amyotrophic Lateral Sclerosis. Front Neurosci. 2018 Nov 28;12:894. doi: 10.3389/fnins.2018.00894. eCollection 2018. PMID: 30546295; PMCID: PMC6279874.
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Fluorescence resonance energy transfer-based screening for protein kinase C ligands using 6-methoxynaphthalene-labeled 1,2-diacylglycerol-lactones.

Organic & biomolecular chemistry

Tsuji K, Ishii T, Kobayakawa T, Ohashi N, Nomura W, Tamamura H.
PMID: 34338277
Org Biomol Chem. 2021 Oct 06;19(38):8264-8271. doi: 10.1039/d1ob00814e.

Protein kinase C (PKC) is associated with a central cellular signal transduction pathway and disorders such as cancer and Alzheimer-type dementia and is therefore a target for the treatment of these diseases. The development of simple methods suitable for...

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Tsuji K, Ishii T, Kobayakawa T, et al. Fluorescence resonance energy transfer-based screening for protein kinase C ligands using 6-methoxynaphthalene-labeled 1,2-diacylglycerol-lactones. Org Biomol Chem. 2021;19(38):8264-8271doi: 10.1039/d1ob00814e.
Tsuji, K., Ishii, T., Kobayakawa, T., Ohashi, N., Nomura, W., & Tamamura, H. (2021). Fluorescence resonance energy transfer-based screening for protein kinase C ligands using 6-methoxynaphthalene-labeled 1,2-diacylglycerol-lactones. Organic & biomolecular chemistry, 19(38), 8264-8271. https://doi.org/10.1039/d1ob00814e
Tsuji, Kohei, et al. "Fluorescence resonance energy transfer-based screening for protein kinase C ligands using 6-methoxynaphthalene-labeled 1,2-diacylglycerol-lactones." Organic & biomolecular chemistry vol. 19,38 (2021): 8264-8271. doi: https://doi.org/10.1039/d1ob00814e
Tsuji K, Ishii T, Kobayakawa T, Ohashi N, Nomura W, Tamamura H. Fluorescence resonance energy transfer-based screening for protein kinase C ligands using 6-methoxynaphthalene-labeled 1,2-diacylglycerol-lactones. Org Biomol Chem. 2021 Oct 06;19(38):8264-8271. doi: 10.1039/d1ob00814e. PMID: 34338277.
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Is it noninferiority?.

Gastrointestinal endoscopy

Kobayakawa M, Matsushita Y, Okubo H.
PMID: 29241856
Gastrointest Endosc. 2018 Jan;87(1):318. doi: 10.1016/j.gie.2017.08.026.

No abstract available.

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Kobayakawa M, Matsushita Y, Okubo H. Is it noninferiority?. Gastrointest Endosc. 2018;87(1):318doi: 10.1016/j.gie.2017.08.026.
Kobayakawa, M., Matsushita, Y., & Okubo, H. (2018). Is it noninferiority?. Gastrointestinal endoscopy, 87(1), 318. https://doi.org/10.1016/j.gie.2017.08.026
Kobayakawa, Masao, et al. "Is it noninferiority?." Gastrointestinal endoscopy vol. 87,1 (2018): 318. doi: https://doi.org/10.1016/j.gie.2017.08.026
Kobayakawa M, Matsushita Y, Okubo H. Is it noninferiority?. Gastrointest Endosc. 2018 Jan;87(1):318. doi: 10.1016/j.gie.2017.08.026. PMID: 29241856.
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Removal of Aβ Oligomers from the Blood: A Potential Therapeutic System for Alzheimer's Disease.

Neuropsychiatric disease and treatment

Saito Y, Sakata M, Kobayakawa M, Kawachi H, Kawaguchi K, Hiki Y, Kato M, Mori M, Hasegawa M, Ohashi N, Yuzawa Y, Kitaguchi N.
PMID: 32210564
Neuropsychiatr Dis Treat. 2020 Mar 03;16:607-627. doi: 10.2147/NDT.S241074. eCollection 2020.

PURPOSE: Amyloid-β protein (Aβ) is one of the causative proteins of Alzheimer's disease. We have been developing extracorporeal blood Aβ-removal systems as a method for enhancing Aβ clearance from the brain. We reported previously that medical adsorbents and hemodialyzers...

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Saito Y, Sakata M, Kobayakawa M, et al. Removal of Aβ Oligomers from the Blood: A Potential Therapeutic System for Alzheimer's Disease. Neuropsychiatr Dis Treat. 2020;16:607-627doi: 10.2147/NDT.S241074.
Saito, Y., Sakata, M., Kobayakawa, M., Kawachi, H., Kawaguchi, K., Hiki, Y., Kato, M., Mori, M., Hasegawa, M., Ohashi, N., Yuzawa, Y., & Kitaguchi, N. (2020). Removal of Aβ Oligomers from the Blood: A Potential Therapeutic System for Alzheimer's Disease. Neuropsychiatric disease and treatment, 16607-627. https://doi.org/10.2147/NDT.S241074
Saito, Yuta, et al. "Removal of Aβ Oligomers from the Blood: A Potential Therapeutic System for Alzheimer's Disease." Neuropsychiatric disease and treatment vol. 16 (2020): 607-627. doi: https://doi.org/10.2147/NDT.S241074
Saito Y, Sakata M, Kobayakawa M, Kawachi H, Kawaguchi K, Hiki Y, Kato M, Mori M, Hasegawa M, Ohashi N, Yuzawa Y, Kitaguchi N. Removal of Aβ Oligomers from the Blood: A Potential Therapeutic System for Alzheimer's Disease. Neuropsychiatr Dis Treat. 2020 Mar 03;16:607-627. doi: 10.2147/NDT.S241074. eCollection 2020. PMID: 32210564; PMCID: PMC7064818.
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Multi-Sip Time⁻Intensity Evaluation of Retronasal Aroma after Swallowing Oolong Tea Beverage.

Foods (Basel, Switzerland)

Gotow N, Omata T, Uchida M, Matsuzaki N, Takata S, Hagiwara I, Kobayakawa T.
PMID: 30366388
Foods. 2018 Oct 25;7(11). doi: 10.3390/foods7110177.

In most cases, a meal cannot be finished with a single bite and sip. During eating and drinking, consumers receive dynamic food perceptions from sensory attributes in foods. Thus, we performed multi-sip time⁻intensity (TI) evaluation of sensory attribute. In...

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Gotow N, Omata T, Uchida M, et al. Multi-Sip Time⁻Intensity Evaluation of Retronasal Aroma after Swallowing Oolong Tea Beverage. Foods. 2018;7(11)doi: 10.3390/foods7110177.
Gotow, N., Omata, T., Uchida, M., Matsuzaki, N., Takata, S., Hagiwara, I., & Kobayakawa, T. (2018). Multi-Sip Time⁻Intensity Evaluation of Retronasal Aroma after Swallowing Oolong Tea Beverage. Foods (Basel, Switzerland), 7(11), . https://doi.org/10.3390/foods7110177
Gotow, Naomi, et al. "Multi-Sip Time⁻Intensity Evaluation of Retronasal Aroma after Swallowing Oolong Tea Beverage." Foods (Basel, Switzerland) vol. 7,11 (2018). doi: https://doi.org/10.3390/foods7110177
Gotow N, Omata T, Uchida M, Matsuzaki N, Takata S, Hagiwara I, Kobayakawa T. Multi-Sip Time⁻Intensity Evaluation of Retronasal Aroma after Swallowing Oolong Tea Beverage. Foods. 2018 Oct 25;7(11). doi: 10.3390/foods7110177. PMID: 30366388; PMCID: PMC6262627.
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Corrigendum to "Behavioral activation can normalize neural hypoactivation in subthreshold depression during a monetary incentive delay task" [J. Affect. Disord. 189 (2016) 254-262].

Journal of affective disorders

Mori A, Okamoto Y, Okada G, Takagaki K, Jinnin R, Takamura M, Kobayakawa M, Yamawaki S.
PMID: 27955756
J Affect Disord. 2017 Jan 15;208:670. doi: 10.1016/j.jad.2015.12.023. Epub 2015 Dec 19.

No abstract available.

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Mori A, Okamoto Y, Okada G, et al. Corrigendum to "Behavioral activation can normalize neural hypoactivation in subthreshold depression during a monetary incentive delay task" [J. Affect. Disord. 189 (2016) 254-262]. J Affect Disord. 2015;208:670doi: 10.1016/j.jad.2015.12.023.
Mori, A., Okamoto, Y., Okada, G., Takagaki, K., Jinnin, R., Takamura, M., Kobayakawa, M., & Yamawaki, S. (2017). Corrigendum to "Behavioral activation can normalize neural hypoactivation in subthreshold depression during a monetary incentive delay task" [J. Affect. Disord. 189 (2016) 254-262]. Journal of affective disorders, 208670. https://doi.org/10.1016/j.jad.2015.12.023
Mori, Asako, et al. "Corrigendum to "Behavioral activation can normalize neural hypoactivation in subthreshold depression during a monetary incentive delay task" [J. Affect. Disord. 189 (2016) 254-262]." Journal of affective disorders vol. 208 (2017): 670. doi: https://doi.org/10.1016/j.jad.2015.12.023
Mori A, Okamoto Y, Okada G, Takagaki K, Jinnin R, Takamura M, Kobayakawa M, Yamawaki S. Corrigendum to "Behavioral activation can normalize neural hypoactivation in subthreshold depression during a monetary incentive delay task" [J. Affect. Disord. 189 (2016) 254-262]. J Affect Disord. 2017 Jan 15;208:670. doi: 10.1016/j.jad.2015.12.023. Epub 2015 Dec 19. PMID: 27955756.
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Application of 2-pyridyl-substituted hemithioindigo as a molecular switch in hydrogen-bonded porphyrins.

The Journal of organic chemistry

Tanaka K, Kohayakawa K, Iwata S, Irie T.
PMID: 18429634
J Org Chem. 2008 May 16;73(10):3768-74. doi: 10.1021/jo800091d. Epub 2008 Apr 23.

When the photochromism of 2-(3'-pyridylmethylene)-7-ethylbenzo[b]thiophen-3(2H)-ones (4) was investigated, high thermal stability of the E isomer of 4, 4(E) and good repeatability of the photoinduced E,Z-isomerization were found. Association constants of the 1:1 complexations of 4(Z) and 4(E) with the...

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Tanaka K, Kohayakawa K, Iwata S, et al. Application of 2-pyridyl-substituted hemithioindigo as a molecular switch in hydrogen-bonded porphyrins. J Org Chem. 2008;73(10):3768-74doi: 10.1021/jo800091d.
Tanaka, K., Kohayakawa, K., Iwata, S., & Irie, T. (2008). Application of 2-pyridyl-substituted hemithioindigo as a molecular switch in hydrogen-bonded porphyrins. The Journal of organic chemistry, 73(10), 3768-74. https://doi.org/10.1021/jo800091d
Tanaka, Kiyoshi, et al. "Application of 2-pyridyl-substituted hemithioindigo as a molecular switch in hydrogen-bonded porphyrins." The Journal of organic chemistry vol. 73,10 (2008): 3768-74. doi: https://doi.org/10.1021/jo800091d
Tanaka K, Kohayakawa K, Iwata S, Irie T. Application of 2-pyridyl-substituted hemithioindigo as a molecular switch in hydrogen-bonded porphyrins. J Org Chem. 2008 May 16;73(10):3768-74. doi: 10.1021/jo800091d. Epub 2008 Apr 23. PMID: 18429634.
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A sleep-like state in .

Science advances

Kanaya HJ, Park S, Kim JH, Kusumi J, Krenenou S, Sawatari E, Sato A, Lee J, Bang H, Kobayakawa Y, Lim C, Itoh TQ.
PMID: 33028524
Sci Adv. 2020 Oct 07;6(41). doi: 10.1126/sciadv.abb9415. Print 2020 Oct.

Sleep behaviors are observed even in nematodes and arthropods, yet little is known about how sleep-regulatory mechanisms have emerged during evolution. Here, we report a sleep-like state in the cnidarian

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Kanaya HJ, Park S, Kim JH, et al. A sleep-like state in . Sci Adv. 2020;6(41)doi: 10.1126/sciadv.abb9415.
Kanaya, H. J., Park, S., Kim, J. H., Kusumi, J., Krenenou, S., Sawatari, E., Sato, A., Lee, J., Bang, H., Kobayakawa, Y., Lim, C., & Itoh, T. Q. (2020). A sleep-like state in . Science advances, 6(41), . https://doi.org/10.1126/sciadv.abb9415
Kanaya, Hiroyuki J, et al. "A sleep-like state in ." Science advances vol. 6,41 (2020). doi: https://doi.org/10.1126/sciadv.abb9415
Kanaya HJ, Park S, Kim JH, Kusumi J, Krenenou S, Sawatari E, Sato A, Lee J, Bang H, Kobayakawa Y, Lim C, Itoh TQ. A sleep-like state in . Sci Adv. 2020 Oct 07;6(41). doi: 10.1126/sciadv.abb9415. Print 2020 Oct. PMID: 33028524; PMCID: PMC7541080.
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