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Showing 1 to 12 of 209 entries
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Comparative effectiveness of surgical interventions aimed at treating underlying venous pathology in patients with chronic venous ulcer.

Journal of vascular surgery. Venous and lymphatic disorders

Malas MB, Qazi U, Lazarus G, Valle MF, Wilson LM, Haberl EB, Bass EB, Zenilman J.
PMID: 26993193
J Vasc Surg Venous Lymphat Disord. 2014 Apr;2(2):212-25. doi: 10.1016/j.jvsv.2013.10.002. Epub 2013 Dec 13.

OBJECTIVE: Chronic venous ulcers (CVUs) remain the leading causes for nonhealing wounds in the lower extremities. Although multilayer compression dressing remains the treatment gold standard, there are various surgical procedures aimed at healing CVUs with little or no evidence...

(1) Two Cases of Cervical Ribs. (2) An Anomalous Arrangement of the Vagi.

Journal of anatomy and physiology

Lucas MF.
PMID: 17233034
J Anat Physiol. 1915 Apr;49:336-42.

No abstract available.

Network-based target ranking for polypharmacological therapies.

Journal of biomedical informatics

Vitali F, Mulas F, Marini P, Bellazzi R.
PMID: 23850841
J Biomed Inform. 2013 Oct;46(5):876-81. doi: 10.1016/j.jbi.2013.06.015. Epub 2013 Jul 10.

With the growing understanding of complex diseases, the focus of drug discovery has shifted from the well-accepted "one target, one drug" model, to a new "multi-target, multi-drug" model, aimed at systemically modulating multiple targets. In this context, polypharmacology has...

Morphometric development of sphincter of oddi in human fetuses during fetal period: microscopic study.

Balkan medical journal

Desdicioğlu K, Bozkurt KK, Uğuz C, Evcil EH, Malas MA.
PMID: 25207017
Balkan Med J. 2012 Sep;29(3):290-4. doi: 10.5152/balkanmedj.2012.013. Epub 2012 Sep 01.

OBJECTIVE: In this study, morphometric developments of the sphincter of Oddi in human fetuses were observed.MATERIAL AND METHODS: We observed 113 human fetuses consisting of 67 male and 46 female subjects, whose ages varied between 14 to 40 weeks...

[Psychogenic paroxysmal disorders in children].

Revista de neurologia

Morant A, Mulas F.
PMID: 10101772
Rev Neurol. 1999 Jan 1-15;28(1):81-3.

INTRODUCTION: Paroxystic psychic disorders which imitate organic disorders of the nervous system may have peripheral effects, present as changes in level of consciousness or appear as paroxystic behaviour changes.DEVELOPMENT AND CONCLUSIONS: The types of crises of psychological origin are:...

Ethanol-Induced Behavioral Sensitization Alters the Synaptic Transcriptome and Exon Utilization in DBA/2J Mice.

Frontiers in genetics

O'Brien MA, Weston RM, Sheth NU, Bradley S, Bigbee J, Pandey A, Williams RW, Wolstenholme JT, Miles MF.
PMID: 30319688
Front Genet. 2018 Sep 24;9:402. doi: 10.3389/fgene.2018.00402. eCollection 2018.

Alcoholism is a complex behavioral disorder characterized by loss of control in limiting intake, and progressive compulsion to seek and consume ethanol. Prior studies have suggested that the characteristic behaviors associated with escalation of drug use are caused, at...

Candidate serum metabolite biomarkers for differentiating gastroesophageal reflux disease, Barrett's esophagus, and high-grade dysplasia/esophageal adenocarcinoma.

Metabolomics : Official journal of the Metabolomic Society

Buas MF, Gu H, Djukovic D, Zhu J, Onstad L, Reid BJ, Raftery D, Vaughan TL.
PMID: 28190989
Metabolomics. 2017 Mar;13(3). doi: 10.1007/s11306-016-1154-y. Epub 2017 Jan 20.

INTRODUCTION/OBJECTIVES: Incidence of esophageal adenocarcinoma (EA), an often fatal cancer, has increased sharply over recent decades. Several important risk factors (reflux, obesity, smoking) have been identified for EA and its precursor, Barrett's esophagus (BE), but a key challenge remains...

Whole-genome sequencing of esophageal adenocarcinoma in Chinese patients reveals distinct mutational signatures and genomic alterations.

Communications biology

Dai JY, Wang X, Buas MF, Zhang C, Ma J, Wei B, Li Y, Zhao B, Hyun TS, Chen X, Loeb KR, Odze R, Yao L, Sun X, Self S, Vaughan TL, Guo Y.
PMID: 30374464
Commun Biol. 2018 Oct 24;1:174. doi: 10.1038/s42003-018-0182-8. eCollection 2018.

While the incidence of esophageal adenocarcinoma (EAC) has risen drastically in Western countries over the last 40 years, a similar trend has not been observed for EAC in China. Here, we analyzed mutational spectrum, copy number alterations, and structural...

An IKK/NF-κB Activation/p53 Deletion Sequence Drives Liver Carcinogenesis and Tumor Differentiation.

Cancers

Svinarenko M, Katz SF, Tharehalli U, Mulaw MA, Maier HJ, Sunami Y, Fischer SK, Chen Y, Heurich S, Erkert L, Tannapfel A, Wirth T, Schirmbeck R, Seufferlein T, Lechel A.
PMID: 31546614
Cancers (Basel). 2019 Sep 21;11(10). doi: 10.3390/cancers11101410.

CONCLUSIONS: In conclusion, activation of NF-κB/p65 mimicking chronic inflammation provokes the formation of liver carcinoma. Collateral disruption of

The deubiquitinase OTUB1 augments NF-κB-dependent immune responses in dendritic cells in infection and inflammation by stabilizing UBC13.

Cellular & molecular immunology

Mulas F, Wang X, Song S, Nishanth G, Yi W, Brunn A, Larsen PK, Isermann B, Kalinke U, Barragan A, Naumann M, Deckert M, Schlüter D.
PMID: 32024978
Cell Mol Immunol. 2021 Jun;18(6):1512-1527. doi: 10.1038/s41423-020-0362-6. Epub 2020 Feb 05.

Dendritic cells (DCs) are indispensable for defense against pathogens but may also contribute to immunopathology. Activation of DCs upon the sensing of pathogens by Toll-like receptors (TLRs) is largely mediated by pattern recognition receptor/nuclear factor-κB (NF-κB) signaling and depends...

Genes Relevant to Tissue Response to Cancer Therapy Display Diurnal Variation in mRNA Expression in Human Oral Mucosa.

Journal of circadian rhythms

Gu F, Gomez EC, Chen J, Buas MF, Schlecht NF, Hulme K, Kulkarni SV, Singh PK, O'Connor R, Ambrosone CB, Singh AK, Wang J.
PMID: 34221066
J Circadian Rhythms. 2021 Jun 17;19:8. doi: 10.5334/jcr.213.

BACKGROUND: To address a critical gap for application of cancer chronotherapy of when would be the best time(s) for treating an individual cancer patient, we conducted a pilot study to characterize diurnal variations of gene expression in oral mucosal...

The influence of light and temperature on detritus degradation rates for kelp species with contrasting thermal affinities.

Marine environmental research

Frontier N, Mulas M, Foggo A, Smale DA.
PMID: 34800869
Mar Environ Res. 2021 Nov 14;173:105529. doi: 10.1016/j.marenvres.2021.105529. Epub 2021 Nov 14.

Kelp detritus fuels coastal food webs and may play an important role as a source of organic matter for natural carbon sequestration. Here, we conducted ex situ and in situ manipulations to evaluate the role of temperature and light...

Showing 1 to 12 of 209 entries