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Showing 1 to 12 of 140 entries
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In vivo imaging reveals rapid astrocyte depletion and axon damage in a model of neuromyelitis optica-related pathology.

Annals of neurology

Herwerth M, Kalluri SR, Srivastava R, Kleele T, Kenet S, Illes Z, Merkler D, Bennett JL, Misgeld T, Hemmer B.
PMID: 26946517
Ann Neurol. 2016 May;79(5):794-805. doi: 10.1002/ana.24630. Epub 2016 Apr 18.

OBJECTIVE: Neuromyelitis optica (NMO) is an autoimmune disease of the central nervous system, which resembles multiple sclerosis (MS). NMO differs from MS, however, in the distribution and histology of neuroinflammatory lesions and shows a more aggressive clinical course. Moreover,...

Homeostatic regulation of adult hippocampal neurogenesis in aging rats: long-term effects of early exercise.

Frontiers in neuroscience

Merkley CM, Jian C, Mosa A, Tan YF, Wojtowicz JM.
PMID: 25071426
Front Neurosci. 2014 Jul 01;8:174. doi: 10.3389/fnins.2014.00174. eCollection 2014.

Adult neurogenesis is highly responsive to environmental and physiological factors. The majority of studies to date have examined short-term consequences of enhancing or blocking neurogenesis but long-term changes remain less well understood. Current evidence for age-related declines in neurogenesis...

Corpus Callosum Area in Children and Adults with Autism.

Research in autism spectrum disorders

Prigge MB, Lange N, Bigler ED, Merkley TL, Neeley ES, Abildskov TJ, Froehlich AL, Nielsen JA, Cooperrider JR, Cariello AN, Ravichandran C, Alexander AL, Lainhart JE.
PMID: 23130086
Res Autism Spectr Disord. 2013;7(2):221-234. doi: 10.1016/j.rasd.2012.09.007. Epub 2012 Nov 01.

Despite repeated findings of abnormal corpus callosum structure in autism, the developmental trajectories of corpus callosum growth in the disorder have not yet been reported. In this study, we examined corpus callosum size from a developmental perspective across a...

Letter to the editor: 'Human based systems: Mechanistic NASH modelling just around the corner?'.

Pharmacological research

Morgan K, Fassoula V, Samuel K, Morley SD, Hayes PC, Plevris JN.
PMID: 30315964
Pharmacol Res. 2018 Nov;137:280-281. doi: 10.1016/j.phrs.2018.09.028. Epub 2018 Oct 10.

No abstract available.

Pediatric Antimicrobial Stewardship: State of the Art.

Current infectious disease reports

Godbout EJ, Pakyz AL, Markley JD, Noda AJ, Stevens MP.
PMID: 30069834
Curr Infect Dis Rep. 2018 Aug 01;20(10):39. doi: 10.1007/s11908-018-0644-7.

PURPOSE OF REVIEW: We aim to systematically review the literature on the effectiveness of pediatric antimicrobial stewardship programs (ASPs) and antimicrobial stewardship (AS) strategies in the United States (US) inpatient setting. Furthermore, we review current gaps and challenges for...

High-frequency induction of adventitious shoots from hypocotyl segments ofLiquidambar styracifiua L. by thidiazuron.

Plant cell reports

Kim MK, Sommer HE, Bongarten BC, Merkle SA.
PMID: 30727574
Plant Cell Rep. 1997 May;16(8):536-540. doi: 10.1007/BF01142319.

The effects of thidiazuron (TDZ) on adventitious bud and shoot formation from hypocotyl segments of sweetgum (Liquidambar styracifiua) were tested alone and in combination with 2,4-dichlorophenoxyacetic acid (2,4-D). The combination of 1 mg/1 TDZ with 0.01 mg/l 2,4-D resulted...

Generic Context-Aware Group Contributions.

IEEE/ACM transactions on computational biology and bioinformatics

Flamm C, Hellmuth M, Merkle D, Nojgaard N, Stadler PF.
PMID: 32750852
IEEE/ACM Trans Comput Biol Bioinform. 2020 Jun 01; doi: 10.1109/TCBB.2020.2998948. Epub 2020 Jun 01.

Many properties of molecules vary systematically with changes in the structural formula and can thus be estimated from regression models defined on small structural building blocks, usually functional groups. Typically, such approaches are limited to a particular class of...

Superconductivity in the ferromagnetic phase of polycrystalline HoMo6S8 films.

Physical review. B, Condensed matter

Berkley DD, Goldman AM, Kang JH, Maps J.
PMID: 9940567
Phys Rev B Condens Matter. 1987 Jan 01;35(1):38-42. doi: 10.1103/physrevb.35.38.

No abstract available.

TSPO PET imaging of natalizumab-associated progressive multifocal leukoencephalopathy.

Brain : a journal of neurology

Mahler C, Schumacher AM, Unterrainer M, Kaiser L, Höllbacher T, Lindner S, Havla J, Ertl-Wagner B, Patzig M, Seelos K, Neitzel J, Mäurer M, Krumbholz M, Metz I, Brück W, Stadelmann C, Merkler D, Gass A, Milenkovic V, Bartenstein P, Albert NL, Kümpfel T, Kerschensteiner M.
PMID: 33757118
Brain. 2021 Oct 22;144(9):2683-2695. doi: 10.1093/brain/awab127.

Progressive multifocal leukoencephalopathy (PML) is a severe infection of the CNS caused by the polyomavirus JC that can occur in multiple sclerosis patients treated with natalizumab. Clinical management of patients with natalizumab-associated PML is challenging not least because current...

Tauopathy induces degeneration and impairs regeneration of sensory nerves in the cornea.

Experimental eye research

Li S, Shi S, Luo B, Xia F, Ha Y, Merkley KH, Motamedi M, Zhang W, Liu H.
PMID: 34929160
Exp Eye Res. 2021 Dec 18;215:108900. doi: 10.1016/j.exer.2021.108900. Epub 2021 Dec 18.

The cornea is transparent and innervated by a dense collection of sensory nerves originating from the ocular branch of the trigeminal nerve. This study was designed to comprehensively analyze alterations of corneal sub-basal nerve plexus in a mouse model...

Tauopathy induces degeneration and impairs regeneration of sensory nerves in the cornea.

Experimental eye research

Li S, Shi S, Luo B, Xia F, Ha Y, Merkley KH, Motamedi M, Zhang W, Liu H.
PMID: 34929160
Exp Eye Res. 2021 Dec 18;215:108900. doi: 10.1016/j.exer.2021.108900. Epub 2021 Dec 18.

The cornea is transparent and innervated by a dense collection of sensory nerves originating from the ocular branch of the trigeminal nerve. This study was designed to comprehensively analyze alterations of corneal sub-basal nerve plexus in a mouse model...

Tauopathy induces degeneration and impairs regeneration of sensory nerves in the cornea.

Experimental eye research

Li S, Shi S, Luo B, Xia F, Ha Y, Merkley KH, Motamedi M, Zhang W, Liu H.
PMID: 34929160
Exp Eye Res. 2021 Dec 18;215:108900. doi: 10.1016/j.exer.2021.108900. Epub 2021 Dec 18.

The cornea is transparent and innervated by a dense collection of sensory nerves originating from the ocular branch of the trigeminal nerve. This study was designed to comprehensively analyze alterations of corneal sub-basal nerve plexus in a mouse model...

Showing 1 to 12 of 140 entries