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Showing 1 to 12 of 50 entries
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Encouraging 5-year olds to attend to landmarks: a way to improve children's wayfinding strategies in a virtual environment.

Frontiers in psychology

Lingwood J, Blades M, Farran EK, Courbois Y, Matthews D.
PMID: 25814960
Front Psychol. 2015 Mar 12;6:174. doi: 10.3389/fpsyg.2015.00174. eCollection 2015.

Wayfinding is defined as the ability to learn and remember a route through an environment. Previous researchers have shown that young children have difficulties remembering routes. However, very few researchers have considered how to improve young children's wayfinding abilities....

Structure, organization and tissue expression of the pig .

Biochemistry and biophysics reports

Barnes SK, Eiby YA, Lee S, Lingwood BE, Dawson PA.
PMID: 28955749
Biochem Biophys Rep. 2017 Apr 13;10:215-223. doi: 10.1016/j.bbrep.2017.04.005. eCollection 2017 Jul.

Sulfate is an obligate nutrient for fetal growth and development. In mice, the renal Slc13a1 sulfate transporter maintains high maternal circulating levels of sulfate in pregnancy, and the placental Slc13a4 sulfate transporter mediates sulfate supply to the fetus. Both...

Endogenous angiotensins and catecholamines do not reduce skin blood flow or prevent hypotension in preterm piglets.

Physiological reports

Eiby YA, Lumbers ER, Staunton MP, Wright LL, Colditz PB, Wright IM, Lingwood BE.
PMID: 25538149
Physiol Rep. 2014 Dec 23;2(12). doi: 10.14814/phy2.12245. Print 2014 Dec 01.

Endocrine control of cardiovascular function is probably immature in the preterm infant; thus, it may contribute to the relative ineffectiveness of current adrenergic treatments for preterm cardiovascular compromise. This study aimed to determine the cardiovascular and hormonal responses to...

Glycolipid-Dependent, Protease Sensitive Internalization of Pseudomonas aeruginosa Into Cultured Human Respiratory Epithelial Cells.

The open microbiology journal

Emam A, Carter WG, Lingwood C.
PMID: 21270937
Open Microbiol J. 2010 Dec 13;4:106-15. doi: 10.2174/1874285801004010106.

Internalization of PAK strain Pseudomonas aeruginosa into human respiratory epithelial cell lines and HeLa cervical cancer cells in vitro was readily demonstrable via a gentamycin protection assay. Depletion of target cell glycosphingolipids (GSLs) using a glucosyl ceramide synthase inhibitor,...

Novel in vitro booster vaccination to rapidly generate antigen-specific human monoclonal antibodies.

The Journal of experimental medicine

Sanjuan Nandin I, Fong C, Deantonio C, Torreno-Pina JA, Pecetta S, Maldonado P, Gasparrini F, Ordovas-Montanes J, Kazer SW, Kjaer S, Borley DW, Nair U, Coleman JA, Lingwood D, Shalek AK, Meffre E, Poignard P, Burton DR, Batista FD.
PMID: 28739603
J Exp Med. 2017 Aug 07;214(8):2471-2490. doi: 10.1084/jem.20170633.

Vaccines remain the most effective tool to prevent infectious diseases. Here, we introduce an in vitro booster vaccination approach that relies on antigen-dependent activation of human memory B cells in culture. This stimulation induces antigen-specific B cell proliferation, differentiation...

Fecal SARS-CoV-2 RNA is associated with decreased COVID-19 survival.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Das Adhikari U, Eng G, Farcasanu M, Avena LE, Choudhary MC, Triant VA, Flagg M, Schiff AE, Gomez I, Froehle LM, Diefenbach TJ, Ronsard L, Lingwood D, Lee GC, Rabi SA, Erstad D, Velmahos G, Li JZ, Hodin R, Stone JR, Honko AN, Griffiths A, Yilmaz O, Kwon DS.
PMID: 34245255
Clin Infect Dis. 2021 Jul 10; doi: 10.1093/cid/ciab623. Epub 2021 Jul 10.

The clinical significance of SARS CoV-2 RNA in stool remains uncertain. We found that extrapulmonary dissemination of infection to the gastrointestinal (GI) tract, assessed by the presence of SARS-CoV-2 RNA in stool, is associated with decreased COVID-19 survival. Measurement...

The Loss of Bcl-6 Expressing T Follicular Helper Cells and the Absence of Germinal Centers in COVID-19.

SSRN

Kaneko N, Kuo HH, Boucau J, Farmer JR, Allard-Chamard H, Mahajan VS, Piechocka-Trocha A, Lefteri K, Osborn M, Bals J, Bartsch YC, Bonheur N, Caradonna TM, Chevalier J, Chowdhury F, Diefenbach TJ, Einkauf K, Fallon J, Feldman J, Finn KK, Garcia-Broncano P, Hartana CA, Hauser BM, Jiang C, Kaplonek P, Karpell M, Koscher EC, Lian X, Liu H, Liu J, Ly NL, Michell AR, Rassadkina Y, Seiger K, Sessa L, Shin S, Singh N, Sun W, Sun X, Ticheli HJ, Waring MT, Zhu AL, Li J, Lingwood D, Schmidt AG, Lichterfeld M, Walker BD, Yu X, Padera RF, Pillai S.
PMID: 32742244
SSRN. 2020 Jul 16;3652322. doi: 10.2139/ssrn.3652322.

Humoral responses in COVID-19 disease are often of limited durability, as seen with other human coronavirus epidemics. To address the underlying etiology, we examined postmortem thoracic lymph nodes and spleens in acute SARS-CoV-2 infection and observed the absence of...

Mannose-binding lectin and complement mediate follicular localization and enhanced immunogenicity of diverse protein nanoparticle immunogens.

Cell reports

Read BJ, Won L, Kraft JC, Sappington I, Aung A, Wu S, Bals J, Chen C, Lee KK, Lingwood D, King NP, Irvine DJ.
PMID: 35021101
Cell Rep. 2022 Jan 11;38(2):110217. doi: 10.1016/j.celrep.2021.110217.

Nanoparticle (NP) vaccine formulations promote immune responses through multiple mechanisms. We recently reported that mannose-binding lectin (MBL) triggers trafficking of glycosylated HIV Env-immunogen NPs to lymph node follicles. Here, we investigate effects of MBL and complement on NP forms...

Naive human B cells engage the receptor binding domain of SARS-CoV-2, variants of concern, and related sarbecoviruses.

bioRxiv : the preprint server for biology

Feldman J, Bals J, Altomare CG, St Denis K, Lam EC, Hauser BM, Ronsard L, Sangesland M, Moreno TB, Okonkwo V, Hartojo N, Balazs AB, Bajic G, Lingwood D, Schmidt AG.
PMID: 33594359
bioRxiv. 2021 Jul 09; doi: 10.1101/2021.02.02.429458.

Exposure to a pathogen elicits an adaptive immune response aimed to control and eradicate. Interrogating the abundance and specificity of the naive B cell repertoire contributes to understanding how to potentially elicit protective responses. Here, we isolated naive B...

A particulate saponin/TLR agonist vaccine adjuvant alters lymph flow and modulates adaptive immunity.

Science immunology

Silva M, Kato Y, Melo MB, Phung I, Freeman BL, Li Z, Roh K, Van Wijnbergen JW, Watkins H, Enemuo CA, Hartwell BL, Chang JYH, Xiao S, Rodrigues KA, Cirelli KM, Li N, Haupt S, Aung A, Cossette B, Abraham W, Kataria S, Bastidas R, Bhiman J, Linde C, Bloom NI, Groschel B, Georgeson E, Phelps N, Thomas A, Bals J, Carnathan DG, Lingwood D, Burton DR, Alter G, Padera TP, Belcher AM, Schief WR, Silvestri G, Ruprecht RM, Crotty S, Irvine DJ.
PMID: 34860581
Sci Immunol. 2021 Dec 03;6(66):eabf1152. doi: 10.1126/sciimmunol.abf1152. Epub 2021 Dec 03.

[Figure: see text].

Correction: Novel in vitro booster vaccination to rapidly generate antigen-specific human monoclonal antibodies.

The Journal of experimental medicine

Nandin IS, Fong C, Deantonio C, Torreno-Pina JA, Pecetta S, Maldonado P, Gasparrini F, Ordovas-Montanes J, Kazer SW, Kjaer S, Borley DW, Nair U, Coleman JA, Lingwood D, Shalek AK, Meffre E, Poignard P, Burton DR, Batista FD.
PMID: 28827449
J Exp Med. 2017 Sep 04;214(9):2811. doi: 10.1084/jem.2017063307262017c. Epub 2017 Aug 21.

No abstract available.

Humidity-modulated phase control and nanoscopic transport in supramolecular assemblies.

The journal of physical chemistry. B

Chen Y, Lingwood MD, Goswami M, Kidd BE, Hernandez JJ, Rosenthal M, Ivanov DA, Perlich J, Zhang H, Zhu X, Möller M, Madsen LA.
PMID: 24555816
J Phys Chem B. 2014 Mar 20;118(11):3207-17. doi: 10.1021/jp409266r. Epub 2014 Mar 07.

Supramolecular assembly allows for enhanced control of bulk material properties through the fine modulation of intermolecular interactions. We present a comprehensive study of a cross-linkable amphiphilic wedge molecule based on a sulfonated trialkoxybenzene with a sodium counterion that forms...

Showing 1 to 12 of 50 entries